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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28974

FusionGeneSummary for PRRC2B_NUP155

check button Fusion gene summary
Fusion gene informationFusion gene name: PRRC2B_NUP155
Fusion gene ID: 28974
HgeneTgene
Gene symbol

PRRC2B

NUP155

Gene ID

84726

9631

Gene nameproline rich coiled-coil 2Bnucleoporin 155
SynonymsBAT2L|BAT2L1|KIAA0515|LQFBS-1ATFB15|N155
Cytomap

9q34.13

5p13.2

Type of geneprotein-codingprotein-coding
Descriptionprotein PRRC2BHLA-B associated transcript 2-likeHLA-B-associated transcript 2-like 1proline-rich coiled-coil protein 2Bprotein BAT2-like 1nuclear pore complex protein Nup155155 kDa nucleoporinnucleoporin 155kDnucleoporin 155kDa
Modification date2018052320180523
UniProtAcc

Q5JSZ5

O75694

Ensembl transtripts involved in fusion geneENST00000405995, ENST00000357304, 
ENST00000458550, ENST00000372249, 
ENST00000465931, 		ENST00000231498, 
ENST00000381843, ENST00000513532, 
ENST00000502533, 
Fusion gene scores* DoF score14 X 14 X 7=13723 X 3 X 3=27
# samples 173
** MAII scorelog2(17/1372*10)=-3.01267383003511
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PRRC2B [Title/Abstract] AND NUP155 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNUP155

GO:0006998

nuclear envelope organization

19070573


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-25-2397-01APRRC2Bchr9

134269650

+NUP155chr5

37293087

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000405995ENST00000231498PRRC2Bchr9

134269650

+NUP155chr5

37293087

-
5UTR-3CDSENST00000405995ENST00000381843PRRC2Bchr9

134269650

+NUP155chr5

37293087

-
5UTR-3CDSENST00000405995ENST00000513532PRRC2Bchr9

134269650

+NUP155chr5

37293087

-
5UTR-5UTRENST00000405995ENST00000502533PRRC2Bchr9

134269650

+NUP155chr5

37293087

-
intron-3CDSENST00000357304ENST00000231498PRRC2Bchr9

134269650

+NUP155chr5

37293087

-
intron-3CDSENST00000357304ENST00000381843PRRC2Bchr9

134269650

+NUP155chr5

37293087

-
intron-3CDSENST00000357304ENST00000513532PRRC2Bchr9

134269650

+NUP155chr5

37293087

-
intron-5UTRENST00000357304ENST00000502533PRRC2Bchr9

134269650

+NUP155chr5

37293087

-
intron-3CDSENST00000458550ENST00000231498PRRC2Bchr9

134269650

+NUP155chr5

37293087

-
intron-3CDSENST00000458550ENST00000381843PRRC2Bchr9

134269650

+NUP155chr5

37293087

-
intron-3CDSENST00000458550ENST00000513532PRRC2Bchr9

134269650

+NUP155chr5

37293087

-
intron-5UTRENST00000458550ENST00000502533PRRC2Bchr9

134269650

+NUP155chr5

37293087

-
intron-3CDSENST00000372249ENST00000231498PRRC2Bchr9

134269650

+NUP155chr5

37293087

-
intron-3CDSENST00000372249ENST00000381843PRRC2Bchr9

134269650

+NUP155chr5

37293087

-
intron-3CDSENST00000372249ENST00000513532PRRC2Bchr9

134269650

+NUP155chr5

37293087

-
intron-5UTRENST00000372249ENST00000502533PRRC2Bchr9

134269650

+NUP155chr5

37293087

-
intron-3CDSENST00000465931ENST00000231498PRRC2Bchr9

134269650

+NUP155chr5

37293087

-
intron-3CDSENST00000465931ENST00000381843PRRC2Bchr9

134269650

+NUP155chr5

37293087

-
intron-3CDSENST00000465931ENST00000513532PRRC2Bchr9

134269650

+NUP155chr5

37293087

-
intron-5UTRENST00000465931ENST00000502533PRRC2Bchr9

134269650

+NUP155chr5

37293087

-

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FusionProtFeatures for PRRC2B_NUP155


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRRC2B

Q5JSZ5

NUP155

O75694

Essential component of nuclear pore complex. Could beessessential for embryogenesis. Nucleoporins may be involved bothin binding and translocating proteins during nucleocytoplasmictransport. {ECO:0000250|UniProtKB:Q99P88}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PRRC2B_NUP155


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PRRC2B_NUP155


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PRRC2BEHMT2, EIF3H, EIF3F, USP11, USP3, TADA2A, IRF4, SIRT7, ATN1, ATXN1, ATXN1L, RERE, APP, KLHL15, ZER1, EIF3I, SCRN2, CLEC11A, UNK, CRK, SRPK2, CEP135, NINL, DPY30, SMS, PICALM, SEC16A, CERK, EYA2, EIF3L, JPH4, PLOD1, NAGK, EIF3E, ARHGDIANUP155GLE1, OTUD7B, DMWD, KBTBD7, HDAC4, SIRT7, CUL3, COPS5, NEDD8, TACC2, FN1, DAB2, ZFYVE9, LMNA, ADRB2, FBXO6, SNX5, TNRC6B, STAU1, EFS, CUL7, OBSL1, CCDC8, HOXB5, UNK, REG1B, NTRK1, NUP35, LCA5, RPGRIP1L, CEP135, EVC2, TMEM17, TMEM216, KPNB1, UBE2I, NUP153, NUP107, MYH14, SEH1L, SNW1, CDC5L, PTPN18, PTPRN2, ALDH3B1, TMEM206, TRIM25, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PRRC2B_NUP155


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PRRC2B_NUP155


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNUP155C4014269ATRIAL FIBRILLATION, FAMILIAL, 151UNIPROT