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Fusion gene ID: 28816 |
FusionGeneSummary for PRMT1_PTOV1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PRMT1_PTOV1 | Fusion gene ID: 28816 | Hgene | Tgene | Gene symbol | PRMT1 | PTOV1 | Gene ID | 3276 | 53635 |
| Gene name | protein arginine methyltransferase 1 | prostate tumor overexpressed 1 | |
| Synonyms | ANM1|HCP1|HRMT1L2|IR1B4 | ACID2|PTOV-1 | |
| Cytomap | 19q13.33 | 19q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein arginine N-methyltransferase 1HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2histone-arginine N-methyltransferase PRMT1interferon receptor 1-bound protein 4 | prostate tumor-overexpressed gene 1 proteinactivator interaction domain-containing protein 2 | |
| Modification date | 20180523 | 20180524 | |
| UniProtAcc | Q99873 | Q86YD1 | |
| Ensembl transtripts involved in fusion gene | ENST00000532489, ENST00000391851, ENST00000454376, ENST00000527866, | ENST00000600603, ENST00000601638, ENST00000221557, ENST00000598325, ENST00000391842, ENST00000599732, ENST00000601675, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 7 X 6 X 5=210 |
| # samples | 3 | 7 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PRMT1 [Title/Abstract] AND PTOV1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PRMT1 | GO:0016571 | histone methylation | 19405910 |
| Hgene | PRMT1 | GO:0018216 | peptidyl-arginine methylation | 18657504|19460357 |
| Hgene | PRMT1 | GO:0043985 | histone H4-R3 methylation | 11448779 |
| Hgene | PRMT1 | GO:0045653 | negative regulation of megakaryocyte differentiation | 20442406 |
| Hgene | PRMT1 | GO:0051260 | protein homooligomerization | 26876602 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-23-1120-01A | PRMT1 | chr19 | 50183845 | + | PTOV1 | chr19 | 50361806 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000532489 | ENST00000600603 | PRMT1 | chr19 | 50183845 | + | PTOV1 | chr19 | 50361806 | + |
| In-frame | ENST00000532489 | ENST00000601638 | PRMT1 | chr19 | 50183845 | + | PTOV1 | chr19 | 50361806 | + |
| In-frame | ENST00000532489 | ENST00000221557 | PRMT1 | chr19 | 50183845 | + | PTOV1 | chr19 | 50361806 | + |
| 5CDS-3UTR | ENST00000532489 | ENST00000598325 | PRMT1 | chr19 | 50183845 | + | PTOV1 | chr19 | 50361806 | + |
| 5CDS-3UTR | ENST00000532489 | ENST00000391842 | PRMT1 | chr19 | 50183845 | + | PTOV1 | chr19 | 50361806 | + |
| 5CDS-3UTR | ENST00000532489 | ENST00000599732 | PRMT1 | chr19 | 50183845 | + | PTOV1 | chr19 | 50361806 | + |
| 5CDS-3UTR | ENST00000532489 | ENST00000601675 | PRMT1 | chr19 | 50183845 | + | PTOV1 | chr19 | 50361806 | + |
| In-frame | ENST00000391851 | ENST00000600603 | PRMT1 | chr19 | 50183845 | + | PTOV1 | chr19 | 50361806 | + |
| In-frame | ENST00000391851 | ENST00000601638 | PRMT1 | chr19 | 50183845 | + | PTOV1 | chr19 | 50361806 | + |
| In-frame | ENST00000391851 | ENST00000221557 | PRMT1 | chr19 | 50183845 | + | PTOV1 | chr19 | 50361806 | + |
| 5CDS-3UTR | ENST00000391851 | ENST00000598325 | PRMT1 | chr19 | 50183845 | + | PTOV1 | chr19 | 50361806 | + |
| 5CDS-3UTR | ENST00000391851 | ENST00000391842 | PRMT1 | chr19 | 50183845 | + | PTOV1 | chr19 | 50361806 | + |
| 5CDS-3UTR | ENST00000391851 | ENST00000599732 | PRMT1 | chr19 | 50183845 | + | PTOV1 | chr19 | 50361806 | + |
| 5CDS-3UTR | ENST00000391851 | ENST00000601675 | PRMT1 | chr19 | 50183845 | + | PTOV1 | chr19 | 50361806 | + |
| In-frame | ENST00000454376 | ENST00000600603 | PRMT1 | chr19 | 50183845 | + | PTOV1 | chr19 | 50361806 | + |
| In-frame | ENST00000454376 | ENST00000601638 | PRMT1 | chr19 | 50183845 | + | PTOV1 | chr19 | 50361806 | + |
| In-frame | ENST00000454376 | ENST00000221557 | PRMT1 | chr19 | 50183845 | + | PTOV1 | chr19 | 50361806 | + |
| 5CDS-3UTR | ENST00000454376 | ENST00000598325 | PRMT1 | chr19 | 50183845 | + | PTOV1 | chr19 | 50361806 | + |
| 5CDS-3UTR | ENST00000454376 | ENST00000391842 | PRMT1 | chr19 | 50183845 | + | PTOV1 | chr19 | 50361806 | + |
| 5CDS-3UTR | ENST00000454376 | ENST00000599732 | PRMT1 | chr19 | 50183845 | + | PTOV1 | chr19 | 50361806 | + |
| 5CDS-3UTR | ENST00000454376 | ENST00000601675 | PRMT1 | chr19 | 50183845 | + | PTOV1 | chr19 | 50361806 | + |
| intron-3CDS | ENST00000527866 | ENST00000600603 | PRMT1 | chr19 | 50183845 | + | PTOV1 | chr19 | 50361806 | + |
| intron-3CDS | ENST00000527866 | ENST00000601638 | PRMT1 | chr19 | 50183845 | + | PTOV1 | chr19 | 50361806 | + |
| intron-3CDS | ENST00000527866 | ENST00000221557 | PRMT1 | chr19 | 50183845 | + | PTOV1 | chr19 | 50361806 | + |
| intron-3UTR | ENST00000527866 | ENST00000598325 | PRMT1 | chr19 | 50183845 | + | PTOV1 | chr19 | 50361806 | + |
| intron-3UTR | ENST00000527866 | ENST00000391842 | PRMT1 | chr19 | 50183845 | + | PTOV1 | chr19 | 50361806 | + |
| intron-3UTR | ENST00000527866 | ENST00000599732 | PRMT1 | chr19 | 50183845 | + | PTOV1 | chr19 | 50361806 | + |
| intron-3UTR | ENST00000527866 | ENST00000601675 | PRMT1 | chr19 | 50183845 | + | PTOV1 | chr19 | 50361806 | + |
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FusionProtFeatures for PRMT1_PTOV1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PRMT1 | PTOV1 |
| May activate transcription. Required for nucleartranslocation of FLOT1. Promotes cell proliferation.{ECO:0000269|PubMed:12598323, ECO:0000269|PubMed:15713644,ECO:0000269|PubMed:17641689}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PRMT1 | chr19:50183845 | chr19:50361806 | ENST00000391851 | + | 2 | 10 | 50_361 | 46 | 354 | Domain | SAM-dependent MTase PRMT-type |
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FusionGeneSequence for PRMT1_PTOV1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PRMT1_ENST00000532489_chr19_50183845_+_PTOV1_ENST00000600603_chr19_50361806_+_113aa MTSKDYYFDSYAHFGIHETTLVPLFRNSRLVQFHFTKDLETLKSLCRIMDNGFRRKSSLASSPMTRATLSTASGVSLPTSSRSCSGTWSR >In-frame_PRMT1_ENST00000532489_chr19_50183845_+_PTOV1_ENST00000601638_chr19_50361806_+_123aa MTSKDYYFDSYAHFGIHETTLVPLFRNSRLVQFHFTKDLETLKSLCRIMDNGFAGCVHFSYKASCEIRVLMLLYSSEKKIFIGLIPHDQG >In-frame_PRMT1_ENST00000532489_chr19_50183845_+_PTOV1_ENST00000221557_chr19_50361806_+_113aa MTSKDYYFDSYAHFGIHETTLVPLFRNSRLVQFHFTKDLETLKSLCRIMDNGFRRKSSLASSPMTRATLSTASGVSLPTSSRSCSGTWSR >In-frame_PRMT1_ENST00000391851_chr19_50183845_+_PTOV1_ENST00000600603_chr19_50361806_+_141aa MAAAEAANCIMEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHETTLVPLFRNSRLVQFHFTKDLETLKSLCRIMDNGFRRKSSLASS >In-frame_PRMT1_ENST00000391851_chr19_50183845_+_PTOV1_ENST00000601638_chr19_50361806_+_151aa MAAAEAANCIMEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHETTLVPLFRNSRLVQFHFTKDLETLKSLCRIMDNGFAGCVHFSYK >In-frame_PRMT1_ENST00000391851_chr19_50183845_+_PTOV1_ENST00000221557_chr19_50361806_+_141aa MAAAEAANCIMEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHETTLVPLFRNSRLVQFHFTKDLETLKSLCRIMDNGFRRKSSLASS >In-frame_PRMT1_ENST00000454376_chr19_50183845_+_PTOV1_ENST00000600603_chr19_50361806_+_159aa MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHETTLVPLFRNSRLVQFHFTKDLETLKS >In-frame_PRMT1_ENST00000454376_chr19_50183845_+_PTOV1_ENST00000601638_chr19_50361806_+_169aa MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHETTLVPLFRNSRLVQFHFTKDLETLKS >In-frame_PRMT1_ENST00000454376_chr19_50183845_+_PTOV1_ENST00000221557_chr19_50361806_+_159aa MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHETTLVPLFRNSRLVQFHFTKDLETLKS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PRMT1_ENST00000532489_chr19_50183845_+_PTOV1_ENST00000600603_chr19_50361806_+_339nt ATGACATCCAAAGATTACTACTTTGACTCCTACGCACACTTTGGCATCCACGAGACCACCCTAGTGCCGCTGTTCCGGAACTCGCGCCTG GTCCAGTTCCACTTCACCAAGGACCTGGAGACACTGAAGAGCCTGTGCCGGATCATGGACAATGGCTTCAGAAGAAAATCTTCATTGGCC TCATCCCCCATGACCAGGGCAACTTTGTCAACGGCATCCGGCGTGTCATTGCCAACCAGCAGCAGGTCCTGCAGCGGAACCTGGAGCAGG >In-frame_PRMT1_ENST00000532489_chr19_50183845_+_PTOV1_ENST00000601638_chr19_50361806_+_369nt ATGACATCCAAAGATTACTACTTTGACTCCTACGCACACTTTGGCATCCACGAGACCACCCTAGTGCCGCTGTTCCGGAACTCGCGCCTG GTCCAGTTCCACTTCACCAAGGACCTGGAGACACTGAAGAGCCTGTGCCGGATCATGGACAATGGCTTCGCCGGCTGCGTGCACTTTTCC TACAAAGCATCGTGTGAGATCCGCGTGCTTATGCTCCTGTACTCTTCAGAGAAGAAAATCTTCATTGGCCTCATCCCCCATGACCAGGGC AACTTTGTCAACGGCATCCGGCGTGTCATTGCCAACCAGCAGCAGGTCCTGCAGCGGAACCTGGAGCAGGAGCAACAGCAACGAGGGATG >In-frame_PRMT1_ENST00000532489_chr19_50183845_+_PTOV1_ENST00000221557_chr19_50361806_+_339nt ATGACATCCAAAGATTACTACTTTGACTCCTACGCACACTTTGGCATCCACGAGACCACCCTAGTGCCGCTGTTCCGGAACTCGCGCCTG GTCCAGTTCCACTTCACCAAGGACCTGGAGACACTGAAGAGCCTGTGCCGGATCATGGACAATGGCTTCAGAAGAAAATCTTCATTGGCC TCATCCCCCATGACCAGGGCAACTTTGTCAACGGCATCCGGCGTGTCATTGCCAACCAGCAGCAGGTCCTGCAGCGGAACCTGGAGCAGG >In-frame_PRMT1_ENST00000391851_chr19_50183845_+_PTOV1_ENST00000600603_chr19_50361806_+_423nt ATGGCGGCAGCCGAGGCCGCGAACTGCATCATGGAGGTGTCCTGTGGCCAGGCGGAAAGCAGTGAGAAGCCCAACGCTGAGGACATGACA TCCAAAGATTACTACTTTGACTCCTACGCACACTTTGGCATCCACGAGACCACCCTAGTGCCGCTGTTCCGGAACTCGCGCCTGGTCCAG TTCCACTTCACCAAGGACCTGGAGACACTGAAGAGCCTGTGCCGGATCATGGACAATGGCTTCAGAAGAAAATCTTCATTGGCCTCATCC CCCATGACCAGGGCAACTTTGTCAACGGCATCCGGCGTGTCATTGCCAACCAGCAGCAGGTCCTGCAGCGGAACCTGGAGCAGGAGCAAC >In-frame_PRMT1_ENST00000391851_chr19_50183845_+_PTOV1_ENST00000601638_chr19_50361806_+_453nt ATGGCGGCAGCCGAGGCCGCGAACTGCATCATGGAGGTGTCCTGTGGCCAGGCGGAAAGCAGTGAGAAGCCCAACGCTGAGGACATGACA TCCAAAGATTACTACTTTGACTCCTACGCACACTTTGGCATCCACGAGACCACCCTAGTGCCGCTGTTCCGGAACTCGCGCCTGGTCCAG TTCCACTTCACCAAGGACCTGGAGACACTGAAGAGCCTGTGCCGGATCATGGACAATGGCTTCGCCGGCTGCGTGCACTTTTCCTACAAA GCATCGTGTGAGATCCGCGTGCTTATGCTCCTGTACTCTTCAGAGAAGAAAATCTTCATTGGCCTCATCCCCCATGACCAGGGCAACTTT GTCAACGGCATCCGGCGTGTCATTGCCAACCAGCAGCAGGTCCTGCAGCGGAACCTGGAGCAGGAGCAACAGCAACGAGGGATGGGGGGG >In-frame_PRMT1_ENST00000391851_chr19_50183845_+_PTOV1_ENST00000221557_chr19_50361806_+_423nt ATGGCGGCAGCCGAGGCCGCGAACTGCATCATGGAGGTGTCCTGTGGCCAGGCGGAAAGCAGTGAGAAGCCCAACGCTGAGGACATGACA TCCAAAGATTACTACTTTGACTCCTACGCACACTTTGGCATCCACGAGACCACCCTAGTGCCGCTGTTCCGGAACTCGCGCCTGGTCCAG TTCCACTTCACCAAGGACCTGGAGACACTGAAGAGCCTGTGCCGGATCATGGACAATGGCTTCAGAAGAAAATCTTCATTGGCCTCATCC CCCATGACCAGGGCAACTTTGTCAACGGCATCCGGCGTGTCATTGCCAACCAGCAGCAGGTCCTGCAGCGGAACCTGGAGCAGGAGCAAC >In-frame_PRMT1_ENST00000454376_chr19_50183845_+_PTOV1_ENST00000600603_chr19_50361806_+_477nt ATGGCGGCAGCCGAGGCCGCGAACTGCATCATGGAGAATTTTGTAGCCACCTTGGCTAATGGGATGAGCCTCCAGCCGCCTCTTGAAGAA GTGTCCTGTGGCCAGGCGGAAAGCAGTGAGAAGCCCAACGCTGAGGACATGACATCCAAAGATTACTACTTTGACTCCTACGCACACTTT GGCATCCACGAGACCACCCTAGTGCCGCTGTTCCGGAACTCGCGCCTGGTCCAGTTCCACTTCACCAAGGACCTGGAGACACTGAAGAGC CTGTGCCGGATCATGGACAATGGCTTCAGAAGAAAATCTTCATTGGCCTCATCCCCCATGACCAGGGCAACTTTGTCAACGGCATCCGGC GTGTCATTGCCAACCAGCAGCAGGTCCTGCAGCGGAACCTGGAGCAGGAGCAACAGCAACGAGGGATGGGGGGGTAGTGGTTACCCCGGG >In-frame_PRMT1_ENST00000454376_chr19_50183845_+_PTOV1_ENST00000601638_chr19_50361806_+_507nt ATGGCGGCAGCCGAGGCCGCGAACTGCATCATGGAGAATTTTGTAGCCACCTTGGCTAATGGGATGAGCCTCCAGCCGCCTCTTGAAGAA GTGTCCTGTGGCCAGGCGGAAAGCAGTGAGAAGCCCAACGCTGAGGACATGACATCCAAAGATTACTACTTTGACTCCTACGCACACTTT GGCATCCACGAGACCACCCTAGTGCCGCTGTTCCGGAACTCGCGCCTGGTCCAGTTCCACTTCACCAAGGACCTGGAGACACTGAAGAGC CTGTGCCGGATCATGGACAATGGCTTCGCCGGCTGCGTGCACTTTTCCTACAAAGCATCGTGTGAGATCCGCGTGCTTATGCTCCTGTAC TCTTCAGAGAAGAAAATCTTCATTGGCCTCATCCCCCATGACCAGGGCAACTTTGTCAACGGCATCCGGCGTGTCATTGCCAACCAGCAG >In-frame_PRMT1_ENST00000454376_chr19_50183845_+_PTOV1_ENST00000221557_chr19_50361806_+_477nt ATGGCGGCAGCCGAGGCCGCGAACTGCATCATGGAGAATTTTGTAGCCACCTTGGCTAATGGGATGAGCCTCCAGCCGCCTCTTGAAGAA GTGTCCTGTGGCCAGGCGGAAAGCAGTGAGAAGCCCAACGCTGAGGACATGACATCCAAAGATTACTACTTTGACTCCTACGCACACTTT GGCATCCACGAGACCACCCTAGTGCCGCTGTTCCGGAACTCGCGCCTGGTCCAGTTCCACTTCACCAAGGACCTGGAGACACTGAAGAGC CTGTGCCGGATCATGGACAATGGCTTCAGAAGAAAATCTTCATTGGCCTCATCCCCCATGACCAGGGCAACTTTGTCAACGGCATCCGGC GTGTCATTGCCAACCAGCAGCAGGTCCTGCAGCGGAACCTGGAGCAGGAGCAACAGCAACGAGGGATGGGGGGGTAGTGGTTACCCCGGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PRMT1_ENST00000532489_chr19_50183845_+_PTOV1_ENST00000600603_chr19_50361806_+_1036nt GGGTTTCACCATGTTAGCCAGGATGGTCTCGACCTCCTGACCTTGTGATCCGCCCGCCTCGGTCTCCCAAAATGCTGGGATTACAGGCGT GAGCCACCGCGCCCGGCCGCCTGGCGTAATTTTTGTATTTTTAATAGAAATGGGGGTTTCACCATGTTGCCCAGACTGGTCTCGAACTCC TGATGTCAAGTGATCCGCCTGCCTCCGCCTCCTAAAGTGCTGGAATTACACCCGTGAGCCATCGCGCCCGAACCCTATTGTAAATTTTAA GTCTCAGGCGTTTGCCAGCGGCACGCCAGAGAGTATAGCCTGCGCGGAGGCCCAGAAACCAAAGAGCGAGCTCATTCCGGGATTGGAGAG AAGTGAACTTTTTCTGCAAATCAAGGAAAGCTTCCCGGAGGAAGTGGTGCCTAAGCTGTGCTCTGATTCACGTTTAGAAGCTGACCAGAC AAAGAGAGGTGTCCTGTGGCCAGGCGGAAAGCAGTGAGAAGCCCAACGCTGAGGACATGACATCCAAAGATTACTACTTTGACTCCTACG CACACTTTGGCATCCACGAGACCACCCTAGTGCCGCTGTTCCGGAACTCGCGCCTGGTCCAGTTCCACTTCACCAAGGACCTGGAGACAC TGAAGAGCCTGTGCCGGATCATGGACAATGGCTTCAGAAGAAAATCTTCATTGGCCTCATCCCCCATGACCAGGGCAACTTTGTCAACGG CATCCGGCGTGTCATTGCCAACCAGCAGCAGGTCCTGCAGCGGAACCTGGAGCAGGAGCAACAGCAACGAGGGATGGGGGGGTAGTGGTT ACCCCGGGCTGGGCCCCTCCAGGAGTCACAGATGAGGCCCCCGCAGAGACTGTGCTTGGGAGCCTGTGGCCAGCAGCCCCCACTGCACCC CTGCCCCCAGGTGACACGCTTCTGAGCAGGGGCCCCTGGGGACTTCAACTGCCCAGCAACATGGAGGATGGTGTCCTGAGGCCTCCAAGG >In-frame_PRMT1_ENST00000532489_chr19_50183845_+_PTOV1_ENST00000601638_chr19_50361806_+_1080nt GGGTTTCACCATGTTAGCCAGGATGGTCTCGACCTCCTGACCTTGTGATCCGCCCGCCTCGGTCTCCCAAAATGCTGGGATTACAGGCGT GAGCCACCGCGCCCGGCCGCCTGGCGTAATTTTTGTATTTTTAATAGAAATGGGGGTTTCACCATGTTGCCCAGACTGGTCTCGAACTCC TGATGTCAAGTGATCCGCCTGCCTCCGCCTCCTAAAGTGCTGGAATTACACCCGTGAGCCATCGCGCCCGAACCCTATTGTAAATTTTAA GTCTCAGGCGTTTGCCAGCGGCACGCCAGAGAGTATAGCCTGCGCGGAGGCCCAGAAACCAAAGAGCGAGCTCATTCCGGGATTGGAGAG AAGTGAACTTTTTCTGCAAATCAAGGAAAGCTTCCCGGAGGAAGTGGTGCCTAAGCTGTGCTCTGATTCACGTTTAGAAGCTGACCAGAC AAAGAGAGGTGTCCTGTGGCCAGGCGGAAAGCAGTGAGAAGCCCAACGCTGAGGACATGACATCCAAAGATTACTACTTTGACTCCTACG CACACTTTGGCATCCACGAGACCACCCTAGTGCCGCTGTTCCGGAACTCGCGCCTGGTCCAGTTCCACTTCACCAAGGACCTGGAGACAC TGAAGAGCCTGTGCCGGATCATGGACAATGGCTTCGCCGGCTGCGTGCACTTTTCCTACAAAGCATCGTGTGAGATCCGCGTGCTTATGC TCCTGTACTCTTCAGAGAAGAAAATCTTCATTGGCCTCATCCCCCATGACCAGGGCAACTTTGTCAACGGCATCCGGCGTGTCATTGCCA ACCAGCAGCAGGTCCTGCAGCGGAACCTGGAGCAGGAGCAACAGCAACGAGGGATGGGGGGGTAGTGGTTACCCCGGGCTGGGCCCCTCC AGGAGTCACAGATGAGGCCCCCGCAGAGACTGTGCTTGGGAGCCTGTGGCCAGCAGCCCCCACTGCACCCCTGCCCCCAGGTGACACGCT TCTGAGCAGGGGCCCCTGGGGACTTCAACTGCCCAGCAACATGGAGGATGGTGTCCTGAGGCCTCCAAGGACGGTCCCCACCCCTCTACG >In-frame_PRMT1_ENST00000532489_chr19_50183845_+_PTOV1_ENST00000221557_chr19_50361806_+_1259nt GGGTTTCACCATGTTAGCCAGGATGGTCTCGACCTCCTGACCTTGTGATCCGCCCGCCTCGGTCTCCCAAAATGCTGGGATTACAGGCGT GAGCCACCGCGCCCGGCCGCCTGGCGTAATTTTTGTATTTTTAATAGAAATGGGGGTTTCACCATGTTGCCCAGACTGGTCTCGAACTCC TGATGTCAAGTGATCCGCCTGCCTCCGCCTCCTAAAGTGCTGGAATTACACCCGTGAGCCATCGCGCCCGAACCCTATTGTAAATTTTAA GTCTCAGGCGTTTGCCAGCGGCACGCCAGAGAGTATAGCCTGCGCGGAGGCCCAGAAACCAAAGAGCGAGCTCATTCCGGGATTGGAGAG AAGTGAACTTTTTCTGCAAATCAAGGAAAGCTTCCCGGAGGAAGTGGTGCCTAAGCTGTGCTCTGATTCACGTTTAGAAGCTGACCAGAC AAAGAGAGGTGTCCTGTGGCCAGGCGGAAAGCAGTGAGAAGCCCAACGCTGAGGACATGACATCCAAAGATTACTACTTTGACTCCTACG CACACTTTGGCATCCACGAGACCACCCTAGTGCCGCTGTTCCGGAACTCGCGCCTGGTCCAGTTCCACTTCACCAAGGACCTGGAGACAC TGAAGAGCCTGTGCCGGATCATGGACAATGGCTTCAGAAGAAAATCTTCATTGGCCTCATCCCCCATGACCAGGGCAACTTTGTCAACGG CATCCGGCGTGTCATTGCCAACCAGCAGCAGGTCCTGCAGCGGAACCTGGAGCAGGAGCAACAGCAACGAGGGATGGGGGGGTAGTGGTT ACCCCGGGCTGGGCCCCTCCAGGAGTCACAGATGAGGCCCCCGCAGAGACTGGTGAGTGGTGACCCTGTCATGTACAGGAGGGACCCTGG GGCATGTGGGGGGGGTGGGGTTGGGAAAGAAGCAGGGCGACCTTGGCCTTGGGGAGAGCAGAGCAGAGGGAGAGGCAGCAGTCCCAGCGG TCCTAGGCTGTCGGGAAACTGCAGCCCAGCCTCAGGGCCATGGGAGGTGGTATCCAGGCCTGGGTGGGGCCAGGCCTCTGCTCACAGGGA TGTGGGGTCAGTGCTTGGGAGCCTGTGGCCAGCAGCCCCCACTGCACCCCTGCCCCCAGGTGACACGCTTCTGAGCAGGGGCCCCTGGGG >In-frame_PRMT1_ENST00000391851_chr19_50183845_+_PTOV1_ENST00000600603_chr19_50361806_+_743nt ATTGCCAATGAAATCTTCCAGCGGGGTCGCGGTAGGCGGGCCGTGGACCCTCTGGTATAAGGCGGTCCCGGGGGAGTGAGGAGAAAGGGG GGGTCTTGGCGGCCGGAGGAGGAGTAGGTGCGGGTGAAGATGGCGGCAGCCGAGGCCGCGAACTGCATCATGGAGGTGTCCTGTGGCCAG GCGGAAAGCAGTGAGAAGCCCAACGCTGAGGACATGACATCCAAAGATTACTACTTTGACTCCTACGCACACTTTGGCATCCACGAGACC ACCCTAGTGCCGCTGTTCCGGAACTCGCGCCTGGTCCAGTTCCACTTCACCAAGGACCTGGAGACACTGAAGAGCCTGTGCCGGATCATG GACAATGGCTTCAGAAGAAAATCTTCATTGGCCTCATCCCCCATGACCAGGGCAACTTTGTCAACGGCATCCGGCGTGTCATTGCCAACC AGCAGCAGGTCCTGCAGCGGAACCTGGAGCAGGAGCAACAGCAACGAGGGATGGGGGGGTAGTGGTTACCCCGGGCTGGGCCCCTCCAGG AGTCACAGATGAGGCCCCCGCAGAGACTGTGCTTGGGAGCCTGTGGCCAGCAGCCCCCACTGCACCCCTGCCCCCAGGTGACACGCTTCT GAGCAGGGGCCCCTGGGGACTTCAACTGCCCAGCAACATGGAGGATGGTGTCCTGAGGCCTCCAAGGACGGTCCCCACCCCTCTACGTTT >In-frame_PRMT1_ENST00000391851_chr19_50183845_+_PTOV1_ENST00000601638_chr19_50361806_+_787nt ATTGCCAATGAAATCTTCCAGCGGGGTCGCGGTAGGCGGGCCGTGGACCCTCTGGTATAAGGCGGTCCCGGGGGAGTGAGGAGAAAGGGG GGGTCTTGGCGGCCGGAGGAGGAGTAGGTGCGGGTGAAGATGGCGGCAGCCGAGGCCGCGAACTGCATCATGGAGGTGTCCTGTGGCCAG GCGGAAAGCAGTGAGAAGCCCAACGCTGAGGACATGACATCCAAAGATTACTACTTTGACTCCTACGCACACTTTGGCATCCACGAGACC ACCCTAGTGCCGCTGTTCCGGAACTCGCGCCTGGTCCAGTTCCACTTCACCAAGGACCTGGAGACACTGAAGAGCCTGTGCCGGATCATG GACAATGGCTTCGCCGGCTGCGTGCACTTTTCCTACAAAGCATCGTGTGAGATCCGCGTGCTTATGCTCCTGTACTCTTCAGAGAAGAAA ATCTTCATTGGCCTCATCCCCCATGACCAGGGCAACTTTGTCAACGGCATCCGGCGTGTCATTGCCAACCAGCAGCAGGTCCTGCAGCGG AACCTGGAGCAGGAGCAACAGCAACGAGGGATGGGGGGGTAGTGGTTACCCCGGGCTGGGCCCCTCCAGGAGTCACAGATGAGGCCCCCG CAGAGACTGTGCTTGGGAGCCTGTGGCCAGCAGCCCCCACTGCACCCCTGCCCCCAGGTGACACGCTTCTGAGCAGGGGCCCCTGGGGAC >In-frame_PRMT1_ENST00000391851_chr19_50183845_+_PTOV1_ENST00000221557_chr19_50361806_+_966nt ATTGCCAATGAAATCTTCCAGCGGGGTCGCGGTAGGCGGGCCGTGGACCCTCTGGTATAAGGCGGTCCCGGGGGAGTGAGGAGAAAGGGG GGGTCTTGGCGGCCGGAGGAGGAGTAGGTGCGGGTGAAGATGGCGGCAGCCGAGGCCGCGAACTGCATCATGGAGGTGTCCTGTGGCCAG GCGGAAAGCAGTGAGAAGCCCAACGCTGAGGACATGACATCCAAAGATTACTACTTTGACTCCTACGCACACTTTGGCATCCACGAGACC ACCCTAGTGCCGCTGTTCCGGAACTCGCGCCTGGTCCAGTTCCACTTCACCAAGGACCTGGAGACACTGAAGAGCCTGTGCCGGATCATG GACAATGGCTTCAGAAGAAAATCTTCATTGGCCTCATCCCCCATGACCAGGGCAACTTTGTCAACGGCATCCGGCGTGTCATTGCCAACC AGCAGCAGGTCCTGCAGCGGAACCTGGAGCAGGAGCAACAGCAACGAGGGATGGGGGGGTAGTGGTTACCCCGGGCTGGGCCCCTCCAGG AGTCACAGATGAGGCCCCCGCAGAGACTGGTGAGTGGTGACCCTGTCATGTACAGGAGGGACCCTGGGGCATGTGGGGGGGGTGGGGTTG GGAAAGAAGCAGGGCGACCTTGGCCTTGGGGAGAGCAGAGCAGAGGGAGAGGCAGCAGTCCCAGCGGTCCTAGGCTGTCGGGAAACTGCA GCCCAGCCTCAGGGCCATGGGAGGTGGTATCCAGGCCTGGGTGGGGCCAGGCCTCTGCTCACAGGGATGTGGGGTCAGTGCTTGGGAGCC TGTGGCCAGCAGCCCCCACTGCACCCCTGCCCCCAGGTGACACGCTTCTGAGCAGGGGCCCCTGGGGACTTCAACTGCCCAGCAACATGG >In-frame_PRMT1_ENST00000454376_chr19_50183845_+_PTOV1_ENST00000600603_chr19_50361806_+_677nt CGGGTGAAGATGGCGGCAGCCGAGGCCGCGAACTGCATCATGGAGAATTTTGTAGCCACCTTGGCTAATGGGATGAGCCTCCAGCCGCCT CTTGAAGAAGTGTCCTGTGGCCAGGCGGAAAGCAGTGAGAAGCCCAACGCTGAGGACATGACATCCAAAGATTACTACTTTGACTCCTAC GCACACTTTGGCATCCACGAGACCACCCTAGTGCCGCTGTTCCGGAACTCGCGCCTGGTCCAGTTCCACTTCACCAAGGACCTGGAGACA CTGAAGAGCCTGTGCCGGATCATGGACAATGGCTTCAGAAGAAAATCTTCATTGGCCTCATCCCCCATGACCAGGGCAACTTTGTCAACG GCATCCGGCGTGTCATTGCCAACCAGCAGCAGGTCCTGCAGCGGAACCTGGAGCAGGAGCAACAGCAACGAGGGATGGGGGGGTAGTGGT TACCCCGGGCTGGGCCCCTCCAGGAGTCACAGATGAGGCCCCCGCAGAGACTGTGCTTGGGAGCCTGTGGCCAGCAGCCCCCACTGCACC CCTGCCCCCAGGTGACACGCTTCTGAGCAGGGGCCCCTGGGGACTTCAACTGCCCAGCAACATGGAGGATGGTGTCCTGAGGCCTCCAAG >In-frame_PRMT1_ENST00000454376_chr19_50183845_+_PTOV1_ENST00000601638_chr19_50361806_+_721nt CGGGTGAAGATGGCGGCAGCCGAGGCCGCGAACTGCATCATGGAGAATTTTGTAGCCACCTTGGCTAATGGGATGAGCCTCCAGCCGCCT CTTGAAGAAGTGTCCTGTGGCCAGGCGGAAAGCAGTGAGAAGCCCAACGCTGAGGACATGACATCCAAAGATTACTACTTTGACTCCTAC GCACACTTTGGCATCCACGAGACCACCCTAGTGCCGCTGTTCCGGAACTCGCGCCTGGTCCAGTTCCACTTCACCAAGGACCTGGAGACA CTGAAGAGCCTGTGCCGGATCATGGACAATGGCTTCGCCGGCTGCGTGCACTTTTCCTACAAAGCATCGTGTGAGATCCGCGTGCTTATG CTCCTGTACTCTTCAGAGAAGAAAATCTTCATTGGCCTCATCCCCCATGACCAGGGCAACTTTGTCAACGGCATCCGGCGTGTCATTGCC AACCAGCAGCAGGTCCTGCAGCGGAACCTGGAGCAGGAGCAACAGCAACGAGGGATGGGGGGGTAGTGGTTACCCCGGGCTGGGCCCCTC CAGGAGTCACAGATGAGGCCCCCGCAGAGACTGTGCTTGGGAGCCTGTGGCCAGCAGCCCCCACTGCACCCCTGCCCCCAGGTGACACGC TTCTGAGCAGGGGCCCCTGGGGACTTCAACTGCCCAGCAACATGGAGGATGGTGTCCTGAGGCCTCCAAGGACGGTCCCCACCCCTCTAC >In-frame_PRMT1_ENST00000454376_chr19_50183845_+_PTOV1_ENST00000221557_chr19_50361806_+_900nt CGGGTGAAGATGGCGGCAGCCGAGGCCGCGAACTGCATCATGGAGAATTTTGTAGCCACCTTGGCTAATGGGATGAGCCTCCAGCCGCCT CTTGAAGAAGTGTCCTGTGGCCAGGCGGAAAGCAGTGAGAAGCCCAACGCTGAGGACATGACATCCAAAGATTACTACTTTGACTCCTAC GCACACTTTGGCATCCACGAGACCACCCTAGTGCCGCTGTTCCGGAACTCGCGCCTGGTCCAGTTCCACTTCACCAAGGACCTGGAGACA CTGAAGAGCCTGTGCCGGATCATGGACAATGGCTTCAGAAGAAAATCTTCATTGGCCTCATCCCCCATGACCAGGGCAACTTTGTCAACG GCATCCGGCGTGTCATTGCCAACCAGCAGCAGGTCCTGCAGCGGAACCTGGAGCAGGAGCAACAGCAACGAGGGATGGGGGGGTAGTGGT TACCCCGGGCTGGGCCCCTCCAGGAGTCACAGATGAGGCCCCCGCAGAGACTGGTGAGTGGTGACCCTGTCATGTACAGGAGGGACCCTG GGGCATGTGGGGGGGGTGGGGTTGGGAAAGAAGCAGGGCGACCTTGGCCTTGGGGAGAGCAGAGCAGAGGGAGAGGCAGCAGTCCCAGCG GTCCTAGGCTGTCGGGAAACTGCAGCCCAGCCTCAGGGCCATGGGAGGTGGTATCCAGGCCTGGGTGGGGCCAGGCCTCTGCTCACAGGG ATGTGGGGTCAGTGCTTGGGAGCCTGTGGCCAGCAGCCCCCACTGCACCCCTGCCCCCAGGTGACACGCTTCTGAGCAGGGGCCCCTGGG GACTTCAACTGCCCAGCAACATGGAGGATGGTGTCCTGAGGCCTCCAAGGACGGTCCCCACCCCTCTACGTTTCCCCAATAAAGCCTTTT |
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FusionGenePPI for PRMT1_PTOV1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PRMT1 | BTG1, SSSCA1, TP53, DHX9, FBL, PRMT1, SUPT5H, IFNAR1, ILF3, KHDRBS1, KHDRBS3, HNRNPK, BTG2, HNRNPA1, NCOA3, NCOA2, NCOA1, ESR1, THRB, AR, CARM1, HNRNPR, ZBTB14, SYNCRIP, CAPRIN1, TAF15, FUS, HNRNPU, CIRBP, ARPC3, S100A8, YLPM1, HABP4, IGSF21, MED31, WDR33, LRIF1, HNRNPUL1, KHDRBS2, NR1I2, TERF1, TERF2, NRIP1, HNF4A, HIST1H4A, MBD2, EIF4A1, YY1, NR1H4, STAT5A, MRE11A, PARP1, EP300, RELA, HIST2H4A, GRIP1, SH3GL1, USF1, CNOT8, HIST4H4, BRCA1, ASH2L, HDAC5, AXIN1, CDC37, ARRB2, RUNX1, HIST1H3A, CUL3, CUL2, CDK2, CAND1, COIL, STAT1, GLTSCR2, MAGOH, EIF4A3, SMURF1, FN1, PRMT8, FGF2, RNF187, EWSR1, FAM9A, OFCC1, SPSB1, SPSB2, VHL, DCAF8, CLK3, GPATCH2L, C17orf53, C20orf196, C4orf17, DCAF16, DAXX, FAM83D, MLST8, GRHL3, CEP162, MECOM, PPARA, SAMD3, SPAG8, TBX6, VPS72, WDFY3, ZMYM5, ZNF451, ACLY, COPS7B, NCL, KPNA2, MCM4, MCM7, CSNK2A2, DGCR8, HUWE1, SPEG, WDYHV1, SHMT2, MOV10, NXF1, CUL7, OBSL1, SUZ12, RPS6KB2, GAR1, NSUN5, CTPS1, KPNA6, SNRNP70, NTRK1, HSF2, BCLAF1, THOC1, RNPS1, FBXO7, CERK, CHTOP, GAN, CRY2, MCM2, UBAP2L, RBM15, SMURF2, CDC25B, TENC1, VIM, DYNLT1, CYLD, DNM1L, TRIM25, G3BP1 | PTOV1 | SFN, DMTN, PIN1, SPTAN1, BECN1, CREBBP, HDAC6, USP16, CUL2, UBC, GNB2L1, RPS6, FLOT1, PEX19, RASSF9, PDZD2, YWHAH, KLHDC2, C16orf71, RFX3, HDAC1, XYLT2, RTCB, MTA2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | PTOV1 | chr19:50183845 | chr19:50361806 | ENST00000221557 | + | 8 | 12 | 184_416 | 280 | 375 | FLOT1 |
| Tgene | PTOV1 | chr19:50183845 | chr19:50361806 | ENST00000391842 | + | 8 | 12 | 184_416 | 312 | 417 | FLOT1 |
| Tgene | PTOV1 | chr19:50183845 | chr19:50361806 | ENST00000599732 | + | 8 | 13 | 184_416 | 312 | 357 | FLOT1 |
| Tgene | PTOV1 | chr19:50183845 | chr19:50361806 | ENST00000600603 | + | 8 | 13 | 184_416 | 280 | 365 | FLOT1 |
| Tgene | PTOV1 | chr19:50183845 | chr19:50361806 | ENST00000601675 | + | 8 | 13 | 184_416 | 312 | 383 | FLOT1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PRMT1_PTOV1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PRMT1_PTOV1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | PTOV1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
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