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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28989

FusionGeneSummary for PRRC2C_PHLDA1

check button Fusion gene summary
Fusion gene informationFusion gene name: PRRC2C_PHLDA1
Fusion gene ID: 28989
HgeneTgene
Gene symbol

PRRC2C

PHLDA1

Gene ID

23215

22822

Gene nameproline rich coiled-coil 2Cpleckstrin homology like domain family A member 1
SynonymsBAT2-iso|BAT2D1|BAT2L2|XTP2DT1P1B11|PHRIP|TDAG51
Cytomap

1q24.3

12q21.2

Type of geneprotein-codingprotein-coding
Descriptionprotein PRRC2CBAT2 domain containing 1BAT2 domain-containing protein 1HBV X-transactivated gene 2 proteinHBV XAg-transactivated protein 2HBxAg transactivated protein 2HLA-B-associated transcript 2-like 2proline-rich and coiled-coil-containing protepleckstrin homology-like domain family A member 1PQ-rich proteinPQR proteinT-cell death-associated gene 51 proteinapoptosis-associated nuclear proteinproline- and glutamine-rich proteinproline- and histidine-rich proteinproline-histidine rich prote
Modification date2018052320180519
UniProtAcc

Q9Y520

Q8WV24

Ensembl transtripts involved in fusion geneENST00000426496, ENST00000392078, 
ENST00000476522, ENST00000367742, 
ENST00000338920, 
ENST00000602540, 
ENST00000266671, 
Fusion gene scores* DoF score12 X 13 X 5=7802 X 3 X 1=6
# samples 173
** MAII scorelog2(17/780*10)=-2.19793937761191
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/6*10)=2.32192809488736
Context

PubMed: PRRC2C [Title/Abstract] AND PHLDA1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG005109PRRC2Cchr1

171546738

+PHLDA1chr12

76424613

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000426496ENST00000602540PRRC2Cchr1

171546738

+PHLDA1chr12

76424613

-
Frame-shitENST00000426496ENST00000266671PRRC2Cchr1

171546738

+PHLDA1chr12

76424613

-
Frame-shitENST00000392078ENST00000602540PRRC2Cchr1

171546738

+PHLDA1chr12

76424613

-
Frame-shitENST00000392078ENST00000266671PRRC2Cchr1

171546738

+PHLDA1chr12

76424613

-
intron-3CDSENST00000476522ENST00000602540PRRC2Cchr1

171546738

+PHLDA1chr12

76424613

-
intron-3CDSENST00000476522ENST00000266671PRRC2Cchr1

171546738

+PHLDA1chr12

76424613

-
Frame-shitENST00000367742ENST00000602540PRRC2Cchr1

171546738

+PHLDA1chr12

76424613

-
Frame-shitENST00000367742ENST00000266671PRRC2Cchr1

171546738

+PHLDA1chr12

76424613

-
Frame-shitENST00000338920ENST00000602540PRRC2Cchr1

171546738

+PHLDA1chr12

76424613

-
Frame-shitENST00000338920ENST00000266671PRRC2Cchr1

171546738

+PHLDA1chr12

76424613

-

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FusionProtFeatures for PRRC2C_PHLDA1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRRC2C

Q9Y520

PHLDA1

Q8WV24

Seems to be involved in regulation of apoptosis. May beinvolved in detachment-mediated programmed cell death. May mediateapoptosis during neuronal development. May be involved inregulation of anti-apoptotic effects of IGF1. May be involved intranslational regulation. {ECO:0000269|PubMed:11369516,ECO:0000269|PubMed:12738777}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PRRC2C_PHLDA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PRRC2C_PHLDA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PRRC2C_PHLDA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PRRC2C_PHLDA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePHLDA1C0162820Dermatitis, Allergic Contact1CTD_human