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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2870

FusionGeneSummary for ARSJ_DNAH9

check button Fusion gene summary
Fusion gene informationFusion gene name: ARSJ_DNAH9
Fusion gene ID: 2870
HgeneTgene
Gene symbol

ARSJ

DNAH9

Gene ID

79642

1770

Gene namearylsulfatase family member Jdynein axonemal heavy chain 9
SynonymsASJDNAH17L|DNEL1|DYH9|Dnahc9|HL-20|HL20
Cytomap

4q26

17p12

Type of geneprotein-codingprotein-coding
Descriptionarylsulfatase Jdynein heavy chain 9, axonemalDNAH9 variant proteinaxonemal beta dynein heavy chain 9ciliary dynein heavy chain 9dynein, axonemal, heavy polypeptide 9
Modification date2018052220180523
UniProtAcc

Q5FYB0

Q9NYC9

Ensembl transtripts involved in fusion geneENST00000315366, ENST00000541197, 
ENST00000503013, 
ENST00000262442, 
ENST00000454412, ENST00000608377, 
ENST00000396001, ENST00000579828, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 4 X 3=36
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ARSJ [Title/Abstract] AND DNAH9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-LL-A8F5-01AARSJchr4

114824409

-DNAH9chr17

11828746

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000315366ENST00000262442ARSJchr4

114824409

-DNAH9chr17

11828746

+
intron-intronENST00000315366ENST00000454412ARSJchr4

114824409

-DNAH9chr17

11828746

+
intron-intronENST00000315366ENST00000608377ARSJchr4

114824409

-DNAH9chr17

11828746

+
intron-intronENST00000315366ENST00000396001ARSJchr4

114824409

-DNAH9chr17

11828746

+
intron-intronENST00000315366ENST00000579828ARSJchr4

114824409

-DNAH9chr17

11828746

+
intron-intronENST00000541197ENST00000262442ARSJchr4

114824409

-DNAH9chr17

11828746

+
intron-intronENST00000541197ENST00000454412ARSJchr4

114824409

-DNAH9chr17

11828746

+
intron-intronENST00000541197ENST00000608377ARSJchr4

114824409

-DNAH9chr17

11828746

+
intron-intronENST00000541197ENST00000396001ARSJchr4

114824409

-DNAH9chr17

11828746

+
intron-intronENST00000541197ENST00000579828ARSJchr4

114824409

-DNAH9chr17

11828746

+
intron-intronENST00000503013ENST00000262442ARSJchr4

114824409

-DNAH9chr17

11828746

+
intron-intronENST00000503013ENST00000454412ARSJchr4

114824409

-DNAH9chr17

11828746

+
intron-intronENST00000503013ENST00000608377ARSJchr4

114824409

-DNAH9chr17

11828746

+
intron-intronENST00000503013ENST00000396001ARSJchr4

114824409

-DNAH9chr17

11828746

+
intron-intronENST00000503013ENST00000579828ARSJchr4

114824409

-DNAH9chr17

11828746

+

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FusionProtFeatures for ARSJ_DNAH9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARSJ

Q5FYB0

DNAH9

Q9NYC9

Force generating protein of respiratory cilia. Producesforce towards the minus ends of microtubules. Dynein has ATPaseactivity; the force-producing power stroke is thought to occur onrelease of ADP.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARSJ_DNAH9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARSJ_DNAH9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ARSJKRT31, TRAF1, TRAF2, ZMIZ2DNAH9BCL6, FAM103A1, SRPK2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARSJ_DNAH9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARSJ_DNAH9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource