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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2879

FusionGeneSummary for AR_NR4A3

check button Fusion gene summary
Fusion gene informationFusion gene name: AR_NR4A3
Fusion gene ID: 2879
HgeneTgene
Gene symbol

AR

NR4A3

Gene ID

374

8013

Gene nameamphiregulinnuclear receptor subfamily 4 group A member 3
SynonymsAR|AREGB|CRDGF|SDGFCHN|CSMF|MINOR|NOR1|TEC
Cytomap

4q13.3

9q31.1

Type of geneprotein-codingprotein-coding
Descriptionamphiregulinamphiregulin Bcolorectum cell-derived growth factorschwannoma-derived growth factornuclear receptor subfamily 4 group A member 3chondrosarcoma, extraskeletal myxoid, fused to EWSmitogen-induced nuclear orphan receptorneuron-derived orphan receptor 1nuclear hormone receptor NOR-1translocated in extraskeletal chondrosarcoma
Modification date2018052320180527
UniProtAcc

P10275

Q92570

Ensembl transtripts involved in fusion geneENST00000374690, ENST00000513847, 
ENST00000504326, ENST00000396044, 
ENST00000396043, 		ENST00000338488, 
ENST00000395097, ENST00000330847, 
Fusion gene scores* DoF score2 X 2 X 2=86 X 6 X 4=144
# samples 210
** MAII scorelog2(2/8*10)=1.32192809488736log2(10/144*10)=-0.526068811667588
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AR [Title/Abstract] AND NR4A3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAR

GO:0007173

epidermal growth factor receptor signaling pathway

12743035

HgeneAR

GO:0007186

G-protein coupled receptor signaling pathway

12743035

TgeneNR4A3

GO:0010828

positive regulation of glucose transmembrane transport

24022864

TgeneNR4A3

GO:0045944

positive regulation of transcription by RNA polymerase II

20558821

TgeneNR4A3

GO:0048008

platelet-derived growth factor receptor signaling pathway

23554459

TgeneNR4A3

GO:0048660

regulation of smooth muscle cell proliferation

25852083


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-G3-A7M8-01AARchrX

66863249

+NR4A3chr9

102587941

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000374690ENST00000338488ARchrX

66863249

+NR4A3chr9

102587941

+
5CDS-5UTRENST00000374690ENST00000395097ARchrX

66863249

+NR4A3chr9

102587941

+
5CDS-intronENST00000374690ENST00000330847ARchrX

66863249

+NR4A3chr9

102587941

+
3UTR-5UTRENST00000513847ENST00000338488ARchrX

66863249

+NR4A3chr9

102587941

+
3UTR-5UTRENST00000513847ENST00000395097ARchrX

66863249

+NR4A3chr9

102587941

+
3UTR-intronENST00000513847ENST00000330847ARchrX

66863249

+NR4A3chr9

102587941

+
5CDS-5UTRENST00000504326ENST00000338488ARchrX

66863249

+NR4A3chr9

102587941

+
5CDS-5UTRENST00000504326ENST00000395097ARchrX

66863249

+NR4A3chr9

102587941

+
5CDS-intronENST00000504326ENST00000330847ARchrX

66863249

+NR4A3chr9

102587941

+
5CDS-5UTRENST00000396044ENST00000338488ARchrX

66863249

+NR4A3chr9

102587941

+
5CDS-5UTRENST00000396044ENST00000395097ARchrX

66863249

+NR4A3chr9

102587941

+
5CDS-intronENST00000396044ENST00000330847ARchrX

66863249

+NR4A3chr9

102587941

+
5CDS-5UTRENST00000396043ENST00000338488ARchrX

66863249

+NR4A3chr9

102587941

+
5CDS-5UTRENST00000396043ENST00000395097ARchrX

66863249

+NR4A3chr9

102587941

+
5CDS-intronENST00000396043ENST00000330847ARchrX

66863249

+NR4A3chr9

102587941

+

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FusionProtFeatures for AR_NR4A3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AR

P10275

NR4A3

Q92570

Steroid hormone receptors are ligand-activatedtranscription factors that regulate eukaryotic gene expression andaffect cellular proliferation and differentiation in targettissues. Transcription factor activity is modulated by boundcoactivator and corepressor proteins. Transcription activation isdown-regulated by NR0B2. Activated, but not phosphorylated, byHIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718,ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767,ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323,ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20980437,ECO:0000269|PubMed:25091737}. Isoform 3 and isoform 4 lack the C-terminal ligand-binding domain and may therefore constitutively activate thetranscription of a specific set of genes independently of steroidhormones. {ECO:0000269|PubMed:19244107}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AR_NR4A3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AR_NR4A3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ARGNB2L1, FLNA, RAN, NR2C2, NCOA3, RNF4, NCOA4, PAK6, RANBP9, RCHY1, PIAS2, HNF4A, AKT1, IL6ST, CALM1, RAD9A, SMAD3, NCOA6, CTNNB1, CCNH, CDK7, AR, DAXX, STAT3, SP1, GSK3B, GSN, SELENBP1, HSPA1A, HSP90AA1, UXT, CAV1, JUN, PRKDC, XRCC5, XRCC6, BAG1, CREBBP, NCOA1, NCOR1, NCOR2, NCOA2, CCND1, FOXO1, FOXA1, RNF14, DCC, MAGEA11, SRC, PTEN, RB1, BRCA1, ZMIZ1, TP53, TGFB1I1, MAPK1, EGFR, GSK3A, KAT7, NR2C1, GRIP1, PELP1, SART3, HDAC3, HDAC4, TDG, PSPC1, NONO, EFCAB6, KAT5, HDAC1, CDK9, NSD1, YWHAQ, PRMT1, TSG101, COX5B, RAF1, NR0B2, POU2F1, POU2F2, DAP3, CEBPA, CEBPB, SVIL, AES, FHL2, CDC37, PIAS4, NR0B1, TMF1, SRY, CCNE1, UBE2I, SMAD4, CALR, SPDEF, PATZ1, ETV5, PA2G4, PIAS1, PIAS3, HMGB1, HMGB2, PRPF6, TRIM24, GTF2F1, GTF2F2, TBP, GTF2H1, MED1, GAPDH, CDC25B, PMEPA1, SMARCA4, SMARCC1, TRIM68, HSPB2, MDM2, WHSC1, MDN1, NLRP10, SMARCA2, ZBTB16, MED24, DENND5A, ZBTB1, MED12L, SMARCD1, SPOP, MLH3, KIFAP3, PHB, SIRT1, HDAC7, ZNF318, SMARCE1, RAD54L2, EP300, ZMIZ2, TGIF1, SREBF1, RUVBL1, KDM5B, SFPQ, GADD45GIP1, ERG, KDM4A, KDM4D, RREB1, SRCAP, TADA3, USP26, RNF6, NELFCD, STUB1, REPS2, KIF1A, RNF40, RNF20, ERCC3, ERCC2, GTF2H2, GTF2H3, CHD8, SETD7, ZBTB7A, E2F1, E2F4, PSMC3, LCOR, LATS2, ZNF451, COPS2, USP10, TAF1, TNK2, DDB2, PAX6, ARID5A, WDR77, TCF20, DCAF6, FKBP5, FKBP4, PPP5C, DNAJC7, PPID, ZBTB32, TAB2, TBL1XR1, SIN3A, SIN3B, PARK7, UBE3A, KDM3A, APPL1, SIAH2, ACTB, JMJD1C, SMAD1, VHL, CUL2, PTGES3, RBL1, USP12, SKP2, REL, WIPI1, NDE1, VCP, DAPK3, AATF, TTC5, KAT2B, IFI16, EZH2, SUZ12, EED, RNF2, BMI1, RELA, PRKG1, MID1, TCF7L2, ELF3, IDE, CDK6, ETS1, KLK3, USP7, HOTAIR, PPP1CA, AHR, WDR20, WDR48, PRPF8, PPP2CA, CACUL1, KDM1A, USP14, SMARCC2, TLE3, GSE1, ARID1A, ARID1B, BCOR, SMARCB1, KMT2D, CHD7, RCOR1, DPF1, RAI1, TFAP2A, PPP2R2A, DPF2, ARID3B, CNBP, ARID5B, NEFL, RPS21, SPATS2L, RCC2, DDX19A, KARS, SUV39H2, BRD4, BRD2, BRD3NR4A3SIX3, KDM5B, TRIM28, COPS5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AR_NR4A3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneARP10275DB00421SpironolactoneAndrogen receptorsmall moleculeapproved
HgeneARP10275DB00623FluphenazineAndrogen receptorsmall moleculeapproved
HgeneARP10275DB00648MitotaneAndrogen receptorsmall moleculeapproved
HgeneARP10275DB00655EstroneAndrogen receptorsmall moleculeapproved
HgeneARP10275DB00675TamoxifenAndrogen receptorsmall moleculeapproved
HgeneARP10275DB01063AcetophenazineAndrogen receptorsmall moleculeapproved
HgeneARP10275DB01128BicalutamideAndrogen receptorsmall moleculeapproved
HgeneARP10275DB01395DrospirenoneAndrogen receptorsmall moleculeapproved
HgeneARP10275DB01406DanazolAndrogen receptorsmall moleculeapproved
HgeneARP10275DB06710MethyltestosteroneAndrogen receptorsmall moleculeapproved
HgeneARP10275DB08867UlipristalAndrogen receptorsmall moleculeapproved
HgeneARP10275DB08899EnzalutamideAndrogen receptorsmall moleculeapproved
HgeneARP10275DB09123DienogestAndrogen receptorsmall moleculeapproved
HgeneARP10275DB09371NorethynodrelAndrogen receptorsmall moleculeapproved
HgeneARP10275DB09389NorgestrelAndrogen receptorsmall moleculeapproved
HgeneARP10275DB11619GestrinoneAndrogen receptorsmall moleculeapproved
HgeneARP10275DB01185FluoxymesteroneAndrogen receptorsmall moleculeapproved|illicit
HgeneARP10275DB06412OxymetholoneAndrogen receptorsmall moleculeapproved|illicit
HgeneARP10275DB00255DiethylstilbestrolAndrogen receptorsmall moleculeapproved|investigational
HgeneARP10275DB00367LevonorgestrelAndrogen receptorsmall moleculeapproved|investigational
HgeneARP10275DB00499FlutamideAndrogen receptorsmall moleculeapproved|investigational
HgeneARP10275DB00621OxandroloneAndrogen receptorsmall moleculeapproved|investigational
HgeneARP10275DB00624TestosteroneAndrogen receptorsmall moleculeapproved|investigational
HgeneARP10275DB00665NilutamideAndrogen receptorsmall moleculeapproved|investigational
HgeneARP10275DB00687FludrocortisoneAndrogen receptorsmall moleculeapproved|investigational
HgeneARP10275DB00957NorgestimateAndrogen receptorsmall moleculeapproved|investigational
HgeneARP10275DB01026KetoconazoleAndrogen receptorsmall moleculeapproved|investigational
HgeneARP10275DB01608PropericiazineAndrogen receptorsmall moleculeapproved|investigational
HgeneARP10275DB04839Cyproterone acetateAndrogen receptorsmall moleculeapproved|investigational
HgeneARP10275DB06713NorelgestrominAndrogen receptorsmall moleculeapproved|investigational
HgeneARP10275DB08604TriclosanAndrogen receptorsmall moleculeapproved|investigational
HgeneARP10275DB01708PrasteroneAndrogen receptorsmall moleculeapproved|investigational|nutraceutical
HgeneARP10275DB00396ProgesteroneAndrogen receptorsmall moleculeapproved|vet_approved
TgeneNR4A3Q92570DB01254DasatinibNuclear receptor subfamily 4 group A member 3small moleculeapproved|investigational

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RelatedDiseases for AR_NR4A3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARC0039585Androgen-Insensitivity Syndrome73CTD_human;ORPHANET;UNIPROT
HgeneARC0268301Reifenstein Syndrome49ORPHANET;UNIPROT
HgeneARC0033578Prostatic Neoplasms20CTD_human
HgeneARC0011570Mental Depression5PSYGENET
HgeneARC0011581Depressive disorder5PSYGENET
HgeneARC0021364Male infertility3CTD_human
HgeneARC0236663Alcohol withdrawal syndrome3PSYGENET
HgeneARC0001973Alcoholic Intoxication, Chronic2PSYGENET
HgeneARC0242788Breast Neoplasms, Male2CTD_human
HgeneARC1458155Mammary Neoplasms2CTD_human
HgeneARC3658267Prostatic Neoplasms, Castration-Resistant2CTD_human
HgeneARC0002170Alopecia1CTD_human
HgeneARC0004114Astrocytoma1CTD_human
HgeneARC0004352Autistic Disorder1CTD_human
HgeneARC0017412Genital Diseases, Male1CTD_human
HgeneARC0020538Hypertensive disease1CTD_human
HgeneARC0021361Female infertility1CTD_human
HgeneARC0021655Insulin Resistance1CTD_human
HgeneARC0023418leukemia1CTD_human
HgeneARC0027643Neoplasm Recurrence, Local1CTD_human
HgeneARC0036341Schizophrenia1PSYGENET
HgeneARC0085207Gestational Diabetes1CTD_human
HgeneARC0282612Prostatic Intraepithelial Neoplasias1CTD_human
HgeneARC0525045Mood Disorders1PSYGENET
HgeneARC0556385Craving for alcohol1PSYGENET
HgeneARC2239176Liver carcinoma1CTD_human
TgeneNR4A3C0003873Rheumatoid Arthritis1CTD_human
TgeneNR4A3C0020443Hypercholesterolemia1CTD_human
TgeneNR4A3C0021655Insulin Resistance1CTD_human
TgeneNR4A3C3495559Juvenile arthritis1CTD_human