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Fusion gene ID: 2886 |
FusionGeneSummary for ASAH1_PCM1 |
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Fusion gene information | Fusion gene name: ASAH1_PCM1 | Fusion gene ID: 2886 | Hgene | Tgene | Gene symbol | ASAH1 | PCM1 | Gene ID | 427 | 5108 |
Gene name | N-acylsphingosine amidohydrolase 1 | pericentriolar material 1 | |
Synonyms | AC|ACDase|ASAH|PHP|PHP32|SMAPME | PTC4|RET/PCM-1 | |
Cytomap | 8p22 | 8p22 | |
Type of gene | protein-coding | protein-coding | |
Description | acid ceramidaseN-acylsphingosine amidohydrolase (acid ceramidase) 1acid CDaseacylsphingosine deacylaseputative 32 kDa heart protein | pericentriolar material 1 proteinPCM-1hPCM-1pericentriolar material 1, PCM1 | |
Modification date | 20180529 | 20180523 | |
UniProtAcc | Q13510 | Q15154 | |
Ensembl transtripts involved in fusion gene | ENST00000262097, ENST00000381733, ENST00000417108, ENST00000520781, ENST00000314146, ENST00000520051, | ENST00000325083, ENST00000519253, ENST00000524226, ENST00000518537, ENST00000518936, ENST00000327578, | |
Fusion gene scores | * DoF score | 6 X 7 X 3=126 | 5 X 5 X 3=75 |
# samples | 7 | 5 | |
** MAII score | log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ASAH1 [Title/Abstract] AND PCM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DB239554 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000262097 | ENST00000325083 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
Frame-shift | ENST00000262097 | ENST00000519253 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
Frame-shift | ENST00000262097 | ENST00000524226 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
5CDS-intron | ENST00000262097 | ENST00000518537 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
5CDS-intron | ENST00000262097 | ENST00000518936 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
5CDS-intron | ENST00000262097 | ENST00000327578 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
Frame-shift | ENST00000381733 | ENST00000325083 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
Frame-shift | ENST00000381733 | ENST00000519253 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
Frame-shift | ENST00000381733 | ENST00000524226 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
5CDS-intron | ENST00000381733 | ENST00000518537 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
5CDS-intron | ENST00000381733 | ENST00000518936 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
5CDS-intron | ENST00000381733 | ENST00000327578 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
5UTR-3CDS | ENST00000417108 | ENST00000325083 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
5UTR-3CDS | ENST00000417108 | ENST00000519253 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
5UTR-3CDS | ENST00000417108 | ENST00000524226 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
5UTR-intron | ENST00000417108 | ENST00000518537 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
5UTR-intron | ENST00000417108 | ENST00000518936 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
5UTR-intron | ENST00000417108 | ENST00000327578 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
Frame-shift | ENST00000520781 | ENST00000325083 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
Frame-shift | ENST00000520781 | ENST00000519253 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
Frame-shift | ENST00000520781 | ENST00000524226 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
5CDS-intron | ENST00000520781 | ENST00000518537 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
5CDS-intron | ENST00000520781 | ENST00000518936 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
5CDS-intron | ENST00000520781 | ENST00000327578 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
Frame-shift | ENST00000314146 | ENST00000325083 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
Frame-shift | ENST00000314146 | ENST00000519253 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
Frame-shift | ENST00000314146 | ENST00000524226 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
5CDS-intron | ENST00000314146 | ENST00000518537 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
5CDS-intron | ENST00000314146 | ENST00000518936 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
5CDS-intron | ENST00000314146 | ENST00000327578 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
5UTR-3CDS | ENST00000520051 | ENST00000325083 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
5UTR-3CDS | ENST00000520051 | ENST00000519253 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
5UTR-3CDS | ENST00000520051 | ENST00000524226 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
5UTR-intron | ENST00000520051 | ENST00000518537 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
5UTR-intron | ENST00000520051 | ENST00000518936 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
5UTR-intron | ENST00000520051 | ENST00000327578 | ASAH1 | chr8 | 17933049 | - | PCM1 | chr8 | 17817523 | + |
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FusionProtFeatures for ASAH1_PCM1 |
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Hgene | Tgene |
ASAH1 | PCM1 |
Hydrolyzes the sphingolipid ceramide into sphingosineand free fatty acid. {ECO:0000269|PubMed:7744740}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ASAH1_PCM1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ASAH1_PCM1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ASAH1 | SETDB1, TSC22D1, PSMA3, FBXO6, CAMK1D, SRPK1, GSG1, PNKD, AAGAB, AAMP, NEFH, CAMK2B, HSF2, HSPB2, HERC2, CYP1A2, GLT1D1, ZIC1, ZSCAN12, FTH1, NONO, TBC1D22B, SLCO6A1, AIRE, HTATIP2, RNF6, TRMT2A, ZNF684, ZNF556, HMP19, LYPD1, NCDN | PCM1 | BBS4, KRT15, ING5, KIAA0368, KRT19, CCDC53, ABI2, EXOC8, EPS8, CEP72, PCNT, HAP1, EWSR1, HNRNPUL1, CLTC, MIB1, FUS, CEP131, PPIB, SIRT7, NEURL4, PAN2, CASK, E2F4, YWHAQ, LATS2, SAV1, CEP250, HAUS2, OBSL1, CCDC8, CSPP1, CCDC183, SLC25A41, SSFA2, RASSF8, RASSF7, IFT81, NTRK1, BTRC, MED4, HERC2, AHI1, CEP162, RPGRIP1L, CC2D2A, CEP128, LCA5, OFD1, CCDC138, CEP170, PIBF1, SSX2IP, WRAP73, HAUS1, HAUS4, KIAA0753, CCDC77, CCNB2, CEP350, CEP95, CSNK1A1, DSP, KIF20A, LUZP1, MCM10, MCRS1, MPRIP, NDC80, SMARCD2, TPGS1, SUPT5H, SSBP1, KIF7, SKA1, TSPYL1, SREK1IP1, CSNK1D, IFT172, CEP55, IFT20, CCDC14, HMMR, CFAP97, IPO5, KCTD12, SNRPE, SPICE1, ABCD3, ACOT9, ATP5L, CAMSAP1, CC2D1A, CCDC66, CEP120, CKAP2, FGFR1OP, HAUS3, HAUS5, HAUS6, HAUS7, HAUS8, IDH3B, IFT57, IFT74, NCKAP5L, RAE1, STAU1, TP53BP2, TTK, TXLNA, TXLNG, TBC1D31, WDR83, XRN1, ZNF280C, ACTR2, ANKRD26, BAIAP2, BICD1, BICD2, BTF3, C11orf49, KNSTRN, C2CD3, CAMSAP2, CCDC112, CCDC18, CCDC22, CCDC85C, CCDC92, CCNB1, CCP110, CDC123, CEP164, CEP192, CEP57L1, CEP63, CEP85, CEP89, CEP97, CKAP2L, CNOT10, COMMD2, COMMD4, CSNK1E, DAPK3, DIAPH3, ERC1, EXOC4, FOPNL, GNAO1, GPATCH1, IBTK, IQCB1, KIAA1328, KIF14, LRRC49, LRRCC1, MAGED1, MAP7D3, MED29, MIS18A, MIS18BP1, MOB4, MPHOSPH9, MYO9A, NAV1, NEDD1, NME7, NOL11, NUF2, ODF2L, ODF2, PCBP3, PKN2, PLK1, KIZ, PPP1R9B, IFT22, RRM2, SCLT1, SDCCAG3, SECISBP2, SMG5, SMG7, SPATA24, SPATS2, SPC24, SRGAP2, STRN4, TANC1, TCHP, TEX9, TNIP1, TRAF3IP1, TTC12, TTF2, TTLL4, TTLL5, CEP104, CEP290, CEP152, CEP135, CNTRL, FBF1, NINL, NIN, POC5, SASS6, RPGRIP1, STIL, CENPJ, CENPE, PPP2CA, PRKAR2B, DYNLL1, MAPRE1, SLAIN2, CEP170P1, PPP2R3C, YWHAE, YWHAZ, MTMR7, C6orf118, BIN3, CCDC172, LPXN, FAM81B, COG5, ING2, CCDC65, LCA5L, CCDC40, DKK3, NECAB2, ATG14, TSC1, RNF168 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ASAH1_PCM1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ASAH1_PCM1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ASAH1 | C0268255 | Farber Lipogranulomatosis | 8 | CTD_human;ORPHANET;UNIPROT |
Hgene | ASAH1 | C0023794 | Lipoidosis | 2 | CTD_human |
Hgene | ASAH1 | C1834569 | Jankovic Rivera syndrome | 2 | ORPHANET;UNIPROT |
Hgene | ASAH1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | ASAH1 | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | ASAH1 | C0221765 | Chronic schizophrenia | 1 | PSYGENET |
Tgene | PCM1 | C0036341 | Schizophrenia | 1 | CTD_human |