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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29072

FusionGeneSummary for PSD3_GNGT1

check button Fusion gene summary
Fusion gene informationFusion gene name: PSD3_GNGT1
Fusion gene ID: 29072
HgeneTgene
Gene symbol

PSD3

GNGT1

Gene ID

23362

2792

Gene namepleckstrin and Sec7 domain containing 3G protein subunit gamma transducin 1
SynonymsEFA6D|EFA6R|HCA67GNG1
Cytomap

8p22

7q21.3

Type of geneprotein-codingprotein-coding
DescriptionPH and SEC7 domain-containing protein 3ADP-ribosylation factor guanine nucleotide factor 6epididymis tissue protein Li 20mPexchange factor for ADP-ribosylation factor guanine nucleotide factor 6exchange factor for ADP-ribosylation factor guanine nucleguanine nucleotide-binding protein G(T) subunit gamma-T1guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1transducin gamma chain
Modification date2018052320180523
UniProtAcc

Q9NYI0

P63211

Ensembl transtripts involved in fusion geneENST00000327040, ENST00000440756, 
ENST00000286485, ENST00000428502, 
ENST00000523619, ENST00000520789, 
ENST00000455502, ENST00000248572, 
ENST00000429473, ENST00000430875, 
ENST00000428834, 
Fusion gene scores* DoF score8 X 7 X 6=3366 X 6 X 3=108
# samples 86
** MAII scorelog2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PSD3 [Title/Abstract] AND GNGT1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1X93851PSD3chr8

18441287

-GNGT1chr7

93346824

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000327040ENST00000455502PSD3chr8

18441287

-GNGT1chr7

93346824

+
intron-intronENST00000327040ENST00000248572PSD3chr8

18441287

-GNGT1chr7

93346824

+
intron-intronENST00000327040ENST00000429473PSD3chr8

18441287

-GNGT1chr7

93346824

+
intron-intronENST00000327040ENST00000430875PSD3chr8

18441287

-GNGT1chr7

93346824

+
intron-intronENST00000327040ENST00000428834PSD3chr8

18441287

-GNGT1chr7

93346824

+
intron-intronENST00000440756ENST00000455502PSD3chr8

18441287

-GNGT1chr7

93346824

+
intron-intronENST00000440756ENST00000248572PSD3chr8

18441287

-GNGT1chr7

93346824

+
intron-intronENST00000440756ENST00000429473PSD3chr8

18441287

-GNGT1chr7

93346824

+
intron-intronENST00000440756ENST00000430875PSD3chr8

18441287

-GNGT1chr7

93346824

+
intron-intronENST00000440756ENST00000428834PSD3chr8

18441287

-GNGT1chr7

93346824

+
intron-intronENST00000286485ENST00000455502PSD3chr8

18441287

-GNGT1chr7

93346824

+
intron-intronENST00000286485ENST00000248572PSD3chr8

18441287

-GNGT1chr7

93346824

+
intron-intronENST00000286485ENST00000429473PSD3chr8

18441287

-GNGT1chr7

93346824

+
intron-intronENST00000286485ENST00000430875PSD3chr8

18441287

-GNGT1chr7

93346824

+
intron-intronENST00000286485ENST00000428834PSD3chr8

18441287

-GNGT1chr7

93346824

+
intron-intronENST00000428502ENST00000455502PSD3chr8

18441287

-GNGT1chr7

93346824

+
intron-intronENST00000428502ENST00000248572PSD3chr8

18441287

-GNGT1chr7

93346824

+
intron-intronENST00000428502ENST00000429473PSD3chr8

18441287

-GNGT1chr7

93346824

+
intron-intronENST00000428502ENST00000430875PSD3chr8

18441287

-GNGT1chr7

93346824

+
intron-intronENST00000428502ENST00000428834PSD3chr8

18441287

-GNGT1chr7

93346824

+
intron-intronENST00000523619ENST00000455502PSD3chr8

18441287

-GNGT1chr7

93346824

+
intron-intronENST00000523619ENST00000248572PSD3chr8

18441287

-GNGT1chr7

93346824

+
intron-intronENST00000523619ENST00000429473PSD3chr8

18441287

-GNGT1chr7

93346824

+
intron-intronENST00000523619ENST00000430875PSD3chr8

18441287

-GNGT1chr7

93346824

+
intron-intronENST00000523619ENST00000428834PSD3chr8

18441287

-GNGT1chr7

93346824

+
intron-intronENST00000520789ENST00000455502PSD3chr8

18441287

-GNGT1chr7

93346824

+
intron-intronENST00000520789ENST00000248572PSD3chr8

18441287

-GNGT1chr7

93346824

+
intron-intronENST00000520789ENST00000429473PSD3chr8

18441287

-GNGT1chr7

93346824

+
intron-intronENST00000520789ENST00000430875PSD3chr8

18441287

-GNGT1chr7

93346824

+
intron-intronENST00000520789ENST00000428834PSD3chr8

18441287

-GNGT1chr7

93346824

+

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FusionProtFeatures for PSD3_GNGT1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PSD3

Q9NYI0

GNGT1

P63211

Guanine nucleotide exchange factor for ARF6.{ECO:0000250}. Guanine nucleotide-binding proteins (G proteins) areinvolved as a modulator or transducer in various transmembranesignaling systems. The beta and gamma chains are required for theGTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PSD3_GNGT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PSD3_GNGT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PSD3_GNGT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PSD3_GNGT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePSD3C0017638Glioma1CTD_human
HgenePSD3C0036341Schizophrenia1PSYGENET
HgenePSD3C0236733Amphetamine-Related Disorders1CTD_human