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Fusion gene ID: 2887 |
FusionGeneSummary for ASAH1_SF3B3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ASAH1_SF3B3 | Fusion gene ID: 2887 | Hgene | Tgene | Gene symbol | ASAH1 | SF3B3 | Gene ID | 427 | 23450 |
| Gene name | N-acylsphingosine amidohydrolase 1 | splicing factor 3b subunit 3 | |
| Synonyms | AC|ACDase|ASAH|PHP|PHP32|SMAPME | RSE1|SAP130|SF3b130|STAF130 | |
| Cytomap | 8p22 | 16q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | acid ceramidaseN-acylsphingosine amidohydrolase (acid ceramidase) 1acid CDaseacylsphingosine deacylaseputative 32 kDa heart protein | splicing factor 3B subunit 3SAP 130pre-mRNA splicing factor SF3b, 130 kDa subunitspliceosome-associated protein 130 | |
| Modification date | 20180529 | 20180523 | |
| UniProtAcc | Q13510 | Q15393 | |
| Ensembl transtripts involved in fusion gene | ENST00000262097, ENST00000381733, ENST00000417108, ENST00000520781, ENST00000314146, ENST00000520051, | ENST00000302516, | |
| Fusion gene scores | * DoF score | 6 X 7 X 3=126 | 3 X 4 X 2=24 |
| # samples | 7 | 4 | |
| ** MAII score | log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ASAH1 [Title/Abstract] AND SF3B3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SF3B3 | GO:0000398 | mRNA splicing, via spliceosome | 28781166 |
| Tgene | SF3B3 | GO:0042177 | negative regulation of protein catabolic process | 23951410 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA755770 | ASAH1 | chr8 | 17933050 | - | SF3B3 | chr16 | 70575572 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000262097 | ENST00000302516 | ASAH1 | chr8 | 17933050 | - | SF3B3 | chr16 | 70575572 | + |
| In-frame | ENST00000381733 | ENST00000302516 | ASAH1 | chr8 | 17933050 | - | SF3B3 | chr16 | 70575572 | + |
| 5UTR-3CDS | ENST00000417108 | ENST00000302516 | ASAH1 | chr8 | 17933050 | - | SF3B3 | chr16 | 70575572 | + |
| In-frame | ENST00000520781 | ENST00000302516 | ASAH1 | chr8 | 17933050 | - | SF3B3 | chr16 | 70575572 | + |
| In-frame | ENST00000314146 | ENST00000302516 | ASAH1 | chr8 | 17933050 | - | SF3B3 | chr16 | 70575572 | + |
| 5UTR-3CDS | ENST00000520051 | ENST00000302516 | ASAH1 | chr8 | 17933050 | - | SF3B3 | chr16 | 70575572 | + |
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FusionProtFeatures for ASAH1_SF3B3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ASAH1 | SF3B3 |
| Hydrolyzes the sphingolipid ceramide into sphingosineand free fatty acid. {ECO:0000269|PubMed:7744740}. | Involved in pre-mRNA splicing as a component of thesplicing factor SF3B complex, a constituent of the spliceosome(PubMed:10490618, PubMed:10882114, PubMed:27720643,PubMed:28781166). SF3B complex is required for 'A' complexassembly formed by the stable binding of U2 snRNP to thebranchpoint sequence (BPS) in pre-mRNA. Sequence independentbinding of SF3A/SF3B complex upstream of the branch site isessential, it may anchor U2 snRNP to the pre-mRNA(PubMed:12234937). May also be involved in the assembly of the 'E'complex (PubMed:10882114). Belongs also to the minor U12-dependentspliceosome, which is involved in the splicing of rare class ofnuclear pre-mRNA intron (PubMed:15146077).{ECO:0000269|PubMed:10490618, ECO:0000269|PubMed:10882114,ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077,ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:28781166}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ASAH1_SF3B3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ASAH1_ENST00000262097_chr8_17933050_-_SF3B3_ENST00000302516_chr16_70575572_+_6128nt GGCTCGGTCCGACTATTGCCCGCGGTGGGGGAGGGGGATGGATCACGCCACGCGCCAAAGGCGATCGCGACTCTCCTTCTGCAGGTAGCC TGGAAGGCTCTCTCTCTTTCTCTACGCCACCCTTTTCGTGGCACTGAAAAGCCCCGTCCTCTCCTCCCAGTCCCGCCTCCTCCGAGCGTT CCCCCTACTGCCTGGAATGGTGCGGTCCCAGGTCGCGGGTCACGCGGCGGAGGGGGCGTGGCCTGCCCCCGGCCCAGCCGGCTCTTCTTT GCCTCTGCTGGAGTCCGGGGAGTGGCGTTGGCTGCTAGAGCGATGCCGGGCCGGAGTTGCGTCGCCTTAGTCCTCCTGGCTGCCGCCGTC AGCTGTGCCGTCGCGCAGCACGCGCCGCCGTGGACAGAGGACTGCAGAAAATCAACCTATCCTCCTTCAGGACCAACTTACTTATATCAA ATTGCACATCTTGGAGATGATGATGAAGAACCTGAGTTTTCATCAGCCATGCCTCTGGAAGAAGGAGACACATTCTTTTTTCAGCCAAGA CCACTTAAAAACCTTGTGCTGGTTGATGAGTTGGACAGCCTCTCTCCCATTCTGTTTTGCCAGATAGCTGATCTGGCCAATGAAGATACT CCACAGTTGTATGTGGCCTGTGGTAGGGGACCCCGATCATCTCTGAGAGTCCTAAGACATGGACTTGAGGTGTCAGAAATGGCTGTTTCT GAGCTACCTGGTAACCCCAACGCTGTCTGGACAGTGCGTCGACACATTGAAGATGAGTTTGATGCCTACATCATTGTGTCTTTCGTGAAT GCCACCCTAGTGTTGTCCATTGGAGAAACTGTAGAAGAAGTGACTGACTCTGGGTTCCTGGGGACCACCCCGACCTTGTCCTGCTCCTTA TTAGGAGATGATGCCTTGGTGCAGGTCTATCCAGATGGCATTCGGCACATACGAGCAGACAAGAGAGTCAATGAGTGGAAGACCCCTGGA AAGAAAACAATTGTGAAGTGTGCAGTGAACCAGCGACAAGTGGTGATTGCCCTGACAGGAGGAGAGCTGGTCTATTTCGAGATGGATCCT TCAGGACAGCTGAATGAGTACACAGAACGGAAGGAGATGTCAGCAGATGTGGTGTGCATGAGTCTGGCCAATGTACCCCCTGGAGAGCAG CGGTCTCGCTTCCTGGCTGTGGGGCTTGTGGACAACACTGTCAGAATCATCTCCCTGGATCCCTCAGACTGTTTGCAACCTCTAAGCATG CAGGCTCTCCCAGCCCAGCCTGAGTCCTTGTGTATCGTGGAAATGGGTGGGACTGAGAAGCAGGATGAGCTGGGTGAGAGGGGCTCGATT GGCTTCCTATACCTGAATATTGGGCTACAGAACGGTGTGCTGCTGAGGACTGTCTTGGACCCTGTCACTGGGGATTTGTCTGATACTCGC ACTCGGTACCTGGGGTCCCGTCCTGTGAAGCTCTTCCGAGTCCGAATGCAAGGCCAGGAGGCAGTATTGGCCATGTCAAGCCGCTCATGG TTGAGCTATTCTTACCAATCTCGCTTCCATCTCACCCCACTGTCTTACGAGACACTGGAATTTGCATCGGGTTTTGCCTCGGAACAGTGT CCCGAGGGCATTGTGGCCATCTCCACCAACACCCTACGGATTTTGGCATTAGAGAAGCTCGGTGCTGTCTTCAATCAAGTAGCCTTCCCA CTGCAGTACACACCCAGGAAATTTGTCATCCACCCTGAGAGTAACAACCTTATTATCATTGAAACGGACCACAATGCCTACACTGAGGCC ACGAAAGCTCAGAGAAAGCAGCAGATGGCAGAGGAAATGGTGGAAGCAGCAGGGGAGGATGAGCGGGAGCTGGCCGCAGAGATGGCAGCA GCATTCCTCAATGAAAACCTCCCTGAATCCATCTTTGGAGCTCCCAAGGCTGGCAATGGGCAGTGGGCCTCTGTGATCCGAGTGATGAAT CCCATTCAAGGGAACACACTGGACCTTGTCCAGCTGGAACAGAATGAGGCAGCTTTTAGTGTGGCTGTGTGCAGGTTTTCCAACACTGGT GAAGACTGGTATGTGCTGGTGGGTGTGGCCAAGGACCTGATACTAAACCCCCGATCTGTGGCAGGGGGCTTCGTCTATACTTACAAGCTT GTGAACAATGGGGAAAAACTGGAGTTTTTGCACAAGACTCCTGTGGAAGAGGTCCCTGCTGCTATTGCCCCATTCCAGGGGAGGGTGTTG ATTGGTGTGGGGAAGCTGTTGCGTGTCTATGACCTGGGAAAGAAGAAGTTACTCCGAAAATGTGAGAATAAGCATATTGCCAATTATATC TCTGGGATCCAGACTATCGGACATAGGGTAATTGTATCTGATGTCCAAGAAAGTTTCATCTGGGTTCGCTACAAGCGTAATGAAAACCAG CTTATCATCTTTGCTGATGATACCTACCCCCGATGGGTCACTACAGCCAGCCTCCTGGACTATGACACTGTGGCTGGGGCAGACAAGTTT GGCAACATATGTGTGGTGAGGCTCCCACCTAACACCAATGATGAAGTAGATGAGGATCCTACAGGAAACAAAGCCCTGTGGGACCGTGGC TTGCTCAATGGGGCCTCCCAGAAGGCAGAGGTGATCATGAACTACCATGTCGGGGAGACGGTGCTGTCCTTGCAGAAGACCACGCTGATC CCTGGAGGCTCAGAATCACTTGTCTATACCACCTTGTCTGGAGGAATTGGCATCCTTGTGCCATTCACGTCCCATGAGGACCATGACTTC TTCCAGCATGTGGAAATGCACCTGCGGTCTGAACATCCCCCTCTCTGTGGGCGGGACCACCTCAGCTTTCGCTCCTACTACTTCCCTGTG AAGAATGTGATTGATGGAGACCTCTGTGAGCAGTTCAATTCCATGGAACCCAACAAACAAAAGAACGTCTCTGAAGAACTGGACCGAACC CCACCCGAAGTGTCCAAGAAACTCGAGGATATCCGGACCCGCTACGCCTTCTGAGCCCTCCTTTCCCGGTGGGGCTTGCCAGAGACTGTG TGTTTTGTTTCCCCCACCACCATCACTGCCACCTGGCTTCTGCCATGTGGCAGGAGGGTGACTGGATAATTAAGACTGCATTATGAAAGT CAACAGCTCTTTCCCCTCAGCTCTTCTCCTGGAATGACTGGCTTCCCCTCAAATTGGCACTGAGATTTGCTACACTTCTCCCCACCTGGT ACATGATACATGACCCCAGGTTCCAGTGTAGAACCTGAGTCCCCCATTCCCCAAAGCCATCCCTGCATTGATATGTCTTGACTCTCCTGT CTACTTTTGCACACACCCTTAATTTTTAATTGGTTTTCTTGTAAATACAGTTTTGTACAATGTTATCTCTGTGGGAGGAAGGAGGCAGGC TGTGGTGGGACTGGGTAGGGTATAGTATCACTCCTGAGTTCCACTGCTCTAGAATCTAACCAGAAATAGAAACCTAGTTTTTAAGGTGAC TGGCATCCATGTGTCTTGTTCTGGAGATGAGGATGTAGGTGGGAGGTTTGAACCCAAGTTAGAGCAGGAAGAACTGAGTAGACTCCTTCC TTCCAGATACCGACTTGGACTTGCGGCACTCTGTGGCTCCCCACCCCCAGGTCTGTGGTGGTTTCTTTGTTTTTTCCTGGTTCTTTTTGC TGTGCTGATGAAACATGACCTCAATAACCATGTGTATACCCACCCCTCTTCCCACTGGGTATTGAGGAAGGGTGGCTGATTCTTCCTCCT CTTCTACTCTGAGGATGTTAGTATGGGGATTTTAGCATGAATTCTAGCTGGGGAGTCTTAACAGATGCCCCTTTTACTGATACAGCACCT AAAGCGATCTTTGGCTCCATAGGACCATAGGAAGGGTCAGTACAGAAGAACCTAGATACTGCCCTGCCCCTGAGAACTGTGTATATGTGG GGCCTGTCTGCAGCACCCATCTCAGGTGGGTTCCAGAGGGCCTTTAGGGTATAATGAGAGCCTGTTAGGTGGAAGAGGCCCAGTTCCAGA AATGTTCCAGCCCACCCCTGAGAATTCCTCCTGTTTAGTTGTGTGGGAAGCCCTCGTCTTCCAGGCTGTCCTTGCGCCTTGAACCTGGAG AAGTGAGCTCACTGTTCTCAATACTTCACAAATGTAAAACTTTCTTTCGTCTGCATGTGCTCAGCCATCTAAATTGAGCAAATGATCTGG TGAGCACTGGGTTAGAATCAGGAATGGTGGAATACAATCTGAACCTCTCAGAGCCCAGAACAGAGGGTTCCTGACACTGTGACACTGTCT CCTGGAACTAAGTATCTCTTGAATCATGACTTGGTTTTAGATCAGTCAAGAGAGACCCAGGTTTTGCCAGGAATCGAATCCCTAAATAAC ATGTTTTTTTCTCACTTAGCTCATGAATTTGCATAGTAGACAGTAGTTCTGAATTAGATTTTGAAAACCTAATTTCAGGGCTCATTTTTT CCTGTGGCCCTAAATCCATTCTATCAAATTGTGTGATACTGACATGCAGTCATCTGAGGAACTCAGCGTAGATACTTGAGCAGCTCCTCG CCTCTTTTCTAACTCAAGTTTGACTAAAATACATACACTCCGTACAGAAGGTAGGGGGTTATGTAAGAAAGGAAAACCTAATCTATGGAA TCAGGAGTTGTCACCACCGAGCTTCCTCTGGAAGTCTGCCCATCAGCTTGCTTGTTCTCTGTTAAGAGGAAGGGCTAGGACAAGGATTTG GGCTTGAATATGTGGAAAGGAATTTTCATAGTTGTTGCTGCAGGACCTACAAAAGTTTAAAATTAGATTGGATGTGACTCAATGACAAGT CCCATCTGTGTAATTGTTAAGGGGACCTGATTGACTCCTGTGGTTTGATTGAGCAACCAGGTAAATAGAGACCTCTCTCCAGCTTTGGCA AAACCCATCAGAGGCTGCTGCAGAACTCAGACAGAGGGATCTGCCCTTGGGTTTGCTTCCATCCTGTTCCATTGCTAAGCCCTTGTGACT TGGATCCTAGGACTGAAAAGTTTTTAGCTGCCTCAGCTTTCCCCTGACCTTACTGGCAGAGGTTCTGCAGATGTTTCCTTTGGAAGATCT CTTGCCAAGAATAGCATTCCTTTGGAGGAGGGGGGTTCTAGTTGGAATGTTGCTTTTCTTGGTTAGTGTAAATGTATTGCTAGTGAGACA GCTGCCGGCGCTGGAAAAGGCTCGTCTCACAGGGAGAGTGCTGGTCCCCAGAATGTGTGCTGTTCCCACGCTGCTGCCTTTCTTGAGCTT GTTAGAGGAAAGCCAGAAAGGCATTCAGATGGGATCAGTCTGGCTTTCAAATTTTTTTTAATTCCTAAGTTCTGTTTTATTTTTTAATTT TTTAAAAAAAATTTTATTAGAGACAGTCTCTCTCTCTTGCCTAGCTGGGAGTGCAGTGGAGTGATCATAGCTCACTGAGGCTTGAACTCC TGGGCTCGAGCAATCCACCTCAGCCTCCAGAGTAGGGGAGACTACAGATGTGTGCCACCATACTCAGCTAATTTTTAAACTTTTGTAGAG ACAGGGTCTCCCTGTGTTGCCCAGGCTGGCCTCGAACTCCTGACCTCAAAAAATCTTCCTGCCTTGGCCTCCCAAAGCACTGGGATTATA GGTGTGAGCCATTGCGCCTGGTCATAAATTCTTGTTTTTTTGTTTGTTTGTTTATTAGAGATGGAATCTCTCTCTCTTGACCAGGCTAGA GGGCTGTGGTGCGATCTCAGCCCACTGCAACCTCTATCTCCTGAGCTCAAGCGATCCTCCTTAGCTTCCCAAATAGCTGGAACTACAGGC ATGTGCCATCACGTCCAGCTAATTTTTGTATTTTTAGTAGAGAAGGTTTTACCATGTTGGACAGGGTGGTCTCGAACTCCTGGCCTAAAG TGGTCCACCTAGCTCAGCCTACCAAAGTGCTGTGATTACAGGCGTGAGCCACCATGCCCAGCCTCTAAATTCTGTTTTCTATTCAAAGTA AAAATGACATGTGTTTGAGTCATCCACTTGCTCATTTGCATATGGAATATTGTATGTGAATATTTTATTACACCCTTAAAATTAATTTTC >In-frame_ASAH1_ENST00000381733_chr8_17933050_-_SF3B3_ENST00000302516_chr16_70575572_+_6031nt GGACTTTGAAATCCAACCCGGTCACCTACCCGCGCGACTGTGTCCACGGATGGCACGAAAGCCAAGCGAGTCCCCCTGCCGAGCTACTCG CGTCCGCCTCCTCCCAAGCTGAGCTCTGCTCCGCCCACCTGAGTCCTTCGCCAGTTAGGAGGAAACACAGCCGCTTAATGAACTGCTGCA TCGGGCTGGGAGAGAAAGCTCGCGGGTCCCACCGGGCCTCCTACCCAAGTCTCAGCGCGCTTTTCACCGAGGCCTCAATTCTGGGATTTG GCAGCTTTGCTGTGAAAGCCCAATGGACAGAGGACTGCAGAAAATCAACCTATCCTCCTTCAGGACCAACTTACTTATATCAAATTGCAC ATCTTGGAGATGATGATGAAGAACCTGAGTTTTCATCAGCCATGCCTCTGGAAGAAGGAGACACATTCTTTTTTCAGCCAAGACCACTTA AAAACCTTGTGCTGGTTGATGAGTTGGACAGCCTCTCTCCCATTCTGTTTTGCCAGATAGCTGATCTGGCCAATGAAGATACTCCACAGT TGTATGTGGCCTGTGGTAGGGGACCCCGATCATCTCTGAGAGTCCTAAGACATGGACTTGAGGTGTCAGAAATGGCTGTTTCTGAGCTAC CTGGTAACCCCAACGCTGTCTGGACAGTGCGTCGACACATTGAAGATGAGTTTGATGCCTACATCATTGTGTCTTTCGTGAATGCCACCC TAGTGTTGTCCATTGGAGAAACTGTAGAAGAAGTGACTGACTCTGGGTTCCTGGGGACCACCCCGACCTTGTCCTGCTCCTTATTAGGAG ATGATGCCTTGGTGCAGGTCTATCCAGATGGCATTCGGCACATACGAGCAGACAAGAGAGTCAATGAGTGGAAGACCCCTGGAAAGAAAA CAATTGTGAAGTGTGCAGTGAACCAGCGACAAGTGGTGATTGCCCTGACAGGAGGAGAGCTGGTCTATTTCGAGATGGATCCTTCAGGAC AGCTGAATGAGTACACAGAACGGAAGGAGATGTCAGCAGATGTGGTGTGCATGAGTCTGGCCAATGTACCCCCTGGAGAGCAGCGGTCTC GCTTCCTGGCTGTGGGGCTTGTGGACAACACTGTCAGAATCATCTCCCTGGATCCCTCAGACTGTTTGCAACCTCTAAGCATGCAGGCTC TCCCAGCCCAGCCTGAGTCCTTGTGTATCGTGGAAATGGGTGGGACTGAGAAGCAGGATGAGCTGGGTGAGAGGGGCTCGATTGGCTTCC TATACCTGAATATTGGGCTACAGAACGGTGTGCTGCTGAGGACTGTCTTGGACCCTGTCACTGGGGATTTGTCTGATACTCGCACTCGGT ACCTGGGGTCCCGTCCTGTGAAGCTCTTCCGAGTCCGAATGCAAGGCCAGGAGGCAGTATTGGCCATGTCAAGCCGCTCATGGTTGAGCT ATTCTTACCAATCTCGCTTCCATCTCACCCCACTGTCTTACGAGACACTGGAATTTGCATCGGGTTTTGCCTCGGAACAGTGTCCCGAGG GCATTGTGGCCATCTCCACCAACACCCTACGGATTTTGGCATTAGAGAAGCTCGGTGCTGTCTTCAATCAAGTAGCCTTCCCACTGCAGT ACACACCCAGGAAATTTGTCATCCACCCTGAGAGTAACAACCTTATTATCATTGAAACGGACCACAATGCCTACACTGAGGCCACGAAAG CTCAGAGAAAGCAGCAGATGGCAGAGGAAATGGTGGAAGCAGCAGGGGAGGATGAGCGGGAGCTGGCCGCAGAGATGGCAGCAGCATTCC TCAATGAAAACCTCCCTGAATCCATCTTTGGAGCTCCCAAGGCTGGCAATGGGCAGTGGGCCTCTGTGATCCGAGTGATGAATCCCATTC AAGGGAACACACTGGACCTTGTCCAGCTGGAACAGAATGAGGCAGCTTTTAGTGTGGCTGTGTGCAGGTTTTCCAACACTGGTGAAGACT GGTATGTGCTGGTGGGTGTGGCCAAGGACCTGATACTAAACCCCCGATCTGTGGCAGGGGGCTTCGTCTATACTTACAAGCTTGTGAACA ATGGGGAAAAACTGGAGTTTTTGCACAAGACTCCTGTGGAAGAGGTCCCTGCTGCTATTGCCCCATTCCAGGGGAGGGTGTTGATTGGTG TGGGGAAGCTGTTGCGTGTCTATGACCTGGGAAAGAAGAAGTTACTCCGAAAATGTGAGAATAAGCATATTGCCAATTATATCTCTGGGA TCCAGACTATCGGACATAGGGTAATTGTATCTGATGTCCAAGAAAGTTTCATCTGGGTTCGCTACAAGCGTAATGAAAACCAGCTTATCA TCTTTGCTGATGATACCTACCCCCGATGGGTCACTACAGCCAGCCTCCTGGACTATGACACTGTGGCTGGGGCAGACAAGTTTGGCAACA TATGTGTGGTGAGGCTCCCACCTAACACCAATGATGAAGTAGATGAGGATCCTACAGGAAACAAAGCCCTGTGGGACCGTGGCTTGCTCA ATGGGGCCTCCCAGAAGGCAGAGGTGATCATGAACTACCATGTCGGGGAGACGGTGCTGTCCTTGCAGAAGACCACGCTGATCCCTGGAG GCTCAGAATCACTTGTCTATACCACCTTGTCTGGAGGAATTGGCATCCTTGTGCCATTCACGTCCCATGAGGACCATGACTTCTTCCAGC ATGTGGAAATGCACCTGCGGTCTGAACATCCCCCTCTCTGTGGGCGGGACCACCTCAGCTTTCGCTCCTACTACTTCCCTGTGAAGAATG TGATTGATGGAGACCTCTGTGAGCAGTTCAATTCCATGGAACCCAACAAACAAAAGAACGTCTCTGAAGAACTGGACCGAACCCCACCCG AAGTGTCCAAGAAACTCGAGGATATCCGGACCCGCTACGCCTTCTGAGCCCTCCTTTCCCGGTGGGGCTTGCCAGAGACTGTGTGTTTTG TTTCCCCCACCACCATCACTGCCACCTGGCTTCTGCCATGTGGCAGGAGGGTGACTGGATAATTAAGACTGCATTATGAAAGTCAACAGC TCTTTCCCCTCAGCTCTTCTCCTGGAATGACTGGCTTCCCCTCAAATTGGCACTGAGATTTGCTACACTTCTCCCCACCTGGTACATGAT ACATGACCCCAGGTTCCAGTGTAGAACCTGAGTCCCCCATTCCCCAAAGCCATCCCTGCATTGATATGTCTTGACTCTCCTGTCTACTTT TGCACACACCCTTAATTTTTAATTGGTTTTCTTGTAAATACAGTTTTGTACAATGTTATCTCTGTGGGAGGAAGGAGGCAGGCTGTGGTG GGACTGGGTAGGGTATAGTATCACTCCTGAGTTCCACTGCTCTAGAATCTAACCAGAAATAGAAACCTAGTTTTTAAGGTGACTGGCATC CATGTGTCTTGTTCTGGAGATGAGGATGTAGGTGGGAGGTTTGAACCCAAGTTAGAGCAGGAAGAACTGAGTAGACTCCTTCCTTCCAGA TACCGACTTGGACTTGCGGCACTCTGTGGCTCCCCACCCCCAGGTCTGTGGTGGTTTCTTTGTTTTTTCCTGGTTCTTTTTGCTGTGCTG ATGAAACATGACCTCAATAACCATGTGTATACCCACCCCTCTTCCCACTGGGTATTGAGGAAGGGTGGCTGATTCTTCCTCCTCTTCTAC TCTGAGGATGTTAGTATGGGGATTTTAGCATGAATTCTAGCTGGGGAGTCTTAACAGATGCCCCTTTTACTGATACAGCACCTAAAGCGA TCTTTGGCTCCATAGGACCATAGGAAGGGTCAGTACAGAAGAACCTAGATACTGCCCTGCCCCTGAGAACTGTGTATATGTGGGGCCTGT CTGCAGCACCCATCTCAGGTGGGTTCCAGAGGGCCTTTAGGGTATAATGAGAGCCTGTTAGGTGGAAGAGGCCCAGTTCCAGAAATGTTC CAGCCCACCCCTGAGAATTCCTCCTGTTTAGTTGTGTGGGAAGCCCTCGTCTTCCAGGCTGTCCTTGCGCCTTGAACCTGGAGAAGTGAG CTCACTGTTCTCAATACTTCACAAATGTAAAACTTTCTTTCGTCTGCATGTGCTCAGCCATCTAAATTGAGCAAATGATCTGGTGAGCAC TGGGTTAGAATCAGGAATGGTGGAATACAATCTGAACCTCTCAGAGCCCAGAACAGAGGGTTCCTGACACTGTGACACTGTCTCCTGGAA CTAAGTATCTCTTGAATCATGACTTGGTTTTAGATCAGTCAAGAGAGACCCAGGTTTTGCCAGGAATCGAATCCCTAAATAACATGTTTT TTTCTCACTTAGCTCATGAATTTGCATAGTAGACAGTAGTTCTGAATTAGATTTTGAAAACCTAATTTCAGGGCTCATTTTTTCCTGTGG CCCTAAATCCATTCTATCAAATTGTGTGATACTGACATGCAGTCATCTGAGGAACTCAGCGTAGATACTTGAGCAGCTCCTCGCCTCTTT TCTAACTCAAGTTTGACTAAAATACATACACTCCGTACAGAAGGTAGGGGGTTATGTAAGAAAGGAAAACCTAATCTATGGAATCAGGAG TTGTCACCACCGAGCTTCCTCTGGAAGTCTGCCCATCAGCTTGCTTGTTCTCTGTTAAGAGGAAGGGCTAGGACAAGGATTTGGGCTTGA ATATGTGGAAAGGAATTTTCATAGTTGTTGCTGCAGGACCTACAAAAGTTTAAAATTAGATTGGATGTGACTCAATGACAAGTCCCATCT GTGTAATTGTTAAGGGGACCTGATTGACTCCTGTGGTTTGATTGAGCAACCAGGTAAATAGAGACCTCTCTCCAGCTTTGGCAAAACCCA TCAGAGGCTGCTGCAGAACTCAGACAGAGGGATCTGCCCTTGGGTTTGCTTCCATCCTGTTCCATTGCTAAGCCCTTGTGACTTGGATCC TAGGACTGAAAAGTTTTTAGCTGCCTCAGCTTTCCCCTGACCTTACTGGCAGAGGTTCTGCAGATGTTTCCTTTGGAAGATCTCTTGCCA AGAATAGCATTCCTTTGGAGGAGGGGGGTTCTAGTTGGAATGTTGCTTTTCTTGGTTAGTGTAAATGTATTGCTAGTGAGACAGCTGCCG GCGCTGGAAAAGGCTCGTCTCACAGGGAGAGTGCTGGTCCCCAGAATGTGTGCTGTTCCCACGCTGCTGCCTTTCTTGAGCTTGTTAGAG GAAAGCCAGAAAGGCATTCAGATGGGATCAGTCTGGCTTTCAAATTTTTTTTAATTCCTAAGTTCTGTTTTATTTTTTAATTTTTTAAAA AAAATTTTATTAGAGACAGTCTCTCTCTCTTGCCTAGCTGGGAGTGCAGTGGAGTGATCATAGCTCACTGAGGCTTGAACTCCTGGGCTC GAGCAATCCACCTCAGCCTCCAGAGTAGGGGAGACTACAGATGTGTGCCACCATACTCAGCTAATTTTTAAACTTTTGTAGAGACAGGGT CTCCCTGTGTTGCCCAGGCTGGCCTCGAACTCCTGACCTCAAAAAATCTTCCTGCCTTGGCCTCCCAAAGCACTGGGATTATAGGTGTGA GCCATTGCGCCTGGTCATAAATTCTTGTTTTTTTGTTTGTTTGTTTATTAGAGATGGAATCTCTCTCTCTTGACCAGGCTAGAGGGCTGT GGTGCGATCTCAGCCCACTGCAACCTCTATCTCCTGAGCTCAAGCGATCCTCCTTAGCTTCCCAAATAGCTGGAACTACAGGCATGTGCC ATCACGTCCAGCTAATTTTTGTATTTTTAGTAGAGAAGGTTTTACCATGTTGGACAGGGTGGTCTCGAACTCCTGGCCTAAAGTGGTCCA CCTAGCTCAGCCTACCAAAGTGCTGTGATTACAGGCGTGAGCCACCATGCCCAGCCTCTAAATTCTGTTTTCTATTCAAAGTAAAAATGA CATGTGTTTGAGTCATCCACTTGCTCATTTGCATATGGAATATTGTATGTGAATATTTTATTACACCCTTAAAATTAATTTTCAAGGGCT >In-frame_ASAH1_ENST00000520781_chr8_17933050_-_SF3B3_ENST00000302516_chr16_70575572_+_6128nt GGCTCGGTCCGACTATTGCCCGCGGTGGGGGAGGGGGATGGATCACGCCACGCGCCAAAGGCGATCGCGACTCTCCTTCTGCAGGTAGCC TGGAAGGCTCTCTCTCTTTCTCTACGCCACCCTTTTCGTGGCACTGAAAAGCCCCGTCCTCTCCTCCCAGTCCCGCCTCCTCCGAGCGTT CCCCCTACTGCCTGGAATGGTGCGGTCCCAGGTCGCGGGTCACGCGGCGGAGGGGGCGTGGCCTGCCCCCGGCCCAGCCGGCTCTTCTTT GCCTCTGCTGGAGTCCGGGGAGTGGCGTTGGCTGCTAGAGCGATGCCGGGCCGGAGTTGCGTCGCCTTAGTCCTCCTGGCTGCCGCCGTC AGCTGTGCCGTCGCGCAGCACGCGCCGCCGTGGACAGAGGACTGCAGAAAATCAACCTATCCTCCTTCAGGACCAACTTACTTATATCAA ATTGCACATCTTGGAGATGATGATGAAGAACCTGAGTTTTCATCAGCCATGCCTCTGGAAGAAGGAGACACATTCTTTTTTCAGCCAAGA CCACTTAAAAACCTTGTGCTGGTTGATGAGTTGGACAGCCTCTCTCCCATTCTGTTTTGCCAGATAGCTGATCTGGCCAATGAAGATACT CCACAGTTGTATGTGGCCTGTGGTAGGGGACCCCGATCATCTCTGAGAGTCCTAAGACATGGACTTGAGGTGTCAGAAATGGCTGTTTCT GAGCTACCTGGTAACCCCAACGCTGTCTGGACAGTGCGTCGACACATTGAAGATGAGTTTGATGCCTACATCATTGTGTCTTTCGTGAAT GCCACCCTAGTGTTGTCCATTGGAGAAACTGTAGAAGAAGTGACTGACTCTGGGTTCCTGGGGACCACCCCGACCTTGTCCTGCTCCTTA TTAGGAGATGATGCCTTGGTGCAGGTCTATCCAGATGGCATTCGGCACATACGAGCAGACAAGAGAGTCAATGAGTGGAAGACCCCTGGA AAGAAAACAATTGTGAAGTGTGCAGTGAACCAGCGACAAGTGGTGATTGCCCTGACAGGAGGAGAGCTGGTCTATTTCGAGATGGATCCT TCAGGACAGCTGAATGAGTACACAGAACGGAAGGAGATGTCAGCAGATGTGGTGTGCATGAGTCTGGCCAATGTACCCCCTGGAGAGCAG CGGTCTCGCTTCCTGGCTGTGGGGCTTGTGGACAACACTGTCAGAATCATCTCCCTGGATCCCTCAGACTGTTTGCAACCTCTAAGCATG CAGGCTCTCCCAGCCCAGCCTGAGTCCTTGTGTATCGTGGAAATGGGTGGGACTGAGAAGCAGGATGAGCTGGGTGAGAGGGGCTCGATT GGCTTCCTATACCTGAATATTGGGCTACAGAACGGTGTGCTGCTGAGGACTGTCTTGGACCCTGTCACTGGGGATTTGTCTGATACTCGC ACTCGGTACCTGGGGTCCCGTCCTGTGAAGCTCTTCCGAGTCCGAATGCAAGGCCAGGAGGCAGTATTGGCCATGTCAAGCCGCTCATGG TTGAGCTATTCTTACCAATCTCGCTTCCATCTCACCCCACTGTCTTACGAGACACTGGAATTTGCATCGGGTTTTGCCTCGGAACAGTGT CCCGAGGGCATTGTGGCCATCTCCACCAACACCCTACGGATTTTGGCATTAGAGAAGCTCGGTGCTGTCTTCAATCAAGTAGCCTTCCCA CTGCAGTACACACCCAGGAAATTTGTCATCCACCCTGAGAGTAACAACCTTATTATCATTGAAACGGACCACAATGCCTACACTGAGGCC ACGAAAGCTCAGAGAAAGCAGCAGATGGCAGAGGAAATGGTGGAAGCAGCAGGGGAGGATGAGCGGGAGCTGGCCGCAGAGATGGCAGCA GCATTCCTCAATGAAAACCTCCCTGAATCCATCTTTGGAGCTCCCAAGGCTGGCAATGGGCAGTGGGCCTCTGTGATCCGAGTGATGAAT CCCATTCAAGGGAACACACTGGACCTTGTCCAGCTGGAACAGAATGAGGCAGCTTTTAGTGTGGCTGTGTGCAGGTTTTCCAACACTGGT GAAGACTGGTATGTGCTGGTGGGTGTGGCCAAGGACCTGATACTAAACCCCCGATCTGTGGCAGGGGGCTTCGTCTATACTTACAAGCTT GTGAACAATGGGGAAAAACTGGAGTTTTTGCACAAGACTCCTGTGGAAGAGGTCCCTGCTGCTATTGCCCCATTCCAGGGGAGGGTGTTG ATTGGTGTGGGGAAGCTGTTGCGTGTCTATGACCTGGGAAAGAAGAAGTTACTCCGAAAATGTGAGAATAAGCATATTGCCAATTATATC TCTGGGATCCAGACTATCGGACATAGGGTAATTGTATCTGATGTCCAAGAAAGTTTCATCTGGGTTCGCTACAAGCGTAATGAAAACCAG CTTATCATCTTTGCTGATGATACCTACCCCCGATGGGTCACTACAGCCAGCCTCCTGGACTATGACACTGTGGCTGGGGCAGACAAGTTT GGCAACATATGTGTGGTGAGGCTCCCACCTAACACCAATGATGAAGTAGATGAGGATCCTACAGGAAACAAAGCCCTGTGGGACCGTGGC TTGCTCAATGGGGCCTCCCAGAAGGCAGAGGTGATCATGAACTACCATGTCGGGGAGACGGTGCTGTCCTTGCAGAAGACCACGCTGATC CCTGGAGGCTCAGAATCACTTGTCTATACCACCTTGTCTGGAGGAATTGGCATCCTTGTGCCATTCACGTCCCATGAGGACCATGACTTC TTCCAGCATGTGGAAATGCACCTGCGGTCTGAACATCCCCCTCTCTGTGGGCGGGACCACCTCAGCTTTCGCTCCTACTACTTCCCTGTG AAGAATGTGATTGATGGAGACCTCTGTGAGCAGTTCAATTCCATGGAACCCAACAAACAAAAGAACGTCTCTGAAGAACTGGACCGAACC CCACCCGAAGTGTCCAAGAAACTCGAGGATATCCGGACCCGCTACGCCTTCTGAGCCCTCCTTTCCCGGTGGGGCTTGCCAGAGACTGTG TGTTTTGTTTCCCCCACCACCATCACTGCCACCTGGCTTCTGCCATGTGGCAGGAGGGTGACTGGATAATTAAGACTGCATTATGAAAGT CAACAGCTCTTTCCCCTCAGCTCTTCTCCTGGAATGACTGGCTTCCCCTCAAATTGGCACTGAGATTTGCTACACTTCTCCCCACCTGGT ACATGATACATGACCCCAGGTTCCAGTGTAGAACCTGAGTCCCCCATTCCCCAAAGCCATCCCTGCATTGATATGTCTTGACTCTCCTGT CTACTTTTGCACACACCCTTAATTTTTAATTGGTTTTCTTGTAAATACAGTTTTGTACAATGTTATCTCTGTGGGAGGAAGGAGGCAGGC TGTGGTGGGACTGGGTAGGGTATAGTATCACTCCTGAGTTCCACTGCTCTAGAATCTAACCAGAAATAGAAACCTAGTTTTTAAGGTGAC TGGCATCCATGTGTCTTGTTCTGGAGATGAGGATGTAGGTGGGAGGTTTGAACCCAAGTTAGAGCAGGAAGAACTGAGTAGACTCCTTCC TTCCAGATACCGACTTGGACTTGCGGCACTCTGTGGCTCCCCACCCCCAGGTCTGTGGTGGTTTCTTTGTTTTTTCCTGGTTCTTTTTGC TGTGCTGATGAAACATGACCTCAATAACCATGTGTATACCCACCCCTCTTCCCACTGGGTATTGAGGAAGGGTGGCTGATTCTTCCTCCT CTTCTACTCTGAGGATGTTAGTATGGGGATTTTAGCATGAATTCTAGCTGGGGAGTCTTAACAGATGCCCCTTTTACTGATACAGCACCT AAAGCGATCTTTGGCTCCATAGGACCATAGGAAGGGTCAGTACAGAAGAACCTAGATACTGCCCTGCCCCTGAGAACTGTGTATATGTGG GGCCTGTCTGCAGCACCCATCTCAGGTGGGTTCCAGAGGGCCTTTAGGGTATAATGAGAGCCTGTTAGGTGGAAGAGGCCCAGTTCCAGA AATGTTCCAGCCCACCCCTGAGAATTCCTCCTGTTTAGTTGTGTGGGAAGCCCTCGTCTTCCAGGCTGTCCTTGCGCCTTGAACCTGGAG AAGTGAGCTCACTGTTCTCAATACTTCACAAATGTAAAACTTTCTTTCGTCTGCATGTGCTCAGCCATCTAAATTGAGCAAATGATCTGG TGAGCACTGGGTTAGAATCAGGAATGGTGGAATACAATCTGAACCTCTCAGAGCCCAGAACAGAGGGTTCCTGACACTGTGACACTGTCT CCTGGAACTAAGTATCTCTTGAATCATGACTTGGTTTTAGATCAGTCAAGAGAGACCCAGGTTTTGCCAGGAATCGAATCCCTAAATAAC ATGTTTTTTTCTCACTTAGCTCATGAATTTGCATAGTAGACAGTAGTTCTGAATTAGATTTTGAAAACCTAATTTCAGGGCTCATTTTTT CCTGTGGCCCTAAATCCATTCTATCAAATTGTGTGATACTGACATGCAGTCATCTGAGGAACTCAGCGTAGATACTTGAGCAGCTCCTCG CCTCTTTTCTAACTCAAGTTTGACTAAAATACATACACTCCGTACAGAAGGTAGGGGGTTATGTAAGAAAGGAAAACCTAATCTATGGAA TCAGGAGTTGTCACCACCGAGCTTCCTCTGGAAGTCTGCCCATCAGCTTGCTTGTTCTCTGTTAAGAGGAAGGGCTAGGACAAGGATTTG GGCTTGAATATGTGGAAAGGAATTTTCATAGTTGTTGCTGCAGGACCTACAAAAGTTTAAAATTAGATTGGATGTGACTCAATGACAAGT CCCATCTGTGTAATTGTTAAGGGGACCTGATTGACTCCTGTGGTTTGATTGAGCAACCAGGTAAATAGAGACCTCTCTCCAGCTTTGGCA AAACCCATCAGAGGCTGCTGCAGAACTCAGACAGAGGGATCTGCCCTTGGGTTTGCTTCCATCCTGTTCCATTGCTAAGCCCTTGTGACT TGGATCCTAGGACTGAAAAGTTTTTAGCTGCCTCAGCTTTCCCCTGACCTTACTGGCAGAGGTTCTGCAGATGTTTCCTTTGGAAGATCT CTTGCCAAGAATAGCATTCCTTTGGAGGAGGGGGGTTCTAGTTGGAATGTTGCTTTTCTTGGTTAGTGTAAATGTATTGCTAGTGAGACA GCTGCCGGCGCTGGAAAAGGCTCGTCTCACAGGGAGAGTGCTGGTCCCCAGAATGTGTGCTGTTCCCACGCTGCTGCCTTTCTTGAGCTT GTTAGAGGAAAGCCAGAAAGGCATTCAGATGGGATCAGTCTGGCTTTCAAATTTTTTTTAATTCCTAAGTTCTGTTTTATTTTTTAATTT TTTAAAAAAAATTTTATTAGAGACAGTCTCTCTCTCTTGCCTAGCTGGGAGTGCAGTGGAGTGATCATAGCTCACTGAGGCTTGAACTCC TGGGCTCGAGCAATCCACCTCAGCCTCCAGAGTAGGGGAGACTACAGATGTGTGCCACCATACTCAGCTAATTTTTAAACTTTTGTAGAG ACAGGGTCTCCCTGTGTTGCCCAGGCTGGCCTCGAACTCCTGACCTCAAAAAATCTTCCTGCCTTGGCCTCCCAAAGCACTGGGATTATA GGTGTGAGCCATTGCGCCTGGTCATAAATTCTTGTTTTTTTGTTTGTTTGTTTATTAGAGATGGAATCTCTCTCTCTTGACCAGGCTAGA GGGCTGTGGTGCGATCTCAGCCCACTGCAACCTCTATCTCCTGAGCTCAAGCGATCCTCCTTAGCTTCCCAAATAGCTGGAACTACAGGC ATGTGCCATCACGTCCAGCTAATTTTTGTATTTTTAGTAGAGAAGGTTTTACCATGTTGGACAGGGTGGTCTCGAACTCCTGGCCTAAAG TGGTCCACCTAGCTCAGCCTACCAAAGTGCTGTGATTACAGGCGTGAGCCACCATGCCCAGCCTCTAAATTCTGTTTTCTATTCAAAGTA AAAATGACATGTGTTTGAGTCATCCACTTGCTCATTTGCATATGGAATATTGTATGTGAATATTTTATTACACCCTTAAAATTAATTTTC >In-frame_ASAH1_ENST00000314146_chr8_17933050_-_SF3B3_ENST00000302516_chr16_70575572_+_6048nt GGGCAGGATTTCCTGCTGGACTTTGAAATCCAACCCGGTCACCTACCCGCGCGACTGTGTCCACGGATGGCACGAAAGCCAAGCGAGTCC CCCTGCCGAGCTACTCGCGTCCGCCTCCTCCCAAGCTGAGCTCTGCTCCGCCCACCTGAGTCCTTCGCCAGTTAGGAGGAAACACAGCCG CTTAATGAACTGCTGCATCGGGCTGGGAGAGAAAGCTCGCGGGTCCCACCGGGCCTCCTACCCAAGTCTCAGCGCGCTTTTCACCGAGGC CTCAATTCTGGGATTTGGCAGCTTTGCTGTGAAAGCCCAATGGACAGAGGACTGCAGAAAATCAACCTATCCTCCTTCAGGACCAACTTA CTTATATCAAATTGCACATCTTGGAGATGATGATGAAGAACCTGAGTTTTCATCAGCCATGCCTCTGGAAGAAGGAGACACATTCTTTTT TCAGCCAAGACCACTTAAAAACCTTGTGCTGGTTGATGAGTTGGACAGCCTCTCTCCCATTCTGTTTTGCCAGATAGCTGATCTGGCCAA TGAAGATACTCCACAGTTGTATGTGGCCTGTGGTAGGGGACCCCGATCATCTCTGAGAGTCCTAAGACATGGACTTGAGGTGTCAGAAAT GGCTGTTTCTGAGCTACCTGGTAACCCCAACGCTGTCTGGACAGTGCGTCGACACATTGAAGATGAGTTTGATGCCTACATCATTGTGTC TTTCGTGAATGCCACCCTAGTGTTGTCCATTGGAGAAACTGTAGAAGAAGTGACTGACTCTGGGTTCCTGGGGACCACCCCGACCTTGTC CTGCTCCTTATTAGGAGATGATGCCTTGGTGCAGGTCTATCCAGATGGCATTCGGCACATACGAGCAGACAAGAGAGTCAATGAGTGGAA GACCCCTGGAAAGAAAACAATTGTGAAGTGTGCAGTGAACCAGCGACAAGTGGTGATTGCCCTGACAGGAGGAGAGCTGGTCTATTTCGA GATGGATCCTTCAGGACAGCTGAATGAGTACACAGAACGGAAGGAGATGTCAGCAGATGTGGTGTGCATGAGTCTGGCCAATGTACCCCC TGGAGAGCAGCGGTCTCGCTTCCTGGCTGTGGGGCTTGTGGACAACACTGTCAGAATCATCTCCCTGGATCCCTCAGACTGTTTGCAACC TCTAAGCATGCAGGCTCTCCCAGCCCAGCCTGAGTCCTTGTGTATCGTGGAAATGGGTGGGACTGAGAAGCAGGATGAGCTGGGTGAGAG GGGCTCGATTGGCTTCCTATACCTGAATATTGGGCTACAGAACGGTGTGCTGCTGAGGACTGTCTTGGACCCTGTCACTGGGGATTTGTC TGATACTCGCACTCGGTACCTGGGGTCCCGTCCTGTGAAGCTCTTCCGAGTCCGAATGCAAGGCCAGGAGGCAGTATTGGCCATGTCAAG CCGCTCATGGTTGAGCTATTCTTACCAATCTCGCTTCCATCTCACCCCACTGTCTTACGAGACACTGGAATTTGCATCGGGTTTTGCCTC GGAACAGTGTCCCGAGGGCATTGTGGCCATCTCCACCAACACCCTACGGATTTTGGCATTAGAGAAGCTCGGTGCTGTCTTCAATCAAGT AGCCTTCCCACTGCAGTACACACCCAGGAAATTTGTCATCCACCCTGAGAGTAACAACCTTATTATCATTGAAACGGACCACAATGCCTA CACTGAGGCCACGAAAGCTCAGAGAAAGCAGCAGATGGCAGAGGAAATGGTGGAAGCAGCAGGGGAGGATGAGCGGGAGCTGGCCGCAGA GATGGCAGCAGCATTCCTCAATGAAAACCTCCCTGAATCCATCTTTGGAGCTCCCAAGGCTGGCAATGGGCAGTGGGCCTCTGTGATCCG AGTGATGAATCCCATTCAAGGGAACACACTGGACCTTGTCCAGCTGGAACAGAATGAGGCAGCTTTTAGTGTGGCTGTGTGCAGGTTTTC CAACACTGGTGAAGACTGGTATGTGCTGGTGGGTGTGGCCAAGGACCTGATACTAAACCCCCGATCTGTGGCAGGGGGCTTCGTCTATAC TTACAAGCTTGTGAACAATGGGGAAAAACTGGAGTTTTTGCACAAGACTCCTGTGGAAGAGGTCCCTGCTGCTATTGCCCCATTCCAGGG GAGGGTGTTGATTGGTGTGGGGAAGCTGTTGCGTGTCTATGACCTGGGAAAGAAGAAGTTACTCCGAAAATGTGAGAATAAGCATATTGC CAATTATATCTCTGGGATCCAGACTATCGGACATAGGGTAATTGTATCTGATGTCCAAGAAAGTTTCATCTGGGTTCGCTACAAGCGTAA TGAAAACCAGCTTATCATCTTTGCTGATGATACCTACCCCCGATGGGTCACTACAGCCAGCCTCCTGGACTATGACACTGTGGCTGGGGC AGACAAGTTTGGCAACATATGTGTGGTGAGGCTCCCACCTAACACCAATGATGAAGTAGATGAGGATCCTACAGGAAACAAAGCCCTGTG GGACCGTGGCTTGCTCAATGGGGCCTCCCAGAAGGCAGAGGTGATCATGAACTACCATGTCGGGGAGACGGTGCTGTCCTTGCAGAAGAC CACGCTGATCCCTGGAGGCTCAGAATCACTTGTCTATACCACCTTGTCTGGAGGAATTGGCATCCTTGTGCCATTCACGTCCCATGAGGA CCATGACTTCTTCCAGCATGTGGAAATGCACCTGCGGTCTGAACATCCCCCTCTCTGTGGGCGGGACCACCTCAGCTTTCGCTCCTACTA CTTCCCTGTGAAGAATGTGATTGATGGAGACCTCTGTGAGCAGTTCAATTCCATGGAACCCAACAAACAAAAGAACGTCTCTGAAGAACT GGACCGAACCCCACCCGAAGTGTCCAAGAAACTCGAGGATATCCGGACCCGCTACGCCTTCTGAGCCCTCCTTTCCCGGTGGGGCTTGCC AGAGACTGTGTGTTTTGTTTCCCCCACCACCATCACTGCCACCTGGCTTCTGCCATGTGGCAGGAGGGTGACTGGATAATTAAGACTGCA TTATGAAAGTCAACAGCTCTTTCCCCTCAGCTCTTCTCCTGGAATGACTGGCTTCCCCTCAAATTGGCACTGAGATTTGCTACACTTCTC CCCACCTGGTACATGATACATGACCCCAGGTTCCAGTGTAGAACCTGAGTCCCCCATTCCCCAAAGCCATCCCTGCATTGATATGTCTTG ACTCTCCTGTCTACTTTTGCACACACCCTTAATTTTTAATTGGTTTTCTTGTAAATACAGTTTTGTACAATGTTATCTCTGTGGGAGGAA GGAGGCAGGCTGTGGTGGGACTGGGTAGGGTATAGTATCACTCCTGAGTTCCACTGCTCTAGAATCTAACCAGAAATAGAAACCTAGTTT TTAAGGTGACTGGCATCCATGTGTCTTGTTCTGGAGATGAGGATGTAGGTGGGAGGTTTGAACCCAAGTTAGAGCAGGAAGAACTGAGTA GACTCCTTCCTTCCAGATACCGACTTGGACTTGCGGCACTCTGTGGCTCCCCACCCCCAGGTCTGTGGTGGTTTCTTTGTTTTTTCCTGG TTCTTTTTGCTGTGCTGATGAAACATGACCTCAATAACCATGTGTATACCCACCCCTCTTCCCACTGGGTATTGAGGAAGGGTGGCTGAT TCTTCCTCCTCTTCTACTCTGAGGATGTTAGTATGGGGATTTTAGCATGAATTCTAGCTGGGGAGTCTTAACAGATGCCCCTTTTACTGA TACAGCACCTAAAGCGATCTTTGGCTCCATAGGACCATAGGAAGGGTCAGTACAGAAGAACCTAGATACTGCCCTGCCCCTGAGAACTGT GTATATGTGGGGCCTGTCTGCAGCACCCATCTCAGGTGGGTTCCAGAGGGCCTTTAGGGTATAATGAGAGCCTGTTAGGTGGAAGAGGCC CAGTTCCAGAAATGTTCCAGCCCACCCCTGAGAATTCCTCCTGTTTAGTTGTGTGGGAAGCCCTCGTCTTCCAGGCTGTCCTTGCGCCTT GAACCTGGAGAAGTGAGCTCACTGTTCTCAATACTTCACAAATGTAAAACTTTCTTTCGTCTGCATGTGCTCAGCCATCTAAATTGAGCA AATGATCTGGTGAGCACTGGGTTAGAATCAGGAATGGTGGAATACAATCTGAACCTCTCAGAGCCCAGAACAGAGGGTTCCTGACACTGT GACACTGTCTCCTGGAACTAAGTATCTCTTGAATCATGACTTGGTTTTAGATCAGTCAAGAGAGACCCAGGTTTTGCCAGGAATCGAATC CCTAAATAACATGTTTTTTTCTCACTTAGCTCATGAATTTGCATAGTAGACAGTAGTTCTGAATTAGATTTTGAAAACCTAATTTCAGGG CTCATTTTTTCCTGTGGCCCTAAATCCATTCTATCAAATTGTGTGATACTGACATGCAGTCATCTGAGGAACTCAGCGTAGATACTTGAG CAGCTCCTCGCCTCTTTTCTAACTCAAGTTTGACTAAAATACATACACTCCGTACAGAAGGTAGGGGGTTATGTAAGAAAGGAAAACCTA ATCTATGGAATCAGGAGTTGTCACCACCGAGCTTCCTCTGGAAGTCTGCCCATCAGCTTGCTTGTTCTCTGTTAAGAGGAAGGGCTAGGA CAAGGATTTGGGCTTGAATATGTGGAAAGGAATTTTCATAGTTGTTGCTGCAGGACCTACAAAAGTTTAAAATTAGATTGGATGTGACTC AATGACAAGTCCCATCTGTGTAATTGTTAAGGGGACCTGATTGACTCCTGTGGTTTGATTGAGCAACCAGGTAAATAGAGACCTCTCTCC AGCTTTGGCAAAACCCATCAGAGGCTGCTGCAGAACTCAGACAGAGGGATCTGCCCTTGGGTTTGCTTCCATCCTGTTCCATTGCTAAGC CCTTGTGACTTGGATCCTAGGACTGAAAAGTTTTTAGCTGCCTCAGCTTTCCCCTGACCTTACTGGCAGAGGTTCTGCAGATGTTTCCTT TGGAAGATCTCTTGCCAAGAATAGCATTCCTTTGGAGGAGGGGGGTTCTAGTTGGAATGTTGCTTTTCTTGGTTAGTGTAAATGTATTGC TAGTGAGACAGCTGCCGGCGCTGGAAAAGGCTCGTCTCACAGGGAGAGTGCTGGTCCCCAGAATGTGTGCTGTTCCCACGCTGCTGCCTT TCTTGAGCTTGTTAGAGGAAAGCCAGAAAGGCATTCAGATGGGATCAGTCTGGCTTTCAAATTTTTTTTAATTCCTAAGTTCTGTTTTAT TTTTTAATTTTTTAAAAAAAATTTTATTAGAGACAGTCTCTCTCTCTTGCCTAGCTGGGAGTGCAGTGGAGTGATCATAGCTCACTGAGG CTTGAACTCCTGGGCTCGAGCAATCCACCTCAGCCTCCAGAGTAGGGGAGACTACAGATGTGTGCCACCATACTCAGCTAATTTTTAAAC TTTTGTAGAGACAGGGTCTCCCTGTGTTGCCCAGGCTGGCCTCGAACTCCTGACCTCAAAAAATCTTCCTGCCTTGGCCTCCCAAAGCAC TGGGATTATAGGTGTGAGCCATTGCGCCTGGTCATAAATTCTTGTTTTTTTGTTTGTTTGTTTATTAGAGATGGAATCTCTCTCTCTTGA CCAGGCTAGAGGGCTGTGGTGCGATCTCAGCCCACTGCAACCTCTATCTCCTGAGCTCAAGCGATCCTCCTTAGCTTCCCAAATAGCTGG AACTACAGGCATGTGCCATCACGTCCAGCTAATTTTTGTATTTTTAGTAGAGAAGGTTTTACCATGTTGGACAGGGTGGTCTCGAACTCC TGGCCTAAAGTGGTCCACCTAGCTCAGCCTACCAAAGTGCTGTGATTACAGGCGTGAGCCACCATGCCCAGCCTCTAAATTCTGTTTTCT ATTCAAAGTAAAAATGACATGTGTTTGAGTCATCCACTTGCTCATTTGCATATGGAATATTGTATGTGAATATTTTATTACACCCTTAAA |
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FusionGenePPI for ASAH1_SF3B3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ASAH1 | SETDB1, TSC22D1, PSMA3, FBXO6, CAMK1D, SRPK1, GSG1, PNKD, AAGAB, AAMP, NEFH, CAMK2B, HSF2, HSPB2, HERC2, CYP1A2, GLT1D1, ZIC1, ZSCAN12, FTH1, NONO, TBC1D22B, SLCO6A1, AIRE, HTATIP2, RNF6, TRMT2A, ZNF684, ZNF556, HMP19, LYPD1, NCDN | SF3B3 | SMNDC1, CFLAR, TNFRSF10D, RNPS1, RNU11, NCOR1, SF3B2, SF3B1, SF3A2, SUPT3H, TAF9, HGS, TCEA1, SRRM1, SRRM2, KAT2A, HDAC5, TOP1, YWHAG, SMAD5, KLF10, OSGEP, RUFY2, RAD9A, ZNF579, NAGK, SMARCAD1, SREK1, TAF10, ARRB2, CUL3, CUL2, CDK2, CUL1, COPS5, CAND1, SF3A1, SNRPD1, HNRNPK, SNRPD2, SF3A3, SNRPA1, SF3B4, SF3B5, SF3B6, PHF5A, SNRNP200, PRPF8, SNRPB2, SRSF1, HNRNPR, TCERG1, EFTUD2, PRPF6, RBMX, YBX1, SNRPA, SRSF7, HNRNPM, U2AF1, U2AF2, SRSF2, DDX5, PRPF31, SFPQ, SMC1A, PRPF19, SART1, SMU1, LMNA, TUBB, WDR18, STOML2, CCT2, TPBG, LAMP2, TRA2A, TXNRD1, ZC3H18, TJAP1, UBE3A, SPDL1, UTP14A, VTN, VPS33B, AGMAT, THRAP3, MTHFD1, TMOD2, STOM, TRIM55, SSR3, MAGOH, EIF4A3, PPIL1, HSPB1, TOE1, HSP90AA1, IFIT3, CD81, IGSF8, SKP1, SKP2, CUL4A, EPS8, RBM6, FBXO6, PRPF40A, WBP4, APBB1, WWOX, RPA3, RPA2, RPA1, ERG, LGR4, NUDCD3, HUWE1, FUS, MDM2, CCDC101, CUL7, OBSL1, CCDC8, EZH2, SUZ12, EED, RNF2, USP7, UNK, BCAS2, CCAR1, CCAR2, DCTN1, ISY1-RAB43, ISY1, LUC7L, PRPF3, PRPF4, CCDC97, CDC40, CDC5L, COPA, COPE, COPG1, DHX15, EIF4G1, ELP4, KPNB1, LMNB1, LSM4, LUC7L2, PLRG1, PSME3, RPL18A, SRRT, USP10, XAB2, SMC3, SNRPD3, SPTAN1, SSSCA1, SYNCRIP, RNU12, NTRK1, SCARNA22, TAF4, HIST1H3E, MCM5, SNW1, AIRE, ZNF746, FLCN, SNRPE, PLK1, CYLD, CD2BP2, TRIM25, BRCA1, YAP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | SF3B3 | chr8:17933050 | chr16:70575572 | ENST00000302516 | + | 7 | 26 | 786_804 | 355 | 1218 | SF3B1 and SF3B5 |
| Tgene | SF3B3 | chr8:17933050 | chr16:70575572 | ENST00000302516 | + | 7 | 26 | 1028_1049 | 355 | 1218 | SF3B1 |
| Tgene | SF3B3 | chr8:17933050 | chr16:70575572 | ENST00000302516 | + | 7 | 26 | 1100_1123 | 355 | 1218 | SF3B5 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | SF3B3 | chr8:17933050 | chr16:70575572 | ENST00000302516 | + | 7 | 26 | 105_119 | 355 | 1218 | PHF5A%2C SF3B1 and SF3B5 |
| Tgene | SF3B3 | chr8:17933050 | chr16:70575572 | ENST00000302516 | + | 7 | 26 | 145_168 | 355 | 1218 | PHF5A%2C SF3B1 and SF3B5 |
| Tgene | SF3B3 | chr8:17933050 | chr16:70575572 | ENST00000302516 | + | 7 | 26 | 193_231 | 355 | 1218 | SF3B1 and SF3B5 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ASAH1_SF3B3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ASAH1_SF3B3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ASAH1 | C0268255 | Farber Lipogranulomatosis | 8 | CTD_human;ORPHANET;UNIPROT |
| Hgene | ASAH1 | C0023794 | Lipoidosis | 2 | CTD_human |
| Hgene | ASAH1 | C1834569 | Jankovic Rivera syndrome | 2 | ORPHANET;UNIPROT |
| Hgene | ASAH1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | ASAH1 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Hgene | ASAH1 | C0221765 | Chronic schizophrenia | 1 | PSYGENET |
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