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Fusion gene ID: 2878 |
FusionGeneSummary for AR_MRPL16 |
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Fusion gene information | Fusion gene name: AR_MRPL16 | Fusion gene ID: 2878 | Hgene | Tgene | Gene symbol | AR | MRPL16 | Gene ID | 374 | 54948 |
Gene name | amphiregulin | mitochondrial ribosomal protein L16 | |
Synonyms | AR|AREGB|CRDGF|SDGF | L16mt|MRP-L16|PNAS-111 | |
Cytomap | 4q13.3 | 11q12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | amphiregulinamphiregulin Bcolorectum cell-derived growth factorschwannoma-derived growth factor | 39S ribosomal protein L16, mitochondrialmitochondrial large ribosomal subunit protein uL16m | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P10275 | Q9NX20 | |
Ensembl transtripts involved in fusion gene | ENST00000374690, ENST00000513847, ENST00000504326, ENST00000396044, ENST00000396043, | ENST00000300151, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 2 X 1=4 |
# samples | 2 | 2 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: AR [Title/Abstract] AND MRPL16 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | AR | GO:0007173 | epidermal growth factor receptor signaling pathway | 12743035 |
Hgene | AR | GO:0007186 | G-protein coupled receptor signaling pathway | 12743035 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CB163511 | AR | chrX | 66949475 | - | MRPL16 | chr11 | 59573715 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3UTR | ENST00000374690 | ENST00000300151 | AR | chrX | 66949475 | - | MRPL16 | chr11 | 59573715 | - |
intron-3UTR | ENST00000513847 | ENST00000300151 | AR | chrX | 66949475 | - | MRPL16 | chr11 | 59573715 | - |
intron-3UTR | ENST00000504326 | ENST00000300151 | AR | chrX | 66949475 | - | MRPL16 | chr11 | 59573715 | - |
intron-3UTR | ENST00000396044 | ENST00000300151 | AR | chrX | 66949475 | - | MRPL16 | chr11 | 59573715 | - |
intron-3UTR | ENST00000396043 | ENST00000300151 | AR | chrX | 66949475 | - | MRPL16 | chr11 | 59573715 | - |
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FusionProtFeatures for AR_MRPL16 |
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Hgene | Tgene |
AR | MRPL16 |
Steroid hormone receptors are ligand-activatedtranscription factors that regulate eukaryotic gene expression andaffect cellular proliferation and differentiation in targettissues. Transcription factor activity is modulated by boundcoactivator and corepressor proteins. Transcription activation isdown-regulated by NR0B2. Activated, but not phosphorylated, byHIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718,ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767,ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323,ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20980437,ECO:0000269|PubMed:25091737}. Isoform 3 and isoform 4 lack the C-terminal ligand-binding domain and may therefore constitutively activate thetranscription of a specific set of genes independently of steroidhormones. {ECO:0000269|PubMed:19244107}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for AR_MRPL16 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for AR_MRPL16 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AR_MRPL16 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | AR | P10275 | DB00421 | Spironolactone | Androgen receptor | small molecule | approved |
Hgene | AR | P10275 | DB00623 | Fluphenazine | Androgen receptor | small molecule | approved |
Hgene | AR | P10275 | DB00648 | Mitotane | Androgen receptor | small molecule | approved |
Hgene | AR | P10275 | DB00655 | Estrone | Androgen receptor | small molecule | approved |
Hgene | AR | P10275 | DB00675 | Tamoxifen | Androgen receptor | small molecule | approved |
Hgene | AR | P10275 | DB01063 | Acetophenazine | Androgen receptor | small molecule | approved |
Hgene | AR | P10275 | DB01128 | Bicalutamide | Androgen receptor | small molecule | approved |
Hgene | AR | P10275 | DB01395 | Drospirenone | Androgen receptor | small molecule | approved |
Hgene | AR | P10275 | DB01406 | Danazol | Androgen receptor | small molecule | approved |
Hgene | AR | P10275 | DB06710 | Methyltestosterone | Androgen receptor | small molecule | approved |
Hgene | AR | P10275 | DB08867 | Ulipristal | Androgen receptor | small molecule | approved |
Hgene | AR | P10275 | DB08899 | Enzalutamide | Androgen receptor | small molecule | approved |
Hgene | AR | P10275 | DB09123 | Dienogest | Androgen receptor | small molecule | approved |
Hgene | AR | P10275 | DB09371 | Norethynodrel | Androgen receptor | small molecule | approved |
Hgene | AR | P10275 | DB09389 | Norgestrel | Androgen receptor | small molecule | approved |
Hgene | AR | P10275 | DB11619 | Gestrinone | Androgen receptor | small molecule | approved |
Hgene | AR | P10275 | DB01185 | Fluoxymesterone | Androgen receptor | small molecule | approved|illicit |
Hgene | AR | P10275 | DB06412 | Oxymetholone | Androgen receptor | small molecule | approved|illicit |
Hgene | AR | P10275 | DB00255 | Diethylstilbestrol | Androgen receptor | small molecule | approved|investigational |
Hgene | AR | P10275 | DB00367 | Levonorgestrel | Androgen receptor | small molecule | approved|investigational |
Hgene | AR | P10275 | DB00499 | Flutamide | Androgen receptor | small molecule | approved|investigational |
Hgene | AR | P10275 | DB00621 | Oxandrolone | Androgen receptor | small molecule | approved|investigational |
Hgene | AR | P10275 | DB00624 | Testosterone | Androgen receptor | small molecule | approved|investigational |
Hgene | AR | P10275 | DB00665 | Nilutamide | Androgen receptor | small molecule | approved|investigational |
Hgene | AR | P10275 | DB00687 | Fludrocortisone | Androgen receptor | small molecule | approved|investigational |
Hgene | AR | P10275 | DB00957 | Norgestimate | Androgen receptor | small molecule | approved|investigational |
Hgene | AR | P10275 | DB01026 | Ketoconazole | Androgen receptor | small molecule | approved|investigational |
Hgene | AR | P10275 | DB01608 | Propericiazine | Androgen receptor | small molecule | approved|investigational |
Hgene | AR | P10275 | DB04839 | Cyproterone acetate | Androgen receptor | small molecule | approved|investigational |
Hgene | AR | P10275 | DB06713 | Norelgestromin | Androgen receptor | small molecule | approved|investigational |
Hgene | AR | P10275 | DB08604 | Triclosan | Androgen receptor | small molecule | approved|investigational |
Hgene | AR | P10275 | DB01708 | Prasterone | Androgen receptor | small molecule | approved|investigational|nutraceutical |
Hgene | AR | P10275 | DB00396 | Progesterone | Androgen receptor | small molecule | approved|vet_approved |
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RelatedDiseases for AR_MRPL16 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | AR | C0039585 | Androgen-Insensitivity Syndrome | 73 | CTD_human;ORPHANET;UNIPROT |
Hgene | AR | C0268301 | Reifenstein Syndrome | 49 | ORPHANET;UNIPROT |
Hgene | AR | C0033578 | Prostatic Neoplasms | 20 | CTD_human |
Hgene | AR | C0011570 | Mental Depression | 5 | PSYGENET |
Hgene | AR | C0011581 | Depressive disorder | 5 | PSYGENET |
Hgene | AR | C0021364 | Male infertility | 3 | CTD_human |
Hgene | AR | C0236663 | Alcohol withdrawal syndrome | 3 | PSYGENET |
Hgene | AR | C0001973 | Alcoholic Intoxication, Chronic | 2 | PSYGENET |
Hgene | AR | C0242788 | Breast Neoplasms, Male | 2 | CTD_human |
Hgene | AR | C1458155 | Mammary Neoplasms | 2 | CTD_human |
Hgene | AR | C3658267 | Prostatic Neoplasms, Castration-Resistant | 2 | CTD_human |
Hgene | AR | C0002170 | Alopecia | 1 | CTD_human |
Hgene | AR | C0004114 | Astrocytoma | 1 | CTD_human |
Hgene | AR | C0004352 | Autistic Disorder | 1 | CTD_human |
Hgene | AR | C0017412 | Genital Diseases, Male | 1 | CTD_human |
Hgene | AR | C0020538 | Hypertensive disease | 1 | CTD_human |
Hgene | AR | C0021361 | Female infertility | 1 | CTD_human |
Hgene | AR | C0021655 | Insulin Resistance | 1 | CTD_human |
Hgene | AR | C0023418 | leukemia | 1 | CTD_human |
Hgene | AR | C0027643 | Neoplasm Recurrence, Local | 1 | CTD_human |
Hgene | AR | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | AR | C0085207 | Gestational Diabetes | 1 | CTD_human |
Hgene | AR | C0282612 | Prostatic Intraepithelial Neoplasias | 1 | CTD_human |
Hgene | AR | C0525045 | Mood Disorders | 1 | PSYGENET |
Hgene | AR | C0556385 | Craving for alcohol | 1 | PSYGENET |
Hgene | AR | C2239176 | Liver carcinoma | 1 | CTD_human |