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Fusion gene ID: 28910 |
FusionGeneSummary for PRR11_SUZ12 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PRR11_SUZ12 | Fusion gene ID: 28910 | Hgene | Tgene | Gene symbol | PRR11 | SUZ12 | Gene ID | 55771 | 23512 |
| Gene name | proline rich 11 | SUZ12, polycomb repressive complex 2 subunit | |
| Synonyms | - | CHET9|JJAZ1 | |
| Cytomap | 17q22 | 17q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | proline-rich protein 11transcription repressor of MHCII | polycomb protein SUZ12chET 9 proteinchromatin precipitated E2F target 9 proteinjoined to JAZF1 proteinsuppressor of zeste 12 protein homolog | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q96HE9 | Q15022 | |
| Ensembl transtripts involved in fusion gene | ENST00000262293, | ENST00000322652, ENST00000580398, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 5 X 5 X 3=75 |
| # samples | 3 | 6 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PRR11 [Title/Abstract] AND SUZ12 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PRR11 | GO:0051726 | regulation of cell cycle | 23246489 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-F7-8298-01A | PRR11 | chr17 | 57275150 | + | SUZ12 | chr17 | 30315339 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000262293 | ENST00000322652 | PRR11 | chr17 | 57275150 | + | SUZ12 | chr17 | 30315339 | + |
| In-frame | ENST00000262293 | ENST00000580398 | PRR11 | chr17 | 57275150 | + | SUZ12 | chr17 | 30315339 | + |
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FusionProtFeatures for PRR11_SUZ12 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PRR11 | SUZ12 |
| Plays a critical role in cell cycle progression.{ECO:0000269|PubMed:23246489}. | Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27'(H3K27me) of histone H3, leading to transcriptional repression ofthe affected target gene. The PRC2/EED-EZH2 complex may also serveas a recruiting platform for DNA methyltransferases, therebylinking two epigenetic repression systems. Genes repressed by thePRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.{ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737,ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16618801,ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18285464,ECO:0000269|PubMed:28229514}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PRR11 | chr17:57275150 | chr17:30315339 | ENST00000262293 | + | 9 | 10 | 174_202 | 338 | 361 | Compositional bias | Note=Pro-rich |
| Hgene | PRR11 | chr17:57275150 | chr17:30315339 | ENST00000262293 | + | 9 | 10 | 34_41 | 338 | 361 | Compositional bias | Note=Poly-Pro |
| Hgene | PRR11 | chr17:57275150 | chr17:30315339 | ENST00000262293 | + | 9 | 10 | 285_291 | 338 | 361 | Motif | Note=Phosphodegron |
| Hgene | PRR11 | chr17:57275150 | chr17:30315339 | ENST00000262293 | + | 9 | 10 | 296_304 | 338 | 361 | Motif | Note=D-box |
| Hgene | PRR11 | chr17:57275150 | chr17:30315339 | ENST00000262293 | + | 9 | 10 | 316_318 | 338 | 361 | Motif | Note=KEN box |
| Hgene | PRR11 | chr17:57275150 | chr17:30315339 | ENST00000262293 | + | 9 | 10 | 325_330 | 338 | 361 | Motif | Note=Phosphodegron |
| Tgene | >SUZ12 | chr17:57275150 | chr17:30315339 | ENST00000322652 | + | 8 | 16 | 563_639 | 341 | 740 | Region | Note=VEFS-box |
| Tgene | >SUZ12 | chr17:57275150 | chr17:30315339 | ENST00000322652 | + | 8 | 16 | 448_471 | 341 | 740 | Zinc finger | Note=C2H2-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | SUZ12 | chr17:57275150 | chr17:30315339 | ENST00000322652 | + | 8 | 16 | 51_59 | 341 | 740 | Compositional bias | Note=Poly-Ser |
| Tgene | SUZ12 | chr17:57275150 | chr17:30315339 | ENST00000322652 | + | 8 | 16 | 60_67 | 341 | 740 | Compositional bias | Note=Poly-Ala |
| Tgene | SUZ12 | chr17:57275150 | chr17:30315339 | ENST00000322652 | + | 8 | 16 | 7_50 | 341 | 740 | Compositional bias | Note=Gly-rich |
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FusionGeneSequence for PRR11_SUZ12 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PRR11_ENST00000262293_chr17_57275150_+_SUZ12_ENST00000322652_chr17_30315339_+_737aa MPKFKQRRRKLKAKAERLFKKKEASHFQSKLITPPPPPPSPERVGISSIDISQSRSWLTSSWNFNFPNIRDAIKLWTNRVWSIYSWCQNC ITQSLEVLKDTIFPSRICHRELYSVKQQFCILESKLCKLQEALKTISESSSCPSCGQTCHMSGKLTNVPACVLITPGDSKAVLPPTLPQP ASHFPPPPPPPPLPPPPPPLAPVLLRKPSLAKALQAGPLKKDGPMQITVKDLLTVKLKKTQSLDEKRKLIPSPKARNPLVTVSDLQHVTL KPNSKVLSTRVTNVLITPGKSQMDLRKLLRKVDVERSPGGTPLTNKENMETGTGLTPVMTQALRRKFQRLPPFETFSQGPTLQFTLRWTG ETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWC TLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEF LESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMN HACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALE >In-frame_PRR11_ENST00000262293_chr17_57275150_+_SUZ12_ENST00000580398_chr17_30315339_+_737aa MPKFKQRRRKLKAKAERLFKKKEASHFQSKLITPPPPPPSPERVGISSIDISQSRSWLTSSWNFNFPNIRDAIKLWTNRVWSIYSWCQNC ITQSLEVLKDTIFPSRICHRELYSVKQQFCILESKLCKLQEALKTISESSSCPSCGQTCHMSGKLTNVPACVLITPGDSKAVLPPTLPQP ASHFPPPPPPPPLPPPPPPLAPVLLRKPSLAKALQAGPLKKDGPMQITVKDLLTVKLKKTQSLDEKRKLIPSPKARNPLVTVSDLQHVTL KPNSKVLSTRVTNVLITPGKSQMDLRKLLRKVDVERSPGGTPLTNKENMETGTGLTPVMTQALRRKFQRLPPFETFSQGPTLQFTLRWTG ETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWC TLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEF LESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMN HACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PRR11_ENST00000262293_chr17_57275150_+_SUZ12_ENST00000322652_chr17_30315339_+_2211nt ATGCCCAAGTTCAAACAACGAAGACGAAAGCTAAAAGCCAAAGCCGAAAGATTATTCAAAAAAAAAGAAGCCTCTCACTTTCAGTCCAAG CTAATTACACCTCCTCCTCCACCACCCTCACCAGAAAGAGTCGGTATTTCTTCAATAGATATATCTCAAAGCAGAAGCTGGCTAACATCA TCCTGGAACTTCAATTTTCCTAACATCAGAGATGCAATAAAACTTTGGACAAATAGAGTATGGTCTATATACAGCTGGTGCCAGAACTGC ATAACCCAGAGTTTAGAAGTATTGAAAGACACCATCTTTCCATCTCGTATCTGCCACCGAGAACTTTACAGTGTAAAACAACAGTTTTGC ATTTTGGAAAGTAAATTATGCAAGCTCCAGGAAGCACTGAAGACCATCTCAGAAAGTTCTTCCTGTCCAAGCTGTGGTCAAACATGTCAC ATGAGTGGTAAACTTACAAATGTGCCTGCCTGCGTTCTGATCACCCCTGGAGACTCCAAAGCTGTGCTTCCTCCCACACTGCCACAGCCA GCCAGCCATTTTCCTCCTCCTCCTCCACCTCCACCTCTGCCACCTCCTCCACCACCACTAGCACCTGTGTTGCTCAGAAAACCCAGTCTC GCTAAAGCACTTCAGGCTGGACCATTAAAAAAAGATGGACCCATGCAGATAACAGTTAAAGATCTGCTGACTGTAAAATTAAAGAAGACA CAGAGTTTAGATGAAAAGAGGAAGCTTATACCATCGCCGAAAGCACGGAATCCACTAGTTACCGTCTCTGACTTGCAGCATGTTACCCTG AAACCTAACTCCAAAGTGTTATCGACTCGAGTTACAAACGTCTTAATCACTCCTGGAAAAAGTCAGATGGATCTGCGGAAACTGCTTAGA AAAGTCGATGTAGAGAGGAGCCCAGGTGGAACCCCTCTTACCAATAAGGAAAATATGGAAACAGGAACAGGACTGACTCCAGTGATGACG CAGGCCTTAAGGAGAAAGTTTCAGAGGCTGCCTCCATTCGAAACATTTTCTCAGGGACCTACGTTGCAGTTCACTCTTCGTTGGACAGGA GAGACCAATGATAAATCTACGGCTCCTATTGCCAAACCTCTTGCCACTAGAAATTCAGAGAGTCTCCATCAGGAAAACAAGCCTGGTTCA GTTAAACCTACTCAAACTATTGCTGTTAAAGAATCATTGACTACAGATCTACAAACAAGAAAAGAAAAGGATACTCCAAATGAAAACCGA CAAAAATTAAGAATATTTTATCAGTTTCTCTATAACAACAATACAAGGCAACAAACTGAAGCAAGAGATGACCTGCATTGCCCTTGGTGT ACTCTGAACTGCCGCAAACTTTATAGTTTACTCAAGCATCTTAAACTCTGCCATAGCAGATTTATCTTCAACTATGTTTATCATCCAAAA GGTGCTAGGATAGATGTTTCTATCAATGAGTGTTATGATGGCTCCTATGCAGGAAATCCTCAGGATATTCATCGCCAACCTGGATTTGCT TTTAGTCGCAACGGACCAGTTAAGAGAACACCTATCACACATATTCTTGTGTGCAGGCCAAAACGAACAAAAGCAAGCATGTCTGAATTT CTTGAATCTGAAGATGGGGAAGTAGAACAGCAAAGAACATATAGTAGTGGCCACAATCGTCTGTATTTCCATAGTGATACCTGCTTACCT CTCCGTCCACAAGAAATGGAAGTAGATAGTGAAGATGAAAAGGATCCTGAATGGCTAAGAGAAAAAACCATTACACAAATTGAAGAGTTT TCTGATGTTAATGAAGGAGAGAAAGAAGTGATGAAACTCTGGAATCTCCATGTCATGAAGCATGGGTTTATTGCTGACAATCAAATGAAT CATGCCTGTATGCTGTTTGTAGAAAATTATGGACAGAAAATAATTAAGAAGAATTTATGTCGAAACTTCATGCTTCATCTAGTCAGCATG CATGACTTTAATCTTATTAGCATAATGTCAATAGATAAAGCTGTTACCAAGCTCCGTGAAATGCAGCAAAAATTAGAAAAGGGGGAATCT GCTTCCCCTGCAAACGAAGAAATAACTGAAGAACAAAATGGGACAGCAAATGGATTTAGTGAAATTAACTCAAAAGAGAAAGCTTTGGAA >In-frame_PRR11_ENST00000262293_chr17_57275150_+_SUZ12_ENST00000580398_chr17_30315339_+_2211nt ATGCCCAAGTTCAAACAACGAAGACGAAAGCTAAAAGCCAAAGCCGAAAGATTATTCAAAAAAAAAGAAGCCTCTCACTTTCAGTCCAAG CTAATTACACCTCCTCCTCCACCACCCTCACCAGAAAGAGTCGGTATTTCTTCAATAGATATATCTCAAAGCAGAAGCTGGCTAACATCA TCCTGGAACTTCAATTTTCCTAACATCAGAGATGCAATAAAACTTTGGACAAATAGAGTATGGTCTATATACAGCTGGTGCCAGAACTGC ATAACCCAGAGTTTAGAAGTATTGAAAGACACCATCTTTCCATCTCGTATCTGCCACCGAGAACTTTACAGTGTAAAACAACAGTTTTGC ATTTTGGAAAGTAAATTATGCAAGCTCCAGGAAGCACTGAAGACCATCTCAGAAAGTTCTTCCTGTCCAAGCTGTGGTCAAACATGTCAC ATGAGTGGTAAACTTACAAATGTGCCTGCCTGCGTTCTGATCACCCCTGGAGACTCCAAAGCTGTGCTTCCTCCCACACTGCCACAGCCA GCCAGCCATTTTCCTCCTCCTCCTCCACCTCCACCTCTGCCACCTCCTCCACCACCACTAGCACCTGTGTTGCTCAGAAAACCCAGTCTC GCTAAAGCACTTCAGGCTGGACCATTAAAAAAAGATGGACCCATGCAGATAACAGTTAAAGATCTGCTGACTGTAAAATTAAAGAAGACA CAGAGTTTAGATGAAAAGAGGAAGCTTATACCATCGCCGAAAGCACGGAATCCACTAGTTACCGTCTCTGACTTGCAGCATGTTACCCTG AAACCTAACTCCAAAGTGTTATCGACTCGAGTTACAAACGTCTTAATCACTCCTGGAAAAAGTCAGATGGATCTGCGGAAACTGCTTAGA AAAGTCGATGTAGAGAGGAGCCCAGGTGGAACCCCTCTTACCAATAAGGAAAATATGGAAACAGGAACAGGACTGACTCCAGTGATGACG CAGGCCTTAAGGAGAAAGTTTCAGAGGCTGCCTCCATTCGAAACATTTTCTCAGGGACCTACGTTGCAGTTCACTCTTCGTTGGACAGGA GAGACCAATGATAAATCTACGGCTCCTATTGCCAAACCTCTTGCCACTAGAAATTCAGAGAGTCTCCATCAGGAAAACAAGCCTGGTTCA GTTAAACCTACTCAAACTATTGCTGTTAAAGAATCATTGACTACAGATCTACAAACAAGAAAAGAAAAGGATACTCCAAATGAAAACCGA CAAAAATTAAGAATATTTTATCAGTTTCTCTATAACAACAATACAAGGCAACAAACTGAAGCAAGAGATGACCTGCATTGCCCTTGGTGT ACTCTGAACTGCCGCAAACTTTATAGTTTACTCAAGCATCTTAAACTCTGCCATAGCAGATTTATCTTCAACTATGTTTATCATCCAAAA GGTGCTAGGATAGATGTTTCTATCAATGAGTGTTATGATGGCTCCTATGCAGGAAATCCTCAGGATATTCATCGCCAACCTGGATTTGCT TTTAGTCGCAACGGACCAGTTAAGAGAACACCTATCACACATATTCTTGTGTGCAGGCCAAAACGAACAAAAGCAAGCATGTCTGAATTT CTTGAATCTGAAGATGGGGAAGTAGAACAGCAAAGAACATATAGTAGTGGCCACAATCGTCTGTATTTCCATAGTGATACCTGCTTACCT CTCCGTCCACAAGAAATGGAAGTAGATAGTGAAGATGAAAAGGATCCTGAATGGCTAAGAGAAAAAACCATTACACAAATTGAAGAGTTT TCTGATGTTAATGAAGGAGAGAAAGAAGTGATGAAACTCTGGAATCTCCATGTCATGAAGCATGGGTTTATTGCTGACAATCAAATGAAT CATGCCTGTATGCTGTTTGTAGAAAATTATGGACAGAAAATAATTAAGAAGAATTTATGTCGAAACTTCATGCTTCATCTAGTCAGCATG CATGACTTTAATCTTATTAGCATAATGTCAATAGATAAAGCTGTTACCAAGCTCCGTGAAATGCAGCAAAAATTAGAAAAGGGGGAATCT GCTTCCCCTGCAAACGAAGAAATAACTGAAGAACAAAATGGGACAGCAAATGGATTTAGTGAAATTAACTCAAAAGAGAAAGCTTTGGAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PRR11_ENST00000262293_chr17_57275150_+_SUZ12_ENST00000322652_chr17_30315339_+_4565nt ACCAGAGCTTCCACCGACAGCAGAGGGGACGTAACACACCTTCTTTCCCCTCCGGCTTTCCTTCCCCTTCTCTCCCGCCTTCTCCTTATT CATACCAGAAGCGCCTCAGCTCTGATTGGCTGGAGCTCTGTGCTATCTCAGCCAATCACAAGCCGGGCTGTGCTCCTACACCATCCGAAG AGCGAATCGTGCAGAGACCGTGTCTACGATTGGCCTCTCCCTGACAAGGATTTAATTTTGAATTTTTCTTTATGGCGTGGGAGAGGCCAC AGCCCGGACTCCATCGACTCCCCCGGCTCTTAGACTAAAATCATGCCCAAGTTCAAACAACGAAGACGAAAGCTAAAAGCCAAAGCCGAA AGATTATTCAAAAAAAAAGAAGCCTCTCACTTTCAGTCCAAGCTAATTACACCTCCTCCTCCACCACCCTCACCAGAAAGAGTCGGTATT TCTTCAATAGATATATCTCAAAGCAGAAGCTGGCTAACATCATCCTGGAACTTCAATTTTCCTAACATCAGAGATGCAATAAAACTTTGG ACAAATAGAGTATGGTCTATATACAGCTGGTGCCAGAACTGCATAACCCAGAGTTTAGAAGTATTGAAAGACACCATCTTTCCATCTCGT ATCTGCCACCGAGAACTTTACAGTGTAAAACAACAGTTTTGCATTTTGGAAAGTAAATTATGCAAGCTCCAGGAAGCACTGAAGACCATC TCAGAAAGTTCTTCCTGTCCAAGCTGTGGTCAAACATGTCACATGAGTGGTAAACTTACAAATGTGCCTGCCTGCGTTCTGATCACCCCT GGAGACTCCAAAGCTGTGCTTCCTCCCACACTGCCACAGCCAGCCAGCCATTTTCCTCCTCCTCCTCCACCTCCACCTCTGCCACCTCCT CCACCACCACTAGCACCTGTGTTGCTCAGAAAACCCAGTCTCGCTAAAGCACTTCAGGCTGGACCATTAAAAAAAGATGGACCCATGCAG ATAACAGTTAAAGATCTGCTGACTGTAAAATTAAAGAAGACACAGAGTTTAGATGAAAAGAGGAAGCTTATACCATCGCCGAAAGCACGG AATCCACTAGTTACCGTCTCTGACTTGCAGCATGTTACCCTGAAACCTAACTCCAAAGTGTTATCGACTCGAGTTACAAACGTCTTAATC ACTCCTGGAAAAAGTCAGATGGATCTGCGGAAACTGCTTAGAAAAGTCGATGTAGAGAGGAGCCCAGGTGGAACCCCTCTTACCAATAAG GAAAATATGGAAACAGGAACAGGACTGACTCCAGTGATGACGCAGGCCTTAAGGAGAAAGTTTCAGAGGCTGCCTCCATTCGAAACATTT TCTCAGGGACCTACGTTGCAGTTCACTCTTCGTTGGACAGGAGAGACCAATGATAAATCTACGGCTCCTATTGCCAAACCTCTTGCCACT AGAAATTCAGAGAGTCTCCATCAGGAAAACAAGCCTGGTTCAGTTAAACCTACTCAAACTATTGCTGTTAAAGAATCATTGACTACAGAT CTACAAACAAGAAAAGAAAAGGATACTCCAAATGAAAACCGACAAAAATTAAGAATATTTTATCAGTTTCTCTATAACAACAATACAAGG CAACAAACTGAAGCAAGAGATGACCTGCATTGCCCTTGGTGTACTCTGAACTGCCGCAAACTTTATAGTTTACTCAAGCATCTTAAACTC TGCCATAGCAGATTTATCTTCAACTATGTTTATCATCCAAAAGGTGCTAGGATAGATGTTTCTATCAATGAGTGTTATGATGGCTCCTAT GCAGGAAATCCTCAGGATATTCATCGCCAACCTGGATTTGCTTTTAGTCGCAACGGACCAGTTAAGAGAACACCTATCACACATATTCTT GTGTGCAGGCCAAAACGAACAAAAGCAAGCATGTCTGAATTTCTTGAATCTGAAGATGGGGAAGTAGAACAGCAAAGAACATATAGTAGT GGCCACAATCGTCTGTATTTCCATAGTGATACCTGCTTACCTCTCCGTCCACAAGAAATGGAAGTAGATAGTGAAGATGAAAAGGATCCT GAATGGCTAAGAGAAAAAACCATTACACAAATTGAAGAGTTTTCTGATGTTAATGAAGGAGAGAAAGAAGTGATGAAACTCTGGAATCTC CATGTCATGAAGCATGGGTTTATTGCTGACAATCAAATGAATCATGCCTGTATGCTGTTTGTAGAAAATTATGGACAGAAAATAATTAAG AAGAATTTATGTCGAAACTTCATGCTTCATCTAGTCAGCATGCATGACTTTAATCTTATTAGCATAATGTCAATAGATAAAGCTGTTACC AAGCTCCGTGAAATGCAGCAAAAATTAGAAAAGGGGGAATCTGCTTCCCCTGCAAACGAAGAAATAACTGAAGAACAAAATGGGACAGCA AATGGATTTAGTGAAATTAACTCAAAAGAGAAAGCTTTGGAAACAGATAGTGTCTCAGGGGTTTCAAAACAGAGCAAAAAACAAAAACTC TGAAAAGCTCTAACCCCATGTTATGGACAAACACTGAAATTACATTTTAGGGAATTCATCCTCTAAGAATTATGTTTTTGTTTTTAATCA TATGTTCCAAACAGGCACTGTTAGATGAAGTAAATGATTTCAACAAGGATATTTGTATCAGGGTTCTACTTCACTTCATTATGCAGCATT ACATGTATATCACTTTTATTGATGTCATTAAAACATTCTGTACTTTAAGCATGAAAAGCAATATTTCAAAGTATTTTTAAACTCAACAAA TGTCATCAAATATGTTGAATTGATCTAGAAATTATTTCATATATAAATCAGAATTTTTTTGCATTTATGAACGGCTGTTTTTCTACTTTG TAATTGTGAGACATTTTCTTGGGGAGGGAAAATTGGAATGGTTCCCTTTTTTAGAAATTGAAGTGGTCTTCATATGTCAACTACAGAAAA GGAAAAAAATAGAAATTGAAGGATTTTTATGAAATTATATTGCATTACTATTTGCAGTCAAACTTTGATCCTTGTTTTTGAAATCATTTG TCAATTCGGAATGAAAAATTATAATGTAATTTTACATTACATAAGTTCCTTTTACAATTAAAAAATAGCACTTCTTCATCTTATGCCTGT TTGAGAAGATATTAAATTTTCACATTGTTGACAGTGAAATGCTATGTTGGTTTATAAGATTACAGACCATTTGTTTTCATGTGGATAATT TTAGTGCATTGCTCACCCGGTATGTTTTTTTTTTTTAACTTGAACATTTTGCTTGTTTTGTTTTTCTTTTTTAATTAGATAATCACACGG AAAATTAAGCTGTTCATATCTTTAAATTAGGATTGCAAACCAAGGAAAGAACGCATTTGAGATTTTAAGATGTCACTTATAAGGGGAGAA GTGTTCTTAAAAAGTCAACCAGAAAACTGTTATGCCTTTTATTTGTTTGCAAGGATGTCTTTGTAATGTGTTTCATGAATAGAATATCCA ATAGAGATAAGCTGACTTGAATCATTTTGAGCAATTTTGCCCTGTGTTATATGTGTTTCACGCACATATTTGCAGTTGGATTTTCTCCAA CAGAAAGTGGATTCACTACTGGCACATTAACAAGCACCAATAGGTTTTTATTCCAACTCCGAGCACTGTGGTTGAGTAACATCACCTCAA TTTTTTATTATCCTTAAAGATATTGCATTTTCATATTCTTTATTTATAAAGGATCAATGCTGCTGTAAATACAGGTATTTTTAATTTTAA AATTTCATTCCACCACCATCAGATGCAGTTCCCTATTTTGTTTAATGAAGGGATATATAAGCTTTCTAATGGTGTCTTCAGAAATTTATA AAATGTAAATACTGATTTGACTGGTCTTTAAGATGTGTTTAACTGTGAGGCTATTTAACGAATAGTGTGGATGTGATTTGTCATCCAGTA TTAAGTTCTTAGTCATTGATTTTTGTGTTTAAAAAAAAATAGGAAAGAGGGAAACTGCAGCTTTCATTACAGATTCCTTGATTGGTAAGC TCTCCAAATGATGAGTTCTAGTAAACTCTGATTTTTGCCTCTGGATAGTAGATCTCGAGCGTTTATCTCGGGCTTTAATTTGCTAAAGCT GTGCACATATGTAAAAAAAAAAAAAAAAAGATTATTTTAGGGGAGATGTAGGTGTAGAATTATTGCTTATGTCATTTCTTAAGCAGTTAT GCTCTTAATGCTTAAAAGAAGGCTAGCATTGTTTGCACAAAAAGTTGGTGATTCCCACCCCAAATAGTAATAAAATTACTTCTGTTGAGT AAACTTTTTATGTCATCGTAAAAGCTGAAAAAATCCCTTTGTTTCTATTTATAAAAAAAGTGCTTTTCTATATGTACCCTTGATAACAGA TTTTGAAGAAATCCTGTAAGATGATAAAGCATTTGAATGGTACAGTAGATGTAAAAAAAATTCAGTTTAAAAGAACATTTGTTTTTACAT >In-frame_PRR11_ENST00000262293_chr17_57275150_+_SUZ12_ENST00000580398_chr17_30315339_+_4169nt ACCAGAGCTTCCACCGACAGCAGAGGGGACGTAACACACCTTCTTTCCCCTCCGGCTTTCCTTCCCCTTCTCTCCCGCCTTCTCCTTATT CATACCAGAAGCGCCTCAGCTCTGATTGGCTGGAGCTCTGTGCTATCTCAGCCAATCACAAGCCGGGCTGTGCTCCTACACCATCCGAAG AGCGAATCGTGCAGAGACCGTGTCTACGATTGGCCTCTCCCTGACAAGGATTTAATTTTGAATTTTTCTTTATGGCGTGGGAGAGGCCAC AGCCCGGACTCCATCGACTCCCCCGGCTCTTAGACTAAAATCATGCCCAAGTTCAAACAACGAAGACGAAAGCTAAAAGCCAAAGCCGAA AGATTATTCAAAAAAAAAGAAGCCTCTCACTTTCAGTCCAAGCTAATTACACCTCCTCCTCCACCACCCTCACCAGAAAGAGTCGGTATT TCTTCAATAGATATATCTCAAAGCAGAAGCTGGCTAACATCATCCTGGAACTTCAATTTTCCTAACATCAGAGATGCAATAAAACTTTGG ACAAATAGAGTATGGTCTATATACAGCTGGTGCCAGAACTGCATAACCCAGAGTTTAGAAGTATTGAAAGACACCATCTTTCCATCTCGT ATCTGCCACCGAGAACTTTACAGTGTAAAACAACAGTTTTGCATTTTGGAAAGTAAATTATGCAAGCTCCAGGAAGCACTGAAGACCATC TCAGAAAGTTCTTCCTGTCCAAGCTGTGGTCAAACATGTCACATGAGTGGTAAACTTACAAATGTGCCTGCCTGCGTTCTGATCACCCCT GGAGACTCCAAAGCTGTGCTTCCTCCCACACTGCCACAGCCAGCCAGCCATTTTCCTCCTCCTCCTCCACCTCCACCTCTGCCACCTCCT CCACCACCACTAGCACCTGTGTTGCTCAGAAAACCCAGTCTCGCTAAAGCACTTCAGGCTGGACCATTAAAAAAAGATGGACCCATGCAG ATAACAGTTAAAGATCTGCTGACTGTAAAATTAAAGAAGACACAGAGTTTAGATGAAAAGAGGAAGCTTATACCATCGCCGAAAGCACGG AATCCACTAGTTACCGTCTCTGACTTGCAGCATGTTACCCTGAAACCTAACTCCAAAGTGTTATCGACTCGAGTTACAAACGTCTTAATC ACTCCTGGAAAAAGTCAGATGGATCTGCGGAAACTGCTTAGAAAAGTCGATGTAGAGAGGAGCCCAGGTGGAACCCCTCTTACCAATAAG GAAAATATGGAAACAGGAACAGGACTGACTCCAGTGATGACGCAGGCCTTAAGGAGAAAGTTTCAGAGGCTGCCTCCATTCGAAACATTT TCTCAGGGACCTACGTTGCAGTTCACTCTTCGTTGGACAGGAGAGACCAATGATAAATCTACGGCTCCTATTGCCAAACCTCTTGCCACT AGAAATTCAGAGAGTCTCCATCAGGAAAACAAGCCTGGTTCAGTTAAACCTACTCAAACTATTGCTGTTAAAGAATCATTGACTACAGAT CTACAAACAAGAAAAGAAAAGGATACTCCAAATGAAAACCGACAAAAATTAAGAATATTTTATCAGTTTCTCTATAACAACAATACAAGG CAACAAACTGAAGCAAGAGATGACCTGCATTGCCCTTGGTGTACTCTGAACTGCCGCAAACTTTATAGTTTACTCAAGCATCTTAAACTC TGCCATAGCAGATTTATCTTCAACTATGTTTATCATCCAAAAGGTGCTAGGATAGATGTTTCTATCAATGAGTGTTATGATGGCTCCTAT GCAGGAAATCCTCAGGATATTCATCGCCAACCTGGATTTGCTTTTAGTCGCAACGGACCAGTTAAGAGAACACCTATCACACATATTCTT GTGTGCAGGCCAAAACGAACAAAAGCAAGCATGTCTGAATTTCTTGAATCTGAAGATGGGGAAGTAGAACAGCAAAGAACATATAGTAGT GGCCACAATCGTCTGTATTTCCATAGTGATACCTGCTTACCTCTCCGTCCACAAGAAATGGAAGTAGATAGTGAAGATGAAAAGGATCCT GAATGGCTAAGAGAAAAAACCATTACACAAATTGAAGAGTTTTCTGATGTTAATGAAGGAGAGAAAGAAGTGATGAAACTCTGGAATCTC CATGTCATGAAGCATGGGTTTATTGCTGACAATCAAATGAATCATGCCTGTATGCTGTTTGTAGAAAATTATGGACAGAAAATAATTAAG AAGAATTTATGTCGAAACTTCATGCTTCATCTAGTCAGCATGCATGACTTTAATCTTATTAGCATAATGTCAATAGATAAAGCTGTTACC AAGCTCCGTGAAATGCAGCAAAAATTAGAAAAGGGGGAATCTGCTTCCCCTGCAAACGAAGAAATAACTGAAGAACAAAATGGGACAGCA AATGGATTTAGTGAAATTAACTCAAAAGAGAAAGCTTTGGAAACAGATAGTGTCTCAGGGGTTTCAAAACAGAGCAAAAAACAAAAACTC TGAAAAGCTCTAACCCCATGTTATGGACAAACACTGAAATTACATTTTAGGGAATTCATCCTCTAAGAATTATGTTTTTGTTTTTAATCA TATGTTCCAAACAGGCACTGTTAGATGAAGTAAATGATTTCAACAAGGATATTTGTATCAGGGTTCTACTTCACTTCATTATGCAGCATT ACATGTATATCACTTTTATTGATGTCATTAAAACATTCTGTACTTTAAGCATGAAAAGCAATATTTCAAAGTATTTTTAAACTCAACAAA TGTCATCAAATATGTTGAATTGATCTAGAAATTATTTCATATATAAATCAGAATTTTTTTGCATTTATGAACGGCTGTTTTTCTACTTTG TAATTGTGAGACATTTTCTTGGGGAGGGAAAATTGGAATGGTTCCCTTTTTTAGAAATTGAAGTGGTCTTCATATGTCAACTACAGAAAA GGAAAAAAATAGAAATTGAAGGATTTTTATGAAATTATATTGCATTACTATTTGCAGTCAAACTTTGATCCTTGTTTTTGAAATCATTTG TCAATTCGGAATGAAAAATTATAATGTAATTTTACATTACATAAGTTCCTTTTACAATTAAAAAATAGCACTTCTTCATCTTATGCCTGT TTGAGAAGATATTAAATTTTCACATTGTTGACAGTGAAATGCTATGTTGGTTTATAAGATTACAGACCATTTGTTTTCATGTGGATAATT TTAGTGCATTGCTCACCCGGTATGTTTTTTTTTTTTAACTTGAACATTTTGCTTGTTTTGTTTTTCTTTTTTAATTAGATAATCACACGG AAAATTAAGCTGTTCATATCTTTAAATTAGGATTGCAAACCAAGGAAAGAACGCATTTGAGATTTTAAGATGTCACTTATAAGGGGAGAA GTGTTCTTAAAAAGTCAACCAGAAAACTGTTATGCCTTTTATTTGTTTGCAAGGATGTCTTTGTAATGTGTTTCATGAATAGAATATCCA ATAGAGATAAGCTGACTTGAATCATTTTGAGCAATTTTGCCCTGTGTTATATGTGTTTCACGCACATATTTGCAGTTGGATTTTCTCCAA CAGAAAGTGGATTCACTACTGGCACATTAACAAGCACCAATAGGTTTTTATTCCAACTCCGAGCACTGTGGTTGAGTAACATCACCTCAA TTTTTTATTATCCTTAAAGATATTGCATTTTCATATTCTTTATTTATAAAGGATCAATGCTGCTGTAAATACAGGTATTTTTAATTTTAA AATTTCATTCCACCACCATCAGATGCAGTTCCCTATTTTGTTTAATGAAGGGATATATAAGCTTTCTAATGGTGTCTTCAGAAATTTATA AAATGTAAATACTGATTTGACTGGTCTTTAAGATGTGTTTAACTGTGAGGCTATTTAACGAATAGTGTGGATGTGATTTGTCATCCAGTA TTAAGTTCTTAGTCATTGATTTTTGTGTTTAAAAAAAAATAGGAAAGAGGGAAACTGCAGCTTTCATTACAGATTCCTTGATTGGTAAGC TCTCCAAATGATGAGTTCTAGTAAACTCTGATTTTTGCCTCTGGATAGTAGATCTCGAGCGTTTATCTCGGGCTTTAATTTGCTAAAGCT |
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FusionGenePPI for PRR11_SUZ12 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PRR11 | NIP7, KNOP1, RBM28, SF3B1, POP1, DDX24, FTSJ3, SF3B2, ZNF668, RPL3, UPF1, ZNF512, RPL10A, DKC1, PABPC4, DHX30, ELAVL2, DDX27, HIST1H1A, GLYR1, SORD, HP1BP3, REXO4, DDX31, MYBBP1A, NOP16, RPL26L1, RPS3A, KRI1, WHSC1, C7orf50, ZCRB1, EBNA1BP2, UTP23, ZCCHC3, RRP12, RSBN1, TTF1, SURF6, LARP1, LYAR, RRP8, STAU2, STAU1, CTCF, NVL, GLTSCR2, LLPH, RPS15, GPATCH4, CCDC86, RBM34, LIN28B, NOC4L, NOC3L, BRIX1, NOP2, RSL24D1, TSR1, MOV10, PWP1, RRS1, KRR1, RPL15, KIAA0020, PAK1IP1, RPL23A, GNL2, RPS13, ZBTB24, ZNF771, ZBTB11, RPL13A, PRDM15, RPL7L1, RPF2, ZNF800, PES1, CASC3, PURA, PPAN-P2RY11, NSA2, ZNF22, NOL12, ZNF189, MRPL38, ZNF689, DUSP11, OSBPL5, IL4R, RPL18A, RPS3, RPL4, BOP1 | SUZ12 | SETDB1, EED, AEBP2, RBBP4, EZH2, VAV1, WDR77, GTF2I, SNAI1, UBE2I, CTCF, JARID2, MTF2, EZH1, SUZ12, CREB1, EWSR1, HIST1H1A, HIST1H1C, KDM5A, SETD8, SIRT1, PHF1, WT1, DNMT1, PPP1R8, USP7, RARG, GATA4, PJA1, CDYL, HIST3H3, RELA, RELB, ELAVL1, CDK19, CDK8, MED6, MED17, UHRF1, HIC1, PML, RARA, HDAC2, PAXIP1, CBX5, SS18, SSX2, DNMT3B, BTRC, BRCA1, FBXW11, RBBP7, PLEC, THRAP3, HIST4H4, ACTG1, MTOR, ERH, ILF3, EIF4A3, PCNT, LUC7L2, ACIN1, NCL, DDX5, H2AFY, PRPF8, BCLAF1, SRSF1, PRMT1, SNRNP200, LIMA1, CDKAL1, UBB, SON, AKAP9, YBX1, PABPC4, RNPS1, TRA2A, TAF15, TRIM28, ARG1, DHX9, HIST1H3D, MYH14, NUMA1, SF3B1, SRSF10, PKP1, AR, RBM14, MLST8, H1F0, GCN1L1, EFTUD2, DYNC1H1, SRSF9, FMR1, ATP5B, DDX3X, CHTOP, HP1BP3, LARP1, IMMT, NCBP1, SNRPN, SNRNP70, ILF2, SAFB2, GNB2L1, PHF19, MAGOH, SRSF5, SF3B2, ATP2A2, SORBS2, DDX39B, U2AF2, HIST1H2BB, NOP58, UPF1, SRSF6, SF3B3, LUC7L, RALY, FBL, SRSF3, XRCC5, HIST1H2BA, ALYREF, SNRPA, C17orf85, MYO1C, PPP1R9B, NAT10, RBM8A, ZNF326, CHCHD3, ADAR, DBN1, FXR2, XAB2, SLTM, SRSF8, SNRPD3, ATAD3A, CHD4, C1QBP, YBX3, HIST2H2AA3, PABPN1, RBM39, U2AF1, FYTTD1, ATP5C1, CRNKL1, HSPA1A, SRSF7, SFXN1, VCP, CBX8, H2AFY2, TUFM, KHSRP, RAN, VGF, PRDX1, PHF5A, PTBP1, PKM, RCC1, CCT3, CALR, CNBP, CBX3, CPSF7, EIF2S2, FXR1, SAP18, LMNB2, MYL6, FIP1L1, SNRPD1, SNRPA1, CDK5RAP2, PHGDH, TRIM25, EIF2AK3, LGALS7, LDHB, NHP2L1, PDLIM5, NDRG1, NOP2, RCN1, RSL1D1, RUVBL2, SF1, SMARCA5, THOC2, TPI1, ZC3H13, SLC39A7, ACACA, AKAP8L, PRKAR2A, CSNK2B, CEP57, MCM7, RANBP2, FLNB, HIST1H2AE, AQR, KHDRBS1, MFAP1, PTCD3, PLG, CDC40, PDIA3, SPRR2G, SF3A1, GATAD2B, YY1, ABLIM1, AIFM1, ATP5O, CPSF6, COPA, CKMT1A, DNAJA1, RNF2, FUBP3, GSDMA, NHP2, DKC1, HEATR1, HIST2H2AB, LUC7L3, SSB, SYNE1, NUP93, NXF1, NOLC1, PPIB, PLRG1, SF3B6, PRPF19, BCAS2, DDX23, PHB, PHB2, DHX30, GLYR1, RCL1, RBM4, PGAM5, SNW1, SAMM50, SF3A3, STOML2, SMC3, TFAM, SART1, AFG3L2, AMOTL1, EPRS, CSRP1, DAZAP1, POLR2B, EMD, ERLIN1, GDAP1, HDAC1, C10orf12, IGLL5, KRR1, LPP, TIMM50, NGDN, NUP88, GTPBP4, ISY1, RBM22, DDX56, PDCD11, PYCR1, RBM34, MSI2, SNRPD2, SF3B4, SSR4, SNRNP40, DDX18, TM7SF2, DDOST, CSE1L, ALDOA, GLDC, C15orf52, KLK2, MTA1, SLC25A11, EBNA1BP2, RBM15B, RBM14-RBM4, REPIN1, FAM208A, RBM4B, RBM5, SKP1, SDF2L1, THOC6, TRAF4, UFD1L, EPB41L5, CANX, DNAJC9, ERGIC1, TBL1Y, H1FX, NUP107, P4HB, G3BP2, RNF114, FUS, U2AF1L4, TBL2, UTP15, HIST1H2BG, TRIM37, PRDM14, DDB2, ESR1, PCGF1, DPPA4, NANOG, POU5F1, MDM2, HNF4A, C17orf96, INTU, LCOR, KHDRBS2, C9orf3, LATS2, MEX3B, UHRF2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PRR11_SUZ12 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PRR11_SUZ12 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | SUZ12 | C0206727 | Nerve Sheath Tumors | 2 | CTD_human |
| Tgene | SUZ12 | C0001430 | Adenoma | 1 | CTD_human |
| Tgene | SUZ12 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
| Tgene | SUZ12 | C0017636 | Glioblastoma | 1 | CTD_human |
| Tgene | SUZ12 | C0017638 | Glioma | 1 | CTD_human |
| Tgene | SUZ12 | C0025202 | melanoma | 1 | CTD_human |
| Tgene | SUZ12 | C0027809 | Neurilemmoma | 1 | CTD_human |
| Tgene | SUZ12 | C0027830 | neurofibroma | 1 | CTD_human |
| Tgene | SUZ12 | C0027962 | Melanocytic nevus | 1 | CTD_human |
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