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Fusion gene ID: 28792 |
FusionGeneSummary for PRKDC_PRIM2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PRKDC_PRIM2 | Fusion gene ID: 28792 | Hgene | Tgene | Gene symbol | PRKDC | PRIM2 | Gene ID | 5591 | 5558 |
| Gene name | protein kinase, DNA-activated, catalytic polypeptide | DNA primase subunit 2 | |
| Synonyms | DNA-PKcs|DNAPK|DNPK1|HYRC|HYRC1|IMD26|XRCC7|p350 | PRIM2A|p58 | |
| Cytomap | 8q11.21 | 6p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA-dependent protein kinase catalytic subunitDNA-PK catalytic subunithyper-radiosensitivity of murine scid mutation, complementing 1p460 | DNA primase large subunitDNA primase 58 kDa subunitprimase (DNA) subunit 2primase, DNA, polypeptide 2 (58kDa) | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P78527 | ||
| Ensembl transtripts involved in fusion gene | ENST00000338368, ENST00000314191, ENST00000523565, | ENST00000607273, ENST00000389488, | |
| Fusion gene scores | * DoF score | 17 X 20 X 10=3400 | 2 X 2 X 2=8 |
| # samples | 22 | 2 | |
| ** MAII score | log2(22/3400*10)=-3.9499593175004 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: PRKDC [Title/Abstract] AND PRIM2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PRKDC | GO:0002218 | activation of innate immune response | 28712728 |
| Hgene | PRKDC | GO:0018105 | peptidyl-serine phosphorylation | 15194694|19303849 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-33-4582-01A | PRKDC | chr8 | 48824970 | - | PRIM2 | chr6 | 57244699 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000338368 | ENST00000607273 | PRKDC | chr8 | 48824970 | - | PRIM2 | chr6 | 57244699 | + |
| 5CDS-3UTR | ENST00000338368 | ENST00000389488 | PRKDC | chr8 | 48824970 | - | PRIM2 | chr6 | 57244699 | + |
| In-frame | ENST00000314191 | ENST00000607273 | PRKDC | chr8 | 48824970 | - | PRIM2 | chr6 | 57244699 | + |
| 5CDS-3UTR | ENST00000314191 | ENST00000389488 | PRKDC | chr8 | 48824970 | - | PRIM2 | chr6 | 57244699 | + |
| 5UTR-3CDS | ENST00000523565 | ENST00000607273 | PRKDC | chr8 | 48824970 | - | PRIM2 | chr6 | 57244699 | + |
| 5UTR-3UTR | ENST00000523565 | ENST00000389488 | PRKDC | chr8 | 48824970 | - | PRIM2 | chr6 | 57244699 | + |
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FusionProtFeatures for PRKDC_PRIM2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PRKDC | PRIM2 |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PRKDC | chr8:48824970 | chr6:57244699 | ENST00000314191 | - | 25 | 87 | 288_323 | 978 | 4128 | Repeat | Note=HEAT 1 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PRKDC | chr8:48824970 | chr6:57244699 | ENST00000314191 | - | 25 | 87 | 2883_3539 | 978 | 4128 | Domain | FAT |
| Hgene | >PRKDC | chr8:48824970 | chr6:57244699 | ENST00000314191 | - | 25 | 87 | 3747_4015 | 978 | 4128 | Domain | PI3K/PI4K |
| Hgene | >PRKDC | chr8:48824970 | chr6:57244699 | ENST00000314191 | - | 25 | 87 | 4096_4128 | 978 | 4128 | Domain | FATC |
| Hgene | >PRKDC | chr8:48824970 | chr6:57244699 | ENST00000314191 | - | 25 | 87 | 1503_1538 | 978 | 4128 | Region | Note=Leucine-zipper |
| Hgene | >PRKDC | chr8:48824970 | chr6:57244699 | ENST00000314191 | - | 25 | 87 | 2436_3212 | 978 | 4128 | Region | Note=KIP-binding |
| Hgene | >PRKDC | chr8:48824970 | chr6:57244699 | ENST00000314191 | - | 25 | 87 | 1004_1040 | 978 | 4128 | Repeat | Note=HEAT 2 |
| Hgene | >PRKDC | chr8:48824970 | chr6:57244699 | ENST00000314191 | - | 25 | 87 | 1723_1756 | 978 | 4128 | Repeat | Note=TPR 1 |
| Hgene | >PRKDC | chr8:48824970 | chr6:57244699 | ENST00000314191 | - | 25 | 87 | 2920_2948 | 978 | 4128 | Repeat | Note=TPR 2 |
| Hgene | >PRKDC | chr8:48824970 | chr6:57244699 | ENST00000314191 | - | 25 | 87 | 2949_2982 | 978 | 4128 | Repeat | Note=TPR 3 |
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FusionGeneSequence for PRKDC_PRIM2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PRKDC_ENST00000338368_chr8_48824970_-_PRIM2_ENST00000607273_chr6_57244699_+_1172aa MAGSGAGVRCSLLRLQETLSAADRCGAALAGHQLIRGLGQECVLSSSPAVLALQTSLVFSRDFGLLVFVRKSLNSIEFRECREEILKFLC IFLEKMGQKIAPYSVEIKNTCTSVYTKDRAAKCKIPALDLLIKLLQTFRSSRLMDEFKIGELFSKFYGELALKKKIPDTVLEKVYELLGL LGEVHPSEMINNAENLFRAFLGELKTQMTSAVREPKLPVLAGCLKGLSSLLCNFTKSMEEDPQTSREIFNFVLKAIRPQIDLKRYAVPSA GLRLFALHASQFSTCLLDNYVSLFEVLLKWCAHTNVELKKAALSALESFLKQVSNMVAKNAEMHKNKLQYFMEQFYGIIRNVDSNNKELS IAIRGYGLFAGPCKVINAKDVDFMYVELIQRCKQMFLTQTDTGDDRVYQMPSFLQSVASVLLYLDTVPEVYTPVLEHLVVMQIDSFPQYS PKMQLVCCRAIVKVFLALAAKGPVLRNCISTVVHQGLIRICSKPVVLPKGPESESEDHRASGEVRTGKWKVPTYKDYVDLFRHLLSSDQM MDSILADEAFFSVNSSSESLNHLLYDEFVKSVLKIVEKLDLTLEIQTVGEQENGDEAPGVWMIPTSDPAANLHPAKPKDFSAFINLVEFC REILPEKQAEFFEPWVYSFSYELILQSTRLPLISGFYKLLSITVRNAKKIKYFEGVSPKSLKHSPEDPEKYSCFALFVKFGKEVAVKMKQ YKDELLASCLTFLLSLPHNIIELDVRAYVPALQMAFKLGLSYTPLAEVGLNALEEWSIYIDRHVMQPYYKDILPCLDGYLKTSALSDETK NNWEVSALSRAAQKGFNKVVLKHLKKTKNLSSNEAISLEEIRIRVVQMLGSLGGQINKNLLTVTSSDEMMKSYVAWDREKRLSFAVPFRE MKPVIFLDVFLPRVTELALTASDRQTKVAACELLHSMVMFMLGKATQMPEGGQGAPPMYQLYKRTFPVLLRLACDVDQISDEEKTLREQE IVASSPSLSGLKLGFESIYKIPFADALDLFRGRKVYLEDGFAYVPLKDIVAIILNEFRAKLSKALALTARSLPAVQSDERLQPLLNHLSH SYTSQDYSTQGNVGKISLDQIDLLSTKSFPLYMHQLHKALRENHHLCHGGRMQYVLFLKGIGLTLEQTLQFWKQEFIKGKMDPDKFDKGY >In-frame_PRKDC_ENST00000314191_chr8_48824970_-_PRIM2_ENST00000607273_chr6_57244699_+_1172aa MAGSGAGVRCSLLRLQETLSAADRCGAALAGHQLIRGLGQECVLSSSPAVLALQTSLVFSRDFGLLVFVRKSLNSIEFRECREEILKFLC IFLEKMGQKIAPYSVEIKNTCTSVYTKDRAAKCKIPALDLLIKLLQTFRSSRLMDEFKIGELFSKFYGELALKKKIPDTVLEKVYELLGL LGEVHPSEMINNAENLFRAFLGELKTQMTSAVREPKLPVLAGCLKGLSSLLCNFTKSMEEDPQTSREIFNFVLKAIRPQIDLKRYAVPSA GLRLFALHASQFSTCLLDNYVSLFEVLLKWCAHTNVELKKAALSALESFLKQVSNMVAKNAEMHKNKLQYFMEQFYGIIRNVDSNNKELS IAIRGYGLFAGPCKVINAKDVDFMYVELIQRCKQMFLTQTDTGDDRVYQMPSFLQSVASVLLYLDTVPEVYTPVLEHLVVMQIDSFPQYS PKMQLVCCRAIVKVFLALAAKGPVLRNCISTVVHQGLIRICSKPVVLPKGPESESEDHRASGEVRTGKWKVPTYKDYVDLFRHLLSSDQM MDSILADEAFFSVNSSSESLNHLLYDEFVKSVLKIVEKLDLTLEIQTVGEQENGDEAPGVWMIPTSDPAANLHPAKPKDFSAFINLVEFC REILPEKQAEFFEPWVYSFSYELILQSTRLPLISGFYKLLSITVRNAKKIKYFEGVSPKSLKHSPEDPEKYSCFALFVKFGKEVAVKMKQ YKDELLASCLTFLLSLPHNIIELDVRAYVPALQMAFKLGLSYTPLAEVGLNALEEWSIYIDRHVMQPYYKDILPCLDGYLKTSALSDETK NNWEVSALSRAAQKGFNKVVLKHLKKTKNLSSNEAISLEEIRIRVVQMLGSLGGQINKNLLTVTSSDEMMKSYVAWDREKRLSFAVPFRE MKPVIFLDVFLPRVTELALTASDRQTKVAACELLHSMVMFMLGKATQMPEGGQGAPPMYQLYKRTFPVLLRLACDVDQISDEEKTLREQE IVASSPSLSGLKLGFESIYKIPFADALDLFRGRKVYLEDGFAYVPLKDIVAIILNEFRAKLSKALALTARSLPAVQSDERLQPLLNHLSH SYTSQDYSTQGNVGKISLDQIDLLSTKSFPLYMHQLHKALRENHHLCHGGRMQYVLFLKGIGLTLEQTLQFWKQEFIKGKMDPDKFDKGY |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PRKDC_ENST00000338368_chr8_48824970_-_PRIM2_ENST00000607273_chr6_57244699_+_3516nt ATGGCGGGCTCCGGAGCCGGTGTGCGTTGCTCCCTGCTGCGGCTGCAGGAGACCTTGTCCGCTGCGGACCGCTGCGGTGCTGCCCTGGCC GGTCATCAACTGATCCGCGGCCTGGGGCAGGAATGCGTCCTGAGCAGCAGCCCCGCGGTGCTGGCATTACAGACATCTTTAGTTTTTTCC AGAGATTTCGGTTTGCTTGTATTTGTCCGGAAGTCACTCAACAGTATTGAATTTCGTGAATGTAGAGAAGAAATCCTAAAGTTTTTATGT ATTTTCTTAGAAAAAATGGGCCAGAAGATCGCACCTTACTCTGTTGAAATTAAGAACACTTGTACCAGTGTTTATACAAAAGATAGAGCT GCTAAATGTAAAATTCCAGCCCTGGACCTTCTTATTAAGTTACTTCAGACTTTTAGAAGTTCTAGACTCATGGATGAATTTAAAATTGGA GAATTATTTAGTAAATTCTATGGAGAACTTGCATTGAAAAAAAAAATACCAGATACAGTTTTAGAAAAAGTATATGAGCTCCTAGGATTA TTGGGTGAAGTTCATCCTAGTGAGATGATAAATAATGCAGAAAACCTGTTCCGCGCTTTTCTGGGTGAACTTAAGACCCAGATGACATCA GCAGTAAGAGAGCCCAAACTACCTGTTCTGGCAGGATGTCTGAAGGGGTTGTCCTCACTTCTGTGCAACTTCACTAAGTCCATGGAAGAA GATCCCCAGACTTCAAGGGAGATTTTTAATTTTGTACTAAAGGCAATTCGTCCTCAGATTGATCTGAAGAGATATGCTGTGCCCTCAGCT GGCTTGCGCCTATTTGCCCTGCATGCATCTCAGTTTAGCACCTGCCTTCTGGACAACTACGTGTCTCTATTTGAAGTCTTGTTAAAGTGG TGTGCCCACACAAATGTAGAATTGAAAAAAGCTGCACTTTCAGCCCTGGAATCCTTTCTGAAACAGGTTTCTAATATGGTGGCGAAAAAT GCAGAAATGCATAAAAATAAACTGCAGTACTTTATGGAGCAGTTTTATGGAATCATCAGAAATGTGGATTCGAACAACAAGGAGTTATCT ATTGCTATCCGTGGATATGGACTTTTTGCAGGACCGTGCAAGGTTATAAACGCAAAAGATGTTGACTTCATGTACGTTGAGCTCATTCAG CGCTGCAAGCAGATGTTCCTCACCCAGACAGACACTGGTGACGACCGTGTTTATCAGATGCCAAGCTTCCTCCAGTCTGTTGCAAGCGTC TTGCTGTACCTTGACACAGTTCCTGAGGTGTATACTCCAGTTCTGGAGCACCTCGTGGTGATGCAGATAGACAGTTTCCCACAGTACAGT CCAAAAATGCAGCTGGTGTGTTGCAGAGCCATAGTGAAGGTGTTCCTAGCTTTGGCAGCAAAAGGGCCAGTTCTCAGGAATTGCATTAGT ACTGTGGTGCATCAGGGTTTAATCAGAATATGTTCTAAACCAGTGGTCCTTCCAAAGGGCCCTGAGTCTGAATCTGAAGACCACCGTGCT TCAGGGGAAGTCAGAACTGGCAAATGGAAGGTGCCCACATACAAAGACTACGTGGATCTCTTCAGACATCTCCTGAGCTCTGACCAGATG ATGGATTCTATTTTAGCAGATGAAGCATTTTTCTCTGTGAATTCCTCCAGTGAAAGTCTGAATCATTTACTTTATGATGAATTTGTAAAA TCCGTTTTGAAGATTGTTGAGAAATTGGATCTTACACTTGAAATACAGACTGTTGGGGAACAAGAGAATGGAGATGAGGCGCCTGGTGTT TGGATGATCCCAACTTCAGATCCAGCGGCTAACTTGCATCCAGCTAAACCTAAAGATTTTTCGGCTTTCATTAACCTGGTGGAATTTTGC AGAGAGATTCTCCCTGAGAAACAAGCAGAATTTTTTGAACCATGGGTGTACTCATTTTCATATGAATTAATTTTGCAATCTACAAGGTTG CCCCTCATCAGTGGTTTCTACAAATTGCTTTCTATTACAGTAAGAAATGCCAAGAAAATAAAATATTTCGAGGGAGTTAGTCCAAAGAGT CTGAAACACTCTCCTGAAGACCCAGAAAAGTATTCTTGCTTTGCTTTATTTGTGAAATTTGGCAAAGAGGTGGCAGTTAAAATGAAGCAG TACAAAGATGAACTTTTGGCCTCTTGTTTGACCTTTCTTCTGTCCTTGCCACACAACATCATTGAACTCGATGTTAGAGCCTACGTTCCT GCACTGCAGATGGCTTTCAAACTGGGCCTGAGCTATACCCCCTTGGCAGAAGTAGGCCTGAATGCTCTAGAAGAATGGTCAATTTATATT GACAGACATGTAATGCAGCCTTATTACAAAGACATTCTCCCCTGCCTGGATGGATACCTGAAGACTTCAGCCTTGTCAGATGAGACCAAG AATAACTGGGAAGTGTCAGCTCTTTCTCGGGCTGCCCAGAAAGGATTTAATAAAGTGGTGTTAAAGCATCTGAAGAAGACAAAGAACCTT TCATCAAACGAAGCAATATCCTTAGAAGAAATAAGAATTAGAGTAGTACAAATGCTTGGATCTCTAGGAGGACAAATAAACAAAAATCTT CTGACAGTCACGTCCTCAGATGAGATGATGAAGAGCTATGTGGCCTGGGACAGAGAGAAGCGGCTGAGCTTTGCAGTGCCCTTTAGAGAG ATGAAACCTGTCATTTTCCTGGATGTGTTCCTGCCTCGAGTCACAGAATTAGCGCTCACAGCCAGTGACAGACAAACTAAAGTTGCAGCC TGTGAACTTTTACATAGCATGGTTATGTTTATGTTGGGCAAAGCCACGCAGATGCCAGAAGGGGGACAGGGAGCCCCACCCATGTACCAG CTCTATAAGCGGACGTTTCCTGTGCTGCTTCGACTTGCGTGTGATGTTGATCAGATAAGTGATGAAGAGAAGACTCTTCGAGAACAGGAG ATTGTTGCCTCATCACCAAGTTTAAGTGGACTTAAGTTGGGGTTCGAGTCCATTTATAAGATCCCTTTTGCTGATGCTCTGGATTTGTTT CGAGGAAGGAAAGTCTATTTGGAAGATGGCTTTGCTTACGTACCACTTAAGGACATTGTGGCAATCATCCTGAATGAATTTAGAGCCAAA CTGTCCAAGGCTTTGGCATTAACAGCCAGGTCCTTGCCTGCTGTGCAGTCTGATGAAAGACTTCAGCCTCTGCTCAATCACCTCAGTCAT TCCTACACTAGCCAAGATTACAGTACCCAGGGAAATGTTGGGAAGATTTCTTTAGATCAGATTGATTTGCTTTCTACCAAATCCTTCCCA CTTTACATGCATCAGTTACATAAAGCCTTGCGGGAAAATCACCATCTTTGTCATGGAGGCCGAATGCAGTATGTCCTATTTCTGAAGGGC ATTGGTTTAACTTTGGAACAGACATTGCAGTTCTGGAAGCAAGAATTTATCAAAGGAAAGATGGATCCAGACAAGTTTGATAAAGGTTAC >In-frame_PRKDC_ENST00000314191_chr8_48824970_-_PRIM2_ENST00000607273_chr6_57244699_+_3516nt ATGGCGGGCTCCGGAGCCGGTGTGCGTTGCTCCCTGCTGCGGCTGCAGGAGACCTTGTCCGCTGCGGACCGCTGCGGTGCTGCCCTGGCC GGTCATCAACTGATCCGCGGCCTGGGGCAGGAATGCGTCCTGAGCAGCAGCCCCGCGGTGCTGGCATTACAGACATCTTTAGTTTTTTCC AGAGATTTCGGTTTGCTTGTATTTGTCCGGAAGTCACTCAACAGTATTGAATTTCGTGAATGTAGAGAAGAAATCCTAAAGTTTTTATGT ATTTTCTTAGAAAAAATGGGCCAGAAGATCGCACCTTACTCTGTTGAAATTAAGAACACTTGTACCAGTGTTTATACAAAAGATAGAGCT GCTAAATGTAAAATTCCAGCCCTGGACCTTCTTATTAAGTTACTTCAGACTTTTAGAAGTTCTAGACTCATGGATGAATTTAAAATTGGA GAATTATTTAGTAAATTCTATGGAGAACTTGCATTGAAAAAAAAAATACCAGATACAGTTTTAGAAAAAGTATATGAGCTCCTAGGATTA TTGGGTGAAGTTCATCCTAGTGAGATGATAAATAATGCAGAAAACCTGTTCCGCGCTTTTCTGGGTGAACTTAAGACCCAGATGACATCA GCAGTAAGAGAGCCCAAACTACCTGTTCTGGCAGGATGTCTGAAGGGGTTGTCCTCACTTCTGTGCAACTTCACTAAGTCCATGGAAGAA GATCCCCAGACTTCAAGGGAGATTTTTAATTTTGTACTAAAGGCAATTCGTCCTCAGATTGATCTGAAGAGATATGCTGTGCCCTCAGCT GGCTTGCGCCTATTTGCCCTGCATGCATCTCAGTTTAGCACCTGCCTTCTGGACAACTACGTGTCTCTATTTGAAGTCTTGTTAAAGTGG TGTGCCCACACAAATGTAGAATTGAAAAAAGCTGCACTTTCAGCCCTGGAATCCTTTCTGAAACAGGTTTCTAATATGGTGGCGAAAAAT GCAGAAATGCATAAAAATAAACTGCAGTACTTTATGGAGCAGTTTTATGGAATCATCAGAAATGTGGATTCGAACAACAAGGAGTTATCT ATTGCTATCCGTGGATATGGACTTTTTGCAGGACCGTGCAAGGTTATAAACGCAAAAGATGTTGACTTCATGTACGTTGAGCTCATTCAG CGCTGCAAGCAGATGTTCCTCACCCAGACAGACACTGGTGACGACCGTGTTTATCAGATGCCAAGCTTCCTCCAGTCTGTTGCAAGCGTC TTGCTGTACCTTGACACAGTTCCTGAGGTGTATACTCCAGTTCTGGAGCACCTCGTGGTGATGCAGATAGACAGTTTCCCACAGTACAGT CCAAAAATGCAGCTGGTGTGTTGCAGAGCCATAGTGAAGGTGTTCCTAGCTTTGGCAGCAAAAGGGCCAGTTCTCAGGAATTGCATTAGT ACTGTGGTGCATCAGGGTTTAATCAGAATATGTTCTAAACCAGTGGTCCTTCCAAAGGGCCCTGAGTCTGAATCTGAAGACCACCGTGCT TCAGGGGAAGTCAGAACTGGCAAATGGAAGGTGCCCACATACAAAGACTACGTGGATCTCTTCAGACATCTCCTGAGCTCTGACCAGATG ATGGATTCTATTTTAGCAGATGAAGCATTTTTCTCTGTGAATTCCTCCAGTGAAAGTCTGAATCATTTACTTTATGATGAATTTGTAAAA TCCGTTTTGAAGATTGTTGAGAAATTGGATCTTACACTTGAAATACAGACTGTTGGGGAACAAGAGAATGGAGATGAGGCGCCTGGTGTT TGGATGATCCCAACTTCAGATCCAGCGGCTAACTTGCATCCAGCTAAACCTAAAGATTTTTCGGCTTTCATTAACCTGGTGGAATTTTGC AGAGAGATTCTCCCTGAGAAACAAGCAGAATTTTTTGAACCATGGGTGTACTCATTTTCATATGAATTAATTTTGCAATCTACAAGGTTG CCCCTCATCAGTGGTTTCTACAAATTGCTTTCTATTACAGTAAGAAATGCCAAGAAAATAAAATATTTCGAGGGAGTTAGTCCAAAGAGT CTGAAACACTCTCCTGAAGACCCAGAAAAGTATTCTTGCTTTGCTTTATTTGTGAAATTTGGCAAAGAGGTGGCAGTTAAAATGAAGCAG TACAAAGATGAACTTTTGGCCTCTTGTTTGACCTTTCTTCTGTCCTTGCCACACAACATCATTGAACTCGATGTTAGAGCCTACGTTCCT GCACTGCAGATGGCTTTCAAACTGGGCCTGAGCTATACCCCCTTGGCAGAAGTAGGCCTGAATGCTCTAGAAGAATGGTCAATTTATATT GACAGACATGTAATGCAGCCTTATTACAAAGACATTCTCCCCTGCCTGGATGGATACCTGAAGACTTCAGCCTTGTCAGATGAGACCAAG AATAACTGGGAAGTGTCAGCTCTTTCTCGGGCTGCCCAGAAAGGATTTAATAAAGTGGTGTTAAAGCATCTGAAGAAGACAAAGAACCTT TCATCAAACGAAGCAATATCCTTAGAAGAAATAAGAATTAGAGTAGTACAAATGCTTGGATCTCTAGGAGGACAAATAAACAAAAATCTT CTGACAGTCACGTCCTCAGATGAGATGATGAAGAGCTATGTGGCCTGGGACAGAGAGAAGCGGCTGAGCTTTGCAGTGCCCTTTAGAGAG ATGAAACCTGTCATTTTCCTGGATGTGTTCCTGCCTCGAGTCACAGAATTAGCGCTCACAGCCAGTGACAGACAAACTAAAGTTGCAGCC TGTGAACTTTTACATAGCATGGTTATGTTTATGTTGGGCAAAGCCACGCAGATGCCAGAAGGGGGACAGGGAGCCCCACCCATGTACCAG CTCTATAAGCGGACGTTTCCTGTGCTGCTTCGACTTGCGTGTGATGTTGATCAGATAAGTGATGAAGAGAAGACTCTTCGAGAACAGGAG ATTGTTGCCTCATCACCAAGTTTAAGTGGACTTAAGTTGGGGTTCGAGTCCATTTATAAGATCCCTTTTGCTGATGCTCTGGATTTGTTT CGAGGAAGGAAAGTCTATTTGGAAGATGGCTTTGCTTACGTACCACTTAAGGACATTGTGGCAATCATCCTGAATGAATTTAGAGCCAAA CTGTCCAAGGCTTTGGCATTAACAGCCAGGTCCTTGCCTGCTGTGCAGTCTGATGAAAGACTTCAGCCTCTGCTCAATCACCTCAGTCAT TCCTACACTAGCCAAGATTACAGTACCCAGGGAAATGTTGGGAAGATTTCTTTAGATCAGATTGATTTGCTTTCTACCAAATCCTTCCCA CTTTACATGCATCAGTTACATAAAGCCTTGCGGGAAAATCACCATCTTTGTCATGGAGGCCGAATGCAGTATGTCCTATTTCTGAAGGGC ATTGGTTTAACTTTGGAACAGACATTGCAGTTCTGGAAGCAAGAATTTATCAAAGGAAAGATGGATCCAGACAAGTTTGATAAAGGTTAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PRKDC_ENST00000338368_chr8_48824970_-_PRIM2_ENST00000607273_chr6_57244699_+_4735nt GGGGCATTTCCGGGTCCGGGCCGAGCGGGCGCACGCGCGGGAGCGGGACTCGGCGGCATGGCGGGCTCCGGAGCCGGTGTGCGTTGCTCC CTGCTGCGGCTGCAGGAGACCTTGTCCGCTGCGGACCGCTGCGGTGCTGCCCTGGCCGGTCATCAACTGATCCGCGGCCTGGGGCAGGAA TGCGTCCTGAGCAGCAGCCCCGCGGTGCTGGCATTACAGACATCTTTAGTTTTTTCCAGAGATTTCGGTTTGCTTGTATTTGTCCGGAAG TCACTCAACAGTATTGAATTTCGTGAATGTAGAGAAGAAATCCTAAAGTTTTTATGTATTTTCTTAGAAAAAATGGGCCAGAAGATCGCA CCTTACTCTGTTGAAATTAAGAACACTTGTACCAGTGTTTATACAAAAGATAGAGCTGCTAAATGTAAAATTCCAGCCCTGGACCTTCTT ATTAAGTTACTTCAGACTTTTAGAAGTTCTAGACTCATGGATGAATTTAAAATTGGAGAATTATTTAGTAAATTCTATGGAGAACTTGCA TTGAAAAAAAAAATACCAGATACAGTTTTAGAAAAAGTATATGAGCTCCTAGGATTATTGGGTGAAGTTCATCCTAGTGAGATGATAAAT AATGCAGAAAACCTGTTCCGCGCTTTTCTGGGTGAACTTAAGACCCAGATGACATCAGCAGTAAGAGAGCCCAAACTACCTGTTCTGGCA GGATGTCTGAAGGGGTTGTCCTCACTTCTGTGCAACTTCACTAAGTCCATGGAAGAAGATCCCCAGACTTCAAGGGAGATTTTTAATTTT GTACTAAAGGCAATTCGTCCTCAGATTGATCTGAAGAGATATGCTGTGCCCTCAGCTGGCTTGCGCCTATTTGCCCTGCATGCATCTCAG TTTAGCACCTGCCTTCTGGACAACTACGTGTCTCTATTTGAAGTCTTGTTAAAGTGGTGTGCCCACACAAATGTAGAATTGAAAAAAGCT GCACTTTCAGCCCTGGAATCCTTTCTGAAACAGGTTTCTAATATGGTGGCGAAAAATGCAGAAATGCATAAAAATAAACTGCAGTACTTT ATGGAGCAGTTTTATGGAATCATCAGAAATGTGGATTCGAACAACAAGGAGTTATCTATTGCTATCCGTGGATATGGACTTTTTGCAGGA CCGTGCAAGGTTATAAACGCAAAAGATGTTGACTTCATGTACGTTGAGCTCATTCAGCGCTGCAAGCAGATGTTCCTCACCCAGACAGAC ACTGGTGACGACCGTGTTTATCAGATGCCAAGCTTCCTCCAGTCTGTTGCAAGCGTCTTGCTGTACCTTGACACAGTTCCTGAGGTGTAT ACTCCAGTTCTGGAGCACCTCGTGGTGATGCAGATAGACAGTTTCCCACAGTACAGTCCAAAAATGCAGCTGGTGTGTTGCAGAGCCATA GTGAAGGTGTTCCTAGCTTTGGCAGCAAAAGGGCCAGTTCTCAGGAATTGCATTAGTACTGTGGTGCATCAGGGTTTAATCAGAATATGT TCTAAACCAGTGGTCCTTCCAAAGGGCCCTGAGTCTGAATCTGAAGACCACCGTGCTTCAGGGGAAGTCAGAACTGGCAAATGGAAGGTG CCCACATACAAAGACTACGTGGATCTCTTCAGACATCTCCTGAGCTCTGACCAGATGATGGATTCTATTTTAGCAGATGAAGCATTTTTC TCTGTGAATTCCTCCAGTGAAAGTCTGAATCATTTACTTTATGATGAATTTGTAAAATCCGTTTTGAAGATTGTTGAGAAATTGGATCTT ACACTTGAAATACAGACTGTTGGGGAACAAGAGAATGGAGATGAGGCGCCTGGTGTTTGGATGATCCCAACTTCAGATCCAGCGGCTAAC TTGCATCCAGCTAAACCTAAAGATTTTTCGGCTTTCATTAACCTGGTGGAATTTTGCAGAGAGATTCTCCCTGAGAAACAAGCAGAATTT TTTGAACCATGGGTGTACTCATTTTCATATGAATTAATTTTGCAATCTACAAGGTTGCCCCTCATCAGTGGTTTCTACAAATTGCTTTCT ATTACAGTAAGAAATGCCAAGAAAATAAAATATTTCGAGGGAGTTAGTCCAAAGAGTCTGAAACACTCTCCTGAAGACCCAGAAAAGTAT TCTTGCTTTGCTTTATTTGTGAAATTTGGCAAAGAGGTGGCAGTTAAAATGAAGCAGTACAAAGATGAACTTTTGGCCTCTTGTTTGACC TTTCTTCTGTCCTTGCCACACAACATCATTGAACTCGATGTTAGAGCCTACGTTCCTGCACTGCAGATGGCTTTCAAACTGGGCCTGAGC TATACCCCCTTGGCAGAAGTAGGCCTGAATGCTCTAGAAGAATGGTCAATTTATATTGACAGACATGTAATGCAGCCTTATTACAAAGAC ATTCTCCCCTGCCTGGATGGATACCTGAAGACTTCAGCCTTGTCAGATGAGACCAAGAATAACTGGGAAGTGTCAGCTCTTTCTCGGGCT GCCCAGAAAGGATTTAATAAAGTGGTGTTAAAGCATCTGAAGAAGACAAAGAACCTTTCATCAAACGAAGCAATATCCTTAGAAGAAATA AGAATTAGAGTAGTACAAATGCTTGGATCTCTAGGAGGACAAATAAACAAAAATCTTCTGACAGTCACGTCCTCAGATGAGATGATGAAG AGCTATGTGGCCTGGGACAGAGAGAAGCGGCTGAGCTTTGCAGTGCCCTTTAGAGAGATGAAACCTGTCATTTTCCTGGATGTGTTCCTG CCTCGAGTCACAGAATTAGCGCTCACAGCCAGTGACAGACAAACTAAAGTTGCAGCCTGTGAACTTTTACATAGCATGGTTATGTTTATG TTGGGCAAAGCCACGCAGATGCCAGAAGGGGGACAGGGAGCCCCACCCATGTACCAGCTCTATAAGCGGACGTTTCCTGTGCTGCTTCGA CTTGCGTGTGATGTTGATCAGATAAGTGATGAAGAGAAGACTCTTCGAGAACAGGAGATTGTTGCCTCATCACCAAGTTTAAGTGGACTT AAGTTGGGGTTCGAGTCCATTTATAAGATCCCTTTTGCTGATGCTCTGGATTTGTTTCGAGGAAGGAAAGTCTATTTGGAAGATGGCTTT GCTTACGTACCACTTAAGGACATTGTGGCAATCATCCTGAATGAATTTAGAGCCAAACTGTCCAAGGCTTTGGCATTAACAGCCAGGTCC TTGCCTGCTGTGCAGTCTGATGAAAGACTTCAGCCTCTGCTCAATCACCTCAGTCATTCCTACACTAGCCAAGATTACAGTACCCAGGGA AATGTTGGGAAGATTTCTTTAGATCAGATTGATTTGCTTTCTACCAAATCCTTCCCACTTTACATGCATCAGTTACATAAAGCCTTGCGG GAAAATCACCATCTTTGTCATGGAGGCCGAATGCAGTATGTCCTATTTCTGAAGGGCATTGGTTTAACTTTGGAACAGACATTGCAGTTC TGGAAGCAAGAATTTATCAAAGGAAAGATGGATCCAGACAAGTTTGATAAAGGTTACTCTTAGAACATCCGTCACAGCTTTGGAAAGGAA GGCAAGAGGACAGACTATACACCTTTCAGTTGCCTGAAGATTATTCTATCCAATCCACCAAGCCAAGGGGATTATCATGGGTGCCCATTC CGTCACAGTGATCCAGAGCTGCTGAAGCAAAAGTTGCAGTCATACAAGATCTCTCCTGGAGGGATAAGCCAGATTTTGGATTTAGTAAAG GGGACACATTACCAGGTAGCCTGTCAAAAATACTTTGAGATGATACACAATGTGGGTGATTGTGGCTTTTCTTTGAATCATCCTAATCAT TTCTTTTGTGAGAGCCAACGTATTCTAAATGGTGGTAAAGACATAAAGAAGGAATCTATCCAACCAGAAACTCCTCAACCCAAACCAAGT GTCCAGAAAACCAAGGATGCATCATCTGCTCTGGCCTCTTTAAATTCCTCTCTGGAAATGGATATGGAAGGACTAGAGGATTACTTTAGT GAAGATTCTTAGGCAGTTTTGTAACCCTTTTTCCTCAATAGCCTGTTTCCTGTTTTTAAGATTTTGCCTTTGTTGTTGAAAAAGTGTTGC ACTCTGTTGTGTAATTGTGACACAATTACAGCTGATTGCAGCCTCAACCTTCCCAGCTCAAGTGATCCTCCTACCTCAGCCTCCCAAGTA GTTGGGACCACAGGTGTGCACCCCATATCCAGCTATTTTTTTTCAATTTTTTTTGTAGAGGGGGGGTCTCCCTATGTTGCCCAGGCAGAT CTCAGACTGCTGGGCTCAAGCGATCCTCACACCTCAGCCTCCCAGAGTGCTGGGATTACAGTTGTGAGCCACTGTGCCTGGCCTTTCTTT TTTTAACCTTTTTGTTTAACTTCTCTCTTCACTGCATCCCAATCCATCTACAGGCATGCACACTTATTAGGAAAGCAGGTTTGAGGTAAC GAGACTTTCACTATATTTTGCTTTGACAGAAGGAAAGAGGAAGAGTTTCTATTAAAATCTGTCACTTGAGTGATGTCATTCAAGTCCTAT TTTAGGAGATAAAAACACCTTTGGGGACTGGTTAAAGTCCCCCAGAAACTACAATAAAGAACAACTTTTGTTTTAACTCTTAATCATTTT >In-frame_PRKDC_ENST00000314191_chr8_48824970_-_PRIM2_ENST00000607273_chr6_57244699_+_4735nt GGGGCATTTCCGGGTCCGGGCCGAGCGGGCGCACGCGCGGGAGCGGGACTCGGCGGCATGGCGGGCTCCGGAGCCGGTGTGCGTTGCTCC CTGCTGCGGCTGCAGGAGACCTTGTCCGCTGCGGACCGCTGCGGTGCTGCCCTGGCCGGTCATCAACTGATCCGCGGCCTGGGGCAGGAA TGCGTCCTGAGCAGCAGCCCCGCGGTGCTGGCATTACAGACATCTTTAGTTTTTTCCAGAGATTTCGGTTTGCTTGTATTTGTCCGGAAG TCACTCAACAGTATTGAATTTCGTGAATGTAGAGAAGAAATCCTAAAGTTTTTATGTATTTTCTTAGAAAAAATGGGCCAGAAGATCGCA CCTTACTCTGTTGAAATTAAGAACACTTGTACCAGTGTTTATACAAAAGATAGAGCTGCTAAATGTAAAATTCCAGCCCTGGACCTTCTT ATTAAGTTACTTCAGACTTTTAGAAGTTCTAGACTCATGGATGAATTTAAAATTGGAGAATTATTTAGTAAATTCTATGGAGAACTTGCA TTGAAAAAAAAAATACCAGATACAGTTTTAGAAAAAGTATATGAGCTCCTAGGATTATTGGGTGAAGTTCATCCTAGTGAGATGATAAAT AATGCAGAAAACCTGTTCCGCGCTTTTCTGGGTGAACTTAAGACCCAGATGACATCAGCAGTAAGAGAGCCCAAACTACCTGTTCTGGCA GGATGTCTGAAGGGGTTGTCCTCACTTCTGTGCAACTTCACTAAGTCCATGGAAGAAGATCCCCAGACTTCAAGGGAGATTTTTAATTTT GTACTAAAGGCAATTCGTCCTCAGATTGATCTGAAGAGATATGCTGTGCCCTCAGCTGGCTTGCGCCTATTTGCCCTGCATGCATCTCAG TTTAGCACCTGCCTTCTGGACAACTACGTGTCTCTATTTGAAGTCTTGTTAAAGTGGTGTGCCCACACAAATGTAGAATTGAAAAAAGCT GCACTTTCAGCCCTGGAATCCTTTCTGAAACAGGTTTCTAATATGGTGGCGAAAAATGCAGAAATGCATAAAAATAAACTGCAGTACTTT ATGGAGCAGTTTTATGGAATCATCAGAAATGTGGATTCGAACAACAAGGAGTTATCTATTGCTATCCGTGGATATGGACTTTTTGCAGGA CCGTGCAAGGTTATAAACGCAAAAGATGTTGACTTCATGTACGTTGAGCTCATTCAGCGCTGCAAGCAGATGTTCCTCACCCAGACAGAC ACTGGTGACGACCGTGTTTATCAGATGCCAAGCTTCCTCCAGTCTGTTGCAAGCGTCTTGCTGTACCTTGACACAGTTCCTGAGGTGTAT ACTCCAGTTCTGGAGCACCTCGTGGTGATGCAGATAGACAGTTTCCCACAGTACAGTCCAAAAATGCAGCTGGTGTGTTGCAGAGCCATA GTGAAGGTGTTCCTAGCTTTGGCAGCAAAAGGGCCAGTTCTCAGGAATTGCATTAGTACTGTGGTGCATCAGGGTTTAATCAGAATATGT TCTAAACCAGTGGTCCTTCCAAAGGGCCCTGAGTCTGAATCTGAAGACCACCGTGCTTCAGGGGAAGTCAGAACTGGCAAATGGAAGGTG CCCACATACAAAGACTACGTGGATCTCTTCAGACATCTCCTGAGCTCTGACCAGATGATGGATTCTATTTTAGCAGATGAAGCATTTTTC TCTGTGAATTCCTCCAGTGAAAGTCTGAATCATTTACTTTATGATGAATTTGTAAAATCCGTTTTGAAGATTGTTGAGAAATTGGATCTT ACACTTGAAATACAGACTGTTGGGGAACAAGAGAATGGAGATGAGGCGCCTGGTGTTTGGATGATCCCAACTTCAGATCCAGCGGCTAAC TTGCATCCAGCTAAACCTAAAGATTTTTCGGCTTTCATTAACCTGGTGGAATTTTGCAGAGAGATTCTCCCTGAGAAACAAGCAGAATTT TTTGAACCATGGGTGTACTCATTTTCATATGAATTAATTTTGCAATCTACAAGGTTGCCCCTCATCAGTGGTTTCTACAAATTGCTTTCT ATTACAGTAAGAAATGCCAAGAAAATAAAATATTTCGAGGGAGTTAGTCCAAAGAGTCTGAAACACTCTCCTGAAGACCCAGAAAAGTAT TCTTGCTTTGCTTTATTTGTGAAATTTGGCAAAGAGGTGGCAGTTAAAATGAAGCAGTACAAAGATGAACTTTTGGCCTCTTGTTTGACC TTTCTTCTGTCCTTGCCACACAACATCATTGAACTCGATGTTAGAGCCTACGTTCCTGCACTGCAGATGGCTTTCAAACTGGGCCTGAGC TATACCCCCTTGGCAGAAGTAGGCCTGAATGCTCTAGAAGAATGGTCAATTTATATTGACAGACATGTAATGCAGCCTTATTACAAAGAC ATTCTCCCCTGCCTGGATGGATACCTGAAGACTTCAGCCTTGTCAGATGAGACCAAGAATAACTGGGAAGTGTCAGCTCTTTCTCGGGCT GCCCAGAAAGGATTTAATAAAGTGGTGTTAAAGCATCTGAAGAAGACAAAGAACCTTTCATCAAACGAAGCAATATCCTTAGAAGAAATA AGAATTAGAGTAGTACAAATGCTTGGATCTCTAGGAGGACAAATAAACAAAAATCTTCTGACAGTCACGTCCTCAGATGAGATGATGAAG AGCTATGTGGCCTGGGACAGAGAGAAGCGGCTGAGCTTTGCAGTGCCCTTTAGAGAGATGAAACCTGTCATTTTCCTGGATGTGTTCCTG CCTCGAGTCACAGAATTAGCGCTCACAGCCAGTGACAGACAAACTAAAGTTGCAGCCTGTGAACTTTTACATAGCATGGTTATGTTTATG TTGGGCAAAGCCACGCAGATGCCAGAAGGGGGACAGGGAGCCCCACCCATGTACCAGCTCTATAAGCGGACGTTTCCTGTGCTGCTTCGA CTTGCGTGTGATGTTGATCAGATAAGTGATGAAGAGAAGACTCTTCGAGAACAGGAGATTGTTGCCTCATCACCAAGTTTAAGTGGACTT AAGTTGGGGTTCGAGTCCATTTATAAGATCCCTTTTGCTGATGCTCTGGATTTGTTTCGAGGAAGGAAAGTCTATTTGGAAGATGGCTTT GCTTACGTACCACTTAAGGACATTGTGGCAATCATCCTGAATGAATTTAGAGCCAAACTGTCCAAGGCTTTGGCATTAACAGCCAGGTCC TTGCCTGCTGTGCAGTCTGATGAAAGACTTCAGCCTCTGCTCAATCACCTCAGTCATTCCTACACTAGCCAAGATTACAGTACCCAGGGA AATGTTGGGAAGATTTCTTTAGATCAGATTGATTTGCTTTCTACCAAATCCTTCCCACTTTACATGCATCAGTTACATAAAGCCTTGCGG GAAAATCACCATCTTTGTCATGGAGGCCGAATGCAGTATGTCCTATTTCTGAAGGGCATTGGTTTAACTTTGGAACAGACATTGCAGTTC TGGAAGCAAGAATTTATCAAAGGAAAGATGGATCCAGACAAGTTTGATAAAGGTTACTCTTAGAACATCCGTCACAGCTTTGGAAAGGAA GGCAAGAGGACAGACTATACACCTTTCAGTTGCCTGAAGATTATTCTATCCAATCCACCAAGCCAAGGGGATTATCATGGGTGCCCATTC CGTCACAGTGATCCAGAGCTGCTGAAGCAAAAGTTGCAGTCATACAAGATCTCTCCTGGAGGGATAAGCCAGATTTTGGATTTAGTAAAG GGGACACATTACCAGGTAGCCTGTCAAAAATACTTTGAGATGATACACAATGTGGGTGATTGTGGCTTTTCTTTGAATCATCCTAATCAT TTCTTTTGTGAGAGCCAACGTATTCTAAATGGTGGTAAAGACATAAAGAAGGAATCTATCCAACCAGAAACTCCTCAACCCAAACCAAGT GTCCAGAAAACCAAGGATGCATCATCTGCTCTGGCCTCTTTAAATTCCTCTCTGGAAATGGATATGGAAGGACTAGAGGATTACTTTAGT GAAGATTCTTAGGCAGTTTTGTAACCCTTTTTCCTCAATAGCCTGTTTCCTGTTTTTAAGATTTTGCCTTTGTTGTTGAAAAAGTGTTGC ACTCTGTTGTGTAATTGTGACACAATTACAGCTGATTGCAGCCTCAACCTTCCCAGCTCAAGTGATCCTCCTACCTCAGCCTCCCAAGTA GTTGGGACCACAGGTGTGCACCCCATATCCAGCTATTTTTTTTCAATTTTTTTTGTAGAGGGGGGGTCTCCCTATGTTGCCCAGGCAGAT CTCAGACTGCTGGGCTCAAGCGATCCTCACACCTCAGCCTCCCAGAGTGCTGGGATTACAGTTGTGAGCCACTGTGCCTGGCCTTTCTTT TTTTAACCTTTTTGTTTAACTTCTCTCTTCACTGCATCCCAATCCATCTACAGGCATGCACACTTATTAGGAAAGCAGGTTTGAGGTAAC GAGACTTTCACTATATTTTGCTTTGACAGAAGGAAAGAGGAAGAGTTTCTATTAAAATCTGTCACTTGAGTGATGTCATTCAAGTCCTAT TTTAGGAGATAAAAACACCTTTGGGGACTGGTTAAAGTCCCCCAGAAACTACAATAAAGAACAACTTTTGTTTTAACTCTTAATCATTTT |
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FusionGenePPI for PRKDC_PRIM2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PRKDC | AR, AP1B1, ATM, BRCA1, CHEK1, E4F1, LIG4, MRE11A, RAD17, RBBP8, TP53, WRN, NCOA6, KAT2A, RPA2, XRCC6, RPA1, ABL1, XRCC5, C1D, IKBKB, CHUK, AKT2, LYN, ILF3, ILF2, EIF2S2, NCF1, NCF2, NCF4, MAPK8, MAPK9, PCNA, CIB1, DCLRE1C, HSF1, CDC5L, HDLBP, RECQL5, MLH1, PMS2, SIRT6, AIRE, TTI1, TELO2, ATG4C, BECN1, ATG101, CAMKK2, CLN3, DDA1, GBAS, PRKAB2, POU2F1, MKNK1, NR1H4, CHD1L, ESR1, PARP1, KAT5, TTI2, SAP25, H2AFX, MGMT, PDX1, AICDA, DHX9, HIST1H1C, XRCC4, YY1, KAT8, MSL3, THRA, THRB, HDAC3, BIRC5, BMI1, HIST1H1A, CHAF1A, PPP2CA, PPP6C, PPP6R1, PPP6R2, PPP6R3, PRKDC, HIST1H3E, H3F3A, MYC, RYK, YWHAQ, USF1, HDAC5, SP1, HOXB7, PIDD1, SMARCAD1, NBN, ATRIP, RAD21, HDGF, CTDP1, CENPA, LMNA, MSH6, TERF1, MDC1, ELAVL1, SIRT7, CSNK2A1, HIST1H3A, HNRNPA1, HNRNPC, ERG, PINK1, CUL3, CUL5, CDK2, COPS5, ARHGEF6, VPRBP, LRRK2, MBP, GRK5, SHC1, AP2M1, UBXN6, XPA, NR3C1, EFTUD2, DDX5, PRPF8, HSPA8, SF3B6, CWC27, THOC6, YBX1, TRA2B, U2AF2, RBM25, DHX38, SRP14, RPS11, SMARCA5, SRSF10, SRP54, PHGDH, RANBP2, PTER, THYN1, TPR, PGR, NOTCH1, IKBKAP, AKT1, PNKP, GSK3A, GSK3B, SRF, JUN, HSP90AA1, HSP90AB1, FN1, VCAM1, GZMB, NOS2, ITGA4, CFTR, CASP3, EIF4EBP1, CHEK2, PAN2, RUVBL1, HDAC11, ADRB2, BAG3, EGFR, IQCB1, FBXO6, CTPS2, GTF2I, PRDX1, C14orf166, RTCB, EHD1, FLII, LRRFIP1, METTL1, NUCB1, RFC2, SNRPA, RPA3, ASB5, LGR4, PHKG2, ILK, ATRX, STAU1, EMD, RELA, RNF144A, CUL7, OBSL1, CCDC8, UBE2I, EED, AUP1, FOXRED2, UBAC2, FAF2, SUMO2, EP300, RASSF1, NTRK1, SCARNA22, NUP85, NUP107, NUP35, CLK1, HSPA5, DNAJC7, POT1, TINF2, DCLRE1B, SKI, CRY1, CRY2, ANAPC2, FZR1, CCNB1, MCM2, SNW1, MEX3C, POU5F1, ALOX15, NFATC2, AHSA1, XRCC1, CDC73, ATOH1, IGF1R, RRM2, MTOR, VHL, CDK4, CDK9, AKTIP, ZNF746, EPHA1, LPAR4, FANCD2, MTNR1B, CYLD, TRIM25, TES, MTF1 | PRIM2 | RAE1, ELAVL1, POLA1, PRIM1, POLA2, MMS19, KDM1A, SUV39H1, FAM96B, CIAO1, MOV10, KLHL20, PRPS2, OBFC1, GFOD1, NTRK1, BAG6, USP37, DUSP9, NLGN4Y, RNF31, RGS20, DCAF10, PM20D2, ERP44 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PRKDC_PRIM2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | PRKDC | P78527 | DB00201 | Caffeine | DNA-dependent protein kinase catalytic subunit | small molecule | approved |
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RelatedDiseases for PRKDC_PRIM2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PRKDC | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
| Hgene | PRKDC | C4014833 | IMMUNODEFICIENCY 26 WITH OR WITHOUT NEUROLOGIC ABNORMALITIES | 2 | ORPHANET;UNIPROT |
| Hgene | PRKDC | C0001364 | Massive Hepatic Necrosis | 1 | CTD_human |
| Hgene | PRKDC | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| Hgene | PRKDC | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Hgene | PRKDC | C0019151 | Hepatic Encephalopathy | 1 | CTD_human |
| Hgene | PRKDC | C0024115 | Lung diseases | 1 | CTD_human |
| Hgene | PRKDC | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
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