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Fusion gene ID: 28989 |
FusionGeneSummary for PRRC2C_PHLDA1 |
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Fusion gene information | Fusion gene name: PRRC2C_PHLDA1 | Fusion gene ID: 28989 | Hgene | Tgene | Gene symbol | PRRC2C | PHLDA1 | Gene ID | 23215 | 22822 |
Gene name | proline rich coiled-coil 2C | pleckstrin homology like domain family A member 1 | |
Synonyms | BAT2-iso|BAT2D1|BAT2L2|XTP2 | DT1P1B11|PHRIP|TDAG51 | |
Cytomap | 1q24.3 | 12q21.2 | |
Type of gene | protein-coding | protein-coding | |
Description | protein PRRC2CBAT2 domain containing 1BAT2 domain-containing protein 1HBV X-transactivated gene 2 proteinHBV XAg-transactivated protein 2HBxAg transactivated protein 2HLA-B-associated transcript 2-like 2proline-rich and coiled-coil-containing prote | pleckstrin homology-like domain family A member 1PQ-rich proteinPQR proteinT-cell death-associated gene 51 proteinapoptosis-associated nuclear proteinproline- and glutamine-rich proteinproline- and histidine-rich proteinproline-histidine rich prote | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9Y520 | Q8WV24 | |
Ensembl transtripts involved in fusion gene | ENST00000426496, ENST00000392078, ENST00000476522, ENST00000367742, ENST00000338920, | ENST00000602540, ENST00000266671, | |
Fusion gene scores | * DoF score | 12 X 13 X 5=780 | 2 X 3 X 1=6 |
# samples | 17 | 3 | |
** MAII score | log2(17/780*10)=-2.19793937761191 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/6*10)=2.32192809488736 | |
Context | PubMed: PRRC2C [Title/Abstract] AND PHLDA1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG005109 | PRRC2C | chr1 | 171546738 | + | PHLDA1 | chr12 | 76424613 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000426496 | ENST00000602540 | PRRC2C | chr1 | 171546738 | + | PHLDA1 | chr12 | 76424613 | - |
Frame-shift | ENST00000426496 | ENST00000266671 | PRRC2C | chr1 | 171546738 | + | PHLDA1 | chr12 | 76424613 | - |
Frame-shift | ENST00000392078 | ENST00000602540 | PRRC2C | chr1 | 171546738 | + | PHLDA1 | chr12 | 76424613 | - |
Frame-shift | ENST00000392078 | ENST00000266671 | PRRC2C | chr1 | 171546738 | + | PHLDA1 | chr12 | 76424613 | - |
intron-3CDS | ENST00000476522 | ENST00000602540 | PRRC2C | chr1 | 171546738 | + | PHLDA1 | chr12 | 76424613 | - |
intron-3CDS | ENST00000476522 | ENST00000266671 | PRRC2C | chr1 | 171546738 | + | PHLDA1 | chr12 | 76424613 | - |
Frame-shift | ENST00000367742 | ENST00000602540 | PRRC2C | chr1 | 171546738 | + | PHLDA1 | chr12 | 76424613 | - |
Frame-shift | ENST00000367742 | ENST00000266671 | PRRC2C | chr1 | 171546738 | + | PHLDA1 | chr12 | 76424613 | - |
Frame-shift | ENST00000338920 | ENST00000602540 | PRRC2C | chr1 | 171546738 | + | PHLDA1 | chr12 | 76424613 | - |
Frame-shift | ENST00000338920 | ENST00000266671 | PRRC2C | chr1 | 171546738 | + | PHLDA1 | chr12 | 76424613 | - |
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FusionProtFeatures for PRRC2C_PHLDA1 |
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Hgene | Tgene |
PRRC2C | PHLDA1 |
Seems to be involved in regulation of apoptosis. May beinvolved in detachment-mediated programmed cell death. May mediateapoptosis during neuronal development. May be involved inregulation of anti-apoptotic effects of IGF1. May be involved intranslational regulation. {ECO:0000269|PubMed:11369516,ECO:0000269|PubMed:12738777}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PRRC2C_PHLDA1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PRRC2C_PHLDA1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PRRC2C_PHLDA1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PRRC2C_PHLDA1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PHLDA1 | C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |