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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29062

FusionGeneSummary for PSAP_THBS3

check button Fusion gene summary
Fusion gene informationFusion gene name: PSAP_THBS3
Fusion gene ID: 29062
HgeneTgene
Gene symbol

PSAP

THBS3

Gene ID

729238

7059

Gene namesurfactant protein A2thrombospondin 3
SynonymsCOLEC5|PSAP|PSP-A|PSPA|SFTP1|SFTPA2B|SP-2A|SP-A|SPA2|SPAIITSP3
Cytomap

10q22.3

1q22

Type of geneprotein-codingprotein-coding
Descriptionpulmonary surfactant-associated protein A235 kDa pulmonary surfactant-associated proteinalveolar proteinosis proteincollectin 5surfactant, pulmonary-associated protein A2Athrombospondin-3
Modification date2018052320180519
UniProtAcc

P07602

P49746

Ensembl transtripts involved in fusion geneENST00000394936, ENST00000394934, 
ENST00000368378, ENST00000541576, 
ENST00000457183, ENST00000541990, 
ENST00000486260, 
Fusion gene scores* DoF score32 X 20 X 10=64006 X 6 X 2=72
# samples 377
** MAII scorelog2(37/6400*10)=-4.11247472925841
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/72*10)=-0.0406419844973459
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PSAP [Title/Abstract] AND THBS3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG995962PSAPchr10

73576299

-THBS3chr1

155167941

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000394936ENST00000368378PSAPchr10

73576299

-THBS3chr1

155167941

-
intron-3CDSENST00000394936ENST00000541576PSAPchr10

73576299

-THBS3chr1

155167941

-
intron-3CDSENST00000394936ENST00000457183PSAPchr10

73576299

-THBS3chr1

155167941

-
intron-3CDSENST00000394936ENST00000541990PSAPchr10

73576299

-THBS3chr1

155167941

-
intron-intronENST00000394936ENST00000486260PSAPchr10

73576299

-THBS3chr1

155167941

-
intron-3CDSENST00000394934ENST00000368378PSAPchr10

73576299

-THBS3chr1

155167941

-
intron-3CDSENST00000394934ENST00000541576PSAPchr10

73576299

-THBS3chr1

155167941

-
intron-3CDSENST00000394934ENST00000457183PSAPchr10

73576299

-THBS3chr1

155167941

-
intron-3CDSENST00000394934ENST00000541990PSAPchr10

73576299

-THBS3chr1

155167941

-
intron-intronENST00000394934ENST00000486260PSAPchr10

73576299

-THBS3chr1

155167941

-

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FusionProtFeatures for PSAP_THBS3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PSAP

P07602

THBS3

P49746

Adhesive glycoprotein that mediates cell-to-cell andcell-to-matrix interactions. Can bind to fibrinogen, fibronectin,laminin and type V collagen.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PSAP_THBS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PSAP_THBS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PSAP_THBS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PSAP_THBS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePSAPC0268262Metachromatic Leukodystrophy due to Saposin B Deficiency5CTD_human;UNIPROT
HgenePSAPC1864651GAUCHER DISEASE, ATYPICAL, DUE TO SAPOSIN C DEFICIENCY2CTD_human;ORPHANET;UNIPROT