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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29004

FusionGeneSummary for PRRX1_PGRMC2

check button Fusion gene summary
Fusion gene informationFusion gene name: PRRX1_PGRMC2
Fusion gene ID: 29004
HgeneTgene
Gene symbol

PRRX1

PGRMC2

Gene ID

5396

10424

Gene namepaired related homeobox 1progesterone receptor membrane component 2
SynonymsAGOTC|PHOX1|PMX1|PRX-1|PRX1DG6|PMBP
Cytomap

1q24.2

4q28.2

Type of geneprotein-codingprotein-coding
Descriptionpaired mesoderm homeobox protein 1homeobox protein PHOX1paired mesoderm homeobox 1 isoform pmx-1bmembrane-associated progesterone receptor component 2progesterone membrane binding proteinsteroid receptor protein DG6
Modification date2018051920180523
UniProtAcc

P54821

O15173

Ensembl transtripts involved in fusion geneENST00000367760, ENST00000239461, 
ENST00000497230, ENST00000476867, 
ENST00000296425, ENST00000520121, 
ENST00000394276, ENST00000512483, 
ENST00000503872, ENST00000503588, 
Fusion gene scores* DoF score2 X 2 X 1=41 X 1 X 1=1
# samples 21
** MAII scorelog2(2/4*10)=2.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: PRRX1 [Title/Abstract] AND PGRMC2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI394219PRRX1chr1

170708337

-PGRMC2chr4

129192113

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000367760ENST00000296425PRRX1chr1

170708337

-PGRMC2chr4

129192113

+
intron-3UTRENST00000367760ENST00000520121PRRX1chr1

170708337

-PGRMC2chr4

129192113

+
intron-3UTRENST00000367760ENST00000394276PRRX1chr1

170708337

-PGRMC2chr4

129192113

+
intron-3UTRENST00000367760ENST00000512483PRRX1chr1

170708337

-PGRMC2chr4

129192113

+
intron-3UTRENST00000367760ENST00000503872PRRX1chr1

170708337

-PGRMC2chr4

129192113

+
intron-3UTRENST00000367760ENST00000503588PRRX1chr1

170708337

-PGRMC2chr4

129192113

+
3UTR-3UTRENST00000239461ENST00000296425PRRX1chr1

170708337

-PGRMC2chr4

129192113

+
3UTR-3UTRENST00000239461ENST00000520121PRRX1chr1

170708337

-PGRMC2chr4

129192113

+
3UTR-3UTRENST00000239461ENST00000394276PRRX1chr1

170708337

-PGRMC2chr4

129192113

+
3UTR-3UTRENST00000239461ENST00000512483PRRX1chr1

170708337

-PGRMC2chr4

129192113

+
3UTR-3UTRENST00000239461ENST00000503872PRRX1chr1

170708337

-PGRMC2chr4

129192113

+
3UTR-3UTRENST00000239461ENST00000503588PRRX1chr1

170708337

-PGRMC2chr4

129192113

+
intron-3UTRENST00000497230ENST00000296425PRRX1chr1

170708337

-PGRMC2chr4

129192113

+
intron-3UTRENST00000497230ENST00000520121PRRX1chr1

170708337

-PGRMC2chr4

129192113

+
intron-3UTRENST00000497230ENST00000394276PRRX1chr1

170708337

-PGRMC2chr4

129192113

+
intron-3UTRENST00000497230ENST00000512483PRRX1chr1

170708337

-PGRMC2chr4

129192113

+
intron-3UTRENST00000497230ENST00000503872PRRX1chr1

170708337

-PGRMC2chr4

129192113

+
intron-3UTRENST00000497230ENST00000503588PRRX1chr1

170708337

-PGRMC2chr4

129192113

+
intron-3UTRENST00000476867ENST00000296425PRRX1chr1

170708337

-PGRMC2chr4

129192113

+
intron-3UTRENST00000476867ENST00000520121PRRX1chr1

170708337

-PGRMC2chr4

129192113

+
intron-3UTRENST00000476867ENST00000394276PRRX1chr1

170708337

-PGRMC2chr4

129192113

+
intron-3UTRENST00000476867ENST00000512483PRRX1chr1

170708337

-PGRMC2chr4

129192113

+
intron-3UTRENST00000476867ENST00000503872PRRX1chr1

170708337

-PGRMC2chr4

129192113

+
intron-3UTRENST00000476867ENST00000503588PRRX1chr1

170708337

-PGRMC2chr4

129192113

+

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FusionProtFeatures for PRRX1_PGRMC2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRRX1

P54821

PGRMC2

O15173

Acts as a transcriptional regulator of muscle creatinekinase (MCK) and so has a role in the establishment of diversemesodermal muscle types. The protein binds to an A/T-rich elementin the muscle creatine enhancer (By similarity). {ECO:0000250}. Receptor for steroids. {ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PRRX1_PGRMC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PRRX1_PGRMC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PRRX1_PGRMC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PRRX1_PGRMC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePRRX1C1876185Dysgnathia complex2CTD_human;ORPHANET;UNIPROT
HgenePRRX1C0004238Atrial Fibrillation1CTD_human
HgenePRRX1C0033578Prostatic Neoplasms1CTD_human
HgenePRRX1C3494422Retrognathia1CTD_human