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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28818

FusionGeneSummary for PRMT2_DIP2A

check button Fusion gene summary
Fusion gene informationFusion gene name: PRMT2_DIP2A
Fusion gene ID: 28818
HgeneTgene
Gene symbol

PRMT2

DIP2A

Gene ID

3275

23181

Gene nameprotein arginine methyltransferase 2disco interacting protein 2 homolog A
SynonymsHRMT1L1C21orf106|DIP2
Cytomap

21q22.3

21q22.3

Type of geneprotein-codingprotein-coding
Descriptionprotein arginine N-methyltransferase 2HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 1HMT1 hnRNP methyltransferase-like 1PRMT2 alphaPRMT2 betaPRMT2 gammahistone-arginine N-methyltransferase PRMT2disco-interacting protein 2 homolog ADIP2 disco-interacting protein 2 homolog ADIP2 homolog Adisco-interacting protein 2A
Modification date2018052320180523
UniProtAcc

P55345

Q14689

Ensembl transtripts involved in fusion geneENST00000355680, ENST00000397638, 
ENST00000291705, ENST00000458387, 
ENST00000451211, ENST00000397637, 
ENST00000334494, ENST00000397628, 
ENST00000440086, ENST00000491389, 
ENST00000400274, ENST00000427143, 
ENST00000318711, ENST00000417564, 
ENST00000457905, ENST00000466639, 
ENST00000435722, ENST00000479654, 
Fusion gene scores* DoF score6 X 6 X 4=1445 X 5 X 3=75
# samples 65
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PRMT2 [Title/Abstract] AND DIP2A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRMT2

GO:0016571

histone methylation

19405910

HgenePRMT2

GO:0032088

negative regulation of NF-kappaB transcription factor activity

16648481

HgenePRMT2

GO:0045892

negative regulation of transcription, DNA-templated

16648481

HgenePRMT2

GO:0045893

positive regulation of transcription, DNA-templated

12039952

HgenePRMT2

GO:0060765

regulation of androgen receptor signaling pathway

17587566

TgeneDIP2A

GO:0010629

negative regulation of gene expression

20860622


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AR-A0U4-01APRMT2chr21

48064400

+DIP2Achr21

47985626

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000355680ENST00000400274PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000355680ENST00000427143PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000355680ENST00000318711PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000355680ENST00000417564PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000355680ENST00000457905PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000355680ENST00000466639PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000355680ENST00000435722PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-3UTRENST00000355680ENST00000479654PRMT2chr21

48064400

+DIP2Achr21

47985626

+
In-frameENST00000397638ENST00000400274PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000397638ENST00000427143PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000397638ENST00000318711PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000397638ENST00000417564PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000397638ENST00000457905PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000397638ENST00000466639PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000397638ENST00000435722PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-3UTRENST00000397638ENST00000479654PRMT2chr21

48064400

+DIP2Achr21

47985626

+
In-frameENST00000291705ENST00000400274PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000291705ENST00000427143PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000291705ENST00000318711PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000291705ENST00000417564PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000291705ENST00000457905PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000291705ENST00000466639PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000291705ENST00000435722PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-3UTRENST00000291705ENST00000479654PRMT2chr21

48064400

+DIP2Achr21

47985626

+
In-frameENST00000458387ENST00000400274PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000458387ENST00000427143PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000458387ENST00000318711PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000458387ENST00000417564PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000458387ENST00000457905PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000458387ENST00000466639PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000458387ENST00000435722PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-3UTRENST00000458387ENST00000479654PRMT2chr21

48064400

+DIP2Achr21

47985626

+
In-frameENST00000451211ENST00000400274PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000451211ENST00000427143PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000451211ENST00000318711PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000451211ENST00000417564PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000451211ENST00000457905PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000451211ENST00000466639PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000451211ENST00000435722PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-3UTRENST00000451211ENST00000479654PRMT2chr21

48064400

+DIP2Achr21

47985626

+
In-frameENST00000397637ENST00000400274PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000397637ENST00000427143PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000397637ENST00000318711PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000397637ENST00000417564PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000397637ENST00000457905PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000397637ENST00000466639PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000397637ENST00000435722PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-3UTRENST00000397637ENST00000479654PRMT2chr21

48064400

+DIP2Achr21

47985626

+
In-frameENST00000334494ENST00000400274PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000334494ENST00000427143PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000334494ENST00000318711PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000334494ENST00000417564PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000334494ENST00000457905PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000334494ENST00000466639PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000334494ENST00000435722PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-3UTRENST00000334494ENST00000479654PRMT2chr21

48064400

+DIP2Achr21

47985626

+
In-frameENST00000397628ENST00000400274PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000397628ENST00000427143PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000397628ENST00000318711PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000397628ENST00000417564PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000397628ENST00000457905PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000397628ENST00000466639PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000397628ENST00000435722PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-3UTRENST00000397628ENST00000479654PRMT2chr21

48064400

+DIP2Achr21

47985626

+
In-frameENST00000440086ENST00000400274PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000440086ENST00000427143PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000440086ENST00000318711PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000440086ENST00000417564PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000440086ENST00000457905PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000440086ENST00000466639PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-intronENST00000440086ENST00000435722PRMT2chr21

48064400

+DIP2Achr21

47985626

+
5CDS-3UTRENST00000440086ENST00000479654PRMT2chr21

48064400

+DIP2Achr21

47985626

+
intron-3CDSENST00000491389ENST00000400274PRMT2chr21

48064400

+DIP2Achr21

47985626

+
intron-intronENST00000491389ENST00000427143PRMT2chr21

48064400

+DIP2Achr21

47985626

+
intron-intronENST00000491389ENST00000318711PRMT2chr21

48064400

+DIP2Achr21

47985626

+
intron-intronENST00000491389ENST00000417564PRMT2chr21

48064400

+DIP2Achr21

47985626

+
intron-intronENST00000491389ENST00000457905PRMT2chr21

48064400

+DIP2Achr21

47985626

+
intron-intronENST00000491389ENST00000466639PRMT2chr21

48064400

+DIP2Achr21

47985626

+
intron-intronENST00000491389ENST00000435722PRMT2chr21

48064400

+DIP2Achr21

47985626

+
intron-3UTRENST00000491389ENST00000479654PRMT2chr21

48064400

+DIP2Achr21

47985626

+

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FusionProtFeatures for PRMT2_DIP2A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRMT2

P55345

DIP2A

Q14689

May provide positional cues for axon pathfinding andpatterning in the central nervous system.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRMT2chr21:48064400chr21:47985626ENST00000334494+4730_89109285DomainSH3
HgenePRMT2chr21:48064400chr21:47985626ENST00000355680+51230_89109434DomainSH3
HgenePRMT2chr21:48064400chr21:47985626ENST00000397637+41130_89109434DomainSH3
HgenePRMT2chr21:48064400chr21:47985626ENST00000397638+41130_89109434DomainSH3
HgenePRMT2chr21:48064400chr21:47985626ENST00000440086+4930_89109332DomainSH3
TgeneDIP2Achr21:48064400chr21:47985626ENST00000400274+34381498_150113841568Compositional biasNote=Poly-Val
TgeneDIP2Achr21:48064400chr21:47985626ENST00000417564+34381498_150113881572Compositional biasNote=Poly-Val
TgeneDIP2Achr21:48064400chr21:47985626ENST00000427143+0281114_1117-641111Compositional biasNote=Poly-Ala
TgeneDIP2Achr21:48064400chr21:47985626ENST00000427143+0281498_1501-641111Compositional biasNote=Poly-Val
TgeneDIP2Achr21:48064400chr21:47985626ENST00000435722+0211114_1117-25842Compositional biasNote=Poly-Ala
TgeneDIP2Achr21:48064400chr21:47985626ENST00000435722+0211498_1501-25842Compositional biasNote=Poly-Val
TgeneDIP2Achr21:48064400chr21:47985626ENST00000457905+0221114_1117-61890Compositional biasNote=Poly-Ala
TgeneDIP2Achr21:48064400chr21:47985626ENST00000457905+0221498_1501-61890Compositional biasNote=Poly-Val
TgeneDIP2Achr21:48064400chr21:47985626ENST00000466639+0201114_1117-52799Compositional biasNote=Poly-Ala
TgeneDIP2Achr21:48064400chr21:47985626ENST00000466639+0201498_1501-52799Compositional biasNote=Poly-Val

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRMT2chr21:48064400chr21:47985626ENST00000334494+4799_432109285DomainSAM-dependent MTase PRMT-type
HgenePRMT2chr21:48064400chr21:47985626ENST00000355680+51299_432109434DomainSAM-dependent MTase PRMT-type
HgenePRMT2chr21:48064400chr21:47985626ENST00000397637+41199_432109434DomainSAM-dependent MTase PRMT-type
HgenePRMT2chr21:48064400chr21:47985626ENST00000397638+41199_432109434DomainSAM-dependent MTase PRMT-type
HgenePRMT2chr21:48064400chr21:47985626ENST00000440086+4999_432109332DomainSAM-dependent MTase PRMT-type
TgeneDIP2Achr21:48064400chr21:47985626ENST00000400274+34381114_111713841568Compositional biasNote=Poly-Ala
TgeneDIP2Achr21:48064400chr21:47985626ENST00000417564+34381114_111713881572Compositional biasNote=Poly-Ala


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FusionGeneSequence for PRMT2_DIP2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PRMT2_DIP2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PRMT2PRRC2A, DMRTB1, CPSF7, HNRNPUL1, ESR1, HNRNPA1, RB1, E2F1, PSMB3, BAG6, FIP1L1, RIPK2, SPAG8, PSRC1, UBB, SALL2, GET4, SHANK3, HTT, TAB1, KANK2, LRFN1, PLEKHH3, POM121, SF1, L3MBTL3, TIGD5, KSR1, KRBA1, RBPMS, PPM1E, ANTXR1, TRAPPC2, SETD1B, SETD1A, PIK3R1, FHOD1, CXXC1, ERF, TTC28, SETD5, SAMD1, VCPIP1, C15orf39, MAP3K7, FASLG, CHEK2, UBR5, PIK3R2DIP2AMRGBP, JMJD6, AES, PTPN3, TRIP13, TMCC2, SORBS3, PSME3, ZBTB43, MBIP, ADAMTSL4, GPATCH2L, TRIM39, CCDC33, FAM214B, CEP44, STAC3, NXF1, SPINT2, EFNB2, TEX264, TGFBR2, BTN2A1, DLK1, LPCAT1, PTGER3, THBS3, C1orf186, EGFR, HAVCR2, MANSC1, SELE, TPCN2, SSSCA1, IL20RA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePRMT2chr21:48064400chr21:47985626ENST00000334494+47133_275109285ESR1
HgenePRMT2chr21:48064400chr21:47985626ENST00000334494+471_277109285ESR1
HgenePRMT2chr21:48064400chr21:47985626ENST00000355680+512133_275109434ESR1
HgenePRMT2chr21:48064400chr21:47985626ENST00000355680+5121_277109434ESR1
HgenePRMT2chr21:48064400chr21:47985626ENST00000397637+411133_275109434ESR1
HgenePRMT2chr21:48064400chr21:47985626ENST00000397637+4111_277109434ESR1
HgenePRMT2chr21:48064400chr21:47985626ENST00000397638+411133_275109434ESR1
HgenePRMT2chr21:48064400chr21:47985626ENST00000397638+4111_277109434ESR1
HgenePRMT2chr21:48064400chr21:47985626ENST00000440086+49133_275109332ESR1
HgenePRMT2chr21:48064400chr21:47985626ENST00000440086+491_277109332ESR1
HgenePRMT2chr21:48064400chr21:47985626ENST00000334494+4783_207109285RB1
HgenePRMT2chr21:48064400chr21:47985626ENST00000355680+51283_207109434RB1
HgenePRMT2chr21:48064400chr21:47985626ENST00000397637+41183_207109434RB1
HgenePRMT2chr21:48064400chr21:47985626ENST00000397638+41183_207109434RB1
HgenePRMT2chr21:48064400chr21:47985626ENST00000440086+4983_207109332RB1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PRMT2_DIP2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PRMT2_DIP2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource