FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 28994

FusionGeneSummary for PRRG1_PLP1

check button Fusion gene summary
Fusion gene informationFusion gene name: PRRG1_PLP1
Fusion gene ID: 28994
HgeneTgene
Gene symbol

PRRG1

PLP1

Gene ID

5638

5354

Gene nameproline rich and Gla domain 1proteolipid protein 1
SynonymsPRGP1GPM6C|HLD1|MMPL|PLP|PLP/DM20|PMD|SPG2
Cytomap

Xp21.1

Xq22.2

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane gamma-carboxyglutamic acid protein 1proline rich Gla (G-carboxyglutamic acid) 1proline-rich Gla (G-carboxyglutamic acid) polypeptide 1myelin proteolipid proteinlipophilinmajor myelin proteolipid protein
Modification date2018051920180523
UniProtAcc

O14668

P60201

Ensembl transtripts involved in fusion geneENST00000378628, ENST00000491253, 
ENST00000543642, ENST00000542554, 
ENST00000449135, ENST00000463135, 
ENST00000418604, ENST00000303958, 
ENST00000361621, ENST00000466486, 
Fusion gene scores* DoF score2 X 2 X 1=49 X 8 X 2=144
# samples 39
** MAII scorelog2(3/4*10)=2.90689059560852log2(9/144*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PRRG1 [Title/Abstract] AND PLP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA348328PRRG1chrX

37285177

+PLP1chrX

103043392

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000378628ENST00000418604PRRG1chrX

37285177

+PLP1chrX

103043392

+
Frame-shiftENST00000378628ENST00000303958PRRG1chrX

37285177

+PLP1chrX

103043392

+
Frame-shiftENST00000378628ENST00000361621PRRG1chrX

37285177

+PLP1chrX

103043392

+
5CDS-3UTRENST00000378628ENST00000466486PRRG1chrX

37285177

+PLP1chrX

103043392

+
intron-3CDSENST00000491253ENST00000418604PRRG1chrX

37285177

+PLP1chrX

103043392

+
intron-3CDSENST00000491253ENST00000303958PRRG1chrX

37285177

+PLP1chrX

103043392

+
intron-3CDSENST00000491253ENST00000361621PRRG1chrX

37285177

+PLP1chrX

103043392

+
intron-3UTRENST00000491253ENST00000466486PRRG1chrX

37285177

+PLP1chrX

103043392

+
Frame-shiftENST00000543642ENST00000418604PRRG1chrX

37285177

+PLP1chrX

103043392

+
Frame-shiftENST00000543642ENST00000303958PRRG1chrX

37285177

+PLP1chrX

103043392

+
Frame-shiftENST00000543642ENST00000361621PRRG1chrX

37285177

+PLP1chrX

103043392

+
5CDS-3UTRENST00000543642ENST00000466486PRRG1chrX

37285177

+PLP1chrX

103043392

+
Frame-shiftENST00000542554ENST00000418604PRRG1chrX

37285177

+PLP1chrX

103043392

+
Frame-shiftENST00000542554ENST00000303958PRRG1chrX

37285177

+PLP1chrX

103043392

+
Frame-shiftENST00000542554ENST00000361621PRRG1chrX

37285177

+PLP1chrX

103043392

+
5CDS-3UTRENST00000542554ENST00000466486PRRG1chrX

37285177

+PLP1chrX

103043392

+
Frame-shiftENST00000449135ENST00000418604PRRG1chrX

37285177

+PLP1chrX

103043392

+
Frame-shiftENST00000449135ENST00000303958PRRG1chrX

37285177

+PLP1chrX

103043392

+
Frame-shiftENST00000449135ENST00000361621PRRG1chrX

37285177

+PLP1chrX

103043392

+
5CDS-3UTRENST00000449135ENST00000466486PRRG1chrX

37285177

+PLP1chrX

103043392

+
Frame-shiftENST00000463135ENST00000418604PRRG1chrX

37285177

+PLP1chrX

103043392

+
Frame-shiftENST00000463135ENST00000303958PRRG1chrX

37285177

+PLP1chrX

103043392

+
Frame-shiftENST00000463135ENST00000361621PRRG1chrX

37285177

+PLP1chrX

103043392

+
5CDS-3UTRENST00000463135ENST00000466486PRRG1chrX

37285177

+PLP1chrX

103043392

+

Top

FusionProtFeatures for PRRG1_PLP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRRG1

O14668

PLP1

P60201

This is the major myelin protein from the centralnervous system. It plays an important role in the formation ormaintenance of the multilamellar structure of myelin.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PRRG1_PLP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PRRG1_PLP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PRRG1_PLP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for PRRG1_PLP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePLP1C0205711Pelizaeus-Merzbacher Disease31CTD_human;HPO;UNIPROT
TgenePLP1C1839264SPASTIC PARAPLEGIA 2, X-LINKED (disorder)9CTD_human;ORPHANET;UNIPROT
TgenePLP1C0036341Schizophrenia4PSYGENET
TgenePLP1C0009171Cocaine Abuse2PSYGENET
TgenePLP1C2673482Increased susceptibility to schizophrenia1PSYGENET