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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28898

FusionGeneSummary for PRPS1_TMEM91

check button Fusion gene summary
Fusion gene informationFusion gene name: PRPS1_TMEM91
Fusion gene ID: 28898
HgeneTgene
Gene symbol

PRPS1

TMEM91

Gene ID

5631

641649

Gene namephosphoribosyl pyrophosphate synthetase 1transmembrane protein 91
SynonymsARTS|CMTX5|DFN2|DFNX1|PPRibP|PRS-I|PRSIDSPC3|IFITMD6
Cytomap

Xq22.3

19q13.2

Type of geneprotein-codingprotein-coding
Descriptionribose-phosphate pyrophosphokinase 1dJ1070B1.2 (phosphoribosyl pyrophosphate synthetase 1)deafness 2, perceptive, congenitaldeafness, X-linked 2, perceptive, congenitalphosphoribosyl pyrophosphate synthase Iribose-phosphate diphosphokinase 1transmembrane protein 91dispanin subfamily C member 3interferon induced transmembrane protein domain containing 6
Modification date2018052320180519
UniProtAcc

P60891

Q6ZNR0

Ensembl transtripts involved in fusion geneENST00000372435, ENST00000372428, 
ENST00000372419, ENST00000543248, 
ENST00000372418, 		ENST00000539627, 
ENST00000604123, ENST00000413014, 
ENST00000392002, ENST00000436170, 
ENST00000447302, ENST00000544232, 
ENST00000542945, ENST00000356385, 
Fusion gene scores* DoF score3 X 3 X 2=183 X 2 X 3=18
# samples 33
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PRPS1 [Title/Abstract] AND TMEM91 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM553232PRPS1chrX

106871888

+TMEM91chr19

41889937

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000372435ENST00000539627PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5CDS-3UTRENST00000372435ENST00000604123PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5CDS-3UTRENST00000372435ENST00000413014PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5CDS-3UTRENST00000372435ENST00000392002PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5CDS-3UTRENST00000372435ENST00000436170PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5CDS-3UTRENST00000372435ENST00000447302PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5CDS-3UTRENST00000372435ENST00000544232PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5CDS-3UTRENST00000372435ENST00000542945PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5CDS-3UTRENST00000372435ENST00000356385PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5UTR-3UTRENST00000372428ENST00000539627PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5UTR-3UTRENST00000372428ENST00000604123PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5UTR-3UTRENST00000372428ENST00000413014PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5UTR-3UTRENST00000372428ENST00000392002PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5UTR-3UTRENST00000372428ENST00000436170PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5UTR-3UTRENST00000372428ENST00000447302PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5UTR-3UTRENST00000372428ENST00000544232PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5UTR-3UTRENST00000372428ENST00000542945PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5UTR-3UTRENST00000372428ENST00000356385PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5CDS-3UTRENST00000372419ENST00000539627PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5CDS-3UTRENST00000372419ENST00000604123PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5CDS-3UTRENST00000372419ENST00000413014PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5CDS-3UTRENST00000372419ENST00000392002PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5CDS-3UTRENST00000372419ENST00000436170PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5CDS-3UTRENST00000372419ENST00000447302PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5CDS-3UTRENST00000372419ENST00000544232PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5CDS-3UTRENST00000372419ENST00000542945PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5CDS-3UTRENST00000372419ENST00000356385PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5CDS-3UTRENST00000543248ENST00000539627PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5CDS-3UTRENST00000543248ENST00000604123PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5CDS-3UTRENST00000543248ENST00000413014PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5CDS-3UTRENST00000543248ENST00000392002PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5CDS-3UTRENST00000543248ENST00000436170PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5CDS-3UTRENST00000543248ENST00000447302PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5CDS-3UTRENST00000543248ENST00000544232PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5CDS-3UTRENST00000543248ENST00000542945PRPS1chrX

106871888

+TMEM91chr19

41889937

+
5CDS-3UTRENST00000543248ENST00000356385PRPS1chrX

106871888

+TMEM91chr19

41889937

+
intron-3UTRENST00000372418ENST00000539627PRPS1chrX

106871888

+TMEM91chr19

41889937

+
intron-3UTRENST00000372418ENST00000604123PRPS1chrX

106871888

+TMEM91chr19

41889937

+
intron-3UTRENST00000372418ENST00000413014PRPS1chrX

106871888

+TMEM91chr19

41889937

+
intron-3UTRENST00000372418ENST00000392002PRPS1chrX

106871888

+TMEM91chr19

41889937

+
intron-3UTRENST00000372418ENST00000436170PRPS1chrX

106871888

+TMEM91chr19

41889937

+
intron-3UTRENST00000372418ENST00000447302PRPS1chrX

106871888

+TMEM91chr19

41889937

+
intron-3UTRENST00000372418ENST00000544232PRPS1chrX

106871888

+TMEM91chr19

41889937

+
intron-3UTRENST00000372418ENST00000542945PRPS1chrX

106871888

+TMEM91chr19

41889937

+
intron-3UTRENST00000372418ENST00000356385PRPS1chrX

106871888

+TMEM91chr19

41889937

+

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FusionProtFeatures for PRPS1_TMEM91


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRPS1

P60891

TMEM91

Q6ZNR0

Catalyzes the synthesis of phosphoribosylpyrophosphate(PRPP) that is essential for nucleotide synthesis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PRPS1_TMEM91


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PRPS1_TMEM91


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PRPS1_TMEM91


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PRPS1_TMEM91


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePRPS1C0043094Weight Gain1CTD_human
HgenePRPS1C0796028ATAXIA, FATAL X-LINKED, WITH DEAFNESS AND LOSS OF VISION1CTD_human;ORPHANET;UNIPROT
HgenePRPS1C1839566CHARCOT-MARIE-TOOTH DISEASE, X-LINKED RECESSIVE, 51CTD_human;ORPHANET;UNIPROT
HgenePRPS1C1844677DEAFNESS, X-LINKED 1 (disorder)1CTD_human;UNIPROT
HgenePRPS1C1970827Phosphoribosylpyrophosphate Synthetase Superactivity1CTD_human;UNIPROT