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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28829

FusionGeneSummary for PRMT7_QKI

check button Fusion gene summary
Fusion gene informationFusion gene name: PRMT7_QKI
Fusion gene ID: 28829
HgeneTgene
Gene symbol

PRMT7

QKI

Gene ID

54496

9444

Gene nameprotein arginine methyltransferase 7QKI, KH domain containing RNA binding
SynonymsSBIDDSHqk|QK|QK1|QK3|hqkI
Cytomap

16q22.1

6q26

Type of geneprotein-codingprotein-coding
Descriptionprotein arginine N-methyltransferase 7[Myelin basic protein]-arginine N-methyltransferase PRMT7histone-arginine N-methyltransferase PRMT7protein quakingQKI/LOC100132735 fusionRNA binding protein HQKhomolog of mouse quaking QKI (KH domain RNA binding protein)quaking homolog, KH domain RNA binding
Modification date2018052320180522
UniProtAcc

Q9NVM4

Q96PU8

Ensembl transtripts involved in fusion geneENST00000449359, ENST00000564441, 
ENST00000441236, ENST00000348497, 
ENST00000339507, 		ENST00000275262, 
ENST00000392127, ENST00000453779, 
ENST00000361752, ENST00000361195, 
ENST00000424802, 
Fusion gene scores* DoF score3 X 3 X 3=2713 X 14 X 6=1092
# samples 318
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(18/1092*10)=-2.60090404459018
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PRMT7 [Title/Abstract] AND QKI [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRMT7

GO:0016571

histone methylation

15494416

HgenePRMT7

GO:0018216

peptidyl-arginine methylation

15044439


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF821829PRMT7chr16

68349561

-QKIchr6

163985899

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000449359ENST00000275262PRMT7chr16

68349561

-QKIchr6

163985899

-
intron-3UTRENST00000449359ENST00000392127PRMT7chr16

68349561

-QKIchr6

163985899

-
intron-intronENST00000449359ENST00000453779PRMT7chr16

68349561

-QKIchr6

163985899

-
intron-intronENST00000449359ENST00000361752PRMT7chr16

68349561

-QKIchr6

163985899

-
intron-intronENST00000449359ENST00000361195PRMT7chr16

68349561

-QKIchr6

163985899

-
intron-intronENST00000449359ENST00000424802PRMT7chr16

68349561

-QKIchr6

163985899

-
intron-3UTRENST00000564441ENST00000275262PRMT7chr16

68349561

-QKIchr6

163985899

-
intron-3UTRENST00000564441ENST00000392127PRMT7chr16

68349561

-QKIchr6

163985899

-
intron-intronENST00000564441ENST00000453779PRMT7chr16

68349561

-QKIchr6

163985899

-
intron-intronENST00000564441ENST00000361752PRMT7chr16

68349561

-QKIchr6

163985899

-
intron-intronENST00000564441ENST00000361195PRMT7chr16

68349561

-QKIchr6

163985899

-
intron-intronENST00000564441ENST00000424802PRMT7chr16

68349561

-QKIchr6

163985899

-
intron-3UTRENST00000441236ENST00000275262PRMT7chr16

68349561

-QKIchr6

163985899

-
intron-3UTRENST00000441236ENST00000392127PRMT7chr16

68349561

-QKIchr6

163985899

-
intron-intronENST00000441236ENST00000453779PRMT7chr16

68349561

-QKIchr6

163985899

-
intron-intronENST00000441236ENST00000361752PRMT7chr16

68349561

-QKIchr6

163985899

-
intron-intronENST00000441236ENST00000361195PRMT7chr16

68349561

-QKIchr6

163985899

-
intron-intronENST00000441236ENST00000424802PRMT7chr16

68349561

-QKIchr6

163985899

-
intron-3UTRENST00000348497ENST00000275262PRMT7chr16

68349561

-QKIchr6

163985899

-
intron-3UTRENST00000348497ENST00000392127PRMT7chr16

68349561

-QKIchr6

163985899

-
intron-intronENST00000348497ENST00000453779PRMT7chr16

68349561

-QKIchr6

163985899

-
intron-intronENST00000348497ENST00000361752PRMT7chr16

68349561

-QKIchr6

163985899

-
intron-intronENST00000348497ENST00000361195PRMT7chr16

68349561

-QKIchr6

163985899

-
intron-intronENST00000348497ENST00000424802PRMT7chr16

68349561

-QKIchr6

163985899

-
intron-3UTRENST00000339507ENST00000275262PRMT7chr16

68349561

-QKIchr6

163985899

-
intron-3UTRENST00000339507ENST00000392127PRMT7chr16

68349561

-QKIchr6

163985899

-
intron-intronENST00000339507ENST00000453779PRMT7chr16

68349561

-QKIchr6

163985899

-
intron-intronENST00000339507ENST00000361752PRMT7chr16

68349561

-QKIchr6

163985899

-
intron-intronENST00000339507ENST00000361195PRMT7chr16

68349561

-QKIchr6

163985899

-
intron-intronENST00000339507ENST00000424802PRMT7chr16

68349561

-QKIchr6

163985899

-

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FusionProtFeatures for PRMT7_QKI


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRMT7

Q9NVM4

QKI

Q96PU8

Arginine methyltransferase that can both catalyze theformation of omega-N monomethylarginine (MMA) and symmetricaldimethylarginine (sDMA), with a preference for the formation ofMMA. Specifically mediates the symmetrical dimethylation ofarginine residues in the small nuclear ribonucleoproteins Sm D1(SNRPD1) and Sm D3 (SNRPD3); such methylation being required forthe assembly and biogenesis of snRNP core particles. Specificallymediates the symmetric dimethylation of histone H4 'Arg-3' to formH4R3me2s. Plays a role in gene imprinting by being recruited byCTCFL at the H19 imprinted control region (ICR) and methylatinghistone H4 to form H4R3me2s, possibly leading to recruit DNAmethyltransferases at these sites. May also play a role inembryonic stem cell (ESC) pluripotency. Also able to mediate thearginine methylation of histone H2A and myelin basic protein (MBP)in vitro; the relevance of such results is however unclear invivo. {ECO:0000269|PubMed:15044439, ECO:0000269|PubMed:15494416,ECO:0000269|PubMed:17709427, ECO:0000269|PubMed:19110445}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PRMT7_QKI


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PRMT7_QKI


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PRMT7_QKI


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PRMT7_QKI


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneQKIC0036341Schizophrenia5PSYGENET
TgeneQKIC0017638Glioma1CTD_human
TgeneQKIC0041696Unipolar Depression1PSYGENET
TgeneQKIC1269683Major Depressive Disorder1PSYGENET