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Fusion gene ID: 28852 |
FusionGeneSummary for PRPF18_CCDC3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PRPF18_CCDC3 | Fusion gene ID: 28852 | Hgene | Tgene | Gene symbol | PRPF18 | CCDC3 | Gene ID | 8559 | 83643 |
| Gene name | pre-mRNA processing factor 18 | coiled-coil domain containing 3 | |
| Synonyms | PRP18|hPrp18 | - | |
| Cytomap | 10p13 | 10p13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pre-mRNA-splicing factor 18PRP18 homologPRP18 pre-mRNA processing factor 18 homologPRP18 pre-mRNA processing factor 18 homolog(PRPF18) | coiled-coil domain-containing protein 3fat/vessel-derived secretory proteinfavine | |
| Modification date | 20180523 | 20180329 | |
| UniProtAcc | Q99633 | Q9BQI4 | |
| Ensembl transtripts involved in fusion gene | ENST00000378572, | ENST00000378825, ENST00000378839, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 3 X 3 X 3=27 |
| # samples | 4 | 3 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PRPF18 [Title/Abstract] AND CCDC3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-49-AAR0-01A | PRPF18 | chr10 | 13629152 | + | CCDC3 | chr10 | 12940679 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000378572 | ENST00000378825 | PRPF18 | chr10 | 13629152 | + | CCDC3 | chr10 | 12940679 | - |
| In-frame | ENST00000378572 | ENST00000378839 | PRPF18 | chr10 | 13629152 | + | CCDC3 | chr10 | 12940679 | - |
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FusionProtFeatures for PRPF18_CCDC3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PRPF18 | CCDC3 |
| Participates in the second step of pre-mRNA splicing.{ECO:0000269|PubMed:9000057}. | Negatively regulates TNF-alpha-induced pro-inflammatoryresponse in endothelial cells (ECs) via inhibition of TNF-alpha-induced NF-kappaB activation in ECs (PubMed:25193116). Positivelyregulates lipid accumulation in adipose cells (By similarity).{ECO:0000250|UniProtKB:Q9D6Y1, ECO:0000269|PubMed:25193116}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PRPF18_CCDC3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PRPF18_ENST00000378572_chr10_13629152_+_CCDC3_ENST00000378839_chr10_12940679_-_110aa MDILKSEILRKRQLVEDRNLLVLMCSSVQKALFEEEDHVKKLQQKVATLEKRNRQLRERVKKVKRSLRQARKKGRHLELANQKLSEKLAA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PRPF18_ENST00000378572_chr10_13629152_+_CCDC3_ENST00000378839_chr10_12940679_-_330nt ATGGACATTCTGAAATCAGAGATCCTTCGGAAGCGGCAGCTGGTGGAGGACAGGAACCTGCTGGTGCTCATGTGCTCCTCGGTGCAGAAG GCCTTGTTTGAGGAGGAGGACCACGTCAAGAAACTGCAGCAGAAAGTGGCCACCCTGGAGAAGCGCAACCGGCAGCTCCGGGAGCGAGTG AAGAAGGTCAAGAGGTCCTTGCGGCAGGCGCGTAAGAAGGGCCGCCACCTGGAGCTGGCGAACCAGAAACTCAGTGAGAAGCTGGCGGCG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PRPF18_ENST00000378572_chr10_13629152_+_CCDC3_ENST00000378839_chr10_12940679_-_2279nt CTCTCTCATCCCAGCTTCCGCCGGAAGCGGCTCCTGTCAGTTGTTCTCAGGTGTTTGGGCTTGTTGTTCCGTATACTCAGTGGGTTCGCG GCCGCCGGCCCAGTGAGGCTGGGTTCGAGGAGCTGGAGCGGGAAACTGGAGCTTAAATTCTGGCGGCGAGATGGACATTCTGAAATCAGA GATCCTTCGGAAGCGGCAGCTGGTGGAGGACAGGAACCTGCTGGTGCTCATGTGCTCCTCGGTGCAGAAGGCCTTGTTTGAGGAGGAGGA CCACGTCAAGAAACTGCAGCAGAAAGTGGCCACCCTGGAGAAGCGCAACCGGCAGCTCCGGGAGCGAGTGAAGAAGGTCAAGAGGTCCTT GCGGCAGGCGCGTAAGAAGGGCCGCCACCTGGAGCTGGCGAACCAGAAACTCAGTGAGAAGCTGGCGGCGGGCGCGCTGCCGCACATCAA TGCCCGGGGGCCCGTGCGCCCCCCCTACCTGCGGGGGTAACGGGCCTGGGGGCTGCCAGGTGTGCAGGGCCAATCCTGACGGTAATTGAG AATGAGTGAGGTTTCGTACATGCAGCTATTTCAAGGGTTGTAAGAGTTTTTGTTTTTAATCACGCATTTGGTAGAGTCTAAATGGATAAA ATGCAAGGCTTGCTTTCCCCTTGGGTGCTGGCCTCAATGTCAGACCCCACGCGCTGCCCCTTCCTGGCCTGACCCCAGACGCAGTGCCTG GCAGTCCAGAGGCAGTGGGATCCCTGAGTGCTGAATGCTCGCCTGCAGAGCAGCCCAGAAAGAGCCCTGACTGGGGAGAGAACATTTTAG AATCTCTAGTGTAAAAGACATCAACGTGCTTAGCCTTTATTTCAGAAAAAAATCAGGGTGGTTCCCAGCTCCCCAGTCCAGGACAACCAT TAGTCCTGATGAGTGAGCTGACGCTGGTGCTGGAACCTGCTGGCACCTCACTGGCCACATCTTTGGAAGGGGATGGTGGCCTTGCATCCA AGATGCCTGAAAATCAGCACGTGCAGGGCCTCCCTATCCAGCCAGCATTTTCCTTCCAGCTGAGGCAGGTGAAGACTTCATAAGCTCATC ACAGGGGAGGGAATTAGGAGCAGGGCAGCAGGTAATTAAACAAGATAAATTATACCTGATTTCCAACACCAGCTACAAAGAGTTGAAGAT GATACCTATGGGTCGCGTTAACACAGGGGGCAACTGCCTTGATCGGCCTGCCATGGGTCATCAGACTGCTTCCTAAATTGAGAGAAACTG AGCAATCTCTCAGCCACTGCTATAGTCTAACTTCTTGTTTGCTGAGTAATTGTTTCTAATGTCTCTGAACTCAAAGTGAGGTGCTCCAAG ACGCTGTGAACTTCTGCAAAGACACCTCCTTACCTACTGGGATCACGTGACCTGACCTCACTCCCAGCCAGGCTCCCAAAGGGCTCATTC CAGCCATTCCAATCTCTTCTTCTTTATGCAAACACTTTTCCCCCACAACAAGCCTTGTTTGTTCCGATAGGAATACGTGTACGTCAGTGC ACTTGTCCTTACGTCAGTTCCTTACACCACCAAAGCACTTCACCTTTCTGGAAATAAAACTTTTAAGACACTACTATAAGTAAAAATGAG AGTATTCACTAGACTTATTGCTCAGGCACATTTGAGTGGGTCCCAGCTGTGTGATTAAGAAGTCAACTGGGTGGCCTTTTCTGGGTTATC TTCTGATCATGGCCTTTCAACCCAACAAGGGCCCTTCCCTGCTCTTCCACCAGTAAAGGCTCCTGGCCTCTCATCAGGATCTGCCCCCCA GAGACCCCCCCCAGACACTGCAGGGCCTGGTGATGCTGTCCTCTGTACCGGAAATGGCAGGCACTGTCAGATTTCCACTCTTCTGCCTTT AGGAAGGCTGGGTGCTTCTTGCTCTGACAGCCAGTCTGGGGAGATGACTCTTACGTTGCTTGAGTCTTGGTGGCAGGCTGCTGTCCACGG GGGAGAAGTCTCTGCTCTGGACTGGACAGAAGAGAGACTTTTACCCTGGGGCACTCACACGGCCAAGCTTCTGCCACCACTTCATTAGCT GTATTCTCCATAGTATGGTGAAATAGCAGGTGCGTCTTCTAGTTTATTCCTCCTGGGGACATTTCCTCAAAGCAGTTTTGCGCCCCCGCA AGGGAATGGTCAGCCTAAGGGTAATGTACAGCCCGTGCTTGGAGAACCATGGAAGCTACACCCCTACAGGTGCATACTGTTCTGCTTTTC |
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FusionGenePPI for PRPF18_CCDC3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PRPF18 | LSM4, GTF2B, YWHAZ, RHOU | CCDC3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PRPF18_CCDC3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PRPF18_CCDC3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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