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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29071

FusionGeneSummary for PSD3_FGL1

check button Fusion gene summary
Fusion gene informationFusion gene name: PSD3_FGL1
Fusion gene ID: 29071
HgeneTgene
Gene symbol

PSD3

FGL1

Gene ID

23362

2267

Gene namepleckstrin and Sec7 domain containing 3fibrinogen like 1
SynonymsEFA6D|EFA6R|HCA67HFREP1|HP-041|LFIRE-1|LFIRE1
Cytomap

8p22

8p22

Type of geneprotein-codingprotein-coding
DescriptionPH and SEC7 domain-containing protein 3ADP-ribosylation factor guanine nucleotide factor 6epididymis tissue protein Li 20mPexchange factor for ADP-ribosylation factor guanine nucleotide factor 6exchange factor for ADP-ribosylation factor guanine nuclefibrinogen-like protein 1hepassocinhepatocellular carcinoma-related sequencehepatocyte-derived fibrinogen-related protein 1liver fibrinogen-related protein 1
Modification date2018052320180519
UniProtAcc

Q9NYI0

Q08830

Ensembl transtripts involved in fusion geneENST00000327040, ENST00000440756, 
ENST00000286485, ENST00000428502, 
ENST00000523619, ENST00000520789, 
ENST00000398056, ENST00000522444, 
ENST00000398054, ENST00000381840, 
ENST00000381841, ENST00000427924, 
ENST00000518650, 
Fusion gene scores* DoF score8 X 7 X 6=3364 X 3 X 5=60
# samples 87
** MAII scorelog2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/60*10)=0.222392421336448
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PSD3 [Title/Abstract] AND FGL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A23T-01APSD3chr8

18711608

-FGL1chr8

17743080

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000327040ENST00000398056PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000327040ENST00000522444PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000327040ENST00000398054PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000327040ENST00000381840PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000327040ENST00000381841PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000327040ENST00000427924PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000327040ENST00000518650PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000440756ENST00000398056PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000440756ENST00000522444PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000440756ENST00000398054PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000440756ENST00000381840PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000440756ENST00000381841PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000440756ENST00000427924PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000440756ENST00000518650PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000286485ENST00000398056PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000286485ENST00000522444PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000286485ENST00000398054PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000286485ENST00000381840PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000286485ENST00000381841PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000286485ENST00000427924PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000286485ENST00000518650PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000428502ENST00000398056PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000428502ENST00000522444PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000428502ENST00000398054PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000428502ENST00000381840PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000428502ENST00000381841PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000428502ENST00000427924PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000428502ENST00000518650PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000523619ENST00000398056PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000523619ENST00000522444PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000523619ENST00000398054PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000523619ENST00000381840PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000523619ENST00000381841PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000523619ENST00000427924PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000523619ENST00000518650PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000520789ENST00000398056PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000520789ENST00000522444PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000520789ENST00000398054PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000520789ENST00000381840PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000520789ENST00000381841PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000520789ENST00000427924PSD3chr8

18711608

-FGL1chr8

17743080

-
intron-5UTRENST00000520789ENST00000518650PSD3chr8

18711608

-FGL1chr8

17743080

-

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FusionProtFeatures for PSD3_FGL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PSD3

Q9NYI0

FGL1

Q08830

Guanine nucleotide exchange factor for ARF6.{ECO:0000250}. Has hepatocyte mitogenic activity.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PSD3_FGL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PSD3_FGL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PSD3MLH1, PMS2, ARAP1, MX1, TP53, CTDSPL, PTPRA, PTPRGFGL1VKORC1, BCL2L11, EPPK1, LSG1, ALDH5A1, NAA35, PXDN, AARS2, CARKD, RAVER1, TBC1D10A, PPIL2, MAP1S, UBR1, CWF19L2, AMMECR1L, COL14A1, DDB2, SORL1, GTF2H2, CMAS, TLE3, TLE1, NSUN2, FBXO38, MLLT4, ARHGEF2, OGFOD1, PPP1R1A, TSR3, DCAF16, NDUFS6, NUCB1, MAPRE2, C1orf198, TUT1, TUBE1, LOH12CR1, DNM1L, PLAT, PTPN23, COL4A2, FAM172A, ERCC3, ETHE1, DPYSL5, GOLM1, ZADH2, UBA5, GTF2H3, NIPSNAP3A, MMADHC, GTF2H1, TFIP11, TUBD1, LCMT2, CENPC, TCF25, SPATS2L, C16orf59, SLTM, C17orf59, PLEKHA7, ATXN2, RBM6, TRIP6, ANKLE2, RIPK1, EPS8


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PSD3_FGL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PSD3_FGL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePSD3C0017638Glioma1CTD_human
HgenePSD3C0036341Schizophrenia1PSYGENET
HgenePSD3C0236733Amphetamine-Related Disorders1CTD_human