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Fusion gene ID: 2884 |
FusionGeneSummary for ASAH1_CTBP1 |
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Fusion gene information | Fusion gene name: ASAH1_CTBP1 | Fusion gene ID: 2884 | Hgene | Tgene | Gene symbol | ASAH1 | CTBP1 | Gene ID | 427 | 1487 |
Gene name | N-acylsphingosine amidohydrolase 1 | C-terminal binding protein 1 | |
Synonyms | AC|ACDase|ASAH|PHP|PHP32|SMAPME | BARS|HADDTS | |
Cytomap | 8p22 | 4p16.3 | |
Type of gene | protein-coding | protein-coding | |
Description | acid ceramidaseN-acylsphingosine amidohydrolase (acid ceramidase) 1acid CDaseacylsphingosine deacylaseputative 32 kDa heart protein | C-terminal-binding protein 1brefeldin A-ribosylated substrate | |
Modification date | 20180529 | 20180522 | |
UniProtAcc | Q13510 | Q13363 | |
Ensembl transtripts involved in fusion gene | ENST00000262097, ENST00000381733, ENST00000417108, ENST00000520781, ENST00000314146, ENST00000520051, | ENST00000382952, ENST00000290921, ENST00000510568, ENST00000515690, | |
Fusion gene scores | * DoF score | 6 X 7 X 3=126 | 8 X 7 X 8=448 |
# samples | 7 | 12 | |
** MAII score | log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/448*10)=-1.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ASAH1 [Title/Abstract] AND CTBP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF988401 | ASAH1 | chr8 | 17923419 | + | CTBP1 | chr4 | 1237036 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000262097 | ENST00000382952 | ASAH1 | chr8 | 17923419 | + | CTBP1 | chr4 | 1237036 | - |
intron-intron | ENST00000262097 | ENST00000290921 | ASAH1 | chr8 | 17923419 | + | CTBP1 | chr4 | 1237036 | - |
intron-intron | ENST00000262097 | ENST00000510568 | ASAH1 | chr8 | 17923419 | + | CTBP1 | chr4 | 1237036 | - |
intron-intron | ENST00000262097 | ENST00000515690 | ASAH1 | chr8 | 17923419 | + | CTBP1 | chr4 | 1237036 | - |
intron-intron | ENST00000381733 | ENST00000382952 | ASAH1 | chr8 | 17923419 | + | CTBP1 | chr4 | 1237036 | - |
intron-intron | ENST00000381733 | ENST00000290921 | ASAH1 | chr8 | 17923419 | + | CTBP1 | chr4 | 1237036 | - |
intron-intron | ENST00000381733 | ENST00000510568 | ASAH1 | chr8 | 17923419 | + | CTBP1 | chr4 | 1237036 | - |
intron-intron | ENST00000381733 | ENST00000515690 | ASAH1 | chr8 | 17923419 | + | CTBP1 | chr4 | 1237036 | - |
intron-intron | ENST00000417108 | ENST00000382952 | ASAH1 | chr8 | 17923419 | + | CTBP1 | chr4 | 1237036 | - |
intron-intron | ENST00000417108 | ENST00000290921 | ASAH1 | chr8 | 17923419 | + | CTBP1 | chr4 | 1237036 | - |
intron-intron | ENST00000417108 | ENST00000510568 | ASAH1 | chr8 | 17923419 | + | CTBP1 | chr4 | 1237036 | - |
intron-intron | ENST00000417108 | ENST00000515690 | ASAH1 | chr8 | 17923419 | + | CTBP1 | chr4 | 1237036 | - |
intron-intron | ENST00000520781 | ENST00000382952 | ASAH1 | chr8 | 17923419 | + | CTBP1 | chr4 | 1237036 | - |
intron-intron | ENST00000520781 | ENST00000290921 | ASAH1 | chr8 | 17923419 | + | CTBP1 | chr4 | 1237036 | - |
intron-intron | ENST00000520781 | ENST00000510568 | ASAH1 | chr8 | 17923419 | + | CTBP1 | chr4 | 1237036 | - |
intron-intron | ENST00000520781 | ENST00000515690 | ASAH1 | chr8 | 17923419 | + | CTBP1 | chr4 | 1237036 | - |
intron-intron | ENST00000314146 | ENST00000382952 | ASAH1 | chr8 | 17923419 | + | CTBP1 | chr4 | 1237036 | - |
intron-intron | ENST00000314146 | ENST00000290921 | ASAH1 | chr8 | 17923419 | + | CTBP1 | chr4 | 1237036 | - |
intron-intron | ENST00000314146 | ENST00000510568 | ASAH1 | chr8 | 17923419 | + | CTBP1 | chr4 | 1237036 | - |
intron-intron | ENST00000314146 | ENST00000515690 | ASAH1 | chr8 | 17923419 | + | CTBP1 | chr4 | 1237036 | - |
intron-intron | ENST00000520051 | ENST00000382952 | ASAH1 | chr8 | 17923419 | + | CTBP1 | chr4 | 1237036 | - |
intron-intron | ENST00000520051 | ENST00000290921 | ASAH1 | chr8 | 17923419 | + | CTBP1 | chr4 | 1237036 | - |
intron-intron | ENST00000520051 | ENST00000510568 | ASAH1 | chr8 | 17923419 | + | CTBP1 | chr4 | 1237036 | - |
intron-intron | ENST00000520051 | ENST00000515690 | ASAH1 | chr8 | 17923419 | + | CTBP1 | chr4 | 1237036 | - |
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FusionProtFeatures for ASAH1_CTBP1 |
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Hgene | Tgene |
ASAH1 | CTBP1 |
Hydrolyzes the sphingolipid ceramide into sphingosineand free fatty acid. {ECO:0000269|PubMed:7744740}. | Corepressor targeting diverse transcription regulatorssuch as GLIS2 or BCL6. Has dehydrogenase activity. Involved incontrolling the equilibrium between tubular and stacked structuresin the Golgi complex. Functions in brown adipose tissue (BAT)differentiation. {ECO:0000269|PubMed:12419229,ECO:0000269|PubMed:15542832, ECO:0000269|PubMed:18212045,ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:9858600}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ASAH1_CTBP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ASAH1_CTBP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ASAH1_CTBP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ASAH1_CTBP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ASAH1 | C0268255 | Farber Lipogranulomatosis | 8 | CTD_human;ORPHANET;UNIPROT |
Hgene | ASAH1 | C0023794 | Lipoidosis | 2 | CTD_human |
Hgene | ASAH1 | C1834569 | Jankovic Rivera syndrome | 2 | ORPHANET;UNIPROT |
Hgene | ASAH1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | ASAH1 | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | ASAH1 | C0221765 | Chronic schizophrenia | 1 | PSYGENET |
Tgene | CTBP1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |