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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28947

FusionGeneSummary for PRR4_RMDN3

check button Fusion gene summary
Fusion gene informationFusion gene name: PRR4_RMDN3
Fusion gene ID: 28947
HgeneTgene
Gene symbol

PRR4

RMDN3

Gene ID

81607

55177

Gene namenectin cell adhesion molecule 4regulator of microtubule dynamics 3
SynonymsEDSS1|LNIR|PRR4|PVRL4|nectin-4FAM82A2|FAM82C|RMD-3|RMD3|ptpip51
Cytomap

1q23.3

15q15.1

Type of geneprotein-codingprotein-coding
Descriptionnectin-4Ig superfamily receptor LNIRnectin 4poliovirus receptor-related 4poliovirus receptor-related protein 4regulator of microtubule dynamics protein 3TCPTP-interacting protein 51cerebral protein 10family with sequence similarity 82, member A2family with sequence similarity 82, member Cmicrotubule-associated proteinprotein tyrosine phosphatase-interacting
Modification date2018052320180522
UniProtAcc

Q16378

Q96TC7

Ensembl transtripts involved in fusion geneENST00000536668, ENST00000544994, 
ENST00000228811, ENST00000540107, 
ENST00000260385, ENST00000338376, 
ENST00000558560, 
Fusion gene scores* DoF score10 X 10 X 3=3002 X 2 X 1=4
# samples 102
** MAII scorelog2(10/300*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: PRR4 [Title/Abstract] AND RMDN3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB200003PRR4chr12

10999907

-RMDN3chr15

41044311

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000536668ENST00000260385PRR4chr12

10999907

-RMDN3chr15

41044311

-
intron-3CDSENST00000536668ENST00000338376PRR4chr12

10999907

-RMDN3chr15

41044311

-
intron-5UTRENST00000536668ENST00000558560PRR4chr12

10999907

-RMDN3chr15

41044311

-
intron-3CDSENST00000544994ENST00000260385PRR4chr12

10999907

-RMDN3chr15

41044311

-
intron-3CDSENST00000544994ENST00000338376PRR4chr12

10999907

-RMDN3chr15

41044311

-
intron-5UTRENST00000544994ENST00000558560PRR4chr12

10999907

-RMDN3chr15

41044311

-
intron-3CDSENST00000228811ENST00000260385PRR4chr12

10999907

-RMDN3chr15

41044311

-
intron-3CDSENST00000228811ENST00000338376PRR4chr12

10999907

-RMDN3chr15

41044311

-
intron-5UTRENST00000228811ENST00000558560PRR4chr12

10999907

-RMDN3chr15

41044311

-
intron-3CDSENST00000540107ENST00000260385PRR4chr12

10999907

-RMDN3chr15

41044311

-
intron-3CDSENST00000540107ENST00000338376PRR4chr12

10999907

-RMDN3chr15

41044311

-
intron-5UTRENST00000540107ENST00000558560PRR4chr12

10999907

-RMDN3chr15

41044311

-

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FusionProtFeatures for PRR4_RMDN3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRR4

Q16378

RMDN3

Q96TC7

Involved in cellular calcium homeostasis regulation. Mayparticipate in differentiation and apoptosis of keratinocytes.Overexpression induces apoptosis. {ECO:0000269|PubMed:16820967,ECO:0000269|PubMed:22131369}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PRR4_RMDN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PRR4_RMDN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PRR4_RMDN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PRR4_RMDN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource