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Fusion gene ID: 2870 |
FusionGeneSummary for ARSJ_DNAH9 |
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Fusion gene information | Fusion gene name: ARSJ_DNAH9 | Fusion gene ID: 2870 | Hgene | Tgene | Gene symbol | ARSJ | DNAH9 | Gene ID | 79642 | 1770 |
Gene name | arylsulfatase family member J | dynein axonemal heavy chain 9 | |
Synonyms | ASJ | DNAH17L|DNEL1|DYH9|Dnahc9|HL-20|HL20 | |
Cytomap | 4q26 | 17p12 | |
Type of gene | protein-coding | protein-coding | |
Description | arylsulfatase J | dynein heavy chain 9, axonemalDNAH9 variant proteinaxonemal beta dynein heavy chain 9ciliary dynein heavy chain 9dynein, axonemal, heavy polypeptide 9 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q5FYB0 | Q9NYC9 | |
Ensembl transtripts involved in fusion gene | ENST00000315366, ENST00000541197, ENST00000503013, | ENST00000262442, ENST00000454412, ENST00000608377, ENST00000396001, ENST00000579828, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 4 X 3=36 |
# samples | 1 | 4 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ARSJ [Title/Abstract] AND DNAH9 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-LL-A8F5-01A | ARSJ | chr4 | 114824409 | - | DNAH9 | chr17 | 11828746 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000315366 | ENST00000262442 | ARSJ | chr4 | 114824409 | - | DNAH9 | chr17 | 11828746 | + |
intron-intron | ENST00000315366 | ENST00000454412 | ARSJ | chr4 | 114824409 | - | DNAH9 | chr17 | 11828746 | + |
intron-intron | ENST00000315366 | ENST00000608377 | ARSJ | chr4 | 114824409 | - | DNAH9 | chr17 | 11828746 | + |
intron-intron | ENST00000315366 | ENST00000396001 | ARSJ | chr4 | 114824409 | - | DNAH9 | chr17 | 11828746 | + |
intron-intron | ENST00000315366 | ENST00000579828 | ARSJ | chr4 | 114824409 | - | DNAH9 | chr17 | 11828746 | + |
intron-intron | ENST00000541197 | ENST00000262442 | ARSJ | chr4 | 114824409 | - | DNAH9 | chr17 | 11828746 | + |
intron-intron | ENST00000541197 | ENST00000454412 | ARSJ | chr4 | 114824409 | - | DNAH9 | chr17 | 11828746 | + |
intron-intron | ENST00000541197 | ENST00000608377 | ARSJ | chr4 | 114824409 | - | DNAH9 | chr17 | 11828746 | + |
intron-intron | ENST00000541197 | ENST00000396001 | ARSJ | chr4 | 114824409 | - | DNAH9 | chr17 | 11828746 | + |
intron-intron | ENST00000541197 | ENST00000579828 | ARSJ | chr4 | 114824409 | - | DNAH9 | chr17 | 11828746 | + |
intron-intron | ENST00000503013 | ENST00000262442 | ARSJ | chr4 | 114824409 | - | DNAH9 | chr17 | 11828746 | + |
intron-intron | ENST00000503013 | ENST00000454412 | ARSJ | chr4 | 114824409 | - | DNAH9 | chr17 | 11828746 | + |
intron-intron | ENST00000503013 | ENST00000608377 | ARSJ | chr4 | 114824409 | - | DNAH9 | chr17 | 11828746 | + |
intron-intron | ENST00000503013 | ENST00000396001 | ARSJ | chr4 | 114824409 | - | DNAH9 | chr17 | 11828746 | + |
intron-intron | ENST00000503013 | ENST00000579828 | ARSJ | chr4 | 114824409 | - | DNAH9 | chr17 | 11828746 | + |
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FusionProtFeatures for ARSJ_DNAH9 |
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Hgene | Tgene |
ARSJ | DNAH9 |
Force generating protein of respiratory cilia. Producesforce towards the minus ends of microtubules. Dynein has ATPaseactivity; the force-producing power stroke is thought to occur onrelease of ADP. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ARSJ_DNAH9 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ARSJ_DNAH9 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ARSJ | KRT31, TRAF1, TRAF2, ZMIZ2 | DNAH9 | BCL6, FAM103A1, SRPK2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ARSJ_DNAH9 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ARSJ_DNAH9 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |