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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28942

FusionGeneSummary for PRR4_FRYL

check button Fusion gene summary
Fusion gene informationFusion gene name: PRR4_FRYL
Fusion gene ID: 28942
HgeneTgene
Gene symbol

PRR4

FRYL

Gene ID

81607

285527

Gene namenectin cell adhesion molecule 4FRY like transcription coactivator
SynonymsEDSS1|LNIR|PRR4|PVRL4|nectin-4AF4p12|KIAA0826|MOR2
Cytomap

1q23.3

4p11

Type of geneprotein-codingprotein-coding
Descriptionnectin-4Ig superfamily receptor LNIRnectin 4poliovirus receptor-related 4poliovirus receptor-related protein 4protein furry homolog-likeALL1-fused gene from chromosome 4p12 proteinFRY-likefurry homolog-likefurry-likemor2 cell polarity protein homolog
Modification date2018052320180523
UniProtAcc

Q16378

O94915

Ensembl transtripts involved in fusion geneENST00000536668, ENST00000544994, 
ENST00000228811, ENST00000540107, 
ENST00000503238, ENST00000358350, 
ENST00000537810, ENST00000264319, 
ENST00000507711, ENST00000514783, 
ENST00000507873, ENST00000506685, 
Fusion gene scores* DoF score10 X 10 X 3=3005 X 6 X 2=60
# samples 109
** MAII scorelog2(10/300*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/60*10)=0.584962500721156
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PRR4 [Title/Abstract] AND FRYL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB349523PRR4chr12

10999719

+FRYLchr4

48517226

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000536668ENST00000503238PRR4chr12

10999719

+FRYLchr4

48517226

+
intron-3CDSENST00000536668ENST00000358350PRR4chr12

10999719

+FRYLchr4

48517226

+
intron-3CDSENST00000536668ENST00000537810PRR4chr12

10999719

+FRYLchr4

48517226

+
intron-5UTRENST00000536668ENST00000264319PRR4chr12

10999719

+FRYLchr4

48517226

+
intron-intronENST00000536668ENST00000507711PRR4chr12

10999719

+FRYLchr4

48517226

+
intron-intronENST00000536668ENST00000514783PRR4chr12

10999719

+FRYLchr4

48517226

+
intron-5UTRENST00000536668ENST00000507873PRR4chr12

10999719

+FRYLchr4

48517226

+
intron-intronENST00000536668ENST00000506685PRR4chr12

10999719

+FRYLchr4

48517226

+
intron-3CDSENST00000544994ENST00000503238PRR4chr12

10999719

+FRYLchr4

48517226

+
intron-3CDSENST00000544994ENST00000358350PRR4chr12

10999719

+FRYLchr4

48517226

+
intron-3CDSENST00000544994ENST00000537810PRR4chr12

10999719

+FRYLchr4

48517226

+
intron-5UTRENST00000544994ENST00000264319PRR4chr12

10999719

+FRYLchr4

48517226

+
intron-intronENST00000544994ENST00000507711PRR4chr12

10999719

+FRYLchr4

48517226

+
intron-intronENST00000544994ENST00000514783PRR4chr12

10999719

+FRYLchr4

48517226

+
intron-5UTRENST00000544994ENST00000507873PRR4chr12

10999719

+FRYLchr4

48517226

+
intron-intronENST00000544994ENST00000506685PRR4chr12

10999719

+FRYLchr4

48517226

+
intron-3CDSENST00000228811ENST00000503238PRR4chr12

10999719

+FRYLchr4

48517226

+
intron-3CDSENST00000228811ENST00000358350PRR4chr12

10999719

+FRYLchr4

48517226

+
intron-3CDSENST00000228811ENST00000537810PRR4chr12

10999719

+FRYLchr4

48517226

+
intron-5UTRENST00000228811ENST00000264319PRR4chr12

10999719

+FRYLchr4

48517226

+
intron-intronENST00000228811ENST00000507711PRR4chr12

10999719

+FRYLchr4

48517226

+
intron-intronENST00000228811ENST00000514783PRR4chr12

10999719

+FRYLchr4

48517226

+
intron-5UTRENST00000228811ENST00000507873PRR4chr12

10999719

+FRYLchr4

48517226

+
intron-intronENST00000228811ENST00000506685PRR4chr12

10999719

+FRYLchr4

48517226

+
intron-3CDSENST00000540107ENST00000503238PRR4chr12

10999719

+FRYLchr4

48517226

+
intron-3CDSENST00000540107ENST00000358350PRR4chr12

10999719

+FRYLchr4

48517226

+
intron-3CDSENST00000540107ENST00000537810PRR4chr12

10999719

+FRYLchr4

48517226

+
intron-5UTRENST00000540107ENST00000264319PRR4chr12

10999719

+FRYLchr4

48517226

+
intron-intronENST00000540107ENST00000507711PRR4chr12

10999719

+FRYLchr4

48517226

+
intron-intronENST00000540107ENST00000514783PRR4chr12

10999719

+FRYLchr4

48517226

+
intron-5UTRENST00000540107ENST00000507873PRR4chr12

10999719

+FRYLchr4

48517226

+
intron-intronENST00000540107ENST00000506685PRR4chr12

10999719

+FRYLchr4

48517226

+

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FusionProtFeatures for PRR4_FRYL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRR4

Q16378

FRYL

O94915

Plays a key role in maintaining the integrity ofpolarized cell extensions during morphogenesis, regulates theactin cytoskeleton and plays a key role in patterning sensoryneuron dendritic fields by promoting avoidance between homologousdendrites as well as by limiting dendritic branching (Bysimilarity). May function as a transcriptional activator.{ECO:0000250, ECO:0000269|PubMed:16061630}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PRR4_FRYL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PRR4_FRYL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PRR4_FRYL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PRR4_FRYL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource