![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 29072 |
FusionGeneSummary for PSD3_GNGT1 |
![]() |
Fusion gene information | Fusion gene name: PSD3_GNGT1 | Fusion gene ID: 29072 | Hgene | Tgene | Gene symbol | PSD3 | GNGT1 | Gene ID | 23362 | 2792 |
Gene name | pleckstrin and Sec7 domain containing 3 | G protein subunit gamma transducin 1 | |
Synonyms | EFA6D|EFA6R|HCA67 | GNG1 | |
Cytomap | 8p22 | 7q21.3 | |
Type of gene | protein-coding | protein-coding | |
Description | PH and SEC7 domain-containing protein 3ADP-ribosylation factor guanine nucleotide factor 6epididymis tissue protein Li 20mPexchange factor for ADP-ribosylation factor guanine nucleotide factor 6exchange factor for ADP-ribosylation factor guanine nucle | guanine nucleotide-binding protein G(T) subunit gamma-T1guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1transducin gamma chain | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9NYI0 | P63211 | |
Ensembl transtripts involved in fusion gene | ENST00000327040, ENST00000440756, ENST00000286485, ENST00000428502, ENST00000523619, ENST00000520789, | ENST00000455502, ENST00000248572, ENST00000429473, ENST00000430875, ENST00000428834, | |
Fusion gene scores | * DoF score | 8 X 7 X 6=336 | 6 X 6 X 3=108 |
# samples | 8 | 6 | |
** MAII score | log2(8/336*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PSD3 [Title/Abstract] AND GNGT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | X93851 | PSD3 | chr8 | 18441287 | - | GNGT1 | chr7 | 93346824 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000327040 | ENST00000455502 | PSD3 | chr8 | 18441287 | - | GNGT1 | chr7 | 93346824 | + |
intron-intron | ENST00000327040 | ENST00000248572 | PSD3 | chr8 | 18441287 | - | GNGT1 | chr7 | 93346824 | + |
intron-intron | ENST00000327040 | ENST00000429473 | PSD3 | chr8 | 18441287 | - | GNGT1 | chr7 | 93346824 | + |
intron-intron | ENST00000327040 | ENST00000430875 | PSD3 | chr8 | 18441287 | - | GNGT1 | chr7 | 93346824 | + |
intron-intron | ENST00000327040 | ENST00000428834 | PSD3 | chr8 | 18441287 | - | GNGT1 | chr7 | 93346824 | + |
intron-intron | ENST00000440756 | ENST00000455502 | PSD3 | chr8 | 18441287 | - | GNGT1 | chr7 | 93346824 | + |
intron-intron | ENST00000440756 | ENST00000248572 | PSD3 | chr8 | 18441287 | - | GNGT1 | chr7 | 93346824 | + |
intron-intron | ENST00000440756 | ENST00000429473 | PSD3 | chr8 | 18441287 | - | GNGT1 | chr7 | 93346824 | + |
intron-intron | ENST00000440756 | ENST00000430875 | PSD3 | chr8 | 18441287 | - | GNGT1 | chr7 | 93346824 | + |
intron-intron | ENST00000440756 | ENST00000428834 | PSD3 | chr8 | 18441287 | - | GNGT1 | chr7 | 93346824 | + |
intron-intron | ENST00000286485 | ENST00000455502 | PSD3 | chr8 | 18441287 | - | GNGT1 | chr7 | 93346824 | + |
intron-intron | ENST00000286485 | ENST00000248572 | PSD3 | chr8 | 18441287 | - | GNGT1 | chr7 | 93346824 | + |
intron-intron | ENST00000286485 | ENST00000429473 | PSD3 | chr8 | 18441287 | - | GNGT1 | chr7 | 93346824 | + |
intron-intron | ENST00000286485 | ENST00000430875 | PSD3 | chr8 | 18441287 | - | GNGT1 | chr7 | 93346824 | + |
intron-intron | ENST00000286485 | ENST00000428834 | PSD3 | chr8 | 18441287 | - | GNGT1 | chr7 | 93346824 | + |
intron-intron | ENST00000428502 | ENST00000455502 | PSD3 | chr8 | 18441287 | - | GNGT1 | chr7 | 93346824 | + |
intron-intron | ENST00000428502 | ENST00000248572 | PSD3 | chr8 | 18441287 | - | GNGT1 | chr7 | 93346824 | + |
intron-intron | ENST00000428502 | ENST00000429473 | PSD3 | chr8 | 18441287 | - | GNGT1 | chr7 | 93346824 | + |
intron-intron | ENST00000428502 | ENST00000430875 | PSD3 | chr8 | 18441287 | - | GNGT1 | chr7 | 93346824 | + |
intron-intron | ENST00000428502 | ENST00000428834 | PSD3 | chr8 | 18441287 | - | GNGT1 | chr7 | 93346824 | + |
intron-intron | ENST00000523619 | ENST00000455502 | PSD3 | chr8 | 18441287 | - | GNGT1 | chr7 | 93346824 | + |
intron-intron | ENST00000523619 | ENST00000248572 | PSD3 | chr8 | 18441287 | - | GNGT1 | chr7 | 93346824 | + |
intron-intron | ENST00000523619 | ENST00000429473 | PSD3 | chr8 | 18441287 | - | GNGT1 | chr7 | 93346824 | + |
intron-intron | ENST00000523619 | ENST00000430875 | PSD3 | chr8 | 18441287 | - | GNGT1 | chr7 | 93346824 | + |
intron-intron | ENST00000523619 | ENST00000428834 | PSD3 | chr8 | 18441287 | - | GNGT1 | chr7 | 93346824 | + |
intron-intron | ENST00000520789 | ENST00000455502 | PSD3 | chr8 | 18441287 | - | GNGT1 | chr7 | 93346824 | + |
intron-intron | ENST00000520789 | ENST00000248572 | PSD3 | chr8 | 18441287 | - | GNGT1 | chr7 | 93346824 | + |
intron-intron | ENST00000520789 | ENST00000429473 | PSD3 | chr8 | 18441287 | - | GNGT1 | chr7 | 93346824 | + |
intron-intron | ENST00000520789 | ENST00000430875 | PSD3 | chr8 | 18441287 | - | GNGT1 | chr7 | 93346824 | + |
intron-intron | ENST00000520789 | ENST00000428834 | PSD3 | chr8 | 18441287 | - | GNGT1 | chr7 | 93346824 | + |
Top |
FusionProtFeatures for PSD3_GNGT1 |
![]() |
Hgene | Tgene |
PSD3 | GNGT1 |
Guanine nucleotide exchange factor for ARF6.{ECO:0000250}. | Guanine nucleotide-binding proteins (G proteins) areinvolved as a modulator or transducer in various transmembranesignaling systems. The beta and gamma chains are required for theGTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for PSD3_GNGT1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for PSD3_GNGT1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for PSD3_GNGT1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for PSD3_GNGT1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PSD3 | C0017638 | Glioma | 1 | CTD_human |
Hgene | PSD3 | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | PSD3 | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |