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Fusion gene ID: 29007 |
FusionGeneSummary for PRSS12_PRSS12 |
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Fusion gene information | Fusion gene name: PRSS12_PRSS12 | Fusion gene ID: 29007 | Hgene | Tgene | Gene symbol | PRSS12 | PRSS12 | Gene ID | 8492 | 8492 |
Gene name | serine protease 12 | serine protease 12 | |
Synonyms | BSSP-3|BSSP3|MRT1 | BSSP-3|BSSP3|MRT1 | |
Cytomap | 4q26 | 4q26 | |
Type of gene | protein-coding | protein-coding | |
Description | neurotrypsinbrain-specific serine protease 3leydinprotease, serine 12protease, serine, 12 (neurotrypsin, motopsin) | neurotrypsinbrain-specific serine protease 3leydinprotease, serine 12protease, serine, 12 (neurotrypsin, motopsin) | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P56730 | P56730 | |
Ensembl transtripts involved in fusion gene | ENST00000296498, ENST00000510903, | ENST00000296498, ENST00000510903, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 1 X 1 X 1=1 |
# samples | 2 | 1 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: PRSS12 [Title/Abstract] AND PRSS12 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BU607278 | PRSS12 | chr4 | 119201250 | + | PRSS12 | chr4 | 119201482 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000296498 | ENST00000296498 | PRSS12 | chr4 | 119201250 | + | PRSS12 | chr4 | 119201482 | - |
intron-intron | ENST00000296498 | ENST00000510903 | PRSS12 | chr4 | 119201250 | + | PRSS12 | chr4 | 119201482 | - |
intron-3UTR | ENST00000510903 | ENST00000296498 | PRSS12 | chr4 | 119201250 | + | PRSS12 | chr4 | 119201482 | - |
intron-intron | ENST00000510903 | ENST00000510903 | PRSS12 | chr4 | 119201250 | + | PRSS12 | chr4 | 119201482 | - |
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FusionProtFeatures for PRSS12_PRSS12 |
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Hgene | Tgene |
PRSS12 | PRSS12 |
Plays a role in neuronal plasticity and the proteolyticaction may subserve structural reorganizations associated withlearning and memory operations. {ECO:0000250}. | Plays a role in neuronal plasticity and the proteolyticaction may subserve structural reorganizations associated withlearning and memory operations. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PRSS12_PRSS12 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PRSS12_PRSS12 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PRSS12_PRSS12 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PRSS12_PRSS12 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |