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Fusion gene ID: 28750 |
FusionGeneSummary for PRKCI_CCDC88B |
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Fusion gene information | Fusion gene name: PRKCI_CCDC88B | Fusion gene ID: 28750 | Hgene | Tgene | Gene symbol | PRKCI | CCDC88B | Gene ID | 5584 | 283234 |
Gene name | protein kinase C iota | coiled-coil domain containing 88B | |
Synonyms | DXS1179E|PKCI|nPKC-iota | BRLZ|CCDC88|HKRP3|gipie | |
Cytomap | 3q26.2 | 11q13.1 | |
Type of gene | protein-coding | protein-coding | |
Description | protein kinase C iota typePRKC-lambda/iotaaPKC-lambda/iotaatypical protein kinase C-lambda/iota | coiled-coil domain-containing protein 88B78 kDa glucose-regulated protein [GRP78]-interacting protein induced by ER stressGRP78-interacting protein induced by ER stressbrain leucine zipper domain-containing proteinbrain leucine zipper proteincoiled-c | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P41743 | A6NC98 | |
Ensembl transtripts involved in fusion gene | ENST00000295797, | ENST00000463837, ENST00000356786, ENST00000301897, ENST00000359902, | |
Fusion gene scores | * DoF score | 6 X 5 X 4=120 | 4 X 4 X 4=64 |
# samples | 6 | 5 | |
** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PRKCI [Title/Abstract] AND CCDC88B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PRKCI | GO:0006468 | protein phosphorylation | 8226978 |
Hgene | PRKCI | GO:0018105 | peptidyl-serine phosphorylation | 21983565 |
Hgene | PRKCI | GO:0043524 | negative regulation of neuron apoptotic process | 10467349 |
Hgene | PRKCI | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 10467349 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CN412349 | PRKCI | chr3 | 169977847 | + | CCDC88B | chr11 | 64110650 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000295797 | ENST00000463837 | PRKCI | chr3 | 169977847 | + | CCDC88B | chr11 | 64110650 | + |
5CDS-3UTR | ENST00000295797 | ENST00000356786 | PRKCI | chr3 | 169977847 | + | CCDC88B | chr11 | 64110650 | + |
5CDS-intron | ENST00000295797 | ENST00000301897 | PRKCI | chr3 | 169977847 | + | CCDC88B | chr11 | 64110650 | + |
5CDS-intron | ENST00000295797 | ENST00000359902 | PRKCI | chr3 | 169977847 | + | CCDC88B | chr11 | 64110650 | + |
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FusionProtFeatures for PRKCI_CCDC88B |
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Hgene | Tgene |
PRKCI | CCDC88B |
Calcium- and diacylglycerol-independent serine/threonine-protein kinase that plays a general protective roleagainst apoptotic stimuli, is involved in NF-kappa-B activation,cell survival, differentiation and polarity, and contributes tothe regulation of microtubule dynamics in the early secretorypathway. Is necessary for BCR-ABL oncogene-mediated resistance toapoptotic drug in leukemia cells, protecting leukemia cellsagainst drug-induced apoptosis. In cultured neurons, preventsamyloid beta protein-induced apoptosis by interrupting cell deathprocess at a very early step. In glioblastoma cells, may functiondownstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 inthe promotion of cell survival by phosphorylating and inhibitingthe pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 andregulate ECT2 oncogenic activity by phosphorylation, which in turnpromotes transformed growth and invasion. In response to nervegrowth factor (NGF), acts downstream of SRC to phosphorylate andactivate IRAK1, allowing the subsequent activation of NF-kappa-Band neuronal cell survival. Functions in the organization of theapical domain in epithelial cells by phosphorylating EZR. Thisstep is crucial for activation and normal distribution of EZR atthe early stages of intestinal epithelial cell differentiation.Forms a protein complex with LLGL1 and PARD6B independently ofPARD3 to regulate epithelial cell polarity. Plays a role inmicrotubule dynamics in the early secretory pathway throughinteraction with RAB2A and GAPDH and recruitment to vesiculartubular clusters (VTCs). In human coronary artery endothelialcells (HCAEC), is activated by saturated fatty acids and mediateslipid-induced apoptosis. {ECO:0000269|PubMed:10356400,ECO:0000269|PubMed:10467349, ECO:0000269|PubMed:10906326,ECO:0000269|PubMed:11042363, ECO:0000269|PubMed:11724794,ECO:0000269|PubMed:12871960, ECO:0000269|PubMed:14684752,ECO:0000269|PubMed:15994303, ECO:0000269|PubMed:18270268,ECO:0000269|PubMed:19327373, ECO:0000269|PubMed:21189248,ECO:0000269|PubMed:21419810, ECO:0000269|PubMed:8226978,ECO:0000269|PubMed:9346882}. | Acts as a positive regulator of T-cell maturation andinflammatory function. Required for several functions of T-cells,in both the CD4(+) and the CD8(+) compartments and this includesexpression of cell surface markers of activation, proliferation,and cytokine production in response to specific or non-specificstimulation (By similarity). Enhances NK cell cytotoxicity bypositively regulating polarization of microtubule-organizingcenter (MTOC) to cytotoxic synapse, lytic granule transport alongmicrotubules, and dynein-mediated clustering to MTOC(PubMed:25762780). Interacts with HSPA5 and stabilizes theinteraction between HSPA5 and ERN1, leading to suppression ofERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099).{ECO:0000250|UniProtKB:Q4QRL3, ECO:0000269|PubMed:21289099,ECO:0000269|PubMed:25762780}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PRKCI_CCDC88B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PRKCI_CCDC88B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PRKCI | PDPK1, PARD6A, BAD, ADAP1, YWHAZ, RAB4A, SQSTM1, SMG1, GAPDH, PARD3, FRS2, USP21, MARK2, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B, SFPQ, VHL, CHUK, IKBKB, DUSP1, YWHAH, MARK4, PARD6B, PARD6G, GBAS, LLGL1, HSP90AA1, LLGL2, CDC37, NIPSNAP1, RAPGEF2, MYO10, PNMA1, FABP4, TTR, TSC22D1, MBP, CDK7, ELAVL1, TJP1, ARHGAP17, MAP2K5, APP, YWHAE, GAB1, NPM1, CRX, CASP8, IL1RAP, IKBKG, AMOT, PRKCZ, RHOJ, RASSF8, KIF23, PPM1A, PPM1B, CEP135, TMEM17, XPO1, SSB, MAGED2, ZNF609, TMEM208, EIF4ENIF1, TRAPPC13, MASTL, SMURF1, MTMR4, FYN, NGEF, KBTBD7, GPR156, FARP2, CD44, FGB, ARHGEF16, KERA, PDGFD, UBC, DCAF7, TRIM25, WWC1 | CCDC88B | PLEKHA5, SRPK2, CDC73 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PRKCI_CCDC88B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PRKCI_CCDC88B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PRKCI | C0005586 | Bipolar Disorder | 2 | PSYGENET |
Hgene | PRKCI | C0011570 | Mental Depression | 1 | PSYGENET |
Hgene | PRKCI | C0011581 | Depressive disorder | 1 | PSYGENET |
Tgene | CCDC88B | C0023343 | Leprosy | 1 | CTD_human |