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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28814

FusionGeneSummary for PRLR_RHOG

check button Fusion gene summary
Fusion gene informationFusion gene name: PRLR_RHOG
Fusion gene ID: 28814
HgeneTgene
Gene symbol

PRLR

RHOG

Gene ID

5618

391

Gene nameprolactin receptorras homolog family member G
SynonymsHPRL|MFAB|RI-PRLR|hPRLrIARHG
Cytomap

5p13.2

11p15.4

Type of geneprotein-codingprotein-coding
Descriptionprolactin receptorhPRL receptorsecreted prolactin binding proteinrho-related GTP-binding protein RhoGras homolog gene family, member G (rho G)
Modification date2018052320180523
UniProtAcc

P16471

P84095

Ensembl transtripts involved in fusion geneENST00000342362, ENST00000382002, 
ENST00000231423, ENST00000513753, 
ENST00000397391, ENST00000348262, 
ENST00000542609, ENST00000310101, 
ENST00000511486, ENST00000509934, 
ENST00000351018, ENST00000396979, 
ENST00000396978, ENST00000533217, 
Fusion gene scores* DoF score7 X 4 X 4=1124 X 3 X 3=36
# samples 74
** MAII scorelog2(7/112*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PRLR [Title/Abstract] AND RHOG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRLR

GO:0007171

activation of transmembrane receptor protein tyrosine kinase activity

10585417

TgeneRHOG

GO:0007266

Rho protein signal transduction

12376551

TgeneRHOG

GO:0016601

Rac protein signal transduction

12376551

TgeneRHOG

GO:0030036

actin cytoskeleton organization

12545154

TgeneRHOG

GO:0045893

positive regulation of transcription, DNA-templated

12545154


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW389483PRLRchr5

35093504

+RHOGchr11

3848610

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000342362ENST00000351018PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-3UTRENST00000342362ENST00000396979PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-intronENST00000342362ENST00000396978PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-intronENST00000342362ENST00000533217PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-3UTRENST00000382002ENST00000351018PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-3UTRENST00000382002ENST00000396979PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-intronENST00000382002ENST00000396978PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-intronENST00000382002ENST00000533217PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-3UTRENST00000231423ENST00000351018PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-3UTRENST00000231423ENST00000396979PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-intronENST00000231423ENST00000396978PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-intronENST00000231423ENST00000533217PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-3UTRENST00000513753ENST00000351018PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-3UTRENST00000513753ENST00000396979PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-intronENST00000513753ENST00000396978PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-intronENST00000513753ENST00000533217PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-3UTRENST00000397391ENST00000351018PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-3UTRENST00000397391ENST00000396979PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-intronENST00000397391ENST00000396978PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-intronENST00000397391ENST00000533217PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-3UTRENST00000348262ENST00000351018PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-3UTRENST00000348262ENST00000396979PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-intronENST00000348262ENST00000396978PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-intronENST00000348262ENST00000533217PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-3UTRENST00000542609ENST00000351018PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-3UTRENST00000542609ENST00000396979PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-intronENST00000542609ENST00000396978PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-intronENST00000542609ENST00000533217PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-3UTRENST00000310101ENST00000351018PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-3UTRENST00000310101ENST00000396979PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-intronENST00000310101ENST00000396978PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-intronENST00000310101ENST00000533217PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-3UTRENST00000511486ENST00000351018PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-3UTRENST00000511486ENST00000396979PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-intronENST00000511486ENST00000396978PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-intronENST00000511486ENST00000533217PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-3UTRENST00000509934ENST00000351018PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-3UTRENST00000509934ENST00000396979PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-intronENST00000509934ENST00000396978PRLRchr5

35093504

+RHOGchr11

3848610

-
intron-intronENST00000509934ENST00000533217PRLRchr5

35093504

+RHOGchr11

3848610

-

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FusionProtFeatures for PRLR_RHOG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRLR

P16471

RHOG

P84095

Required for the formation of membrane ruffles duringmacropinocytosis. Plays a role in cell migration and is requiredfor the formation of cup-like structures during trans-endothelialmigration of leukocytes. In case of Salmonella enterica infection,activated by SopB and ARHGEF26/SGEF, which induces cytoskeletonrearrangements and promotes bacterial entry.{ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17074883,ECO:0000269|PubMed:17875742, ECO:0000269|PubMed:20679435}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PRLR_RHOG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PRLR_RHOG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PRLR_RHOG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePRLRP16471DB01185FluoxymesteroneProlactin receptorsmall moleculeapproved|illicit
HgenePRLRP16471DB00052SomatotropinProlactin receptorbiotechapproved|investigational

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RelatedDiseases for PRLR_RHOG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePRLRC0024667Animal Mammary Neoplasms2CTD_human
HgenePRLRC0000786Spontaneous abortion1CTD_human
HgenePRLRC0004352Autistic Disorder1CTD_human
HgenePRLRC0014175Endometriosis1CTD_human
HgenePRLRC0020514Hyperprolactinemia1HPO;ORPHANET;UNIPROT
HgenePRLRC0023893Liver Cirrhosis, Experimental1CTD_human
HgenePRLRC0024668Mammary Neoplasms, Experimental1CTD_human
HgenePRLRC3809918MULTIPLE FIBROADENOMAS OF THE BREAST1ORPHANET;UNIPROT