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Fusion gene ID: 2873 |
FusionGeneSummary for ART3_NUP54 |
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Fusion gene information | Fusion gene name: ART3_NUP54 | Fusion gene ID: 2873 | Hgene | Tgene | Gene symbol | ART3 | NUP54 | Gene ID | 419 | 53371 |
Gene name | ADP-ribosyltransferase 3 | nucleoporin 54 | |
Synonyms | ARTC3 | - | |
Cytomap | 4q21.1|4p15.1-p14 | 4q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | ecto-ADP-ribosyltransferase 3ADP-ribosyltransferase C2 and C3 toxin-like 3NAD(P)(+)--arginine ADP-ribosyltransferase 3mono(ADP-ribosyl)transferase 3mono-ADP-ribosyltransferase | nucleoporin p5454 kDa nucleoporinnucleoporin 54kDnucleoporin 54kDa | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q13508 | Q7Z3B4 | |
Ensembl transtripts involved in fusion gene | ENST00000341029, ENST00000355810, ENST00000349321, ENST00000513494, | ENST00000264883, ENST00000342467, ENST00000514987, ENST00000458189, ENST00000515460, | |
Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 2 X 2 X 2=8 |
# samples | 4 | 2 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: ART3 [Title/Abstract] AND NUP54 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUSC | TCGA-43-3920-01A | ART3 | chr4 | 77025122 | + | NUP54 | chr4 | 77036647 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000341029 | ENST00000264883 | ART3 | chr4 | 77025122 | + | NUP54 | chr4 | 77036647 | - |
Frame-shift | ENST00000341029 | ENST00000342467 | ART3 | chr4 | 77025122 | + | NUP54 | chr4 | 77036647 | - |
In-frame | ENST00000341029 | ENST00000514987 | ART3 | chr4 | 77025122 | + | NUP54 | chr4 | 77036647 | - |
In-frame | ENST00000341029 | ENST00000458189 | ART3 | chr4 | 77025122 | + | NUP54 | chr4 | 77036647 | - |
5CDS-intron | ENST00000341029 | ENST00000515460 | ART3 | chr4 | 77025122 | + | NUP54 | chr4 | 77036647 | - |
Frame-shift | ENST00000355810 | ENST00000264883 | ART3 | chr4 | 77025122 | + | NUP54 | chr4 | 77036647 | - |
Frame-shift | ENST00000355810 | ENST00000342467 | ART3 | chr4 | 77025122 | + | NUP54 | chr4 | 77036647 | - |
In-frame | ENST00000355810 | ENST00000514987 | ART3 | chr4 | 77025122 | + | NUP54 | chr4 | 77036647 | - |
In-frame | ENST00000355810 | ENST00000458189 | ART3 | chr4 | 77025122 | + | NUP54 | chr4 | 77036647 | - |
5CDS-intron | ENST00000355810 | ENST00000515460 | ART3 | chr4 | 77025122 | + | NUP54 | chr4 | 77036647 | - |
Frame-shift | ENST00000349321 | ENST00000264883 | ART3 | chr4 | 77025122 | + | NUP54 | chr4 | 77036647 | - |
Frame-shift | ENST00000349321 | ENST00000342467 | ART3 | chr4 | 77025122 | + | NUP54 | chr4 | 77036647 | - |
In-frame | ENST00000349321 | ENST00000514987 | ART3 | chr4 | 77025122 | + | NUP54 | chr4 | 77036647 | - |
In-frame | ENST00000349321 | ENST00000458189 | ART3 | chr4 | 77025122 | + | NUP54 | chr4 | 77036647 | - |
5CDS-intron | ENST00000349321 | ENST00000515460 | ART3 | chr4 | 77025122 | + | NUP54 | chr4 | 77036647 | - |
intron-3CDS | ENST00000513494 | ENST00000264883 | ART3 | chr4 | 77025122 | + | NUP54 | chr4 | 77036647 | - |
intron-3CDS | ENST00000513494 | ENST00000342467 | ART3 | chr4 | 77025122 | + | NUP54 | chr4 | 77036647 | - |
intron-3CDS | ENST00000513494 | ENST00000514987 | ART3 | chr4 | 77025122 | + | NUP54 | chr4 | 77036647 | - |
intron-3CDS | ENST00000513494 | ENST00000458189 | ART3 | chr4 | 77025122 | + | NUP54 | chr4 | 77036647 | - |
intron-intron | ENST00000513494 | ENST00000515460 | ART3 | chr4 | 77025122 | + | NUP54 | chr4 | 77036647 | - |
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FusionProtFeatures for ART3_NUP54 |
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Hgene | Tgene |
ART3 | NUP54 |
Component of the nuclear pore complex, a complexrequired for the trafficking across the nuclear membrane.{ECO:0000250|UniProtKB:P70582}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ART3_NUP54 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ART3_NUP54 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ART3 | ALCAM, PRKCD, MDN1, ATP12A, PIGO, RAB39B, DDX19B, CHD1L, DYNC2LI1, PAM, NAGLU, ARSK, HSPA12A, GPD1L, ITGA7, MGAT5, CBWD3, POGLUT1, SPG7, PSEN2, MAP2K2, SCAMP2, GALNT7, ITGA8 | NUP54 | NUP62, AP2B1, CCDC85B, NUTF2, KPNA1, KPNB1, APC, HDAC1, NUP153, SPEN, DGCR6, VCP, KRT15, HGS, NUPL1, IFT20, HAUS1, OBSL1, WDFY2, RNF166, NUP98, RAE1, NTRK1, IFI16, NUP35, SCLT1, ADD1, NUP107, TIGD6, NEDD1, NUP62CL, BFSP1, NDEL1, CEP250, LPXN, HOMER1, NDE1, CDK16, COG4, WDR59, HOMER3, EXOC1, CPNE2, CRNN |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ART3_NUP54 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ART3_NUP54 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |