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Fusion gene ID: 29001 |
FusionGeneSummary for PRRG4_RAPGEFL1 |
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Fusion gene information | Fusion gene name: PRRG4_RAPGEFL1 | Fusion gene ID: 29001 | Hgene | Tgene | Gene symbol | PRRG4 | RAPGEFL1 | Gene ID | 79056 | 51195 |
Gene name | proline rich and Gla domain 4 | Rap guanine nucleotide exchange factor like 1 | |
Synonyms | PRGP4|TMG4 | Link-GEFII | |
Cytomap | 11p13 | 17q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | transmembrane gamma-carboxyglutamic acid protein 4proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)proline rich Gla 4 (transmembrane) isoform 1proline rich Gla 4 (transmembrane) isoform 2proline rich Gla 4 (transmembrane) isoform 3proline-r | rap guanine nucleotide exchange factor-like 1Link guanine nucleotide exchange factor IIRap guanine nucleotide exchange factor (GEF)-like 1link GEFII | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q9BZD6 | Q9UHV5 | |
Ensembl transtripts involved in fusion gene | ENST00000257836, | ENST00000456989, ENST00000544503, ENST00000264644, ENST00000540388, ENST00000436615, | |
Fusion gene scores | * DoF score | 4 X 2 X 4=32 | 2 X 2 X 2=8 |
# samples | 4 | 2 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: PRRG4 [Title/Abstract] AND RAPGEFL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-B6-A0IG-01A | PRRG4 | chr11 | 32852178 | + | RAPGEFL1 | chr17 | 38345118 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000257836 | ENST00000456989 | PRRG4 | chr11 | 32852178 | + | RAPGEFL1 | chr17 | 38345118 | + |
Frame-shift | ENST00000257836 | ENST00000544503 | PRRG4 | chr11 | 32852178 | + | RAPGEFL1 | chr17 | 38345118 | + |
Frame-shift | ENST00000257836 | ENST00000264644 | PRRG4 | chr11 | 32852178 | + | RAPGEFL1 | chr17 | 38345118 | + |
5CDS-3UTR | ENST00000257836 | ENST00000540388 | PRRG4 | chr11 | 32852178 | + | RAPGEFL1 | chr17 | 38345118 | + |
5CDS-3UTR | ENST00000257836 | ENST00000436615 | PRRG4 | chr11 | 32852178 | + | RAPGEFL1 | chr17 | 38345118 | + |
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FusionProtFeatures for PRRG4_RAPGEFL1 |
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Hgene | Tgene |
PRRG4 | RAPGEFL1 |
Probable guanine nucleotide exchange factor (GEF). |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PRRG4_RAPGEFL1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PRRG4_RAPGEFL1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PRRG4 | HLA-C, HDAC1, BCL10, VEGFA, UBE2K, RBBP8, AOC3, STXBP4, YAP1 | RAPGEFL1 | APP, MLH1, SHMT2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PRRG4_RAPGEFL1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PRRG4_RAPGEFL1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |