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Fusion gene ID: 28947 |
FusionGeneSummary for PRR4_RMDN3 |
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Fusion gene information | Fusion gene name: PRR4_RMDN3 | Fusion gene ID: 28947 | Hgene | Tgene | Gene symbol | PRR4 | RMDN3 | Gene ID | 81607 | 55177 |
Gene name | nectin cell adhesion molecule 4 | regulator of microtubule dynamics 3 | |
Synonyms | EDSS1|LNIR|PRR4|PVRL4|nectin-4 | FAM82A2|FAM82C|RMD-3|RMD3|ptpip51 | |
Cytomap | 1q23.3 | 15q15.1 | |
Type of gene | protein-coding | protein-coding | |
Description | nectin-4Ig superfamily receptor LNIRnectin 4poliovirus receptor-related 4poliovirus receptor-related protein 4 | regulator of microtubule dynamics protein 3TCPTP-interacting protein 51cerebral protein 10family with sequence similarity 82, member A2family with sequence similarity 82, member Cmicrotubule-associated proteinprotein tyrosine phosphatase-interacting | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q16378 | Q96TC7 | |
Ensembl transtripts involved in fusion gene | ENST00000536668, ENST00000544994, ENST00000228811, ENST00000540107, | ENST00000260385, ENST00000338376, ENST00000558560, | |
Fusion gene scores | * DoF score | 10 X 10 X 3=300 | 2 X 2 X 1=4 |
# samples | 10 | 2 | |
** MAII score | log2(10/300*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: PRR4 [Title/Abstract] AND RMDN3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DB200003 | PRR4 | chr12 | 10999907 | - | RMDN3 | chr15 | 41044311 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000536668 | ENST00000260385 | PRR4 | chr12 | 10999907 | - | RMDN3 | chr15 | 41044311 | - |
intron-3CDS | ENST00000536668 | ENST00000338376 | PRR4 | chr12 | 10999907 | - | RMDN3 | chr15 | 41044311 | - |
intron-5UTR | ENST00000536668 | ENST00000558560 | PRR4 | chr12 | 10999907 | - | RMDN3 | chr15 | 41044311 | - |
intron-3CDS | ENST00000544994 | ENST00000260385 | PRR4 | chr12 | 10999907 | - | RMDN3 | chr15 | 41044311 | - |
intron-3CDS | ENST00000544994 | ENST00000338376 | PRR4 | chr12 | 10999907 | - | RMDN3 | chr15 | 41044311 | - |
intron-5UTR | ENST00000544994 | ENST00000558560 | PRR4 | chr12 | 10999907 | - | RMDN3 | chr15 | 41044311 | - |
intron-3CDS | ENST00000228811 | ENST00000260385 | PRR4 | chr12 | 10999907 | - | RMDN3 | chr15 | 41044311 | - |
intron-3CDS | ENST00000228811 | ENST00000338376 | PRR4 | chr12 | 10999907 | - | RMDN3 | chr15 | 41044311 | - |
intron-5UTR | ENST00000228811 | ENST00000558560 | PRR4 | chr12 | 10999907 | - | RMDN3 | chr15 | 41044311 | - |
intron-3CDS | ENST00000540107 | ENST00000260385 | PRR4 | chr12 | 10999907 | - | RMDN3 | chr15 | 41044311 | - |
intron-3CDS | ENST00000540107 | ENST00000338376 | PRR4 | chr12 | 10999907 | - | RMDN3 | chr15 | 41044311 | - |
intron-5UTR | ENST00000540107 | ENST00000558560 | PRR4 | chr12 | 10999907 | - | RMDN3 | chr15 | 41044311 | - |
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FusionProtFeatures for PRR4_RMDN3 |
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Hgene | Tgene |
PRR4 | RMDN3 |
Involved in cellular calcium homeostasis regulation. Mayparticipate in differentiation and apoptosis of keratinocytes.Overexpression induces apoptosis. {ECO:0000269|PubMed:16820967,ECO:0000269|PubMed:22131369}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PRR4_RMDN3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PRR4_RMDN3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PRR4_RMDN3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PRR4_RMDN3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |