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Fusion gene ID: 28854 |
FusionGeneSummary for PRPF19_DDB1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PRPF19_DDB1 | Fusion gene ID: 28854 | Hgene | Tgene | Gene symbol | PRPF19 | DDB1 | Gene ID | 27339 | 1642 |
| Gene name | pre-mRNA processing factor 19 | damage specific DNA binding protein 1 | |
| Synonyms | NMP200|PRP19|PSO4|SNEV|UBOX4|hPSO4 | DDBA|UV-DDB1|XAP1|XPCE|XPE|XPE-BF | |
| Cytomap | 11q12.2 | 11q12.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pre-mRNA-processing factor 19PRP19/PSO4 homologPRP19/PSO4 pre-mRNA processing factor 19 homologRING-type E3 ubiquitin transferase PRP19nuclear matrix protein 200nuclear matrix protein NMP200 related to splicing factor PRP19psoralen 4senescence evas | DNA damage-binding protein 1DDB p127 subunitDNA damage-binding protein aHBV X-associated protein 1UV-DDB 1UV-damaged DNA-binding factorUV-damaged DNA-binding protein 1XAP-1XPE-binding factordamage-specific DNA binding protein 1, 127kDaxeroderma | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UMS4 | Q16531 | |
| Ensembl transtripts involved in fusion gene | ENST00000227524, | ENST00000301764, ENST00000450997, ENST00000451943, ENST00000538470, ENST00000545930, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 4 X 4 X 2=32 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/32*10)=0.643856189774725 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PRPF19 [Title/Abstract] AND DDB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PRPF19 | GO:0000209 | protein polyubiquitination | 11435423 |
| Hgene | PRPF19 | GO:0000244 | spliceosomal tri-snRNP complex assembly | 20595234 |
| Hgene | PRPF19 | GO:0000398 | mRNA splicing, via spliceosome | 20176811 |
| Tgene | DDB1 | GO:0006511 | ubiquitin-dependent protein catabolic process | 11673459 |
| Tgene | DDB1 | GO:0035518 | histone H2A monoubiquitination | 22334663 |
| Tgene | DDB1 | GO:0051702 | interaction with symbiont | 23137809 |
| Tgene | DDB1 | GO:0070914 | UV-damage excision repair | 22334663 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A8-A07W-01A | PRPF19 | chr11 | 60668054 | - | DDB1 | chr11 | 61091609 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000227524 | ENST00000301764 | PRPF19 | chr11 | 60668054 | - | DDB1 | chr11 | 61091609 | - |
| 5CDS-intron | ENST00000227524 | ENST00000450997 | PRPF19 | chr11 | 60668054 | - | DDB1 | chr11 | 61091609 | - |
| 5CDS-intron | ENST00000227524 | ENST00000451943 | PRPF19 | chr11 | 60668054 | - | DDB1 | chr11 | 61091609 | - |
| 5CDS-intron | ENST00000227524 | ENST00000538470 | PRPF19 | chr11 | 60668054 | - | DDB1 | chr11 | 61091609 | - |
| 5CDS-5UTR | ENST00000227524 | ENST00000545930 | PRPF19 | chr11 | 60668054 | - | DDB1 | chr11 | 61091609 | - |
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FusionProtFeatures for PRPF19_DDB1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PRPF19 | DDB1 |
| Ubiquitin-protein ligase which is a core component ofseveral complexes mainly involved pre-mRNA splicing and DNArepair. Core component of the PRP19C/Prp19 complex/NTC/Nineteencomplex which is part of the spliceosome and participates in itsassembly, its remodeling and is required for its activity. Duringassembly of the spliceosome, mediates 'Lys-63'-linkedpolyubiquitination of the U4 spliceosomal protein PRPF3.Ubiquitination of PRPF3 allows its recognition by the U5 componentPRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex(PubMed:20595234). Recruited to RNA polymerase II C-terminaldomain (CTD) and the pre-mRNA, it may also couple thetranscriptional and spliceosomal machineries (PubMed:21536736).The XAB2 complex, which contains PRPF19, is also involved in pre-mRNA splicing, transcription and transcription-coupled repair(PubMed:17981804). Beside its role in pre-mRNA splicing PRPF19, aspart of the PRP19-CDC5L complex, plays a role in the DNA damageresponse/DDR. It is recruited to the sites of DNA damage by theRPA complex where PRPF19 directly ubiquitinates RPA1 and RPA2.'Lys-63'-linked polyubiquitination of the RPA complex allows therecruitment of the ATR-ATRIP complex and the activation of ATR, amaster regulator of the DNA damage response (PubMed:24332808). Mayalso play a role in DNA double-strand break (DSB) repair byrecruiting the repair factor SETMAR to altered DNA(PubMed:18263876). As part of the PSO4 complex may also beinvolved in the DNA interstrand cross-links/ICLs repair process(PubMed:16223718). In addition, may also mediate 'Lys-48'-linkedpolyubiquitination of substrates and play a role in proteasomaldegradation (PubMed:11435423). May play a role in the biogenesisof lipid droplets (By similarity). May play a role in neuraldifferentiation possibly through its function as part of thespliceosome (By similarity). {ECO:0000250|UniProtKB:Q99KP6,ECO:0000250|UniProtKB:Q9JMJ4, ECO:0000269|PubMed:11082287,ECO:0000269|PubMed:11435423, ECO:0000269|PubMed:12960389,ECO:0000269|PubMed:15660529, ECO:0000269|PubMed:16223718,ECO:0000269|PubMed:16332694, ECO:0000269|PubMed:16388800,ECO:0000269|PubMed:17349974, ECO:0000269|PubMed:18263876,ECO:0000269|PubMed:21536736, ECO:0000269|PubMed:24332808,ECO:0000303|PubMed:17981804, ECO:0000303|PubMed:20595234}. | Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruitproteins of the nucleotide excision repair pathway (the NERpathway) to initiate DNA repair. The UV-DDB complex preferentiallybinds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts(6-4 PP), apurinic sites and short mismatches. Also appears tofunction as a component of numerous distinct DCX (DDB1-CUL4-X-box)E3 ubiquitin-protein ligase complexes which mediate theubiquitination and subsequent proteasomal degradation of targetproteins. The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substraterecognition component recruited by DDB1. DCX(DDB2) (also known asDDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinatehistone H2A, histone H3 and histone H4 at sites of UV-induced DNAdamage. The ubiquitination of histones may facilitate theirremoval from the nucleosome and promote subsequent DNA repair.DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding byXPC and promote NER. DCX(DTL) plays a role in PCNA-dependentpolyubiquitination of CDT1 and MDM2-dependent ubiquitination ofTP53 in response to radiation-induced DNA damage and during DNAreplication. DCX(ERCC8) (the CSA complex) plays a role intranscription-coupled repair (TCR). May also play a role inubiquitination of CDKN1B/p27kip when associated with CUL4 andSKP2. {ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:14739464,ECO:0000269|PubMed:15448697, ECO:0000269|PubMed:15882621,ECO:0000269|PubMed:16260596, ECO:0000269|PubMed:16407242,ECO:0000269|PubMed:16407252, ECO:0000269|PubMed:16473935,ECO:0000269|PubMed:16482215, ECO:0000269|PubMed:16678110,ECO:0000269|PubMed:16940174, ECO:0000269|PubMed:17041588,ECO:0000269|PubMed:17079684, ECO:0000269|PubMed:18332868,ECO:0000269|PubMed:18381890, ECO:0000269|PubMed:18593899,ECO:0000269|PubMed:19966799, ECO:0000269|PubMed:22118460,ECO:0000269|PubMed:25043012, ECO:0000269|PubMed:25108355}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PRPF19 | chr11:60668054 | chr11:61091609 | ENST00000227524 | - | 10 | 16 | 2_73 | 276 | 505 | Domain | Note=U-box |
| Hgene | PRPF19 | chr11:60668054 | chr11:61091609 | ENST00000227524 | - | 10 | 16 | 219_259 | 276 | 505 | Repeat | Note=WD 1 |
| Tgene | >DDB1 | chr11:60668054 | chr11:61091609 | ENST00000301764 | - | 5 | 27 | 709_1043 | 254 | 1141 | Region | Note=WD repeat beta-propeller C |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PRPF19 | chr11:60668054 | chr11:61091609 | ENST00000227524 | - | 10 | 16 | 262_301 | 276 | 505 | Repeat | Note=WD 2 |
| Hgene | >PRPF19 | chr11:60668054 | chr11:61091609 | ENST00000227524 | - | 10 | 16 | 304_345 | 276 | 505 | Repeat | Note=WD 3 |
| Hgene | >PRPF19 | chr11:60668054 | chr11:61091609 | ENST00000227524 | - | 10 | 16 | 348_387 | 276 | 505 | Repeat | Note=WD 4 |
| Hgene | >PRPF19 | chr11:60668054 | chr11:61091609 | ENST00000227524 | - | 10 | 16 | 390_429 | 276 | 505 | Repeat | Note=WD 5 |
| Hgene | >PRPF19 | chr11:60668054 | chr11:61091609 | ENST00000227524 | - | 10 | 16 | 433_472 | 276 | 505 | Repeat | Note=WD 6 |
| Hgene | >PRPF19 | chr11:60668054 | chr11:61091609 | ENST00000227524 | - | 10 | 16 | 473_503 | 276 | 505 | Repeat | Note=WD 7 |
| Tgene | DDB1 | chr11:60668054 | chr11:61091609 | ENST00000301764 | - | 5 | 27 | 13_356 | 254 | 1141 | Region | Note=WD repeat beta-propeller A |
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FusionGeneSequence for PRPF19_DDB1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PRPF19_ENST00000227524_chr11_60668054_-_DDB1_ENST00000301764_chr11_61091609_-_1163aa MSLICSISNEVPEHPCVSPVSNHVYERRLIEKYIAENGTDPINNQPLSEEQLIDIKVAHPIRPKPPSATSIPAILKALQDEWDAVMLHSF TLRQQLQTTRQELSHALYQHDAACRVIARLTKEVTAAREALATLKPQAGLIVPQAVPSSQPSVVGAGEPMDLGELVGMTPEIIQKLQDKA TVLTTERKKRGKTVPEELVKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSV VFHPSQQSTIVCHNRVDPNGSRYLLGDMEGRLFMLLLEKEEQMDGTVTLKDLRVELLGETSIAECLTYLDNGVVFVGSRLGDSQLVKLNV DSNEQGSYVVAMETFTNLGPIVDMCVVDLERQGQGQLVTCSGAFKEGSLRIIRNGIGIHEHASIDLPGIKGLWPLRSDPNRETDDTLVLS FVGQTRVLMLNGEEVEETELMGFVDDQQTFFCGNVAHQQLIQITSASVRLVSQEPKALVSEWKEPQAKNISVASCNSSQVVVAVGRALYY LQIHPQELRQISHTEMEHEVACLDITPLGDSNGLSPLCAIGLWTDISARILKLPSFELLHKEMLGGEIIPRSILMTTFESSHYLLCALGD GALFYFGLNIETGLLSDRKKVTLGTQPTVLRTFRSLSTTNVFACSDRPTVIYSSNHKLVFSNVNLKEVNYMCPLNSDGYPDSLALANNST LTIGTIDEIQKLHIRTVPLYESPRKICYQEVSQCFGVLSSRIEVQDTSGGTTALRPSASTQALSSSVSSSKLFSSSTAPHETSFGEEVEV HNLLIIDQHTFEVLHAHQFLQNEYALSLVSCKLGKDPNTYFIVGTAMVYPEEAEPKQGRIVVFQYSDGKLQTVAEKEVKGAVYSMVEFNG KLLASINSTVRLYEWTTEKELRTECNHYNNIMALYLKTKGDFILVGDLMRSVLLLAYKPMEGNFEEIARDFNPNWMSAVEILDDDNFLGA ENAFNLFVCQKDSAATTDEERQHLQEVGLFHLGEFVNVFCHGSLVMQNLGETSTPTQGSVLFGTVNGMIGLVTSLSESWYNLLLDMQNRL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PRPF19_ENST00000227524_chr11_60668054_-_DDB1_ENST00000301764_chr11_61091609_-_3489nt ATGTCCCTAATCTGCTCCATCTCTAACGAAGTGCCGGAGCACCCATGTGTATCCCCTGTCTCTAATCATGTTTATGAGCGGCGGCTCATC GAGAAGTACATTGCGGAGAATGGTACCGACCCCATCAACAACCAGCCTCTCTCCGAGGAGCAGCTCATCGACATCAAAGTTGCTCACCCA ATCCGGCCCAAGCCTCCCTCAGCCACCAGCATCCCGGCCATTCTGAAAGCTTTGCAGGATGAGTGGGATGCAGTCATGCTGCACAGCTTC ACTCTGCGCCAGCAGCTGCAGACAACCCGCCAAGAGCTGTCACACGCTCTGTACCAGCACGATGCCGCCTGCCGTGTCATTGCCCGTCTC ACCAAGGAAGTCACTGCTGCCCGAGAAGCTCTGGCTACCCTGAAACCACAGGCTGGCCTCATTGTGCCCCAGGCTGTGCCAAGTTCCCAA CCAAGTGTTGTGGGTGCGGGTGAGCCAATGGATTTGGGTGAGCTGGTGGGAATGACCCCAGAGATTATTCAGAAGCTTCAAGACAAAGCC ACTGTGCTAACCACGGAGCGCAAGAAGAGAGGGAAGACTGTGCCTGAGGAGCTGGTGAAGCCAGAAGAGCTCAGCAAATACCGGCAGGTG GCATCCCACGTGGGGTTGCACAGTGCCAGCATTCCTGGGATCCTGGCCCTGGACCTCTGCCCGTCCGACACCAACAAGATCCTCACTGGT GGGGCGGATAAAAATGTCGTTGTGTTTGACAAAAGTTCTGAACAAATCCTGGCTACCCTCAAAGGCCATACCAAGAAGGTCACCAGCGTG GTGTTTCACCCTTCCCAGCAAAGCACGATTGTGTGCCACAATCGAGTGGACCCTAATGGCTCAAGATACCTGCTGGGAGACATGGAAGGC CGGCTCTTCATGCTGCTTTTGGAGAAGGAGGAACAGATGGATGGCACCGTCACTCTCAAGGATCTCCGTGTAGAACTCCTTGGAGAGACC TCTATTGCTGAGTGCTTGACATACCTTGATAATGGTGTTGTGTTTGTCGGGTCTCGCCTGGGTGACTCCCAGCTTGTGAAGCTCAACGTT GACAGTAATGAACAAGGCTCCTATGTAGTGGCCATGGAAACCTTTACCAACTTAGGACCCATTGTCGATATGTGCGTGGTGGACCTGGAG AGGCAGGGGCAGGGGCAGCTGGTCACTTGCTCTGGGGCTTTCAAGGAAGGTTCTTTGCGGATCATCCGGAATGGAATTGGAATCCACGAG CATGCCAGCATTGACTTACCAGGCATCAAAGGATTATGGCCACTGCGGTCTGACCCTAATCGTGAGACTGATGACACTTTGGTGCTCTCT TTTGTGGGCCAGACAAGAGTTCTCATGTTAAATGGAGAGGAGGTAGAAGAAACCGAACTGATGGGTTTCGTGGATGATCAGCAGACTTTC TTCTGTGGCAACGTGGCTCATCAGCAGCTTATCCAGATCACTTCAGCATCGGTGAGGTTGGTCTCTCAAGAACCCAAAGCTCTGGTCAGT GAATGGAAGGAGCCTCAGGCCAAGAACATCAGTGTGGCCTCCTGCAATAGCAGCCAGGTGGTGGTGGCTGTAGGCAGGGCCCTCTACTAT CTGCAGATCCATCCTCAGGAGCTCCGGCAGATCAGCCACACAGAGATGGAACATGAAGTGGCTTGCTTGGACATCACCCCATTAGGAGAC AGCAATGGACTGTCCCCTCTTTGTGCCATTGGCCTCTGGACGGACATCTCGGCTCGTATCTTGAAGTTGCCCTCTTTTGAACTACTGCAC AAGGAGATGCTGGGTGGAGAGATCATTCCTCGCTCCATCCTGATGACCACCTTTGAGAGTAGCCATTACCTCCTTTGTGCCTTGGGAGAT GGAGCGCTTTTCTACTTTGGGCTCAACATTGAGACAGGTCTGTTGAGCGACCGTAAGAAGGTGACTTTGGGCACCCAGCCCACCGTATTG AGGACTTTTCGTTCTCTTTCTACCACCAACGTCTTTGCTTGTTCTGACCGCCCCACTGTCATCTATAGCAGCAACCACAAATTGGTCTTC TCAAATGTCAACCTCAAGGAAGTGAACTACATGTGTCCCCTCAATTCAGATGGCTATCCTGACAGCCTGGCGCTGGCCAACAATAGCACC CTCACCATTGGCACCATCGATGAGATCCAGAAGCTGCACATTCGCACAGTTCCCCTCTATGAGTCTCCAAGGAAGATCTGCTACCAGGAA GTGTCCCAGTGTTTCGGGGTCCTCTCCAGCCGCATTGAAGTCCAAGACACGAGTGGGGGCACGACAGCCTTGAGGCCCAGCGCTAGCACC CAGGCTCTGTCCAGCAGTGTAAGCTCCAGCAAGCTGTTCTCCAGCAGCACTGCTCCTCATGAGACCTCCTTTGGAGAAGAGGTGGAGGTG CACAACCTACTTATCATTGACCAACACACCTTTGAAGTGCTTCATGCCCACCAGTTTCTGCAGAATGAATATGCCCTCAGTCTGGTTTCC TGCAAGCTGGGCAAAGACCCCAACACTTACTTCATTGTGGGCACAGCAATGGTGTATCCTGAAGAGGCAGAGCCCAAGCAGGGTCGCATT GTGGTCTTTCAGTATTCGGATGGAAAACTACAGACTGTGGCTGAAAAGGAAGTGAAAGGGGCCGTGTACTCTATGGTGGAATTTAACGGG AAGCTGTTAGCCAGCATCAATAGCACGGTGCGGCTCTATGAGTGGACAACAGAGAAGGAGCTGCGCACTGAGTGCAACCACTACAACAAC ATCATGGCCCTCTACCTGAAGACCAAGGGCGACTTCATCCTGGTGGGCGACCTTATGCGCTCAGTGCTGCTGCTTGCCTACAAGCCCATG GAAGGAAACTTTGAAGAGATTGCTCGAGACTTTAATCCCAACTGGATGAGTGCTGTGGAAATCTTGGATGATGACAATTTTCTGGGGGCT GAAAATGCCTTTAACTTGTTTGTGTGTCAAAAGGATAGCGCTGCCACCACTGACGAGGAGCGGCAGCACCTCCAGGAGGTTGGTCTTTTC CACCTGGGCGAGTTTGTCAATGTCTTTTGCCACGGCTCTCTGGTAATGCAGAATCTGGGTGAGACTTCCACCCCCACACAAGGCTCGGTG CTCTTCGGCACGGTCAACGGCATGATAGGGCTGGTGACCTCACTGTCAGAGAGCTGGTACAACCTCCTGCTGGACATGCAGAATCGACTC AATAAAGTCATCAAAAGTGTGGGGAAGATCGAGCACTCCTTCTGGAGATCCTTTCACACCGAGCGGAAGACAGAACCAGCCACAGGTTTC ATCGACGGTGACTTGATTGAGAGTTTCCTGGATATTAGCCGCCCCAAGATGCAGGAGGTGGTGGCAAACCTACAGTATGACGATGGCAGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PRPF19_ENST00000227524_chr11_60668054_-_DDB1_ENST00000301764_chr11_61091609_-_4380nt GGCAATTTCCGTTAGGTGCTGAAGGCTGTGGCGCGCGGCTGTCCCCATTCCCACGTGAAGCGCTACGCTAGCATCGCTCGGCTGGCGGCT CCCAGCTCGCCGCGGAGCAGTCCCGGCAGCAGCGGGGGACCGGAAGTGGCTCGCGGAGGCTCAGAAGCTAGTCCCGGAGCCCGGCGTGTG GCGCCTCGGAGCACGGTGACGGCGCCATGTCCCTAATCTGCTCCATCTCTAACGAAGTGCCGGAGCACCCATGTGTATCCCCTGTCTCTA ATCATGTTTATGAGCGGCGGCTCATCGAGAAGTACATTGCGGAGAATGGTACCGACCCCATCAACAACCAGCCTCTCTCCGAGGAGCAGC TCATCGACATCAAAGTTGCTCACCCAATCCGGCCCAAGCCTCCCTCAGCCACCAGCATCCCGGCCATTCTGAAAGCTTTGCAGGATGAGT GGGATGCAGTCATGCTGCACAGCTTCACTCTGCGCCAGCAGCTGCAGACAACCCGCCAAGAGCTGTCACACGCTCTGTACCAGCACGATG CCGCCTGCCGTGTCATTGCCCGTCTCACCAAGGAAGTCACTGCTGCCCGAGAAGCTCTGGCTACCCTGAAACCACAGGCTGGCCTCATTG TGCCCCAGGCTGTGCCAAGTTCCCAACCAAGTGTTGTGGGTGCGGGTGAGCCAATGGATTTGGGTGAGCTGGTGGGAATGACCCCAGAGA TTATTCAGAAGCTTCAAGACAAAGCCACTGTGCTAACCACGGAGCGCAAGAAGAGAGGGAAGACTGTGCCTGAGGAGCTGGTGAAGCCAG AAGAGCTCAGCAAATACCGGCAGGTGGCATCCCACGTGGGGTTGCACAGTGCCAGCATTCCTGGGATCCTGGCCCTGGACCTCTGCCCGT CCGACACCAACAAGATCCTCACTGGTGGGGCGGATAAAAATGTCGTTGTGTTTGACAAAAGTTCTGAACAAATCCTGGCTACCCTCAAAG GCCATACCAAGAAGGTCACCAGCGTGGTGTTTCACCCTTCCCAGCAAAGCACGATTGTGTGCCACAATCGAGTGGACCCTAATGGCTCAA GATACCTGCTGGGAGACATGGAAGGCCGGCTCTTCATGCTGCTTTTGGAGAAGGAGGAACAGATGGATGGCACCGTCACTCTCAAGGATC TCCGTGTAGAACTCCTTGGAGAGACCTCTATTGCTGAGTGCTTGACATACCTTGATAATGGTGTTGTGTTTGTCGGGTCTCGCCTGGGTG ACTCCCAGCTTGTGAAGCTCAACGTTGACAGTAATGAACAAGGCTCCTATGTAGTGGCCATGGAAACCTTTACCAACTTAGGACCCATTG TCGATATGTGCGTGGTGGACCTGGAGAGGCAGGGGCAGGGGCAGCTGGTCACTTGCTCTGGGGCTTTCAAGGAAGGTTCTTTGCGGATCA TCCGGAATGGAATTGGAATCCACGAGCATGCCAGCATTGACTTACCAGGCATCAAAGGATTATGGCCACTGCGGTCTGACCCTAATCGTG AGACTGATGACACTTTGGTGCTCTCTTTTGTGGGCCAGACAAGAGTTCTCATGTTAAATGGAGAGGAGGTAGAAGAAACCGAACTGATGG GTTTCGTGGATGATCAGCAGACTTTCTTCTGTGGCAACGTGGCTCATCAGCAGCTTATCCAGATCACTTCAGCATCGGTGAGGTTGGTCT CTCAAGAACCCAAAGCTCTGGTCAGTGAATGGAAGGAGCCTCAGGCCAAGAACATCAGTGTGGCCTCCTGCAATAGCAGCCAGGTGGTGG TGGCTGTAGGCAGGGCCCTCTACTATCTGCAGATCCATCCTCAGGAGCTCCGGCAGATCAGCCACACAGAGATGGAACATGAAGTGGCTT GCTTGGACATCACCCCATTAGGAGACAGCAATGGACTGTCCCCTCTTTGTGCCATTGGCCTCTGGACGGACATCTCGGCTCGTATCTTGA AGTTGCCCTCTTTTGAACTACTGCACAAGGAGATGCTGGGTGGAGAGATCATTCCTCGCTCCATCCTGATGACCACCTTTGAGAGTAGCC ATTACCTCCTTTGTGCCTTGGGAGATGGAGCGCTTTTCTACTTTGGGCTCAACATTGAGACAGGTCTGTTGAGCGACCGTAAGAAGGTGA CTTTGGGCACCCAGCCCACCGTATTGAGGACTTTTCGTTCTCTTTCTACCACCAACGTCTTTGCTTGTTCTGACCGCCCCACTGTCATCT ATAGCAGCAACCACAAATTGGTCTTCTCAAATGTCAACCTCAAGGAAGTGAACTACATGTGTCCCCTCAATTCAGATGGCTATCCTGACA GCCTGGCGCTGGCCAACAATAGCACCCTCACCATTGGCACCATCGATGAGATCCAGAAGCTGCACATTCGCACAGTTCCCCTCTATGAGT CTCCAAGGAAGATCTGCTACCAGGAAGTGTCCCAGTGTTTCGGGGTCCTCTCCAGCCGCATTGAAGTCCAAGACACGAGTGGGGGCACGA CAGCCTTGAGGCCCAGCGCTAGCACCCAGGCTCTGTCCAGCAGTGTAAGCTCCAGCAAGCTGTTCTCCAGCAGCACTGCTCCTCATGAGA CCTCCTTTGGAGAAGAGGTGGAGGTGCACAACCTACTTATCATTGACCAACACACCTTTGAAGTGCTTCATGCCCACCAGTTTCTGCAGA ATGAATATGCCCTCAGTCTGGTTTCCTGCAAGCTGGGCAAAGACCCCAACACTTACTTCATTGTGGGCACAGCAATGGTGTATCCTGAAG AGGCAGAGCCCAAGCAGGGTCGCATTGTGGTCTTTCAGTATTCGGATGGAAAACTACAGACTGTGGCTGAAAAGGAAGTGAAAGGGGCCG TGTACTCTATGGTGGAATTTAACGGGAAGCTGTTAGCCAGCATCAATAGCACGGTGCGGCTCTATGAGTGGACAACAGAGAAGGAGCTGC GCACTGAGTGCAACCACTACAACAACATCATGGCCCTCTACCTGAAGACCAAGGGCGACTTCATCCTGGTGGGCGACCTTATGCGCTCAG TGCTGCTGCTTGCCTACAAGCCCATGGAAGGAAACTTTGAAGAGATTGCTCGAGACTTTAATCCCAACTGGATGAGTGCTGTGGAAATCT TGGATGATGACAATTTTCTGGGGGCTGAAAATGCCTTTAACTTGTTTGTGTGTCAAAAGGATAGCGCTGCCACCACTGACGAGGAGCGGC AGCACCTCCAGGAGGTTGGTCTTTTCCACCTGGGCGAGTTTGTCAATGTCTTTTGCCACGGCTCTCTGGTAATGCAGAATCTGGGTGAGA CTTCCACCCCCACACAAGGCTCGGTGCTCTTCGGCACGGTCAACGGCATGATAGGGCTGGTGACCTCACTGTCAGAGAGCTGGTACAACC TCCTGCTGGACATGCAGAATCGACTCAATAAAGTCATCAAAAGTGTGGGGAAGATCGAGCACTCCTTCTGGAGATCCTTTCACACCGAGC GGAAGACAGAACCAGCCACAGGTTTCATCGACGGTGACTTGATTGAGAGTTTCCTGGATATTAGCCGCCCCAAGATGCAGGAGGTGGTGG CAAACCTACAGTATGACGATGGCAGCGGTATGAAGCGAGAGGCCACTGCAGACGACCTCATCAAGGTTGTGGAGGAGCTAACTCGGATCC ATTAGCCAAGGGCAGGGGGCCCCTTTGCTGACCCTCCCCAAAGGCTTTGCCCTGCTGCCCTCCCCCTCCTCTCCACCATCGTCTTCTTGG CCATGGGAGGCCTTTCCCTAAGCCAGCTGCCCCCAGAGCCACAGTTCCCCTATGTGGAAGTGGGGCGGGCTTCATAGAGACTTGGGAATG AGCTGAAGGTGAAACATTTTCTCCCTGGATTTTTACCAGTCTCACATGATTCCAGCCATCACCTTAGACCACCAAGCCTTGATTGGTGTT GCCAGTTGTCCTCCTTCCGGGGAAGGATTTTGCAGTTCTTTGGCTGAAAGGAAGCTGTGCGTGTGTGTGTGTGTATGTGTGTGTGTGTAT GTGTATCTCACACTCATGCATTGTCCTCTTTTTATTTAGATTGGCAGTGTAGGGAGTTGTGGGTAGTGGGGAAGAGGGTTAGGAGGGTTT CATTGTCTGTGAAGTGAGACCTTCCTTTTACTTTTCTTCTATTGCCTCTGAGAGCATCAGGCCTAGAGGCCTGACTGCCAAGCCATGGGT AGCCTGGGTGTAAAACCTGGAGATGGTGGATGATCCCCACGCCACAGCCCTTTTGTCTCTGCAAACTGCCTTCTTCGGAAAGAAGAAGGT |
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FusionGenePPI for PRPF19_DDB1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PRPF19 | EXOC7, PLRG1, DNTT, CDC5L, SRRM2, SRRM1, CTNNBL1, KPNA2, KPNA1, SETMAR, TADA2A, UBC, EGLN3, EGLN2, PRPF19, PRPF3, HDAC5, YWHAG, PSMA3, SMARCAD1, SF3A2, PSMB4, PSMA2, HNRNPA1, CUL3, CUL1, COPS5, CAND1, APEX1, KIAA0907, U2AF2, BCAS2, POLR2A, CWC15, USB1, PRPF8, SNRPA, SNRPD2, SF3A1, SNRPD1, SRSF1, PRPF4, SNRPA1, PRPF6, SF3B3, SNRNP70, XAB2, SF3A3, SART1, SNRNP200, SRSF5, U2AF1, SF3B6, RBM25, HNRNPM, EFTUD2, RNPS1, DDX5, SRSF11, RBM39, LAMP2, SON, RPS10, UTP14A, VTN, TRIM55, RBM14, SRP14, RPS24, NOTCH1, EIF4A3, MAGOH, FN1, RBM10, RBM5, PRCC, HSPB1, CDC40, DDX42, HSP90AA1, UCHL5, GSTK1, TARDBP, PARK2, SEC13, MEPCE, RPA3, RPA2, RPA1, EXOC3, CSNK2A2, LIN28A, CEP250, CEP57, CEP76, TUBGCP3, VCP, HUWE1, USP4, UBE2D3, ENO1, MOV10, NXF1, CUL7, OBSL1, SUZ12, EED, RNF2, ESR1, CCDC94, KNSTRN, LGALS3, CWC22, DHX8, LTN1, MTCH1, BUD31, C1orf123, DHX15, ISY1, ISY1-RAB43, MTHFD1, PDIA5, UBE2A, RNF113B, RPN1, SF3B1, SNW1, STUB1, UBXN1, USP39, NTRK1, SCARNA22, AHSA1, PRPS1, SNCA, SMC1A, NF2, USP37, LINC00673, PTPN11, PPP4C, GCC1, SENP6, ZDBF2, GPATCH1, CWF19L2, AQR, WDR83, GCFC2, DHX35, CCDC18, CCDC12, TFIP11, CWF19L1, SLMAP, TP53BP2, CRNKL1, SYF2, DGCR14, PPIE, RBM22, ZNF830, STRN, FAM167A, NDEL1, CYLD, AAR2, CD2BP2, EAPP, ECD, INO80B, SLC7A6OS, TSSC4, ZNHIT2, ZNHIT3, DLD, DLST, HSD17B10, PDHA1, TRIM25, BRCA1, LMNA, MTF1 | DDB1 | DET1, RFWD2, DDB2, SUPT3H, KAT2A, CDKN1A, CUL4A, CUL4B, FBXW5, NF2, POLR2J, GPN1, PMS2, UBC, PCNA, TRPC4AP, DDA1, NEDD8, CRBN, COPS3, COPS4, COPS5, COPS2, COPS8, COPS7B, COPS7A, COPS6, DCAF11, DCAF5, BRWD1, PHIP, DCAF6, DCAF12, DCAF10, DCAF4, WDTC1, DCAF8, ERCC8, VPRBP, DTL, AMBRA1, DCAF7, DCAF13, DCAF15, DCAF16, DCAF17, GPS1, RBX1, SKP2, TOR1AIP2, BANF1, XPC, HOXD3, CNOT2, MAFB, ZNF277, EED, RBBP5, HIST1H3A, CAND1, CDT1, CDKN1B, CENPA, CHEK1, TADA2A, TERF1, TERF2, SETD8, ERCC6, SNW1, UNG, HDAC5, UBXN7, FAF2, UBXN1, DYRK2, UBR5, KATNA1, MYC, RASSF1, RAG1, RAG2, CTNNB1, AHR, PIDD1, SALL2, RAD21, UBA1, HOXB4, MCM10, RECQL, SIRT7, SAMHD1, EP300, UBE2E3, POLR2A, FBXW8, WSB1, WSB2, NUP43, BTRC, PWP1, RBBP4, GRWD1, CUL3, CUL5, CUL1, DCUN1D1, SLX4, DCLRE1C, MYB, PTPN14, LRWD1, MDM2, KCND3, FZR1, E2F1, ABL1, RORA, XPA, GRK5, GRK6, SHC1, TP73, SRSF9, TCERG1, TAF15, PUF60, RPS7, STRIP1, NUP133, TPR, NUMA1, STRN4, TPM2, FLNC, ATP6V1F, NCOA5, CSTF2, RANBP9, VTN, NXF1, SAP30BP, MBD3, RTN4, RPTOR, MTOR, RICTOR, UCHL1, TERT, DDB1, INO80, ACTR5, ALB, DDIT4, INVS, NPHP4, LMO4, UVSSA, STAT1, MEF2A, DYRK1B, TOPBP1, MIB1, DLC1, PIN1, VASP, RPA3, RPA2, RPA1, NR1I2, ASB4, NR2C2, FTSJ3, AURKA, AURKB, CEP250, CEP57, CEP72, TP53, TUBGCP2, HDAC1, HDAC2, SIN3A, ARID4B, SAP130, SUDS3, SAP30, RBP1, HUWE1, IP6K1, BRCA1, HIST1H1A, HIST1H1C, CUL7, OBSL1, SIRT6, CLCN1, EPB41L3, RASSF9, RASSF10, RPS6KB2, BECN1, TRAF6, TET2, TET1, TET3, CORO1B, ACAT1, APEX1, CGGBP1, CLIC1, CLIC4, CMAS, LASP1, MCM5, NHP2L1, PSMA1, SNX2, YARS, LSM2, SF3A3, NTRK1, FBXO44, RGS2, PTEN, EWSR1, CAMKK1, PYGO2, HDAC3, HDAC8, CRY2, GNB2, RBBP7, CDC5L, PCGF1, DPPA4, BCOR, NANOG, POU5F1, DCUN1D5, UVRAG, MYO6, MOAP1, DERL1, ZNF746, CCNG1, CYLD, TRIM25, CEP78, CCP110, DCAF4L2, MUS81, EME1, XRCC5, RNF169 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | DDB1 | chr11:60668054 | chr11:61091609 | ENST00000301764 | - | 5 | 27 | 771_1140 | 254 | 1141 | CDT1 and CUL4A |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | DDB1 | chr11:60668054 | chr11:61091609 | ENST00000301764 | - | 5 | 27 | 2_768 | 254 | 1141 | CDT1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PRPF19_DDB1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PRPF19_DDB1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PRPF19 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Tgene | DDB1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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