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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28716

FusionGeneSummary for PRKCA_IGF2BP3

check button Fusion gene summary
Fusion gene informationFusion gene name: PRKCA_IGF2BP3
Fusion gene ID: 28716
HgeneTgene
Gene symbol

PRKCA

IGF2BP3

Gene ID

5578

10643

Gene nameprotein kinase C alphainsulin like growth factor 2 mRNA binding protein 3
SynonymsAAG6|PKC-alpha|PKCA|PRKACACT98|IMP-3|IMP3|KOC|KOC1|VICKZ3
Cytomap

17q24.2

7p15.3

Type of geneprotein-codingprotein-coding
Descriptionprotein kinase C alpha typePKC-Aaging-associated gene 6insulin-like growth factor 2 mRNA-binding protein 3IGF-II mRNA-binding protein 3IGF2 mRNA-binding protein 3KH domain containing protein overexpressed in cancerVICKZ family member 3cancer/testis antigen 98
Modification date2018052320180519
UniProtAcc

P17252

O00425

Ensembl transtripts involved in fusion geneENST00000413366, ENST00000583361, 
ENST00000258729, ENST00000491719, 
Fusion gene scores* DoF score27 X 12 X 10=32403 X 3 X 3=27
# samples 293
** MAII scorelog2(29/3240*10)=-3.48186900775705
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PRKCA [Title/Abstract] AND IGF2BP3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Kinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRKCA

GO:0006468

protein phosphorylation

10770950

HgenePRKCA

GO:0035408

histone H3-T6 phosphorylation

20228790

HgenePRKCA

GO:0043536

positive regulation of blood vessel endothelial cell migration

20011604

HgenePRKCA

GO:0090330

regulation of platelet aggregation

12724315


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-33-4587-01APRKCAchr17

64492401

+IGF2BP3chr7

23358873

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000413366ENST00000258729PRKCAchr17

64492401

+IGF2BP3chr7

23358873

-
5CDS-intronENST00000413366ENST00000491719PRKCAchr17

64492401

+IGF2BP3chr7

23358873

-
intron-3CDSENST00000583361ENST00000258729PRKCAchr17

64492401

+IGF2BP3chr7

23358873

-
intron-intronENST00000583361ENST00000491719PRKCAchr17

64492401

+IGF2BP3chr7

23358873

-

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FusionProtFeatures for PRKCA_IGF2BP3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRKCA

P17252

IGF2BP3

O00425

Calcium-activated, phospholipid- and diacylglycerol(DAG)-dependent serine/threonine-protein kinase that is involvedin positive and negative regulation of cell proliferation,apoptosis, differentiation, migration and adhesion, tumorigenesis,cardiac hypertrophy, angiogenesis, platelet function andinflammation, by directly phosphorylating targets such as RAF1,BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involvingMAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation andcell growth arrest by positive and negative regulation of the cellcycle. Can promote cell growth by phosphorylating and activatingRAF1, which mediates the activation of the MAPK/ERK signalingcascade, and/or by up-regulating CDKN1A, which facilitates activecyclin-dependent kinase (CDK) complex formation in glioma cells.In intestinal cells stimulated by the phorbol ester PMA, cantrigger a cell cycle arrest program which is associated with theaccumulation of the hyper-phosphorylated growth-suppressive formof RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B.Exhibits anti-apoptotic function in glioma cells and protects themfrom apoptosis by suppressing the p53/TP53-mediated activation ofIGFBP3, and in leukemia cells mediates anti-apoptotic action byphosphorylating BCL2. During macrophage differentiation induced bymacrophage colony-stimulating factor (CSF1), is translocated tothe nucleus and is associated with macrophage development. Afterwounding, translocates from focal contacts to lamellipodia andparticipates in the modulation of desmosomal adhesion. Plays arole in cell motility by phosphorylating CSPG4, which inducesassociation of CSPG4 with extensive lamellipodia at the cellperiphery and polarization of the cell accompanied by increases incell motility. During chemokine-induced CD4(+) T cell migration,phosphorylates CDC42-guanine exchange factor DOCK8 resulting inits dissociation from LRCH1 and the activation of GTPase CDC42(PubMed:28028151). Is highly expressed in a number of cancer cellswhere it can act as a tumor promoter and is implicated inmalignant phenotypes of several tumors such as gliomas and breastcancers. Negatively regulates myocardial contractility andpositively regulates angiogenesis, platelet aggregation andthrombus formation in arteries. Mediates hypertrophic growth ofneonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is requiredto induce cardiomyocyte hypertrophy up to heart failure and death,by increasing protein synthesis, protein-DNA ratio and cellsurface area. Regulates cardiomyocyte function by phosphorylatingcardiac troponin T (TNNT2/CTNT), which induces significantreduction in actomyosin ATPase activity, myofilament calciumsensitivity and myocardial contractility. In angiogenesis, isrequired for full endothelial cell migration, adhesion tovitronectin (VTN), and vascular endothelial growth factor A(VEGFA)-dependent regulation of kinase activation and vasculartube formation. Involved in the stabilization of VEGFA mRNA atpost-transcriptional level and mediates VEGFA-induced cellproliferation. In the regulation of calcium-induced plateletaggregation, mediates signals from the CD36/GP4 receptor forgranule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response tolipopolysaccharides (LPS), may regulate selective LPS-inducedmacrophage functions involved in host defense and inflammation.But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1,which modulates EIF4G1 binding to MKNK1 and may be involved in theregulation of EIF4E phosphorylation. Phosphorylates KIT, leadingto inhibition of KIT activity. Phosphorylates ATF2 which promotescooperation between ATF2 and JUN, activating transcription.{ECO:0000269|PubMed:10848585, ECO:0000269|PubMed:11909826,ECO:0000269|PubMed:12724315, ECO:0000269|PubMed:12832403,ECO:0000269|PubMed:15016832, ECO:0000269|PubMed:15504744,ECO:0000269|PubMed:15526160, ECO:0000269|PubMed:18056764,ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:21576361,ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:28028151,ECO:0000269|PubMed:9738012, ECO:0000269|PubMed:9830023,ECO:0000269|PubMed:9873035, ECO:0000269|PubMed:9927633}. RNA-binding factor that may recruit target transcriptsto cytoplasmic protein-RNA complexes (mRNPs). This transcript'caging' into mRNPs allows mRNA transport and transient storage.It also modulates the rate and location at which targettranscripts encounter the translational apparatus and shields themfrom endonuclease attacks or microRNA-mediated degradation. Bindsto the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes celladhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5'-UTR of theinsulin-like growth factor 2 (IGF2) mRNAs.{ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:23640942}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRKCAchr17:64492401chr7:23358873ENST00000413366+31736_8696673Zinc fingerPhorbol-ester/DAG-type 1
TgeneIGF2BP3chr17:64492401chr7:23358873ENST00000258729-915405_470401580DomainKH 3
TgeneIGF2BP3chr17:64492401chr7:23358873ENST00000258729-915487_553401580DomainKH 4

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRKCAchr17:64492401chr7:23358873ENST00000413366+317172_26096673DomainC2
HgenePRKCAchr17:64492401chr7:23358873ENST00000413366+317339_59796673DomainProtein kinase
HgenePRKCAchr17:64492401chr7:23358873ENST00000413366+317598_66896673DomainNote=AGC-kinase C-terminal
HgenePRKCAchr17:64492401chr7:23358873ENST00000413366+317345_35396673Nucleotide bindingATP
HgenePRKCAchr17:64492401chr7:23358873ENST00000413366+317101_15196673Zinc fingerPhorbol-ester/DAG-type 2
TgeneIGF2BP3chr17:64492401chr7:23358873ENST00000258729-915195_260401580DomainKH 1
TgeneIGF2BP3chr17:64492401chr7:23358873ENST00000258729-915276_343401580DomainKH 2
TgeneIGF2BP3chr17:64492401chr7:23358873ENST00000258729-9152_75401580DomainRRM 1
TgeneIGF2BP3chr17:64492401chr7:23358873ENST00000258729-91581_156401580DomainRRM 2


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FusionGeneSequence for PRKCA_IGF2BP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PRKCA_ENST00000413366_chr17_64492401_+_IGF2BP3_ENST00000258729_chr7_23358873_-_275aa
MADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGAD
KGPDTDQSETETVHLFIPALSVGAIIGKQGQHIKQLSRFAGASIKIAPAEAPDAKVRMVIITGPPEAQFKAQGRITGKIKEENFVSPKEE
VKLEAHIRVPSFAAGRVIGKGGKTVNELQNLSSAEVVVPRDQTPDENDQVVVKITGHFTACQVAQRKIQEILTQVKQHQQQKALQSGPPQ


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PRKCA_ENST00000413366_chr17_64492401_+_IGF2BP3_ENST00000258729_chr7_23358873_-_825nt
ATGGCTGACGTTTTCCCGGGCAACGACTCCACGGCGTCTCAGGACGTGGCCAACCGCTTCGCCCGCAAAGGGGCGCTGAGGCAGAAGAAC
GTGCACGAGGTGAAGGACCACAAATTCATCGCGCGCTTCTTCAAGCAGCCCACCTTCTGCAGCCACTGCACCGACTTCATCTGGGGGTTT
GGGAAACAAGGCTTCCAGTGCCAAGTTTGCTGTTTTGTGGTCCACAAGAGGTGCCATGAATTTGTTACTTTTTCTTGTCCGGGTGCGGAT
AAGGGACCCGACACTGATCAATCAGAAACGGAGACTGTTCATCTGTTTATCCCAGCTCTATCAGTCGGTGCCATCATCGGCAAGCAGGGC
CAGCACATCAAGCAGCTTTCTCGCTTTGCTGGAGCTTCAATTAAGATTGCTCCAGCGGAAGCACCAGATGCTAAAGTGAGGATGGTGATT
ATCACTGGACCACCAGAGGCTCAGTTCAAGGCTCAGGGAAGAATTTATGGAAAAATTAAAGAAGAAAACTTTGTTAGTCCTAAAGAAGAG
GTGAAACTTGAAGCTCATATCAGAGTGCCATCCTTTGCTGCTGGCAGAGTTATTGGAAAAGGAGGCAAAACGGTGAATGAACTTCAGAAT
TTGTCAAGTGCAGAAGTTGTTGTCCCTCGTGACCAGACACCTGATGAGAATGACCAAGTGGTTGTCAAAATAACTGGTCACTTCTATGCT
TGCCAGGTTGCCCAGAGAAAAATTCAGGAAATTCTGACTCAGGTAAAGCAGCACCAACAACAGAAGGCTCTGCAAAGTGGACCACCTCAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_PRKCA_ENST00000413366_chr17_64492401_+_IGF2BP3_ENST00000258729_chr7_23358873_-_3004nt
GAGGCAAGAGGTGGTTGGGGGGGACCATGGCTGACGTTTTCCCGGGCAACGACTCCACGGCGTCTCAGGACGTGGCCAACCGCTTCGCCC
GCAAAGGGGCGCTGAGGCAGAAGAACGTGCACGAGGTGAAGGACCACAAATTCATCGCGCGCTTCTTCAAGCAGCCCACCTTCTGCAGCC
ACTGCACCGACTTCATCTGGGGGTTTGGGAAACAAGGCTTCCAGTGCCAAGTTTGCTGTTTTGTGGTCCACAAGAGGTGCCATGAATTTG
TTACTTTTTCTTGTCCGGGTGCGGATAAGGGACCCGACACTGATCAATCAGAAACGGAGACTGTTCATCTGTTTATCCCAGCTCTATCAG
TCGGTGCCATCATCGGCAAGCAGGGCCAGCACATCAAGCAGCTTTCTCGCTTTGCTGGAGCTTCAATTAAGATTGCTCCAGCGGAAGCAC
CAGATGCTAAAGTGAGGATGGTGATTATCACTGGACCACCAGAGGCTCAGTTCAAGGCTCAGGGAAGAATTTATGGAAAAATTAAAGAAG
AAAACTTTGTTAGTCCTAAAGAAGAGGTGAAACTTGAAGCTCATATCAGAGTGCCATCCTTTGCTGCTGGCAGAGTTATTGGAAAAGGAG
GCAAAACGGTGAATGAACTTCAGAATTTGTCAAGTGCAGAAGTTGTTGTCCCTCGTGACCAGACACCTGATGAGAATGACCAAGTGGTTG
TCAAAATAACTGGTCACTTCTATGCTTGCCAGGTTGCCCAGAGAAAAATTCAGGAAATTCTGACTCAGGTAAAGCAGCACCAACAACAGA
AGGCTCTGCAAAGTGGACCACCTCAGTCAAGACGGAAGTAAAGGCTCAGGAAACAGCCCACCACAGAGGCAGATGCCAAACCAAAGACAG
ATTGCTTAACCAACAGATGGGCGCTGACCCCCTATCCAGAATCACATGCACAAGTTTTTACCTAGCCAGTTGTTTCTGAGGACCAGGCAA
CTTTTGAACTCCTGTCTCTGTGAGAATGTATACTTTATGCTCTCTGAAATGTATGACACCCAGCTTTAAAACAAACAAACAAACAAACAA
AAAAAGGGTGGGGGAGGGAGGGAAAGAGAAGAGCTCTGCACTTCCCTTTGTTGTAGTCTCACAGTATAACAGATATTCTAATTCTTCTTA
ATATTCCCCCATAATGCCAGAAATTGGCTTAATGATGCTTTCACTAAATTCATCAAATAGATTGCTCCTAAATCCAATTGTTAAAATTGG
ATCAGAATAATTATCACAGGAACTTAAATGTTAAGCCATTAGCATAGAAAAACTGTTCTCAGTTTTATTTTTACCTAACACTAACATGAG
TAACCTAAGGGAAGTGCTGAATGGTGTTGGCAGGGGTATTAAACGTGCATTTTTACTCAACTACCTCAGGTATTCAGTAATACAATGAAA
AGCAAAATTGTTCCTTTTTTTTGAAAATTTTATATACTTTATAATGATAGAAGTCCAACCGTTTTTTAAAAAATAAATTTAAAATTTAAC
AGCAATCAGCTAACAGGCAAATTAAGATTTTTACTTCTGGCTGGTGACAGTAAAGCTGGAAAATTAATTTCAGGGTTTTTTGAGGCTTTT
GACACAGTTATTAGTTAAATCAAATGTTCAAAAATACGGAGCAGTGCCTAGTATCTGGAGAGCAGCACTACCATTTATTCTTTCATTTAT
AGTTGGGAAAGTTTTTGACGGTACTAACAAAGTGGTCGCAGGAGATTTTGGAACGGCTGGTTTAAATGGCTTCAGGAGACTTCAGTTTTT
TGTTTAGCTACATGATTGAATGCATAATAAATGCTTTGTGCTTCTGACTATCAATACCTAAAGAAAGTGCATCAGTGAAGAGATGCAAGA
CTTTCAACTGACTGGCAAAAAGCAAGCTTTAGCTTGTCTTATAGGATGCTTAGTTTGCCACTACACTTCAGACCAATGGGACAGTCATAG
ATGGTGTGACAGTGTTTAAACGCAACAAAAGGCTACATTTCCATGGGGCCAGCACTGTCATGAGCCTCACTAAGCTATTTTGAAGATTTT
TAAGCACTGATAAATTAAAAAAAAAAAATTAGACTCCACCTTAAGTAGTAAAGTATAACAGGATTTCTGTATACTGTGCAATCAGTTCTT
TGAAAAAAAAGTCAAAAGATAGAGAATACAAGAAAAGTTTTTGGGATATAATTTGAATGACTGTGAAAACATATGACCTTTGATAACGAA
CTCATTTGCTCACTCCTTGACAGCAAAGCCCAGTACGTACAATTGTGTTGGGTGTGGGTGGTCTCCAAGGCCACGCTGCTCTCTGAATTG
ATTTTTTGAGTTTTGTTTGTAAGATGATCACAGTCATGTTACACTGATCTAAAGGACATATATATAACCCTTTAAAAAAAAAATCACTGC
CTCATTCTTATTTCAAGATGAATTTCTATACAGACTAGATGTTTTTCTGAAGATCAATTAGACATTTTGAAAATGATTTAAAGTGTTTTC
CTTAATGTTCTCTGAAAACAAGTTTCTTTTGTAGTTTTAACCAAAAAAGTGCCCTTTTTGTCACTGGATTCTCCTAGCATTCATGATTTT
TTTTTCATACAATGAATTAAAATTGCTAAAATCATGGACTGGCTTTCTGGTTGGATTTCAGGTAAGATGTGTTTAAGGCCAGAGCTTTTC
TCAGTATTTGATTTTTTTCCCCAATATTTGATTTTTTAAAAATATACACATAGGTGCTGCATTTATATCTGCTGGTTTAAATTCTGTCAT
ATTTCACTTCTAGCCTTTTAGTATGGCAAATCATATTTTACTTTTACTTAAGCATTTGTAATTTGGAGTATCTGGTACTAGCTAAGAAAT
AATTCTATAATTGAGTTTTGTACTCACCATATATGGATCATTCCTCATGTATAATGTGCCCCAAATGCAGCTTCATTTTCCAGATACCTT


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FusionGenePPI for PRKCA_IGF2BP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PRKCAATP1A1, HABP4, HAND1, HAND2, FSCN1, EGFR, SLC1A1, PLD1, KLF5, GABRB3, MGMT, PLD2, PICK1, GRM7, AKAP12, GJA1, YWHAG, C1QBP, AVPR1A, AVPR1B, GSK3B, RGS2, OGG1, YWHAZ, TIAM1, GNB2L1, ITGB1, AFAP1, EZR, DLG4, LMNB1, LMNA, CD53, CD9, TRIM41, HMGA1, HMGA2, TNP1, TNP2, HIST1H3A, CHUK, IKBKB, NFE2L2, PRKCA, MTOR, TRPV6, AKAP5, DDX58, HIST1H1A, HIST1H1B, HIST1H1C, HIST1H1D, HIST1H1E, HIST1H1T, EIF4EBP1, MBP, HDAC6, CTNNB1, NR1H2, ELAVL1, HIST3H3, ANXA6, LNX1, LNX2, GLI3, IBTK, SCRIB, CBL, TOP2A, RICTOR, MAPKAP1, SELL, PFKFB1, NCF1, ACIN1, DSP, RALBP1, PPP1R14A, PLCG2, VTN, SDC2, ITGB2, HSP90AA1, GSK3A, GRIN1, GRIN2B, CASR, RRAD, NFKBIA, HMGN1, HMGN2, NPM1, NUMB, FBXO25, CDKN2A, PSMB4, SACM1L, PTGIR, TBXA2R, CYP3A4, RBCK1, RNF31, MOV10, NXF1, EP300, PPARG, CCDC8, EIF2S1, SLC25A41, SLC25A11, TAS2R7, TMEM185A, JSRP1, CCNL2, VPS4B, UQCRB, WWC2, WWC3, WWC1, MAPK7, NTRK1, NOXA1, GRM5, AKAP13, STXBP1, SPAG1, BTG2, CACYBP, SLC9A3R1, SLC9A3R2, KIF2A, KIF11, FAS, NF2, PLA2G4A, SMURF1, PRKCB, PRKCG, PRKCH, PIP5K1A, SHCBP1, GCLM, STARD7, CYP2S1, FGD4, DUSP11, FBXO21, HR, PPM1A, ATM, TESIGF2BP3PUF60, CNBP, HNRNPA1, MEPCE, KHDRBS2, UBC, ELAVL1, SIRT7, CUL3, CDK2, COPS5, CAND1, RAE1, DDX5, LAPTM4A, LGMN, HNRNPUL2, USP16, NDUFAF4, MYC, FN1, CBX6, CBX8, HDAC11, FBXO6, CRYZ, HNRNPA2B1, HNRNPM, HNRNPU, IARS, ABCF1, C14orf166, RTCB, NELFB, YBX3, DDX1, DHX9, DIMT1, EDC4, EIF2B2, EIF2B3, EPRS, FKBP3, FLII, ILF2, MAP2, NMT1, QARS, RFC4, RPL26L1, RPL38, KRT17, MRE11A, PA2G4, RPL23A, WWOX, EIF2AK2, LIN28A, STAU1, MDM2, AURKA, TP53, TUBGCP3, MEOX2, PIH1D2, MOV10, CUL7, OBSL1, CCDC8, NTRK1, G3BP2, IGF2BP1, PDCD6, RPL6, RAB2A, RPL37A, MED20, NPM1, ZNF746, SH3BGR, ELAVL2, GSPT2, MRPS34, HIST1H1E, APOBEC3D, PPAN, RBM3, TRIM25, G3BP1, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PRKCA_IGF2BP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePRKCAP17252DB00675TamoxifenProtein kinase C alpha typesmall moleculeapproved
HgenePRKCAP17252DB05013Ingenol MebutateProtein kinase C alpha typesmall moleculeapproved

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RelatedDiseases for PRKCA_IGF2BP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePRKCAC0036341Schizophrenia2PSYGENET
HgenePRKCAC0011853Diabetes Mellitus, Experimental1CTD_human
HgenePRKCAC0018800Cardiomegaly1CTD_human
HgenePRKCAC0021841Intestinal Neoplasms1CTD_human
HgenePRKCAC0032617Polyuria1CTD_human
HgenePRKCAC0033975Psychotic Disorders1PSYGENET
HgenePRKCAC0036337Schizoaffective Disorder1PSYGENET
HgenePRKCAC0162283Nephrogenic Diabetes Insipidus1CTD_human
HgenePRKCAC0349204Nonorganic psychosis1PSYGENET
TgeneIGF2BP3C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneIGF2BP3C0031149Peritoneal Neoplasms1CTD_human
TgeneIGF2BP3C0345967Malignant mesothelioma1CTD_human