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Fusion gene ID: 28828 |
FusionGeneSummary for PRMT7_NFATC3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PRMT7_NFATC3 | Fusion gene ID: 28828 | Hgene | Tgene | Gene symbol | PRMT7 | NFATC3 | Gene ID | 54496 | 4775 |
| Gene name | protein arginine methyltransferase 7 | nuclear factor of activated T cells 3 | |
| Synonyms | SBIDDS | NFAT4|NFATX | |
| Cytomap | 16q22.1 | 16q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein arginine N-methyltransferase 7[Myelin basic protein]-arginine N-methyltransferase PRMT7histone-arginine N-methyltransferase PRMT7 | nuclear factor of activated T-cells, cytoplasmic 3NF-ATc3T cell transcription factor NFAT4nuclear factor of activated T-cells c3 isoform IE-Xanuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q9NVM4 | Q12968 | |
| Ensembl transtripts involved in fusion gene | ENST00000449359, ENST00000564441, ENST00000441236, ENST00000348497, ENST00000339507, | ENST00000575270, ENST00000349223, ENST00000329524, ENST00000346183, ENST00000535127, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 6 X 8 X 4=192 |
| # samples | 3 | 10 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(10/192*10)=-0.941106310946431 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PRMT7 [Title/Abstract] AND NFATC3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PRMT7 | GO:0016571 | histone methylation | 15494416 |
| Hgene | PRMT7 | GO:0018216 | peptidyl-arginine methylation | 15044439 |
| Tgene | NFATC3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 18815128 |
| Tgene | NFATC3 | GO:1905064 | negative regulation of vascular smooth muscle cell differentiation | 23853098 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-E2-A1LE-01A | PRMT7 | chr16 | 68389786 | + | NFATC3 | chr16 | 68260253 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000449359 | ENST00000575270 | PRMT7 | chr16 | 68389786 | + | NFATC3 | chr16 | 68260253 | + |
| 5CDS-intron | ENST00000449359 | ENST00000349223 | PRMT7 | chr16 | 68389786 | + | NFATC3 | chr16 | 68260253 | + |
| 5CDS-3UTR | ENST00000449359 | ENST00000329524 | PRMT7 | chr16 | 68389786 | + | NFATC3 | chr16 | 68260253 | + |
| 5CDS-3UTR | ENST00000449359 | ENST00000346183 | PRMT7 | chr16 | 68389786 | + | NFATC3 | chr16 | 68260253 | + |
| 5CDS-3UTR | ENST00000449359 | ENST00000535127 | PRMT7 | chr16 | 68389786 | + | NFATC3 | chr16 | 68260253 | + |
| intron-intron | ENST00000564441 | ENST00000575270 | PRMT7 | chr16 | 68389786 | + | NFATC3 | chr16 | 68260253 | + |
| intron-intron | ENST00000564441 | ENST00000349223 | PRMT7 | chr16 | 68389786 | + | NFATC3 | chr16 | 68260253 | + |
| intron-3UTR | ENST00000564441 | ENST00000329524 | PRMT7 | chr16 | 68389786 | + | NFATC3 | chr16 | 68260253 | + |
| intron-3UTR | ENST00000564441 | ENST00000346183 | PRMT7 | chr16 | 68389786 | + | NFATC3 | chr16 | 68260253 | + |
| intron-3UTR | ENST00000564441 | ENST00000535127 | PRMT7 | chr16 | 68389786 | + | NFATC3 | chr16 | 68260253 | + |
| 5CDS-intron | ENST00000441236 | ENST00000575270 | PRMT7 | chr16 | 68389786 | + | NFATC3 | chr16 | 68260253 | + |
| 5CDS-intron | ENST00000441236 | ENST00000349223 | PRMT7 | chr16 | 68389786 | + | NFATC3 | chr16 | 68260253 | + |
| 5CDS-3UTR | ENST00000441236 | ENST00000329524 | PRMT7 | chr16 | 68389786 | + | NFATC3 | chr16 | 68260253 | + |
| 5CDS-3UTR | ENST00000441236 | ENST00000346183 | PRMT7 | chr16 | 68389786 | + | NFATC3 | chr16 | 68260253 | + |
| 5CDS-3UTR | ENST00000441236 | ENST00000535127 | PRMT7 | chr16 | 68389786 | + | NFATC3 | chr16 | 68260253 | + |
| 5CDS-intron | ENST00000348497 | ENST00000575270 | PRMT7 | chr16 | 68389786 | + | NFATC3 | chr16 | 68260253 | + |
| 5CDS-intron | ENST00000348497 | ENST00000349223 | PRMT7 | chr16 | 68389786 | + | NFATC3 | chr16 | 68260253 | + |
| 5CDS-3UTR | ENST00000348497 | ENST00000329524 | PRMT7 | chr16 | 68389786 | + | NFATC3 | chr16 | 68260253 | + |
| 5CDS-3UTR | ENST00000348497 | ENST00000346183 | PRMT7 | chr16 | 68389786 | + | NFATC3 | chr16 | 68260253 | + |
| 5CDS-3UTR | ENST00000348497 | ENST00000535127 | PRMT7 | chr16 | 68389786 | + | NFATC3 | chr16 | 68260253 | + |
| 5CDS-intron | ENST00000339507 | ENST00000575270 | PRMT7 | chr16 | 68389786 | + | NFATC3 | chr16 | 68260253 | + |
| 5CDS-intron | ENST00000339507 | ENST00000349223 | PRMT7 | chr16 | 68389786 | + | NFATC3 | chr16 | 68260253 | + |
| 5CDS-3UTR | ENST00000339507 | ENST00000329524 | PRMT7 | chr16 | 68389786 | + | NFATC3 | chr16 | 68260253 | + |
| 5CDS-3UTR | ENST00000339507 | ENST00000346183 | PRMT7 | chr16 | 68389786 | + | NFATC3 | chr16 | 68260253 | + |
| 5CDS-3UTR | ENST00000339507 | ENST00000535127 | PRMT7 | chr16 | 68389786 | + | NFATC3 | chr16 | 68260253 | + |
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FusionProtFeatures for PRMT7_NFATC3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PRMT7 | NFATC3 |
| Arginine methyltransferase that can both catalyze theformation of omega-N monomethylarginine (MMA) and symmetricaldimethylarginine (sDMA), with a preference for the formation ofMMA. Specifically mediates the symmetrical dimethylation ofarginine residues in the small nuclear ribonucleoproteins Sm D1(SNRPD1) and Sm D3 (SNRPD3); such methylation being required forthe assembly and biogenesis of snRNP core particles. Specificallymediates the symmetric dimethylation of histone H4 'Arg-3' to formH4R3me2s. Plays a role in gene imprinting by being recruited byCTCFL at the H19 imprinted control region (ICR) and methylatinghistone H4 to form H4R3me2s, possibly leading to recruit DNAmethyltransferases at these sites. May also play a role inembryonic stem cell (ESC) pluripotency. Also able to mediate thearginine methylation of histone H2A and myelin basic protein (MBP)in vitro; the relevance of such results is however unclear invivo. {ECO:0000269|PubMed:15044439, ECO:0000269|PubMed:15494416,ECO:0000269|PubMed:17709427, ECO:0000269|PubMed:19110445}. | Acts as a regulator of transcriptional activation. Playsa role in the inducible expression of cytokine genes in T-cells,especially in the induction of the IL-2.{ECO:0000269|PubMed:18815128}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PRMT7_NFATC3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PRMT7_NFATC3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PRMT7 | PRDM1, PIK3CG, CTCFL, HIST2H2AC, HIST1H4A, DIO3, SNRPB, HIST1H3A, POT1, H3F3C, MNDA, ZBTB24, THAP8, EIF2S2, DNAJC13, SSR3, REPS2, GANAB, ICE1, FAM19A3, TRMT2A, INHBE, KIAA1683 | NFATC3 | NCOA3, MAPK8, MAPK9, CDK6, ENO1, SHMT2, MOV10, NXF1, CSNK1A1, SUFU, CEP128, ZMIZ1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PRMT7_NFATC3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PRMT7_NFATC3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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