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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2873

FusionGeneSummary for ART3_NUP54

check button Fusion gene summary
Fusion gene informationFusion gene name: ART3_NUP54
Fusion gene ID: 2873
HgeneTgene
Gene symbol

ART3

NUP54

Gene ID

419

53371

Gene nameADP-ribosyltransferase 3nucleoporin 54
SynonymsARTC3-
Cytomap

4q21.1|4p15.1-p14

4q21.1

Type of geneprotein-codingprotein-coding
Descriptionecto-ADP-ribosyltransferase 3ADP-ribosyltransferase C2 and C3 toxin-like 3NAD(P)(+)--arginine ADP-ribosyltransferase 3mono(ADP-ribosyl)transferase 3mono-ADP-ribosyltransferasenucleoporin p5454 kDa nucleoporinnucleoporin 54kDnucleoporin 54kDa
Modification date2018052320180523
UniProtAcc

Q13508

Q7Z3B4

Ensembl transtripts involved in fusion geneENST00000341029, ENST00000355810, 
ENST00000349321, ENST00000513494, 
ENST00000264883, ENST00000342467, 
ENST00000514987, ENST00000458189, 
ENST00000515460, 
Fusion gene scores* DoF score4 X 4 X 2=322 X 2 X 2=8
# samples 42
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: ART3 [Title/Abstract] AND NUP54 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-43-3920-01AART3chr4

77025122

+NUP54chr4

77036647

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000341029ENST00000264883ART3chr4

77025122

+NUP54chr4

77036647

-
Frame-shiftENST00000341029ENST00000342467ART3chr4

77025122

+NUP54chr4

77036647

-
In-frameENST00000341029ENST00000514987ART3chr4

77025122

+NUP54chr4

77036647

-
In-frameENST00000341029ENST00000458189ART3chr4

77025122

+NUP54chr4

77036647

-
5CDS-intronENST00000341029ENST00000515460ART3chr4

77025122

+NUP54chr4

77036647

-
Frame-shiftENST00000355810ENST00000264883ART3chr4

77025122

+NUP54chr4

77036647

-
Frame-shiftENST00000355810ENST00000342467ART3chr4

77025122

+NUP54chr4

77036647

-
In-frameENST00000355810ENST00000514987ART3chr4

77025122

+NUP54chr4

77036647

-
In-frameENST00000355810ENST00000458189ART3chr4

77025122

+NUP54chr4

77036647

-
5CDS-intronENST00000355810ENST00000515460ART3chr4

77025122

+NUP54chr4

77036647

-
Frame-shiftENST00000349321ENST00000264883ART3chr4

77025122

+NUP54chr4

77036647

-
Frame-shiftENST00000349321ENST00000342467ART3chr4

77025122

+NUP54chr4

77036647

-
In-frameENST00000349321ENST00000514987ART3chr4

77025122

+NUP54chr4

77036647

-
In-frameENST00000349321ENST00000458189ART3chr4

77025122

+NUP54chr4

77036647

-
5CDS-intronENST00000349321ENST00000515460ART3chr4

77025122

+NUP54chr4

77036647

-
intron-3CDSENST00000513494ENST00000264883ART3chr4

77025122

+NUP54chr4

77036647

-
intron-3CDSENST00000513494ENST00000342467ART3chr4

77025122

+NUP54chr4

77036647

-
intron-3CDSENST00000513494ENST00000514987ART3chr4

77025122

+NUP54chr4

77036647

-
intron-3CDSENST00000513494ENST00000458189ART3chr4

77025122

+NUP54chr4

77036647

-
intron-intronENST00000513494ENST00000515460ART3chr4

77025122

+NUP54chr4

77036647

-

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FusionProtFeatures for ART3_NUP54


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ART3

Q13508

NUP54

Q7Z3B4

Component of the nuclear pore complex, a complexrequired for the trafficking across the nuclear membrane.{ECO:0000250|UniProtKB:P70582}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ART3_NUP54


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ART3_NUP54


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ART3ALCAM, PRKCD, MDN1, ATP12A, PIGO, RAB39B, DDX19B, CHD1L, DYNC2LI1, PAM, NAGLU, ARSK, HSPA12A, GPD1L, ITGA7, MGAT5, CBWD3, POGLUT1, SPG7, PSEN2, MAP2K2, SCAMP2, GALNT7, ITGA8NUP54NUP62, AP2B1, CCDC85B, NUTF2, KPNA1, KPNB1, APC, HDAC1, NUP153, SPEN, DGCR6, VCP, KRT15, HGS, NUPL1, IFT20, HAUS1, OBSL1, WDFY2, RNF166, NUP98, RAE1, NTRK1, IFI16, NUP35, SCLT1, ADD1, NUP107, TIGD6, NEDD1, NUP62CL, BFSP1, NDEL1, CEP250, LPXN, HOMER1, NDE1, CDK16, COG4, WDR59, HOMER3, EXOC1, CPNE2, CRNN


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ART3_NUP54


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ART3_NUP54


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource