FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 28743

FusionGeneSummary for PRKCE_GPR126

check button Fusion gene summary
Fusion gene informationFusion gene name: PRKCE_GPR126
Fusion gene ID: 28743
HgeneTgene
Gene symbol

PRKCE

GPR126

Gene ID

5581

57211

Gene nameprotein kinase C epsilonadhesion G protein-coupled receptor G6
SynonymsPKCE|nPKC-epsilonAPG1|DREG|GPR126|LCCS9|PR126|PS1TP2|VIGR
Cytomap

2p21

6q24.2

Type of geneprotein-codingprotein-coding
Descriptionprotein kinase C epsilon typeadhesion G-protein coupled receptor G6G-protein coupled receptor 126HBV PreS1-transactivated protein 2developmentally regulated G-protein-coupled receptorvascular-inducible G protein-coupled receptor
Modification date2018052320180523
UniProtAcc

Q02156

Ensembl transtripts involved in fusion geneENST00000306156, ENST00000467135, 
ENST00000394874, 		ENST00000230173, 
ENST00000367608, ENST00000296932, 
ENST00000367609, ENST00000545477, 
Fusion gene scores* DoF score3 X 4 X 3=362 X 2 X 2=8
# samples 52
** MAII scorelog2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/8*10)=1.32192809488736
Context

PubMed: PRKCE [Title/Abstract] AND GPR126 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRKCE

GO:0006468

protein phosphorylation

18556656

HgenePRKCE

GO:0018105

peptidyl-serine phosphorylation

15695813


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-EB-A6L9-06APRKCEchr2

46070202

+GPR126chr6

142758571

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000306156ENST00000230173PRKCEchr2

46070202

+GPR126chr6

142758571

+
In-frameENST00000306156ENST00000367608PRKCEchr2

46070202

+GPR126chr6

142758571

+
In-frameENST00000306156ENST00000296932PRKCEchr2

46070202

+GPR126chr6

142758571

+
In-frameENST00000306156ENST00000367609PRKCEchr2

46070202

+GPR126chr6

142758571

+
5CDS-intronENST00000306156ENST00000545477PRKCEchr2

46070202

+GPR126chr6

142758571

+
3UTR-3CDSENST00000467135ENST00000230173PRKCEchr2

46070202

+GPR126chr6

142758571

+
3UTR-3CDSENST00000467135ENST00000367608PRKCEchr2

46070202

+GPR126chr6

142758571

+
3UTR-3CDSENST00000467135ENST00000296932PRKCEchr2

46070202

+GPR126chr6

142758571

+
3UTR-3CDSENST00000467135ENST00000367609PRKCEchr2

46070202

+GPR126chr6

142758571

+
3UTR-intronENST00000467135ENST00000545477PRKCEchr2

46070202

+GPR126chr6

142758571

+
intron-3CDSENST00000394874ENST00000230173PRKCEchr2

46070202

+GPR126chr6

142758571

+
intron-3CDSENST00000394874ENST00000367608PRKCEchr2

46070202

+GPR126chr6

142758571

+
intron-3CDSENST00000394874ENST00000296932PRKCEchr2

46070202

+GPR126chr6

142758571

+
intron-3CDSENST00000394874ENST00000367609PRKCEchr2

46070202

+GPR126chr6

142758571

+
intron-intronENST00000394874ENST00000545477PRKCEchr2

46070202

+GPR126chr6

142758571

+

Top

FusionProtFeatures for PRKCE_GPR126


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRKCE

Q02156

GPR126

Calcium-independent, phospholipid- and diacylglycerol(DAG)-dependent serine/threonine-protein kinase that playsessential roles in the regulation of multiple cellular processeslinked to cytoskeletal proteins, such as cell adhesion, motility,migration and cell cycle, functions in neuron growth and ionchannel regulation, and is involved in immune response, cancercell invasion and regulation of apoptosis. Mediates cell adhesionto the extracellular matrix via integrin-dependent signaling, bymediating angiotensin-2-induced activation of integrin beta-1(ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, whichphosphorylates and activates PTK2/FAK, leading to the spread ofcardiomyocytes. Involved in the control of the directionaltransport of ITGB1 in mesenchymal cells by phosphorylatingvimentin (VIM), an intermediate filament (IF) protein. Inepithelial cells, associates with and phosphorylates keratin-8(KRT8), which induces targeting of desmoplakin at desmosomes andregulates cell-cell contact. Phosphorylates IQGAP1, which binds toCDC42, mediating epithelial cell-cell detachment prior tomigration. In HeLa cells, contributes to hepatocyte growth factor(HGF)-induced cell migration, and in human corneal epithelialcells, plays a critical role in wound healing after activation byHGF. During cytokinesis, forms a complex with YWHAB, which iscrucial for daughter cell separation, and facilitates abscissionby a mechanism which may implicate the regulation of RHOA. Incardiac myocytes, regulates myofilament function and excitationcoupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-inducedcardiomyocyte hypertrophy, mediates activation of PTK2/FAK, whichis critical for cardiomyocyte survival and regulation of sarcomerelength. Plays a role in the pathogenesis of dilated cardiomyopathyvia persistent phosphorylation of troponin I (TNNI3). Involved innerve growth factor (NFG)-induced neurite outgrowth and neuronmorphological change independently of its kinase activity, byinhibition of RHOA pathway, activation of CDC42 and cytoskeletalrearrangement. May be involved in presynaptic facilitation bymediating phorbol ester-induced synaptic potentiation.Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2(GABRG2), which reduces the response of GABA receptors to ethanoland benzodiazepines and may mediate acute tolerance to theintoxicating effects of ethanol. Upon PMA treatment,phosphorylates the capsaicin- and heat-activated cation channelTRPV1, which is required for bradykinin-induced sensitization ofthe heat response in nociceptive neurons. Is able to form acomplex with PDLIM5 and N-type calcium channel, and may enhancechannel activities and potentiates fast synaptic transmission byphosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2).In prostate cancer cells, interacts with and phosphorylates STAT3,which increases DNA-binding and transcriptional activity of STAT3and seems to be essential for prostate cancer cell invasion.Downstream of TLR4, plays an important role in thelipopolysaccharide (LPS)-induced immune response byphosphorylating and activating TICAM2/TRAM, which in turnactivates the transcription factor IRF3 and subsequent cytokinesproduction. In differentiating erythroid progenitors, is regulatedby EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation ofthe insulin-induced phosphorylation and activation of AKT1.{ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:1374067,ECO:0000269|PubMed:15355962, ECO:0000269|PubMed:16757566,ECO:0000269|PubMed:17603037, ECO:0000269|PubMed:17875639,ECO:0000269|PubMed:17875724}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRKCEchr2:46070202chr6:142758571ENST00000306156+2151_99137738DomainC2
TgeneGPR126chr2:46070202chr6:142758571ENST00000230173+21261153_120511061222Compositional biasNote=Ser-rich
TgeneGPR126chr2:46070202chr6:142758571ENST00000296932+20251153_120510781194Compositional biasNote=Ser-rich
TgeneGPR126chr2:46070202chr6:142758571ENST00000367608+20241153_120510781223Compositional biasNote=Ser-rich
TgeneGPR126chr2:46070202chr6:142758571ENST00000367609+21251153_120511061251Compositional biasNote=Ser-rich
TgeneGPR126chr2:46070202chr6:142758571ENST00000230173+21261114_122111061222Topological domainCytoplasmic
TgeneGPR126chr2:46070202chr6:142758571ENST00000296932+20251091_109210781194Topological domainExtracellular
TgeneGPR126chr2:46070202chr6:142758571ENST00000296932+20251114_122110781194Topological domainCytoplasmic
TgeneGPR126chr2:46070202chr6:142758571ENST00000367608+20241091_109210781223Topological domainExtracellular
TgeneGPR126chr2:46070202chr6:142758571ENST00000367608+20241114_122110781223Topological domainCytoplasmic
TgeneGPR126chr2:46070202chr6:142758571ENST00000367609+21251114_122111061251Topological domainCytoplasmic
TgeneGPR126chr2:46070202chr6:142758571ENST00000296932+20251093_111310781194TransmembraneHelical%3B Name%3D7
TgeneGPR126chr2:46070202chr6:142758571ENST00000367608+20241093_111310781223TransmembraneHelical%3B Name%3D7

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRKCEchr2:46070202chr6:142758571ENST00000306156+215408_668137738DomainProtein kinase
HgenePRKCEchr2:46070202chr6:142758571ENST00000306156+215669_737137738DomainNote=AGC-kinase C-terminal
HgenePRKCEchr2:46070202chr6:142758571ENST00000306156+215414_422137738Nucleotide bindingATP
HgenePRKCEchr2:46070202chr6:142758571ENST00000306156+215169_220137738Zinc fingerPhorbol-ester/DAG-type 1
HgenePRKCEchr2:46070202chr6:142758571ENST00000306156+215242_292137738Zinc fingerPhorbol-ester/DAG-type 2
TgeneGPR126chr2:46070202chr6:142758571ENST00000230173+2126154_35611061222DomainPentraxin (PTX)
TgeneGPR126chr2:46070202chr6:142758571ENST00000230173+212641_14911061222DomainCUB
TgeneGPR126chr2:46070202chr6:142758571ENST00000230173+2126800_85211061222DomainGPS
TgeneGPR126chr2:46070202chr6:142758571ENST00000296932+2025154_35610781194DomainPentraxin (PTX)
TgeneGPR126chr2:46070202chr6:142758571ENST00000296932+202541_14910781194DomainCUB
TgeneGPR126chr2:46070202chr6:142758571ENST00000296932+2025800_85210781194DomainGPS
TgeneGPR126chr2:46070202chr6:142758571ENST00000367608+2024154_35610781223DomainPentraxin (PTX)
TgeneGPR126chr2:46070202chr6:142758571ENST00000367608+202441_14910781223DomainCUB
TgeneGPR126chr2:46070202chr6:142758571ENST00000367608+2024800_85210781223DomainGPS
TgeneGPR126chr2:46070202chr6:142758571ENST00000367609+2125154_35611061251DomainPentraxin (PTX)
TgeneGPR126chr2:46070202chr6:142758571ENST00000367609+212541_14911061251DomainCUB
TgeneGPR126chr2:46070202chr6:142758571ENST00000367609+2125800_85211061251DomainGPS
TgeneGPR126chr2:46070202chr6:142758571ENST00000230173+2126842_85011061222MotifStachel
TgeneGPR126chr2:46070202chr6:142758571ENST00000296932+2025842_85010781194MotifStachel
TgeneGPR126chr2:46070202chr6:142758571ENST00000367608+2024842_85010781223MotifStachel
TgeneGPR126chr2:46070202chr6:142758571ENST00000367609+2125842_85011061251MotifStachel
TgeneGPR126chr2:46070202chr6:142758571ENST00000230173+212641_85211061222RegionInhibits receptor signaling in absence of type IV collagen
TgeneGPR126chr2:46070202chr6:142758571ENST00000296932+202541_85210781194RegionInhibits receptor signaling in absence of type IV collagen
TgeneGPR126chr2:46070202chr6:142758571ENST00000367608+202441_85210781223RegionInhibits receptor signaling in absence of type IV collagen
TgeneGPR126chr2:46070202chr6:142758571ENST00000367609+212541_85211061251RegionInhibits receptor signaling in absence of type IV collagen
TgeneGPR126chr2:46070202chr6:142758571ENST00000230173+21261046_106911061222Topological domainCytoplasmic
TgeneGPR126chr2:46070202chr6:142758571ENST00000230173+21261091_109211061222Topological domainExtracellular
TgeneGPR126chr2:46070202chr6:142758571ENST00000230173+212638_86211061222Topological domainExtracellular
TgeneGPR126chr2:46070202chr6:142758571ENST00000230173+2126884_90311061222Topological domainCytoplasmic
TgeneGPR126chr2:46070202chr6:142758571ENST00000230173+2126925_92911061222Topological domainExtracellular
TgeneGPR126chr2:46070202chr6:142758571ENST00000230173+2126951_97011061222Topological domainCytoplasmic
TgeneGPR126chr2:46070202chr6:142758571ENST00000230173+2126992_102411061222Topological domainExtracellular
TgeneGPR126chr2:46070202chr6:142758571ENST00000296932+20251046_106910781194Topological domainCytoplasmic
TgeneGPR126chr2:46070202chr6:142758571ENST00000296932+202538_86210781194Topological domainExtracellular
TgeneGPR126chr2:46070202chr6:142758571ENST00000296932+2025884_90310781194Topological domainCytoplasmic
TgeneGPR126chr2:46070202chr6:142758571ENST00000296932+2025925_92910781194Topological domainExtracellular
TgeneGPR126chr2:46070202chr6:142758571ENST00000296932+2025951_97010781194Topological domainCytoplasmic
TgeneGPR126chr2:46070202chr6:142758571ENST00000296932+2025992_102410781194Topological domainExtracellular
TgeneGPR126chr2:46070202chr6:142758571ENST00000367608+20241046_106910781223Topological domainCytoplasmic
TgeneGPR126chr2:46070202chr6:142758571ENST00000367608+202438_86210781223Topological domainExtracellular
TgeneGPR126chr2:46070202chr6:142758571ENST00000367608+2024884_90310781223Topological domainCytoplasmic
TgeneGPR126chr2:46070202chr6:142758571ENST00000367608+2024925_92910781223Topological domainExtracellular
TgeneGPR126chr2:46070202chr6:142758571ENST00000367608+2024951_97010781223Topological domainCytoplasmic
TgeneGPR126chr2:46070202chr6:142758571ENST00000367608+2024992_102410781223Topological domainExtracellular
TgeneGPR126chr2:46070202chr6:142758571ENST00000367609+21251046_106911061251Topological domainCytoplasmic
TgeneGPR126chr2:46070202chr6:142758571ENST00000367609+21251091_109211061251Topological domainExtracellular
TgeneGPR126chr2:46070202chr6:142758571ENST00000367609+212538_86211061251Topological domainExtracellular
TgeneGPR126chr2:46070202chr6:142758571ENST00000367609+2125884_90311061251Topological domainCytoplasmic
TgeneGPR126chr2:46070202chr6:142758571ENST00000367609+2125925_92911061251Topological domainExtracellular
TgeneGPR126chr2:46070202chr6:142758571ENST00000367609+2125951_97011061251Topological domainCytoplasmic
TgeneGPR126chr2:46070202chr6:142758571ENST00000367609+2125992_102411061251Topological domainExtracellular
TgeneGPR126chr2:46070202chr6:142758571ENST00000230173+21261025_104511061222TransmembraneHelical%3B Name%3D5
TgeneGPR126chr2:46070202chr6:142758571ENST00000230173+21261070_109011061222TransmembraneHelical%3B Name%3D6
TgeneGPR126chr2:46070202chr6:142758571ENST00000230173+21261093_111311061222TransmembraneHelical%3B Name%3D7
TgeneGPR126chr2:46070202chr6:142758571ENST00000230173+2126863_88311061222TransmembraneHelical%3B Name%3D1
TgeneGPR126chr2:46070202chr6:142758571ENST00000230173+2126904_92411061222TransmembraneHelical%3B Name%3D2
TgeneGPR126chr2:46070202chr6:142758571ENST00000230173+2126930_95011061222TransmembraneHelical%3B Name%3D3
TgeneGPR126chr2:46070202chr6:142758571ENST00000230173+2126971_99111061222TransmembraneHelical%3B Name%3D4
TgeneGPR126chr2:46070202chr6:142758571ENST00000296932+20251025_104510781194TransmembraneHelical%3B Name%3D5
TgeneGPR126chr2:46070202chr6:142758571ENST00000296932+20251070_109010781194TransmembraneHelical%3B Name%3D6
TgeneGPR126chr2:46070202chr6:142758571ENST00000296932+2025863_88310781194TransmembraneHelical%3B Name%3D1
TgeneGPR126chr2:46070202chr6:142758571ENST00000296932+2025904_92410781194TransmembraneHelical%3B Name%3D2
TgeneGPR126chr2:46070202chr6:142758571ENST00000296932+2025930_95010781194TransmembraneHelical%3B Name%3D3
TgeneGPR126chr2:46070202chr6:142758571ENST00000296932+2025971_99110781194TransmembraneHelical%3B Name%3D4
TgeneGPR126chr2:46070202chr6:142758571ENST00000367608+20241025_104510781223TransmembraneHelical%3B Name%3D5
TgeneGPR126chr2:46070202chr6:142758571ENST00000367608+20241070_109010781223TransmembraneHelical%3B Name%3D6
TgeneGPR126chr2:46070202chr6:142758571ENST00000367608+2024863_88310781223TransmembraneHelical%3B Name%3D1
TgeneGPR126chr2:46070202chr6:142758571ENST00000367608+2024904_92410781223TransmembraneHelical%3B Name%3D2
TgeneGPR126chr2:46070202chr6:142758571ENST00000367608+2024930_95010781223TransmembraneHelical%3B Name%3D3
TgeneGPR126chr2:46070202chr6:142758571ENST00000367608+2024971_99110781223TransmembraneHelical%3B Name%3D4
TgeneGPR126chr2:46070202chr6:142758571ENST00000367609+21251025_104511061251TransmembraneHelical%3B Name%3D5
TgeneGPR126chr2:46070202chr6:142758571ENST00000367609+21251070_109011061251TransmembraneHelical%3B Name%3D6
TgeneGPR126chr2:46070202chr6:142758571ENST00000367609+21251093_111311061251TransmembraneHelical%3B Name%3D7
TgeneGPR126chr2:46070202chr6:142758571ENST00000367609+2125863_88311061251TransmembraneHelical%3B Name%3D1
TgeneGPR126chr2:46070202chr6:142758571ENST00000367609+2125904_92411061251TransmembraneHelical%3B Name%3D2
TgeneGPR126chr2:46070202chr6:142758571ENST00000367609+2125930_95011061251TransmembraneHelical%3B Name%3D3
TgeneGPR126chr2:46070202chr6:142758571ENST00000367609+2125971_99111061251TransmembraneHelical%3B Name%3D4


Top

FusionGeneSequence for PRKCE_GPR126


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PRKCE_ENST00000306156_chr2_46070202_+_GPR126_ENST00000230173_chr6_142758571_+_253aa
MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKTNSPAWHDEFVTDVCNGRKIELAVFHDAPIG
YDDFVANCTIQFEELLQNGSRHFEDWIDLEPEGRVYVIIDLSGSSGEGLFIFIFHCAMKENVQKQWRQHLCCGRFRLADNSDWSKTATNI

>In-frame_PRKCE_ENST00000306156_chr2_46070202_+_GPR126_ENST00000367608_chr6_142758571_+_282aa
MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKTNSPAWHDEFVTDVCNGRKIELAVFHDAPIG
YDDFVANCTIQFEELLQNGSRHFEDWIDLEPEGRVYVIIDLSGSSGEGLFIFIFHCAMKENVQKQWRQHLCCGRFRLADNSDWSKTATNI
IKKSSDNLGKSLSSSSIGSNSTYLTSKSKSSSTTYFKRNSHTDSASMDKSLSKLAHADGDQTSIIPVHQVIDKVKGYCNAHSDNFYKNII

>In-frame_PRKCE_ENST00000306156_chr2_46070202_+_GPR126_ENST00000296932_chr6_142758571_+_253aa
MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKTNSPAWHDEFVTDVCNGRKIELAVFHDAPIG
YDDFVANCTIQFEELLQNGSRHFEDWIDLEPEGRVYVIIDLSGSSGEGLFIFIFHCAMKENVQKQWRQHLCCGRFRLADNSDWSKTATNI

>In-frame_PRKCE_ENST00000306156_chr2_46070202_+_GPR126_ENST00000367609_chr6_142758571_+_282aa
MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKTNSPAWHDEFVTDVCNGRKIELAVFHDAPIG
YDDFVANCTIQFEELLQNGSRHFEDWIDLEPEGRVYVIIDLSGSSGEGLFIFIFHCAMKENVQKQWRQHLCCGRFRLADNSDWSKTATNI
IKKSSDNLGKSLSSSSIGSNSTYLTSKSKSSSTTYFKRNSHTDSASMDKSLSKLAHADGDQTSIIPVHQVIDKVKGYCNAHSDNFYKNII


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PRKCE_ENST00000306156_chr2_46070202_+_GPR126_ENST00000230173_chr6_142758571_+_759nt
ATGGTAGTGTTCAATGGCCTTCTTAAGATCAAAATCTGCGAGGCCGTGAGCTTGAAGCCCACAGCCTGGTCGCTGCGCCATGCGGTGGGA
CCCCGGCCGCAGACTTTCCTTCTCGACCCCTACATTGCCCTCAATGTGGACGACTCGCGCATCGGCCAAACGGCCACCAAGCAGAAGACC
AACAGCCCGGCCTGGCACGACGAGTTCGTCACCGATGTGTGCAACGGACGCAAGATCGAGCTGGCTGTCTTTCACGATGCCCCCATAGGC
TACGACGACTTCGTGGCCAACTGCACCATCCAGTTTGAGGAGCTGCTGCAGAACGGGAGCCGCCACTTCGAGGACTGGATTGATCTGGAG
CCAGAAGGAAGAGTGTATGTGATCATCGATCTCTCAGGGTCGTCGGGTGAAGGCTTATTTATATTCATCTTCCACTGTGCTATGAAGGAG
AATGTTCAGAAACAGTGGCGGCAGCATCTCTGCTGTGGTAGATTTCGGTTAGCAGATAACTCAGATTGGAGTAAGACAGCTACCAATATC
ATCAAGAAAAGTTCTGATAATCTAGGAAAATCTTTGTCTTCAAGCTCCATTGGTTCCAACTCAACCTATCTTACATCCAAATCTAAATCC
AGCTCTACCACCTATTTCAAAAGGAATAGCCACACAGATAATGTCTCCTATGAGCATTCCTTCAACAAAAGTGGATCACTCAGACAGTGC

>In-frame_PRKCE_ENST00000306156_chr2_46070202_+_GPR126_ENST00000367608_chr6_142758571_+_846nt
ATGGTAGTGTTCAATGGCCTTCTTAAGATCAAAATCTGCGAGGCCGTGAGCTTGAAGCCCACAGCCTGGTCGCTGCGCCATGCGGTGGGA
CCCCGGCCGCAGACTTTCCTTCTCGACCCCTACATTGCCCTCAATGTGGACGACTCGCGCATCGGCCAAACGGCCACCAAGCAGAAGACC
AACAGCCCGGCCTGGCACGACGAGTTCGTCACCGATGTGTGCAACGGACGCAAGATCGAGCTGGCTGTCTTTCACGATGCCCCCATAGGC
TACGACGACTTCGTGGCCAACTGCACCATCCAGTTTGAGGAGCTGCTGCAGAACGGGAGCCGCCACTTCGAGGACTGGATTGATCTGGAG
CCAGAAGGAAGAGTGTATGTGATCATCGATCTCTCAGGGTCGTCGGGTGAAGGCTTATTTATATTCATCTTCCACTGTGCTATGAAGGAG
AATGTTCAGAAACAGTGGCGGCAGCATCTCTGCTGTGGTAGATTTCGGTTAGCAGATAACTCAGATTGGAGTAAGACAGCTACCAATATC
ATCAAGAAAAGTTCTGATAATCTAGGAAAATCTTTGTCTTCAAGCTCCATTGGTTCCAACTCAACCTATCTTACATCCAAATCTAAATCC
AGCTCTACCACCTATTTCAAAAGGAATAGCCACACAGACAGTGCTTCCATGGACAAGTCCTTGTCAAAACTGGCCCATGCTGATGGAGAT
CAAACATCAATCATCCCTGTCCATCAGGTCATTGATAAGGTCAAGGGTTATTGCAATGCTCATTCAGACAACTTCTATAAAAATATTATC

>In-frame_PRKCE_ENST00000306156_chr2_46070202_+_GPR126_ENST00000296932_chr6_142758571_+_759nt
ATGGTAGTGTTCAATGGCCTTCTTAAGATCAAAATCTGCGAGGCCGTGAGCTTGAAGCCCACAGCCTGGTCGCTGCGCCATGCGGTGGGA
CCCCGGCCGCAGACTTTCCTTCTCGACCCCTACATTGCCCTCAATGTGGACGACTCGCGCATCGGCCAAACGGCCACCAAGCAGAAGACC
AACAGCCCGGCCTGGCACGACGAGTTCGTCACCGATGTGTGCAACGGACGCAAGATCGAGCTGGCTGTCTTTCACGATGCCCCCATAGGC
TACGACGACTTCGTGGCCAACTGCACCATCCAGTTTGAGGAGCTGCTGCAGAACGGGAGCCGCCACTTCGAGGACTGGATTGATCTGGAG
CCAGAAGGAAGAGTGTATGTGATCATCGATCTCTCAGGGTCGTCGGGTGAAGGCTTATTTATATTCATCTTCCACTGTGCTATGAAGGAG
AATGTTCAGAAACAGTGGCGGCAGCATCTCTGCTGTGGTAGATTTCGGTTAGCAGATAACTCAGATTGGAGTAAGACAGCTACCAATATC
ATCAAGAAAAGTTCTGATAATCTAGGAAAATCTTTGTCTTCAAGCTCCATTGGTTCCAACTCAACCTATCTTACATCCAAATCTAAATCC
AGCTCTACCACCTATTTCAAAAGGAATAGCCACACAGATAATGTCTCCTATGAGCATTCCTTCAACAAAAGTGGATCACTCAGACAGTGC

>In-frame_PRKCE_ENST00000306156_chr2_46070202_+_GPR126_ENST00000367609_chr6_142758571_+_846nt
ATGGTAGTGTTCAATGGCCTTCTTAAGATCAAAATCTGCGAGGCCGTGAGCTTGAAGCCCACAGCCTGGTCGCTGCGCCATGCGGTGGGA
CCCCGGCCGCAGACTTTCCTTCTCGACCCCTACATTGCCCTCAATGTGGACGACTCGCGCATCGGCCAAACGGCCACCAAGCAGAAGACC
AACAGCCCGGCCTGGCACGACGAGTTCGTCACCGATGTGTGCAACGGACGCAAGATCGAGCTGGCTGTCTTTCACGATGCCCCCATAGGC
TACGACGACTTCGTGGCCAACTGCACCATCCAGTTTGAGGAGCTGCTGCAGAACGGGAGCCGCCACTTCGAGGACTGGATTGATCTGGAG
CCAGAAGGAAGAGTGTATGTGATCATCGATCTCTCAGGGTCGTCGGGTGAAGGCTTATTTATATTCATCTTCCACTGTGCTATGAAGGAG
AATGTTCAGAAACAGTGGCGGCAGCATCTCTGCTGTGGTAGATTTCGGTTAGCAGATAACTCAGATTGGAGTAAGACAGCTACCAATATC
ATCAAGAAAAGTTCTGATAATCTAGGAAAATCTTTGTCTTCAAGCTCCATTGGTTCCAACTCAACCTATCTTACATCCAAATCTAAATCC
AGCTCTACCACCTATTTCAAAAGGAATAGCCACACAGACAGTGCTTCCATGGACAAGTCCTTGTCAAAACTGGCCCATGCTGATGGAGAT
CAAACATCAATCATCCCTGTCCATCAGGTCATTGATAAGGTCAAGGGTTATTGCAATGCTCATTCAGACAACTTCTATAAAAATATTATC


* Fusion transcript sequences (Full-length transcript).
>In-frame_PRKCE_ENST00000306156_chr2_46070202_+_GPR126_ENST00000230173_chr6_142758571_+_3970nt
CAGCCCCCGCGGCTTGCAGCGGAGCCGACAGCTCGTCTTCTCTTCTGGAGGTGCAGCTGGTGGTCGGGGGGAGAGACTTGCTCCAAACAC
GGACATCCCCCAGCTCTCCCCCCTCCCTGTTTTCCGTTAGGAACCCGGCGAGGAAATACATGCACTGGCTGAGAATCGCCCGCGCCAGGG
CGCAACGCCACAAGGTGTAGGGAGTGTGCGGGGTGGGGCGAAAGGGGACCCAAGAGTCCCTGTGGCTCGGAGTGCCGGGCCGTCGGTTCT
TCATTCCTGCCCTCGGGGCAGACGGAGTGACCCCGGCCCCCACTCCCCGCCCCGACCATGGTAGTGTTCAATGGCCTTCTTAAGATCAAA
ATCTGCGAGGCCGTGAGCTTGAAGCCCACAGCCTGGTCGCTGCGCCATGCGGTGGGACCCCGGCCGCAGACTTTCCTTCTCGACCCCTAC
ATTGCCCTCAATGTGGACGACTCGCGCATCGGCCAAACGGCCACCAAGCAGAAGACCAACAGCCCGGCCTGGCACGACGAGTTCGTCACC
GATGTGTGCAACGGACGCAAGATCGAGCTGGCTGTCTTTCACGATGCCCCCATAGGCTACGACGACTTCGTGGCCAACTGCACCATCCAG
TTTGAGGAGCTGCTGCAGAACGGGAGCCGCCACTTCGAGGACTGGATTGATCTGGAGCCAGAAGGAAGAGTGTATGTGATCATCGATCTC
TCAGGGTCGTCGGGTGAAGGCTTATTTATATTCATCTTCCACTGTGCTATGAAGGAGAATGTTCAGAAACAGTGGCGGCAGCATCTCTGC
TGTGGTAGATTTCGGTTAGCAGATAACTCAGATTGGAGTAAGACAGCTACCAATATCATCAAGAAAAGTTCTGATAATCTAGGAAAATCT
TTGTCTTCAAGCTCCATTGGTTCCAACTCAACCTATCTTACATCCAAATCTAAATCCAGCTCTACCACCTATTTCAAAAGGAATAGCCAC
ACAGATAATGTCTCCTATGAGCATTCCTTCAACAAAAGTGGATCACTCAGACAGTGCTTCCATGGACAAGTCCTTGTCAAAACTGGCCCA
TGCTGATGGAGATCAAACATCAATCATCCCTGTCCATCAGGTCATTGATAAGGTCAAGGGTTATTGCAATGCTCATTCAGACAACTTCTA
TAAAAATATTATCATGTCAGACACCTTCAGCCACAGCACAAAGTTTTAATGTCTTTAAGAAAAAGAAATCAATCTGCAGAAATGTGAAGA
TTTGCAAGCAGTGTAAACTGCAACTAGTGATGTAAATGTGCTATTACCTAGGTAACTGCATATATATAAGGAATGTATTTTGTTAAGAAG
GCTTTTGTGAAATTCAGAATTTTTCTTTTTAATATATTTCTTCCATGGAAGAGTTGTCATCACTAAAACTTCAGTACTGAGAGTAACATG
ACTCAGTAGCCACAGAAGCTATGATTTGTAAAATATATAATTGAATCAGAGTAATCATAATGCAGGGGAGACATTCAAATTAGAGACAAG
GGAGAAGCAATGCTGAGGAAGACCCTAGATAGAGCTCATTTTACTCCACCTAATCGTTATATCTGGATATACCCATTTTCTGCATCTTCT
TTCTCAACAATAAAAAATGTAACTATTTTGAATGCCCACAAATCCCATTCCAGTGTTACTTTCTGTGAATGCAGTACCATATTCTCATTT
TCAATGACATTTCAACCACAGGCAGAAAAGACTGTTTACTCCTTGACCCAAAGATTAAAAAGGATTTTTTATTATTTTAAATATTACACC
TTCAGAACCATAACATGCTTAAGAAAACTTTCCCAAAATGTTGACCTAGTTAAATGAGGCTATATAAATTTCTAATATTTTACTTATTCT
ATTCAAGGCATAGGGCCAAAGCATTAAGTATAATTTAATCCCATACATTCGAGTTAAGTTTAGTGTTGATGTTCCATCATTCTGGACCTC
CCAGGAGTTGTTTAAGAATGAATCTCTTACACCTCTACTTTTGCCCCTCTACTGTATATTAAGCCCATAGGCTTGTGGGAGGAAGGAGAA
TTTCCATTAGGCAAGCTGTATGCAGTGGAATTTTCCTTTTAGGAGACACACAATTAAGACTCTCTGGTTCTGTCCTTGCTTTGGAGACTT
TAAGACATTTCCTAAAGCACAAATAAAAGCCTCGTATTTCCCCATTGAGAGTTTTGTTCCAAGGAATATGAAGTGAGACATATGGGTGAG
TCATAATAATCAAAATAATTTATGAAGAGCTGGGTCTGCAATAGCTAGTCTAAAAACTACTTGTGTGTCAGTCCTCTGGTTATAGTATAT
AAGAGCCTGAGGAGGTCTGGCAAGATAGATGGTGTATTATTTATGGATCAGGCTGCTGCATACAAACCTTGCATACTATTATGCAGCTTA
CCTAACTCTCAGACTATTCTGAGTAATGCTTGCTTGCTAATGAATGTATAGGAGACCACATTGTAATTGTTCTTAGATGATGGAGTCCAT
GCAGTTTCTTAGAAATCGGTCTCAGTGCATGCTGTGCTTTTTCACATTTGCTCTGGGTTATCTGGGAAGTATCAGGTTCTGGGAGGCAAC
AGCATTAAGTGATAAGAAAAGGAGACATTCTGGCAAAGCCAATCTGCTTAAAGGCAAAGTCCAGAACCTGGAACCTAGAGGCCTTTCTCT
CTGCACGAAAAACAGGTAGTTTGCAGTCTGAGATATGGGAGAGCTTTTAGGCTACACAGCAACCCAAGGGACCTCTCACCTTTTGCTGAG
CTTCAATCAGGAAGCTATTTGCCTGGCTCCAGCAGATGATGAGATAATGAGGTAGTGGGTTTTTTATTACTGTTCCATTTTGCAACATCC
TGCAACACCATCCTGGGAGACAAGAGCATTACCCAGCTTGGCTTTCACGGGGGAGGGTTGTATTCAGTAAAAAAGAATAGTAAATATAAG
GTCACTGAGATTCTAAGTAAGATAGTAAATCTAAGGTCACTGAGCCAAATCCTTTTCAATAGGCATATATTAACAGGCTGCTTATTTTGG
CGGAGGTTACATATGGATGAAAATGAATCTTAGTCACTGAATATTCATATACATTTCCCCCAAAACCTTAGACATTCATAGTAGATTTTA
ATTAGTTAGCTTTCTAACTAGTCAGATTTCTGCCCAAAGTGCTTAGTCAATAGTAATTAAGATATAGCTTCAAAAATGGCTTTGCTTTTG
ATTTCTACTCATATTCGTATGGCTCCAGAAAAATATTTTTTTCATATTTGACAATGTCAGCTCCACTTTAGAAATTTTCAATAACCAGAT
GAGAAAAAAATTAAGAAATTGCTCAAGGGAAACATTTGTAAATGGATTTGAAAGATTGAGCCAAATTCTGTTGTCAGTTCTAAGCATGCA
GTTCTCACCTCCATTTAGTCCCCCATCAGAACAGAGGTCAGGAATTTAGCTGGGGAGCCTAAATTTAGTTCAGCTTACCTTTGAGAATAG
CATCAATTCAGACTCTCTTTTCATTATGTTTTCTTTTCTTTTTCCCTCTTTTTAAACTACATTGTGTTAGAGTCATAGTCTAGGATCCTG
AGAGATTTTCCATTCTTGTCACCATTCACTTGCATTGTAAAGATTTTCTTTGTCTGTTGTTGGCATAGATTCTTTTGTACATATTTATTT
ATTTGTGTTTATATATGTCAATTGGTTTCCTTTCTTAGCTTGATATTGCCTAGCTTTGTTGTTTTAATTAACTTTCTATTAGAGAGACTG
TATATATTTTTTCTAAATACTTTGTGAAATCATTTTTGGTAGCAATATCTTTGAATATGATGAATAAAAGTGACTGTGAGTGCAAATAGA
ATTAGCAGTAAGAAGCTACTCTAGCTAATTTGCCATTTTACTTAAATGGAAAATGTTTTTCAAATAAATACTTATGTTGTTCATGTTCCA

>In-frame_PRKCE_ENST00000306156_chr2_46070202_+_GPR126_ENST00000367608_chr6_142758571_+_3912nt
CAGCCCCCGCGGCTTGCAGCGGAGCCGACAGCTCGTCTTCTCTTCTGGAGGTGCAGCTGGTGGTCGGGGGGAGAGACTTGCTCCAAACAC
GGACATCCCCCAGCTCTCCCCCCTCCCTGTTTTCCGTTAGGAACCCGGCGAGGAAATACATGCACTGGCTGAGAATCGCCCGCGCCAGGG
CGCAACGCCACAAGGTGTAGGGAGTGTGCGGGGTGGGGCGAAAGGGGACCCAAGAGTCCCTGTGGCTCGGAGTGCCGGGCCGTCGGTTCT
TCATTCCTGCCCTCGGGGCAGACGGAGTGACCCCGGCCCCCACTCCCCGCCCCGACCATGGTAGTGTTCAATGGCCTTCTTAAGATCAAA
ATCTGCGAGGCCGTGAGCTTGAAGCCCACAGCCTGGTCGCTGCGCCATGCGGTGGGACCCCGGCCGCAGACTTTCCTTCTCGACCCCTAC
ATTGCCCTCAATGTGGACGACTCGCGCATCGGCCAAACGGCCACCAAGCAGAAGACCAACAGCCCGGCCTGGCACGACGAGTTCGTCACC
GATGTGTGCAACGGACGCAAGATCGAGCTGGCTGTCTTTCACGATGCCCCCATAGGCTACGACGACTTCGTGGCCAACTGCACCATCCAG
TTTGAGGAGCTGCTGCAGAACGGGAGCCGCCACTTCGAGGACTGGATTGATCTGGAGCCAGAAGGAAGAGTGTATGTGATCATCGATCTC
TCAGGGTCGTCGGGTGAAGGCTTATTTATATTCATCTTCCACTGTGCTATGAAGGAGAATGTTCAGAAACAGTGGCGGCAGCATCTCTGC
TGTGGTAGATTTCGGTTAGCAGATAACTCAGATTGGAGTAAGACAGCTACCAATATCATCAAGAAAAGTTCTGATAATCTAGGAAAATCT
TTGTCTTCAAGCTCCATTGGTTCCAACTCAACCTATCTTACATCCAAATCTAAATCCAGCTCTACCACCTATTTCAAAAGGAATAGCCAC
ACAGACAGTGCTTCCATGGACAAGTCCTTGTCAAAACTGGCCCATGCTGATGGAGATCAAACATCAATCATCCCTGTCCATCAGGTCATT
GATAAGGTCAAGGGTTATTGCAATGCTCATTCAGACAACTTCTATAAAAATATTATCATGTCAGACACCTTCAGCCACAGCACAAAGTTT
TAATGTCTTTAAGAAAAAGAAATCAATCTGCAGAAATGTGAAGATTTGCAAGCAGTGTAAACTGCAACTAGTGATGTAAATGTGCTATTA
CCTAGGTAACTGCATATATATAAGGAATGTATTTTGTTAAGAAGGCTTTTGTGAAATTCAGAATTTTTCTTTTTAATATATTTCTTCCAT
GGAAGAGTTGTCATCACTAAAACTTCAGTACTGAGAGTAACATGACTCAGTAGCCACAGAAGCTATGATTTGTAAAATATATAATTGAAT
CAGAGTAATCATAATGCAGGGGAGACATTCAAATTAGAGACAAGGGAGAAGCAATGCTGAGGAAGACCCTAGATAGAGCTCATTTTACTC
CACCTAATCGTTATATCTGGATATACCCATTTTCTGCATCTTCTTTCTCAACAATAAAAAATGTAACTATTTTGAATGCCCACAAATCCC
ATTCCAGTGTTACTTTCTGTGAATGCAGTACCATATTCTCATTTTCAATGACATTTCAACCACAGGCAGAAAAGACTGTTTACTCCTTGA
CCCAAAGATTAAAAAGGATTTTTTATTATTTTAAATATTACACCTTCAGAACCATAACATGCTTAAGAAAACTTTCCCAAAATGTTGACC
TAGTTAAATGAGGCTATATAAATTTCTAATATTTTACTTATTCTATTCAAGGCATAGGGCCAAAGCATTAAGTATAATTTAATCCCATAC
ATTCGAGTTAAGTTTAGTGTTGATGTTCCATCATTCTGGACCTCCCAGGAGTTGTTTAAGAATGAATCTCTTACACCTCTACTTTTGCCC
CTCTACTGTATATTAAGCCCATAGGCTTGTGGGAGGAAGGAGAATTTCCATTAGGCAAGCTGTATGCAGTGGAATTTTCCTTTTAGGAGA
CACACAATTAAGACTCTCTGGTTCTGTCCTTGCTTTGGAGACTTTAAGACATTTCCTAAAGCACAAATAAAAGCCTCGTATTTCCCCATT
GAGAGTTTTGTTCCAAGGAATATGAAGTGAGACATATGGGTGAGTCATAATAATCAAAATAATTTATGAAGAGCTGGGTCTGCAATAGCT
AGTCTAAAAACTACTTGTGTGTCAGTCCTCTGGTTATAGTATATAAGAGCCTGAGGAGGTCTGGCAAGATAGATGGTGTATTATTTATGG
ATCAGGCTGCTGCATACAAACCTTGCATACTATTATGCAGCTTACCTAACTCTCAGACTATTCTGAGTAATGCTTGCTTGCTAATGAATG
TATAGGAGACCACATTGTAATTGTTCTTAGATGATGGAGTCCATGCAGTTTCTTAGAAATCGGTCTCAGTGCATGCTGTGCTTTTTCACA
TTTGCTCTGGGTTATCTGGGAAGTATCAGGTTCTGGGAGGCAACAGCATTAAGTGATAAGAAAAGGAGACATTCTGGCAAAGCCAATCTG
CTTAAAGGCAAAGTCCAGAACCTGGAACCTAGAGGCCTTTCTCTCTGCACGAAAAACAGGTAGTTTGCAGTCTGAGATATGGGAGAGCTT
TTAGGCTACACAGCAACCCAAGGGACCTCTCACCTTTTGCTGAGCTTCAATCAGGAAGCTATTTGCCTGGCTCCAGCAGATGATGAGATA
ATGAGGTAGTGGGTTTTTTATTACTGTTCCATTTTGCAACATCCTGCAACACCATCCTGGGAGACAAGAGCATTACCCAGCTTGGCTTTC
ACGGGGGAGGGTTGTATTCAGTAAAAAAGAATAGTAAATATAAGGTCACTGAGATTCTAAGTAAGATAGTAAATCTAAGGTCACTGAGCC
AAATCCTTTTCAATAGGCATATATTAACAGGCTGCTTATTTTGGCGGAGGTTACATATGGATGAAAATGAATCTTAGTCACTGAATATTC
ATATACATTTCCCCCAAAACCTTAGACATTCATAGTAGATTTTAATTAGTTAGCTTTCTAACTAGTCAGATTTCTGCCCAAAGTGCTTAG
TCAATAGTAATTAAGATATAGCTTCAAAAATGGCTTTGCTTTTGATTTCTACTCATATTCGTATGGCTCCAGAAAAATATTTTTTTCATA
TTTGACAATGTCAGCTCCACTTTAGAAATTTTCAATAACCAGATGAGAAAAAAATTAAGAAATTGCTCAAGGGAAACATTTGTAAATGGA
TTTGAAAGATTGAGCCAAATTCTGTTGTCAGTTCTAAGCATGCAGTTCTCACCTCCATTTAGTCCCCCATCAGAACAGAGGTCAGGAATT
TAGCTGGGGAGCCTAAATTTAGTTCAGCTTACCTTTGAGAATAGCATCAATTCAGACTCTCTTTTCATTATGTTTTCTTTTCTTTTTCCC
TCTTTTTAAACTACATTGTGTTAGAGTCATAGTCTAGGATCCTGAGAGATTTTCCATTCTTGTCACCATTCACTTGCATTGTAAAGATTT
TCTTTGTCTGTTGTTGGCATAGATTCTTTTGTACATATTTATTTATTTGTGTTTATATATGTCAATTGGTTTCCTTTCTTAGCTTGATAT
TGCCTAGCTTTGTTGTTTTAATTAACTTTCTATTAGAGAGACTGTATATATTTTTTCTAAATACTTTGTGAAATCATTTTTGGTAGCAAT
ATCTTTGAATATGATGAATAAAAGTGACTGTGAGTGCAAATAGAATTAGCAGTAAGAAGCTACTCTAGCTAATTTGCCATTTTACTTAAA

>In-frame_PRKCE_ENST00000306156_chr2_46070202_+_GPR126_ENST00000296932_chr6_142758571_+_3952nt
CAGCCCCCGCGGCTTGCAGCGGAGCCGACAGCTCGTCTTCTCTTCTGGAGGTGCAGCTGGTGGTCGGGGGGAGAGACTTGCTCCAAACAC
GGACATCCCCCAGCTCTCCCCCCTCCCTGTTTTCCGTTAGGAACCCGGCGAGGAAATACATGCACTGGCTGAGAATCGCCCGCGCCAGGG
CGCAACGCCACAAGGTGTAGGGAGTGTGCGGGGTGGGGCGAAAGGGGACCCAAGAGTCCCTGTGGCTCGGAGTGCCGGGCCGTCGGTTCT
TCATTCCTGCCCTCGGGGCAGACGGAGTGACCCCGGCCCCCACTCCCCGCCCCGACCATGGTAGTGTTCAATGGCCTTCTTAAGATCAAA
ATCTGCGAGGCCGTGAGCTTGAAGCCCACAGCCTGGTCGCTGCGCCATGCGGTGGGACCCCGGCCGCAGACTTTCCTTCTCGACCCCTAC
ATTGCCCTCAATGTGGACGACTCGCGCATCGGCCAAACGGCCACCAAGCAGAAGACCAACAGCCCGGCCTGGCACGACGAGTTCGTCACC
GATGTGTGCAACGGACGCAAGATCGAGCTGGCTGTCTTTCACGATGCCCCCATAGGCTACGACGACTTCGTGGCCAACTGCACCATCCAG
TTTGAGGAGCTGCTGCAGAACGGGAGCCGCCACTTCGAGGACTGGATTGATCTGGAGCCAGAAGGAAGAGTGTATGTGATCATCGATCTC
TCAGGGTCGTCGGGTGAAGGCTTATTTATATTCATCTTCCACTGTGCTATGAAGGAGAATGTTCAGAAACAGTGGCGGCAGCATCTCTGC
TGTGGTAGATTTCGGTTAGCAGATAACTCAGATTGGAGTAAGACAGCTACCAATATCATCAAGAAAAGTTCTGATAATCTAGGAAAATCT
TTGTCTTCAAGCTCCATTGGTTCCAACTCAACCTATCTTACATCCAAATCTAAATCCAGCTCTACCACCTATTTCAAAAGGAATAGCCAC
ACAGATAATGTCTCCTATGAGCATTCCTTCAACAAAAGTGGATCACTCAGACAGTGCTTCCATGGACAAGTCCTTGTCAAAACTGGCCCA
TGCTGATGGAGATCAAACATCAATCATCCCTGTCCATCAGGTCATTGATAAGGTCAAGGGTTATTGCAATGCTCATTCAGACAACTTCTA
TAAAAATATTATCATGTCAGACACCTTCAGCCACAGCACAAAGTTTTAATGTCTTTAAGAAAAAGAAATCAATCTGCAGAAATGTGAAGA
TTTGCAAGCAGTGTAAACTGCAACTAGTGATGTAAATGTGCTATTACCTAGGTAACTGCATATATATAAGGAATGTATTTTGTTAAGAAG
GCTTTTGTGAAATTCAGAATTTTTCTTTTTAATATATTTCTTCCATGGAAGAGTTGTCATCACTAAAACTTCAGTACTGAGAGTAACATG
ACTCAGTAGCCACAGAAGCTATGATTTGTAAAATATATAATTGAATCAGAGTAATCATAATGCAGGGGAGACATTCAAATTAGAGACAAG
GGAGAAGCAATGCTGAGGAAGACCCTAGATAGAGCTCATTTTACTCCACCTAATCGTTATATCTGGATATACCCATTTTCTGCATCTTCT
TTCTCAACAATAAAAAATGTAACTATTTTGAATGCCCACAAATCCCATTCCAGTGTTACTTTCTGTGAATGCAGTACCATATTCTCATTT
TCAATGACATTTCAACCACAGGCAGAAAAGACTGTTTACTCCTTGACCCAAAGATTAAAAAGGATTTTTTATTATTTTAAATATTACACC
TTCAGAACCATAACATGCTTAAGAAAACTTTCCCAAAATGTTGACCTAGTTAAATGAGGCTATATAAATTTCTAATATTTTACTTATTCT
ATTCAAGGCATAGGGCCAAAGCATTAAGTATAATTTAATCCCATACATTCGAGTTAAGTTTAGTGTTGATGTTCCATCATTCTGGACCTC
CCAGGAGTTGTTTAAGAATGAATCTCTTACACCTCTACTTTTGCCCCTCTACTGTATATTAAGCCCATAGGCTTGTGGGAGGAAGGAGAA
TTTCCATTAGGCAAGCTGTATGCAGTGGAATTTTCCTTTTAGGAGACACACAATTAAGACTCTCTGGTTCTGTCCTTGCTTTGGAGACTT
TAAGACATTTCCTAAAGCACAAATAAAAGCCTCGTATTTCCCCATTGAGAGTTTTGTTCCAAGGAATATGAAGTGAGACATATGGGTGAG
TCATAATAATCAAAATAATTTATGAAGAGCTGGGTCTGCAATAGCTAGTCTAAAAACTACTTGTGTGTCAGTCCTCTGGTTATAGTATAT
AAGAGCCTGAGGAGGTCTGGCAAGATAGATGGTGTATTATTTATGGATCAGGCTGCTGCATACAAACCTTGCATACTATTATGCAGCTTA
CCTAACTCTCAGACTATTCTGAGTAATGCTTGCTTGCTAATGAATGTATAGGAGACCACATTGTAATTGTTCTTAGATGATGGAGTCCAT
GCAGTTTCTTAGAAATCGGTCTCAGTGCATGCTGTGCTTTTTCACATTTGCTCTGGGTTATCTGGGAAGTATCAGGTTCTGGGAGGCAAC
AGCATTAAGTGATAAGAAAAGGAGACATTCTGGCAAAGCCAATCTGCTTAAAGGCAAAGTCCAGAACCTGGAACCTAGAGGCCTTTCTCT
CTGCACGAAAAACAGGTAGTTTGCAGTCTGAGATATGGGAGAGCTTTTAGGCTACACAGCAACCCAAGGGACCTCTCACCTTTTGCTGAG
CTTCAATCAGGAAGCTATTTGCCTGGCTCCAGCAGATGATGAGATAATGAGGTAGTGGGTTTTTTATTACTGTTCCATTTTGCAACATCC
TGCAACACCATCCTGGGAGACAAGAGCATTACCCAGCTTGGCTTTCACGGGGGAGGGTTGTATTCAGTAAAAAAGAATAGTAAATATAAG
GTCACTGAGATTCTAAGTAAGATAGTAAATCTAAGGTCACTGAGCCAAATCCTTTTCAATAGGCATATATTAACAGGCTGCTTATTTTGG
CGGAGGTTACATATGGATGAAAATGAATCTTAGTCACTGAATATTCATATACATTTCCCCCAAAACCTTAGACATTCATAGTAGATTTTA
ATTAGTTAGCTTTCTAACTAGTCAGATTTCTGCCCAAAGTGCTTAGTCAATAGTAATTAAGATATAGCTTCAAAAATGGCTTTGCTTTTG
ATTTCTACTCATATTCGTATGGCTCCAGAAAAATATTTTTTTCATATTTGACAATGTCAGCTCCACTTTAGAAATTTTCAATAACCAGAT
GAGAAAAAAATTAAGAAATTGCTCAAGGGAAACATTTGTAAATGGATTTGAAAGATTGAGCCAAATTCTGTTGTCAGTTCTAAGCATGCA
GTTCTCACCTCCATTTAGTCCCCCATCAGAACAGAGGTCAGGAATTTAGCTGGGGAGCCTAAATTTAGTTCAGCTTACCTTTGAGAATAG
CATCAATTCAGACTCTCTTTTCATTATGTTTTCTTTTCTTTTTCCCTCTTTTTAAACTACATTGTGTTAGAGTCATAGTCTAGGATCCTG
AGAGATTTTCCATTCTTGTCACCATTCACTTGCATTGTAAAGATTTTCTTTGTCTGTTGTTGGCATAGATTCTTTTGTACATATTTATTT
ATTTGTGTTTATATATGTCAATTGGTTTCCTTTCTTAGCTTGATATTGCCTAGCTTTGTTGTTTTAATTAACTTTCTATTAGAGAGACTG
TATATATTTTTTCTAAATACTTTGTGAAATCATTTTTGGTAGCAATATCTTTGAATATGATGAATAAAAGTGACTGTGAGTGCAAATAGA

>In-frame_PRKCE_ENST00000306156_chr2_46070202_+_GPR126_ENST00000367609_chr6_142758571_+_3906nt
CAGCCCCCGCGGCTTGCAGCGGAGCCGACAGCTCGTCTTCTCTTCTGGAGGTGCAGCTGGTGGTCGGGGGGAGAGACTTGCTCCAAACAC
GGACATCCCCCAGCTCTCCCCCCTCCCTGTTTTCCGTTAGGAACCCGGCGAGGAAATACATGCACTGGCTGAGAATCGCCCGCGCCAGGG
CGCAACGCCACAAGGTGTAGGGAGTGTGCGGGGTGGGGCGAAAGGGGACCCAAGAGTCCCTGTGGCTCGGAGTGCCGGGCCGTCGGTTCT
TCATTCCTGCCCTCGGGGCAGACGGAGTGACCCCGGCCCCCACTCCCCGCCCCGACCATGGTAGTGTTCAATGGCCTTCTTAAGATCAAA
ATCTGCGAGGCCGTGAGCTTGAAGCCCACAGCCTGGTCGCTGCGCCATGCGGTGGGACCCCGGCCGCAGACTTTCCTTCTCGACCCCTAC
ATTGCCCTCAATGTGGACGACTCGCGCATCGGCCAAACGGCCACCAAGCAGAAGACCAACAGCCCGGCCTGGCACGACGAGTTCGTCACC
GATGTGTGCAACGGACGCAAGATCGAGCTGGCTGTCTTTCACGATGCCCCCATAGGCTACGACGACTTCGTGGCCAACTGCACCATCCAG
TTTGAGGAGCTGCTGCAGAACGGGAGCCGCCACTTCGAGGACTGGATTGATCTGGAGCCAGAAGGAAGAGTGTATGTGATCATCGATCTC
TCAGGGTCGTCGGGTGAAGGCTTATTTATATTCATCTTCCACTGTGCTATGAAGGAGAATGTTCAGAAACAGTGGCGGCAGCATCTCTGC
TGTGGTAGATTTCGGTTAGCAGATAACTCAGATTGGAGTAAGACAGCTACCAATATCATCAAGAAAAGTTCTGATAATCTAGGAAAATCT
TTGTCTTCAAGCTCCATTGGTTCCAACTCAACCTATCTTACATCCAAATCTAAATCCAGCTCTACCACCTATTTCAAAAGGAATAGCCAC
ACAGACAGTGCTTCCATGGACAAGTCCTTGTCAAAACTGGCCCATGCTGATGGAGATCAAACATCAATCATCCCTGTCCATCAGGTCATT
GATAAGGTCAAGGGTTATTGCAATGCTCATTCAGACAACTTCTATAAAAATATTATCATGTCAGACACCTTCAGCCACAGCACAAAGTTT
TAATGTCTTTAAGAAAAAGAAATCAATCTGCAGAAATGTGAAGATTTGCAAGCAGTGTAAACTGCAACTAGTGATGTAAATGTGCTATTA
CCTAGGTAACTGCATATATATAAGGAATGTATTTTGTTAAGAAGGCTTTTGTGAAATTCAGAATTTTTCTTTTTAATATATTTCTTCCAT
GGAAGAGTTGTCATCACTAAAACTTCAGTACTGAGAGTAACATGACTCAGTAGCCACAGAAGCTATGATTTGTAAAATATATAATTGAAT
CAGAGTAATCATAATGCAGGGGAGACATTCAAATTAGAGACAAGGGAGAAGCAATGCTGAGGAAGACCCTAGATAGAGCTCATTTTACTC
CACCTAATCGTTATATCTGGATATACCCATTTTCTGCATCTTCTTTCTCAACAATAAAAAATGTAACTATTTTGAATGCCCACAAATCCC
ATTCCAGTGTTACTTTCTGTGAATGCAGTACCATATTCTCATTTTCAATGACATTTCAACCACAGGCAGAAAAGACTGTTTACTCCTTGA
CCCAAAGATTAAAAAGGATTTTTTATTATTTTAAATATTACACCTTCAGAACCATAACATGCTTAAGAAAACTTTCCCAAAATGTTGACC
TAGTTAAATGAGGCTATATAAATTTCTAATATTTTACTTATTCTATTCAAGGCATAGGGCCAAAGCATTAAGTATAATTTAATCCCATAC
ATTCGAGTTAAGTTTAGTGTTGATGTTCCATCATTCTGGACCTCCCAGGAGTTGTTTAAGAATGAATCTCTTACACCTCTACTTTTGCCC
CTCTACTGTATATTAAGCCCATAGGCTTGTGGGAGGAAGGAGAATTTCCATTAGGCAAGCTGTATGCAGTGGAATTTTCCTTTTAGGAGA
CACACAATTAAGACTCTCTGGTTCTGTCCTTGCTTTGGAGACTTTAAGACATTTCCTAAAGCACAAATAAAAGCCTCGTATTTCCCCATT
GAGAGTTTTGTTCCAAGGAATATGAAGTGAGACATATGGGTGAGTCATAATAATCAAAATAATTTATGAAGAGCTGGGTCTGCAATAGCT
AGTCTAAAAACTACTTGTGTGTCAGTCCTCTGGTTATAGTATATAAGAGCCTGAGGAGGTCTGGCAAGATAGATGGTGTATTATTTATGG
ATCAGGCTGCTGCATACAAACCTTGCATACTATTATGCAGCTTACCTAACTCTCAGACTATTCTGAGTAATGCTTGCTTGCTAATGAATG
TATAGGAGACCACATTGTAATTGTTCTTAGATGATGGAGTCCATGCAGTTTCTTAGAAATCGGTCTCAGTGCATGCTGTGCTTTTTCACA
TTTGCTCTGGGTTATCTGGGAAGTATCAGGTTCTGGGAGGCAACAGCATTAAGTGATAAGAAAAGGAGACATTCTGGCAAAGCCAATCTG
CTTAAAGGCAAAGTCCAGAACCTGGAACCTAGAGGCCTTTCTCTCTGCACGAAAAACAGGTAGTTTGCAGTCTGAGATATGGGAGAGCTT
TTAGGCTACACAGCAACCCAAGGGACCTCTCACCTTTTGCTGAGCTTCAATCAGGAAGCTATTTGCCTGGCTCCAGCAGATGATGAGATA
ATGAGGTAGTGGGTTTTTTATTACTGTTCCATTTTGCAACATCCTGCAACACCATCCTGGGAGACAAGAGCATTACCCAGCTTGGCTTTC
ACGGGGGAGGGTTGTATTCAGTAAAAAAGAATAGTAAATATAAGGTCACTGAGATTCTAAGTAAGATAGTAAATCTAAGGTCACTGAGCC
AAATCCTTTTCAATAGGCATATATTAACAGGCTGCTTATTTTGGCGGAGGTTACATATGGATGAAAATGAATCTTAGTCACTGAATATTC
ATATACATTTCCCCCAAAACCTTAGACATTCATAGTAGATTTTAATTAGTTAGCTTTCTAACTAGTCAGATTTCTGCCCAAAGTGCTTAG
TCAATAGTAATTAAGATATAGCTTCAAAAATGGCTTTGCTTTTGATTTCTACTCATATTCGTATGGCTCCAGAAAAATATTTTTTTCATA
TTTGACAATGTCAGCTCCACTTTAGAAATTTTCAATAACCAGATGAGAAAAAAATTAAGAAATTGCTCAAGGGAAACATTTGTAAATGGA
TTTGAAAGATTGAGCCAAATTCTGTTGTCAGTTCTAAGCATGCAGTTCTCACCTCCATTTAGTCCCCCATCAGAACAGAGGTCAGGAATT
TAGCTGGGGAGCCTAAATTTAGTTCAGCTTACCTTTGAGAATAGCATCAATTCAGACTCTCTTTTCATTATGTTTTCTTTTCTTTTTCCC
TCTTTTTAAACTACATTGTGTTAGAGTCATAGTCTAGGATCCTGAGAGATTTTCCATTCTTGTCACCATTCACTTGCATTGTAAAGATTT
TCTTTGTCTGTTGTTGGCATAGATTCTTTTGTACATATTTATTTATTTGTGTTTATATATGTCAATTGGTTTCCTTTCTTAGCTTGATAT
TGCCTAGCTTTGTTGTTTTAATTAACTTTCTATTAGAGAGACTGTATATATTTTTTCTAAATACTTTGTGAAATCATTTTTGGTAGCAAT
ATCTTTGAATATGATGAATAAAAGTGACTGTGAGTGCAAATAGAATTAGCAGTAAGAAGCTACTCTAGCTAATTTGCCATTTTACTTAAA


Top

FusionGenePPI for PRKCE_GPR126


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PRKCERASGRP3, GAD2, GAD1, ADAP1, VDAC1, SLC25A4, HK2, MAPK1, RAF1, GJA1, GNB2L1, CFTR, GNA12, GNA13, MYH9, COPB2, KRT1, ACTA1, YWHAZ, TIAM1, PDLIM5, PIK3CB, AFAP1, KRT8, KRT18, DSP, MAP4K4, STAT1, HSP90AB1, PRKCE, KAT5, HIST1H1A, IBTK, MARK2, PPP1R14A, IKBKB, IKBKG, ITGB2, ATF2, RPS6KB2, BRAF, HSP90AA1, ELAVL1, NUMB, KEAP1, IL32, ZBTB16, NANOG, EGFR, BAD, BCL6GPR126FBXO6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PRKCE_GPR126


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for PRKCE_GPR126


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePRKCEC0020429Hyperalgesia3CTD_human
HgenePRKCEC0009404Colorectal Neoplasms1CTD_human
HgenePRKCEC0011853Diabetes Mellitus, Experimental1CTD_human
HgenePRKCEC0011881Diabetic Nephropathy1CTD_human
HgenePRKCEC0023903Liver neoplasms1CTD_human
HgenePRKCEC0027051Myocardial Infarction1CTD_human
HgenePRKCEC0031117Peripheral Neuropathy1CTD_human
HgenePRKCEC0151744Myocardial Ischemia1CTD_human
HgenePRKCEC0236969Substance-Related Disorders1CTD_human
HgenePRKCEC0242231Coronary Stenosis1CTD_human
HgenePRKCEC0878544Cardiomyopathies1CTD_human