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Fusion gene ID: 28938 |
FusionGeneSummary for PRR16_IGKJ2 |
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Fusion gene information | Fusion gene name: PRR16_IGKJ2 | Fusion gene ID: 28938 | Hgene | Tgene | Gene symbol | PRR16 | IGKJ2 | Gene ID | 51334 | 28949 |
Gene name | proline rich 16 | immunoglobulin kappa joining 2 | |
Synonyms | DSC54|LARGEN | J2 | |
Cytomap | 5q23.1 | 2p11.2 | |
Type of gene | protein-coding | other | |
Description | protein Largenmesenchymal stem cell protein DSC54proline-rich protein 16 | - | |
Modification date | 20180519 | 20180329 | |
UniProtAcc | Q569H4 | ||
Ensembl transtripts involved in fusion gene | ENST00000407149, ENST00000379551, ENST00000505123, ENST00000446965, | ENST00000390241, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 1 X 2=4 |
# samples | 2 | 2 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: PRR16 [Title/Abstract] AND IGKJ2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PRR16 | GO:0045727 | positive regulation of translation | 24656129 |
Hgene | PRR16 | GO:0045793 | positive regulation of cell size | 24656129 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | THCA | TCGA-FE-A230-01A | PRR16 | chr5 | 119801377 | + | IGKJ2 | chr2 | 89161068 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000407149 | ENST00000390241 | PRR16 | chr5 | 119801377 | + | IGKJ2 | chr2 | 89161068 | - |
intron-3CDS | ENST00000379551 | ENST00000390241 | PRR16 | chr5 | 119801377 | + | IGKJ2 | chr2 | 89161068 | - |
intron-3CDS | ENST00000505123 | ENST00000390241 | PRR16 | chr5 | 119801377 | + | IGKJ2 | chr2 | 89161068 | - |
intron-3CDS | ENST00000446965 | ENST00000390241 | PRR16 | chr5 | 119801377 | + | IGKJ2 | chr2 | 89161068 | - |
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FusionProtFeatures for PRR16_IGKJ2 |
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Hgene | Tgene |
PRR16 | IGKJ2 |
Regulator of cell size that promotes cell size increaseindependently of mTOR and Hippo signaling pathways. Acts bystimulating the translation of specific mRNAs, including thoseencoding proteins affecting mitochondrial functions. Increasesmitochondrial mass and respiration. {ECO:0000269|PubMed:24656129}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PRR16_IGKJ2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PRR16_IGKJ2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PRR16 | NEDD4, NEDD4L, PPP1CA, APP, PPP1CC, ABI2, SMURF1 | IGKJ2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PRR16_IGKJ2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PRR16_IGKJ2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |