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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29076

FusionGeneSummary for PSD3_PAGE4

check button Fusion gene summary
Fusion gene informationFusion gene name: PSD3_PAGE4
Fusion gene ID: 29076
HgeneTgene
Gene symbol

PSD3

PAGE4

Gene ID

23362

9506

Gene namepleckstrin and Sec7 domain containing 3PAGE family member 4
SynonymsEFA6D|EFA6R|HCA67CT16.7|GAGE-9|GAGEC1|JM-27|JM27|PAGE-1|PAGE-4
Cytomap

8p22

Xp11.23

Type of geneprotein-codingprotein-coding
DescriptionPH and SEC7 domain-containing protein 3ADP-ribosylation factor guanine nucleotide factor 6epididymis tissue protein Li 20mPexchange factor for ADP-ribosylation factor guanine nucleotide factor 6exchange factor for ADP-ribosylation factor guanine nucleP antigen family member 4P antigen family, member 4 (prostate associated)g antigen family C member 1prostate-associated gene protein 4
Modification date2018052320180329
UniProtAcc

Q9NYI0

O60829

Ensembl transtripts involved in fusion geneENST00000327040, ENST00000440756, 
ENST00000286485, ENST00000428502, 
ENST00000523619, ENST00000520789, 
ENST00000376141, ENST00000218068, 
ENST00000478785, 
Fusion gene scores* DoF score8 X 7 X 6=3362 X 1 X 2=4
# samples 82
** MAII scorelog2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: PSD3 [Title/Abstract] AND PAGE4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A2-A04U-01APSD3chr8

18871073

-PAGE4chrX

49595002

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000327040ENST00000376141PSD3chr8

18871073

-PAGE4chrX

49595002

+
5CDS-5UTRENST00000327040ENST00000218068PSD3chr8

18871073

-PAGE4chrX

49595002

+
5CDS-3UTRENST00000327040ENST00000478785PSD3chr8

18871073

-PAGE4chrX

49595002

+
5CDS-5UTRENST00000440756ENST00000376141PSD3chr8

18871073

-PAGE4chrX

49595002

+
5CDS-5UTRENST00000440756ENST00000218068PSD3chr8

18871073

-PAGE4chrX

49595002

+
5CDS-3UTRENST00000440756ENST00000478785PSD3chr8

18871073

-PAGE4chrX

49595002

+
intron-5UTRENST00000286485ENST00000376141PSD3chr8

18871073

-PAGE4chrX

49595002

+
intron-5UTRENST00000286485ENST00000218068PSD3chr8

18871073

-PAGE4chrX

49595002

+
intron-3UTRENST00000286485ENST00000478785PSD3chr8

18871073

-PAGE4chrX

49595002

+
intron-5UTRENST00000428502ENST00000376141PSD3chr8

18871073

-PAGE4chrX

49595002

+
intron-5UTRENST00000428502ENST00000218068PSD3chr8

18871073

-PAGE4chrX

49595002

+
intron-3UTRENST00000428502ENST00000478785PSD3chr8

18871073

-PAGE4chrX

49595002

+
intron-5UTRENST00000523619ENST00000376141PSD3chr8

18871073

-PAGE4chrX

49595002

+
intron-5UTRENST00000523619ENST00000218068PSD3chr8

18871073

-PAGE4chrX

49595002

+
intron-3UTRENST00000523619ENST00000478785PSD3chr8

18871073

-PAGE4chrX

49595002

+
intron-5UTRENST00000520789ENST00000376141PSD3chr8

18871073

-PAGE4chrX

49595002

+
intron-5UTRENST00000520789ENST00000218068PSD3chr8

18871073

-PAGE4chrX

49595002

+
intron-3UTRENST00000520789ENST00000478785PSD3chr8

18871073

-PAGE4chrX

49595002

+

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FusionProtFeatures for PSD3_PAGE4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PSD3

Q9NYI0

PAGE4

O60829

Guanine nucleotide exchange factor for ARF6.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PSD3_PAGE4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PSD3_PAGE4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PSD3MLH1, PMS2, ARAP1, MX1, TP53, CTDSPL, PTPRA, PTPRGPAGE4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PSD3_PAGE4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PSD3_PAGE4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePSD3C0017638Glioma1CTD_human
HgenePSD3C0036341Schizophrenia1PSYGENET
HgenePSD3C0236733Amphetamine-Related Disorders1CTD_human
TgenePAGE4C0027626Neoplasm Invasiveness1CTD_human