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Fusion gene ID: 29059 |
FusionGeneSummary for PSAP_RNF187 |
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Fusion gene information | Fusion gene name: PSAP_RNF187 | Fusion gene ID: 29059 | Hgene | Tgene | Gene symbol | PSAP | RNF187 | Gene ID | 729238 | 149603 |
Gene name | surfactant protein A2 | ring finger protein 187 | |
Synonyms | COLEC5|PSAP|PSP-A|PSPA|SFTP1|SFTPA2B|SP-2A|SP-A|SPA2|SPAII | RACO-1|RACO1 | |
Cytomap | 10q22.3 | 1q42.13 | |
Type of gene | protein-coding | protein-coding | |
Description | pulmonary surfactant-associated protein A235 kDa pulmonary surfactant-associated proteinalveolar proteinosis proteincollectin 5surfactant, pulmonary-associated protein A2A | E3 ubiquitin-protein ligase RNF187RING domain AP1 coactivator 1RING-type E3 ubiquitin transferase RNF187protein RNF187ring domain AP-1 co-activator 1 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P07602 | Q5TA31 | |
Ensembl transtripts involved in fusion gene | ENST00000394936, ENST00000394934, | ENST00000305943, ENST00000482739, | |
Fusion gene scores | * DoF score | 32 X 20 X 10=6400 | 3 X 3 X 1=9 |
# samples | 37 | 3 | |
** MAII score | log2(37/6400*10)=-4.11247472925841 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PSAP [Title/Abstract] AND RNF187 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | RNF187 | GO:0051865 | protein autoubiquitination | 20852630 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG996012 | PSAP | chr10 | 73576217 | - | RNF187 | chr1 | 228682196 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000394936 | ENST00000305943 | PSAP | chr10 | 73576217 | - | RNF187 | chr1 | 228682196 | - |
intron-3UTR | ENST00000394936 | ENST00000482739 | PSAP | chr10 | 73576217 | - | RNF187 | chr1 | 228682196 | - |
intron-3UTR | ENST00000394934 | ENST00000305943 | PSAP | chr10 | 73576217 | - | RNF187 | chr1 | 228682196 | - |
intron-3UTR | ENST00000394934 | ENST00000482739 | PSAP | chr10 | 73576217 | - | RNF187 | chr1 | 228682196 | - |
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FusionProtFeatures for PSAP_RNF187 |
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Hgene | Tgene |
PSAP | RNF187 |
E3 ubiquitin-protein ligase that acts as a coactivatorof JUN-mediated gene activation in response to growth factorsignaling via the MAP3K1 pathway, independently from MAPK8.{ECO:0000269|PubMed:20852630}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PSAP_RNF187 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PSAP_RNF187 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PSAP_RNF187 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PSAP_RNF187 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PSAP | C0268262 | Metachromatic Leukodystrophy due to Saposin B Deficiency | 5 | CTD_human;UNIPROT |
Hgene | PSAP | C1864651 | GAUCHER DISEASE, ATYPICAL, DUE TO SAPOSIN C DEFICIENCY | 2 | CTD_human;ORPHANET;UNIPROT |