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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29002

FusionGeneSummary for PRRG4_ZNF215

check button Fusion gene summary
Fusion gene informationFusion gene name: PRRG4_ZNF215
Fusion gene ID: 29002
HgeneTgene
Gene symbol

PRRG4

ZNF215

Gene ID

79056

7762

Gene nameproline rich and Gla domain 4zinc finger protein 215
SynonymsPRGP4|TMG4BAZ-2|BAZ2|ZKSCAN11|ZSCAN43
Cytomap

11p13

11p15.4

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane gamma-carboxyglutamic acid protein 4proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)proline rich Gla 4 (transmembrane) isoform 1proline rich Gla 4 (transmembrane) isoform 2proline rich Gla 4 (transmembrane) isoform 3proline-rzinc finger protein 215BWSCR2-associated zinc finger protein 2zinc finger protein with KRAB and SCAN domains 11
Modification date2018051920180519
UniProtAcc

Q9BZD6

Q9UL58

Ensembl transtripts involved in fusion geneENST00000257836, ENST00000527171, 
ENST00000278319, ENST00000414517, 
ENST00000529903, 
Fusion gene scores* DoF score4 X 2 X 4=321 X 1 X 1=1
# samples 41
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: PRRG4 [Title/Abstract] AND ZNF215 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A1KU-01APRRG4chr11

32861785

+ZNF215chr11

6953325

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000257836ENST00000527171PRRG4chr11

32861785

+ZNF215chr11

6953325

+
5CDS-5UTRENST00000257836ENST00000278319PRRG4chr11

32861785

+ZNF215chr11

6953325

+
5CDS-5UTRENST00000257836ENST00000414517PRRG4chr11

32861785

+ZNF215chr11

6953325

+
5CDS-intronENST00000257836ENST00000529903PRRG4chr11

32861785

+ZNF215chr11

6953325

+

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FusionProtFeatures for PRRG4_ZNF215


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRRG4

Q9BZD6

ZNF215

Q9UL58

May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PRRG4_ZNF215


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PRRG4_ZNF215


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PRRG4HLA-C, HDAC1, BCL10, VEGFA, UBE2K, RBBP8, AOC3, STXBP4, YAP1ZNF215HSP90AA1, SHMT2, ZSCAN20


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PRRG4_ZNF215


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PRRG4_ZNF215


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource