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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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RelatedDiseases

Fusion gene ID: 28683

FusionGeneSummary for PRKAG2_CCDC132

check button Fusion gene summary
Fusion gene informationFusion gene name: PRKAG2_CCDC132
Fusion gene ID: 28683
HgeneTgene
Gene symbol

PRKAG2

CCDC132

Gene ID

51422

55610

Gene nameprotein kinase AMP-activated non-catalytic subunit gamma 2VPS50, EARP/GARPII complex subunit
SynonymsAAKG|AAKG2|CMH6|H91620p|WPWSCCDC132|VPS54L
Cytomap

7q36.1

7q21.2-q21.3

Type of geneprotein-codingprotein-coding
Description5'-AMP-activated protein kinase subunit gamma-2AMPK subunit gamma-2protein kinase, AMP-activated, gamma 2 non-catalytic subunitsyndetinEARP/GARPII complex subunit VPS50coiled-coil domain containing 132coiled-coil domain-containing protein 132
Modification date2018052920180519
UniProtAcc

Q9UGJ0

Ensembl transtripts involved in fusion geneENST00000287878, ENST00000418337, 
ENST00000433631, ENST00000492843, 
ENST00000392801, ENST00000461529, 
ENST00000305866, ENST00000541136, 
ENST00000544910, ENST00000535481, 
ENST00000317751, ENST00000251739, 
ENST00000474412, 
Fusion gene scores* DoF score10 X 7 X 7=4903 X 3 X 2=18
# samples 113
** MAII scorelog2(11/490*10)=-2.15527822547791
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PRKAG2 [Title/Abstract] AND CCDC132 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRKAG2

GO:0006469

negative regulation of protein kinase activity

17255938

TgeneCCDC132

GO:0032456

endocytic recycling

25799061


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-B6-A2IU-01APRKAG2chr7

151573592

-CCDC132chr7

92970739

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000287878ENST00000305866PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
In-frameENST00000287878ENST00000541136PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
In-frameENST00000287878ENST00000544910PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
In-frameENST00000287878ENST00000535481PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
5CDS-intronENST00000287878ENST00000317751PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
5CDS-intronENST00000287878ENST00000251739PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
5CDS-3UTRENST00000287878ENST00000474412PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-3CDSENST00000418337ENST00000305866PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-3CDSENST00000418337ENST00000541136PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-3CDSENST00000418337ENST00000544910PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-3CDSENST00000418337ENST00000535481PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-intronENST00000418337ENST00000317751PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-intronENST00000418337ENST00000251739PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-3UTRENST00000418337ENST00000474412PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-3CDSENST00000433631ENST00000305866PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-3CDSENST00000433631ENST00000541136PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-3CDSENST00000433631ENST00000544910PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-3CDSENST00000433631ENST00000535481PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-intronENST00000433631ENST00000317751PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-intronENST00000433631ENST00000251739PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-3UTRENST00000433631ENST00000474412PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-3CDSENST00000492843ENST00000305866PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-3CDSENST00000492843ENST00000541136PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-3CDSENST00000492843ENST00000544910PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-3CDSENST00000492843ENST00000535481PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-intronENST00000492843ENST00000317751PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-intronENST00000492843ENST00000251739PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-3UTRENST00000492843ENST00000474412PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-3CDSENST00000392801ENST00000305866PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-3CDSENST00000392801ENST00000541136PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-3CDSENST00000392801ENST00000544910PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-3CDSENST00000392801ENST00000535481PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-intronENST00000392801ENST00000317751PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-intronENST00000392801ENST00000251739PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-3UTRENST00000392801ENST00000474412PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-3CDSENST00000461529ENST00000305866PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-3CDSENST00000461529ENST00000541136PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-3CDSENST00000461529ENST00000544910PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-3CDSENST00000461529ENST00000535481PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-intronENST00000461529ENST00000317751PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-intronENST00000461529ENST00000251739PRKAG2chr7

151573592

-CCDC132chr7

92970739

+
intron-3UTRENST00000461529ENST00000474412PRKAG2chr7

151573592

-CCDC132chr7

92970739

+

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FusionProtFeatures for PRKAG2_CCDC132


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRKAG2

Q9UGJ0

CCDC132

AMP/ATP-binding subunit of AMP-activated protein kinase(AMPK), an energy sensor protein kinase that plays a key role inregulating cellular energy metabolism. In response to reduction ofintracellular ATP levels, AMPK activates energy-producing pathwaysand inhibits energy-consuming processes: inhibits protein,carbohydrate and lipid biosynthesis, as well as cell growth andproliferation. AMPK acts via direct phosphorylation of metabolicenzymes, and by longer-term effects via phosphorylation oftranscription regulators. Also acts as a regulator of cellularpolarity by remodeling the actin cytoskeleton; probably byindirectly activating myosin. Gamma non-catalytic subunit mediatesbinding to AMP, ADP and ATP, leading to activate or inhibit AMPK:AMP-binding results in allosteric activation of alpha catalyticsubunit (PRKAA1 or PRKAA2) both by inducing phosphorylation andpreventing dephosphorylation of catalytic subunits. ADP alsostimulates phosphorylation, without stimulating alreadyphosphorylated catalytic subunit. ATP promotes dephosphorylationof catalytic subunit, rendering the AMPK enzyme inactive.{ECO:0000269|PubMed:14722619}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCCDC132chr7:151573592chr7:92970739ENST00000251739+012216_244-43328Coiled coilOntology_term=ECO:0000255
TgeneCCDC132chr7:151573592chr7:92970739ENST00000251739+01282_105-43328Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRKAG2chr7:151573592chr7:92970739ENST00000287878-116275_33538570DomainCBS 1
HgenePRKAG2chr7:151573592chr7:92970739ENST00000287878-116357_41538570DomainCBS 2
HgenePRKAG2chr7:151573592chr7:92970739ENST00000287878-116430_49238570DomainCBS 3
HgenePRKAG2chr7:151573592chr7:92970739ENST00000287878-116504_56238570DomainCBS 4
HgenePRKAG2chr7:151573592chr7:92970739ENST00000392801-116275_335-148526DomainCBS 1
HgenePRKAG2chr7:151573592chr7:92970739ENST00000392801-116357_415-148526DomainCBS 2
HgenePRKAG2chr7:151573592chr7:92970739ENST00000392801-116430_492-148526DomainCBS 3
HgenePRKAG2chr7:151573592chr7:92970739ENST00000392801-116504_562-148526DomainCBS 4
HgenePRKAG2chr7:151573592chr7:92970739ENST00000418337-112275_335-85329DomainCBS 1
HgenePRKAG2chr7:151573592chr7:92970739ENST00000418337-112357_415-85329DomainCBS 2
HgenePRKAG2chr7:151573592chr7:92970739ENST00000418337-112430_492-85329DomainCBS 3
HgenePRKAG2chr7:151573592chr7:92970739ENST00000418337-112504_562-85329DomainCBS 4
HgenePRKAG2chr7:151573592chr7:92970739ENST00000287878-116370_39138570MotifNote=AMPK pseudosubstrate
HgenePRKAG2chr7:151573592chr7:92970739ENST00000392801-116370_391-148526MotifNote=AMPK pseudosubstrate
HgenePRKAG2chr7:151573592chr7:92970739ENST00000418337-112370_391-85329MotifNote=AMPK pseudosubstrate
HgenePRKAG2chr7:151573592chr7:92970739ENST00000287878-116319_32238570Nucleotide bindingAMP%2C ADP or ATP 1
HgenePRKAG2chr7:151573592chr7:92970739ENST00000287878-116383_38438570Nucleotide bindingAMP%2C ADP or ATP 1
HgenePRKAG2chr7:151573592chr7:92970739ENST00000287878-116458_45938570Nucleotide bindingAMP 3
HgenePRKAG2chr7:151573592chr7:92970739ENST00000287878-116474_47738570Nucleotide bindingAMP%2C ADP or ATP 2
HgenePRKAG2chr7:151573592chr7:92970739ENST00000287878-116530_53138570Nucleotide bindingAMP%2C ADP or ATP 2
HgenePRKAG2chr7:151573592chr7:92970739ENST00000287878-116546_54938570Nucleotide bindingAMP 3
HgenePRKAG2chr7:151573592chr7:92970739ENST00000392801-116319_322-148526Nucleotide bindingAMP%2C ADP or ATP 1
HgenePRKAG2chr7:151573592chr7:92970739ENST00000392801-116383_384-148526Nucleotide bindingAMP%2C ADP or ATP 1
HgenePRKAG2chr7:151573592chr7:92970739ENST00000392801-116458_459-148526Nucleotide bindingAMP 3
HgenePRKAG2chr7:151573592chr7:92970739ENST00000392801-116474_477-148526Nucleotide bindingAMP%2C ADP or ATP 2
HgenePRKAG2chr7:151573592chr7:92970739ENST00000392801-116530_531-148526Nucleotide bindingAMP%2C ADP or ATP 2
HgenePRKAG2chr7:151573592chr7:92970739ENST00000392801-116546_549-148526Nucleotide bindingAMP 3
HgenePRKAG2chr7:151573592chr7:92970739ENST00000418337-112319_322-85329Nucleotide bindingAMP%2C ADP or ATP 1
HgenePRKAG2chr7:151573592chr7:92970739ENST00000418337-112383_384-85329Nucleotide bindingAMP%2C ADP or ATP 1
HgenePRKAG2chr7:151573592chr7:92970739ENST00000418337-112458_459-85329Nucleotide bindingAMP 3
HgenePRKAG2chr7:151573592chr7:92970739ENST00000418337-112474_477-85329Nucleotide bindingAMP%2C ADP or ATP 2
HgenePRKAG2chr7:151573592chr7:92970739ENST00000418337-112530_531-85329Nucleotide bindingAMP%2C ADP or ATP 2
HgenePRKAG2chr7:151573592chr7:92970739ENST00000418337-112546_549-85329Nucleotide bindingAMP 3
TgeneCCDC132chr7:151573592chr7:92970739ENST00000305866+2128216_244686965Coiled coilOntology_term=ECO:0000255
TgeneCCDC132chr7:151573592chr7:92970739ENST00000305866+212882_105686965Coiled coilOntology_term=ECO:0000255
TgeneCCDC132chr7:151573592chr7:92970739ENST00000544910+2229216_244656935Coiled coilOntology_term=ECO:0000255
TgeneCCDC132chr7:151573592chr7:92970739ENST00000544910+222982_105656935Coiled coilOntology_term=ECO:0000255


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FusionGeneSequence for PRKAG2_CCDC132


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PRKAG2_ENST00000287878_chr7_151573592_-_CCDC132_ENST00000305866_chr7_92970739_+_317aa
MGSAVMDTKKKKDVSSPGGSGGKKNASQKRRSLRVHIPEVSADPTATLTAAEERKEKVPSPHLSHLVVLTSGDTLYGLAERVVATESLVF
LAEQFEFLQPHLDAVMPAVKKPFLQQFYSQTVSTASELRKPIYWIVAGKALDYEQMLLLMANVKWDVKEIMSQHNIYVDALLKEFEQFNR
RLNEVSKRVRIPLPVSNILWEHCIRLANRTIVEGYANVKKCSNEGRALMQLDFQQFLMKLEKLTDIRPIPDKEFVETYIKAYYLTENDME

>In-frame_PRKAG2_ENST00000287878_chr7_151573592_-_CCDC132_ENST00000541136_chr7_92970739_+_135aa
MGSAVMDTKKKKDVSSPGGSGGKKNASQKRRSLRVHIPEVSADPTATLTAAEERKEKVPSPHLSHLVVLTSGDTLYGLAERVVATESLVF

>In-frame_PRKAG2_ENST00000287878_chr7_151573592_-_CCDC132_ENST00000544910_chr7_92970739_+_317aa
MGSAVMDTKKKKDVSSPGGSGGKKNASQKRRSLRVHIPEVSADPTATLTAAEERKEKVPSPHLSHLVVLTSGDTLYGLAERVVATESLVF
LAEQFEFLQPHLDAVMPAVKKPFLQQFYSQTVSTASELRKPIYWIVAGKALDYEQMLLLMANVKWDVKEIMSQHNIYVDALLKEFEQFNR
RLNEVSKRVRIPLPVSNILWEHCIRLANRTIVEGYANVKKCSNEGRALMQLDFQQFLMKLEKLTDIRPIPDKEFVETYIKAYYLTENDME

>In-frame_PRKAG2_ENST00000287878_chr7_151573592_-_CCDC132_ENST00000535481_chr7_92970739_+_317aa
MGSAVMDTKKKKDVSSPGGSGGKKNASQKRRSLRVHIPEVSADPTATLTAAEERKEKVPSPHLSHLVVLTSGDTLYGLAERVVATESLVF
LAEQFEFLQPHLDAVMPAVKKPFLQQFYSQTVSTASELRKPIYWIVAGKALDYEQMLLLMANVKWDVKEIMSQHNIYVDALLKEFEQFNR
RLNEVSKRVRIPLPVSNILWEHCIRLANRTIVEGYANVKKCSNEGRALMQLDFQQFLMKLEKLTDIRPIPDKEFVETYIKAYYLTENDME


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PRKAG2_ENST00000287878_chr7_151573592_-_CCDC132_ENST00000305866_chr7_92970739_+_951nt
ATGGGAAGCGCGGTTATGGACACCAAGAAGAAAAAAGATGTTTCCAGCCCCGGCGGGAGCGGCGGCAAGAAAAATGCCAGCCAGAAGAGG
CGTTCGCTGCGCGTGCACATTCCGGAAGTTTCAGCTGATCCTACTGCCACACTCACAGCAGCAGAAGAAAGAAAGGAGAAGGTGCCAAGT
CCACACCTCAGTCACCTAGTGGTTTTGACATCTGGGGATACGCTGTATGGGTTGGCAGAAAGAGTGGTAGCCACGGAATCCTTGGTATTC
TTGGCTGAACAGTTTGAGTTCCTTCAGCCACATCTGGATGCTGTGATGCCTGCAGTCAAAAAGCCCTTTCTTCAGCAGTTCTATTCTCAG
ACAGTCTCAACCGCCAGTGAACTACGGAAACCAATTTACTGGATTGTAGCTGGTAAAGCCCTTGATTATGAACAGATGCTGCTTCTCATG
GCTAATGTGAAATGGGATGTAAAAGAAATTATGTCACAGCACAACATATATGTAGATGCACTATTAAAGGAATTTGAGCAGTTTAACAGG
AGGCTAAATGAAGTTTCTAAGAGAGTTCGCATACCCTTGCCTGTGTCTAATATACTTTGGGAACATTGTATACGATTGGCTAATCGAACT
ATTGTAGAAGGATATGCCAATGTCAAGAAATGCAGTAATGAGGGTCGTGCCCTGATGCAATTGGATTTTCAACAGTTTTTAATGAAACTT
GAAAAACTAACAGATATTAGACCCATTCCTGATAAAGAATTTGTAGAAACTTATATTAAAGCTTATTACCTAACTGAGAATGACATGGAA
CGGTGGATCAAAGAGCACAGGGAATATTCAACGAAGCAGCTGACCAATCTGGTGAATGTTTGCCTGGGATCCCATATCAATAAGAAAGCA

>In-frame_PRKAG2_ENST00000287878_chr7_151573592_-_CCDC132_ENST00000541136_chr7_92970739_+_405nt
ATGGGAAGCGCGGTTATGGACACCAAGAAGAAAAAAGATGTTTCCAGCCCCGGCGGGAGCGGCGGCAAGAAAAATGCCAGCCAGAAGAGG
CGTTCGCTGCGCGTGCACATTCCGGAAGTTTCAGCTGATCCTACTGCCACACTCACAGCAGCAGAAGAAAGAAAGGAGAAGGTGCCAAGT
CCACACCTCAGTCACCTAGTGGTTTTGACATCTGGGGATACGCTGTATGGGTTGGCAGAAAGAGTGGTAGCCACGGAATCCTTGGTATTC
TTGGCTGAACAGTTTGAGTTCCTTCAGCCACATCTGGATGCTGTGATGCCTGCAGTCAAAAAGCCCTTTCTTCAGCAGTTCTATTCTCAG

>In-frame_PRKAG2_ENST00000287878_chr7_151573592_-_CCDC132_ENST00000544910_chr7_92970739_+_951nt
ATGGGAAGCGCGGTTATGGACACCAAGAAGAAAAAAGATGTTTCCAGCCCCGGCGGGAGCGGCGGCAAGAAAAATGCCAGCCAGAAGAGG
CGTTCGCTGCGCGTGCACATTCCGGAAGTTTCAGCTGATCCTACTGCCACACTCACAGCAGCAGAAGAAAGAAAGGAGAAGGTGCCAAGT
CCACACCTCAGTCACCTAGTGGTTTTGACATCTGGGGATACGCTGTATGGGTTGGCAGAAAGAGTGGTAGCCACGGAATCCTTGGTATTC
TTGGCTGAACAGTTTGAGTTCCTTCAGCCACATCTGGATGCTGTGATGCCTGCAGTCAAAAAGCCCTTTCTTCAGCAGTTCTATTCTCAG
ACAGTCTCAACCGCCAGTGAACTACGGAAACCAATTTACTGGATTGTAGCTGGTAAAGCCCTTGATTATGAACAGATGCTGCTTCTCATG
GCTAATGTGAAATGGGATGTAAAAGAAATTATGTCACAGCACAACATATATGTAGATGCACTATTAAAGGAATTTGAGCAGTTTAACAGG
AGGCTAAATGAAGTTTCTAAGAGAGTTCGCATACCCTTGCCTGTGTCTAATATACTTTGGGAACATTGTATACGATTGGCTAATCGAACT
ATTGTAGAAGGATATGCCAATGTCAAGAAATGCAGTAATGAGGGTCGTGCCCTGATGCAATTGGATTTTCAACAGTTTTTAATGAAACTT
GAAAAACTAACAGATATTAGACCCATTCCTGATAAAGAATTTGTAGAAACTTATATTAAAGCTTATTACCTAACTGAGAATGACATGGAA
CGGTGGATCAAAGAGCACAGGGAATATTCAACGAAGCAGCTGACCAATCTGGTGAATGTTTGCCTGGGATCCCATATCAATAAGAAAGCA

>In-frame_PRKAG2_ENST00000287878_chr7_151573592_-_CCDC132_ENST00000535481_chr7_92970739_+_951nt
ATGGGAAGCGCGGTTATGGACACCAAGAAGAAAAAAGATGTTTCCAGCCCCGGCGGGAGCGGCGGCAAGAAAAATGCCAGCCAGAAGAGG
CGTTCGCTGCGCGTGCACATTCCGGAAGTTTCAGCTGATCCTACTGCCACACTCACAGCAGCAGAAGAAAGAAAGGAGAAGGTGCCAAGT
CCACACCTCAGTCACCTAGTGGTTTTGACATCTGGGGATACGCTGTATGGGTTGGCAGAAAGAGTGGTAGCCACGGAATCCTTGGTATTC
TTGGCTGAACAGTTTGAGTTCCTTCAGCCACATCTGGATGCTGTGATGCCTGCAGTCAAAAAGCCCTTTCTTCAGCAGTTCTATTCTCAG
ACAGTCTCAACCGCCAGTGAACTACGGAAACCAATTTACTGGATTGTAGCTGGTAAAGCCCTTGATTATGAACAGATGCTGCTTCTCATG
GCTAATGTGAAATGGGATGTAAAAGAAATTATGTCACAGCACAACATATATGTAGATGCACTATTAAAGGAATTTGAGCAGTTTAACAGG
AGGCTAAATGAAGTTTCTAAGAGAGTTCGCATACCCTTGCCTGTGTCTAATATACTTTGGGAACATTGTATACGATTGGCTAATCGAACT
ATTGTAGAAGGATATGCCAATGTCAAGAAATGCAGTAATGAGGGTCGTGCCCTGATGCAATTGGATTTTCAACAGTTTTTAATGAAACTT
GAAAAACTAACAGATATTAGACCCATTCCTGATAAAGAATTTGTAGAAACTTATATTAAAGCTTATTACCTAACTGAGAATGACATGGAA
CGGTGGATCAAAGAGCACAGGGAATATTCAACGAAGCAGCTGACCAATCTGGTGAATGTTTGCCTGGGATCCCATATCAATAAGAAAGCA


* Fusion transcript sequences (Full-length transcript).
>In-frame_PRKAG2_ENST00000287878_chr7_151573592_-_CCDC132_ENST00000305866_chr7_92970739_+_2046nt
GAGCTGGTTTATTCTGCGGCCGAGGATTACATTTATGCACGAACGGGCTTACTGGTTCCAGATTCCCCACTTGGGCACAGGCATAGGAGG
CTTGTTTTCCAAATTGCTGGTTTTAATTGCACCTGCCTTTCAGATTACCTCTGGGAATCTGTGGGAGGAGCCGAGAGGGTGGAAAATGTT
TCTTAGCTTTGCAAAAGGAAGAAAACTTTGTCACCCAGCGGGAGACCTCAGCCACGAGTAACCCGGGGAGACACCAGAACCGGGACGGGC
TTTGACTGATTTGCCTACGAGGGTTCCGTAGGAAAGGACGCTTGAATTCGGCGCTTCGGCGGCGGCGGCGGCCGCGCGAGTTCCCTGCTC
ACCCTCCCTCTCCGCGGAAGTCCCCACGAGGTGGCTTCAGGGTGTAACAGAGCGCGCGGCTCCAGTCCGAAGGCAGCGGCCGGGGGAGGG
AAGGAGGGGACCGAACCCCCGAGGAGTTTCGCAGAATCAACTTCTGGTTAGAGTTATGGGAAGCGCGGTTATGGACACCAAGAAGAAAAA
AGATGTTTCCAGCCCCGGCGGGAGCGGCGGCAAGAAAAATGCCAGCCAGAAGAGGCGTTCGCTGCGCGTGCACATTCCGGAAGTTTCAGC
TGATCCTACTGCCACACTCACAGCAGCAGAAGAAAGAAAGGAGAAGGTGCCAAGTCCACACCTCAGTCACCTAGTGGTTTTGACATCTGG
GGATACGCTGTATGGGTTGGCAGAAAGAGTGGTAGCCACGGAATCCTTGGTATTCTTGGCTGAACAGTTTGAGTTCCTTCAGCCACATCT
GGATGCTGTGATGCCTGCAGTCAAAAAGCCCTTTCTTCAGCAGTTCTATTCTCAGACAGTCTCAACCGCCAGTGAACTACGGAAACCAAT
TTACTGGATTGTAGCTGGTAAAGCCCTTGATTATGAACAGATGCTGCTTCTCATGGCTAATGTGAAATGGGATGTAAAAGAAATTATGTC
ACAGCACAACATATATGTAGATGCACTATTAAAGGAATTTGAGCAGTTTAACAGGAGGCTAAATGAAGTTTCTAAGAGAGTTCGCATACC
CTTGCCTGTGTCTAATATACTTTGGGAACATTGTATACGATTGGCTAATCGAACTATTGTAGAAGGATATGCCAATGTCAAGAAATGCAG
TAATGAGGGTCGTGCCCTGATGCAATTGGATTTTCAACAGTTTTTAATGAAACTTGAAAAACTAACAGATATTAGACCCATTCCTGATAA
AGAATTTGTAGAAACTTATATTAAAGCTTATTACCTAACTGAGAATGACATGGAACGGTGGATCAAAGAGCACAGGGAATATTCAACGAA
GCAGCTGACCAATCTGGTGAATGTTTGCCTGGGATCCCATATCAATAAGAAAGCAAGACAAAAACTTCTAGCAGCTATAGATGATATAGA
CAGACCTAAAAGATAATGAACACAGCTCTCTTTCCTCAATGGCATTGATCCTCACTCAACATATATGACCTGAAAGCCAGTTTTTTTATG
CACTTCTGACAACTATCTGCTAAGAAAACTTTGTGCATGTTTTTTTGACTGGAAAGTGGAAAATATTGAAATGTGTGTGGTGTTCTCATG
ACTTTTATATGCTGTGGTCTCTTCAACTTTTGGTCTCATTTGTTGTAATCTGAAATGATGTTGCCGCCTTGTCATAACAATGGTTATGTG
ACTACAGTTATACATTTTACAGAAGAATGTACCATAAGTATATAATTAGAAGAACAGTGGCTTAATATATGTATGGGAAGTTTATGGAAA
ATGAAGTTGGCACTTTTCTACCCTCTGAGCTTGGTTCTTAATAAGCATAATGTGAGGGTGAATATGTAGTATCTCCTAATTATGAGCACT
GCATGAGAATTAAAAAACACATGTAAGTAAAATAGTTGAAAAATCAGTATGTTCTCTGTTTTTAAAATGTCAAAGTTTATGTCAGGGTTA

>In-frame_PRKAG2_ENST00000287878_chr7_151573592_-_CCDC132_ENST00000541136_chr7_92970739_+_2040nt
GAGCTGGTTTATTCTGCGGCCGAGGATTACATTTATGCACGAACGGGCTTACTGGTTCCAGATTCCCCACTTGGGCACAGGCATAGGAGG
CTTGTTTTCCAAATTGCTGGTTTTAATTGCACCTGCCTTTCAGATTACCTCTGGGAATCTGTGGGAGGAGCCGAGAGGGTGGAAAATGTT
TCTTAGCTTTGCAAAAGGAAGAAAACTTTGTCACCCAGCGGGAGACCTCAGCCACGAGTAACCCGGGGAGACACCAGAACCGGGACGGGC
TTTGACTGATTTGCCTACGAGGGTTCCGTAGGAAAGGACGCTTGAATTCGGCGCTTCGGCGGCGGCGGCGGCCGCGCGAGTTCCCTGCTC
ACCCTCCCTCTCCGCGGAAGTCCCCACGAGGTGGCTTCAGGGTGTAACAGAGCGCGCGGCTCCAGTCCGAAGGCAGCGGCCGGGGGAGGG
AAGGAGGGGACCGAACCCCCGAGGAGTTTCGCAGAATCAACTTCTGGTTAGAGTTATGGGAAGCGCGGTTATGGACACCAAGAAGAAAAA
AGATGTTTCCAGCCCCGGCGGGAGCGGCGGCAAGAAAAATGCCAGCCAGAAGAGGCGTTCGCTGCGCGTGCACATTCCGGAAGTTTCAGC
TGATCCTACTGCCACACTCACAGCAGCAGAAGAAAGAAAGGAGAAGGTGCCAAGTCCACACCTCAGTCACCTAGTGGTTTTGACATCTGG
GGATACGCTGTATGGGTTGGCAGAAAGAGTGGTAGCCACGGAATCCTTGGTATTCTTGGCTGAACAGTTTGAGTTCCTTCAGCCACATCT
GGATGCTGTGATGCCTGCAGTCAAAAAGCCCTTTCTTCAGCAGTTCTATTCTCAGTCTCAACCGCCAGTGAACTACGGAAACCAATTTAC
TGGATTGTAGCTGGTAAAGCCCTTGATTATGAACAGATGCTGCTTCTCATGGCTAATGTGAAATGGGATGTAAAAGAAATTATGTCACAG
CACAACATATATGTAGATGCACTATTAAAGGAATTTGAGCAGTTTAACAGGAGGCTAAATGAAGTTTCTAAGAGAGTTCGCATACCCTTG
CCTGTGTCTAATATACTTTGGGAACATTGTATACGATTGGCTAATCGAACTATTGTAGAAGGATATGCCAATGTCAAGAAATGCAGTAAT
GAGGGTCGTGCCCTGATGCAATTGGATTTTCAACAGTTTTTAATGAAACTTGAAAAACTAACAGATATTAGACCCATTCCTGATAAAGAA
TTTGTAGAAACTTATATTAAAGCTTATTACCTAACTGAGAATGACATGGAACGGTGGATCAAAGAGCACAGGGAATATTCAACGAAGCAG
CTGACCAATCTGGTGAATGTTTGCCTGGGATCCCATATCAATAAGAAAGCAAGACAAAAACTTCTAGCAGCTATAGATGATATAGACAGA
CCTAAAAGATAATGAACACAGCTCTCTTTCCTCAATGGCATTGATCCTCACTCAACATATATGACCTGAAAGCCAGTTTTTTTATGCACT
TCTGACAACTATCTGCTAAGAAAACTTTGTGCATGTTTTTTTGACTGGAAAGTGGAAAATATTGAAATGTGTGTGGTGTTCTCATGACTT
TTATATGCTGTGGTCTCTTCAACTTTTGGTCTCATTTGTTGTAATCTGAAATGATGTTGCCGCCTTGTCATAACAATGGTTATGTGACTA
CAGTTATACATTTTACAGAAGAATGTACCATAAGTATATAATTAGAAGAACAGTGGCTTAATATATGTATGGGAAGTTTATGGAAAATGA
AGTTGGCACTTTTCTACCCTCTGAGCTTGGTTCTTAATAAGCATAATGTGAGGGTGAATATGTAGTATCTCCTAATTATGAGCACTGCAT
GAGAATTAAAAAACACATGTAAGTAAAATAGTTGAAAAATCAGTATGTTCTCTGTTTTTAAAATGTCAAAGTTTATGTCAGGGTTAATTT

>In-frame_PRKAG2_ENST00000287878_chr7_151573592_-_CCDC132_ENST00000544910_chr7_92970739_+_2045nt
GAGCTGGTTTATTCTGCGGCCGAGGATTACATTTATGCACGAACGGGCTTACTGGTTCCAGATTCCCCACTTGGGCACAGGCATAGGAGG
CTTGTTTTCCAAATTGCTGGTTTTAATTGCACCTGCCTTTCAGATTACCTCTGGGAATCTGTGGGAGGAGCCGAGAGGGTGGAAAATGTT
TCTTAGCTTTGCAAAAGGAAGAAAACTTTGTCACCCAGCGGGAGACCTCAGCCACGAGTAACCCGGGGAGACACCAGAACCGGGACGGGC
TTTGACTGATTTGCCTACGAGGGTTCCGTAGGAAAGGACGCTTGAATTCGGCGCTTCGGCGGCGGCGGCGGCCGCGCGAGTTCCCTGCTC
ACCCTCCCTCTCCGCGGAAGTCCCCACGAGGTGGCTTCAGGGTGTAACAGAGCGCGCGGCTCCAGTCCGAAGGCAGCGGCCGGGGGAGGG
AAGGAGGGGACCGAACCCCCGAGGAGTTTCGCAGAATCAACTTCTGGTTAGAGTTATGGGAAGCGCGGTTATGGACACCAAGAAGAAAAA
AGATGTTTCCAGCCCCGGCGGGAGCGGCGGCAAGAAAAATGCCAGCCAGAAGAGGCGTTCGCTGCGCGTGCACATTCCGGAAGTTTCAGC
TGATCCTACTGCCACACTCACAGCAGCAGAAGAAAGAAAGGAGAAGGTGCCAAGTCCACACCTCAGTCACCTAGTGGTTTTGACATCTGG
GGATACGCTGTATGGGTTGGCAGAAAGAGTGGTAGCCACGGAATCCTTGGTATTCTTGGCTGAACAGTTTGAGTTCCTTCAGCCACATCT
GGATGCTGTGATGCCTGCAGTCAAAAAGCCCTTTCTTCAGCAGTTCTATTCTCAGACAGTCTCAACCGCCAGTGAACTACGGAAACCAAT
TTACTGGATTGTAGCTGGTAAAGCCCTTGATTATGAACAGATGCTGCTTCTCATGGCTAATGTGAAATGGGATGTAAAAGAAATTATGTC
ACAGCACAACATATATGTAGATGCACTATTAAAGGAATTTGAGCAGTTTAACAGGAGGCTAAATGAAGTTTCTAAGAGAGTTCGCATACC
CTTGCCTGTGTCTAATATACTTTGGGAACATTGTATACGATTGGCTAATCGAACTATTGTAGAAGGATATGCCAATGTCAAGAAATGCAG
TAATGAGGGTCGTGCCCTGATGCAATTGGATTTTCAACAGTTTTTAATGAAACTTGAAAAACTAACAGATATTAGACCCATTCCTGATAA
AGAATTTGTAGAAACTTATATTAAAGCTTATTACCTAACTGAGAATGACATGGAACGGTGGATCAAAGAGCACAGGGAATATTCAACGAA
GCAGCTGACCAATCTGGTGAATGTTTGCCTGGGATCCCATATCAATAAGAAAGCAAGACAAAAACTTCTAGCAGCTATAGATGATATAGA
CAGACCTAAAAGATAATGAACACAGCTCTCTTTCCTCAATGGCATTGATCCTCACTCAACATATATGACCTGAAAGCCAGTTTTTTTATG
CACTTCTGACAACTATCTGCTAAGAAAACTTTGTGCATGTTTTTTTGACTGGAAAGTGGAAAATATTGAAATGTGTGTGGTGTTCTCATG
ACTTTTATATGCTGTGGTCTCTTCAACTTTTGGTCTCATTTGTTGTAATCTGAAATGATGTTGCCGCCTTGTCATAACAATGGTTATGTG
ACTACAGTTATACATTTTACAGAAGAATGTACCATAAGTATATAATTAGAAGAACAGTGGCTTAATATATGTATGGGAAGTTTATGGAAA
ATGAAGTTGGCACTTTTCTACCCTCTGAGCTTGGTTCTTAATAAGCATAATGTGAGGGTGAATATGTAGTATCTCCTAATTATGAGCACT
GCATGAGAATTAAAAAACACATGTAAGTAAAATAGTTGAAAAATCAGTATGTTCTCTGTTTTTAAAATGTCAAAGTTTATGTCAGGGTTA

>In-frame_PRKAG2_ENST00000287878_chr7_151573592_-_CCDC132_ENST00000535481_chr7_92970739_+_1797nt
GAGCTGGTTTATTCTGCGGCCGAGGATTACATTTATGCACGAACGGGCTTACTGGTTCCAGATTCCCCACTTGGGCACAGGCATAGGAGG
CTTGTTTTCCAAATTGCTGGTTTTAATTGCACCTGCCTTTCAGATTACCTCTGGGAATCTGTGGGAGGAGCCGAGAGGGTGGAAAATGTT
TCTTAGCTTTGCAAAAGGAAGAAAACTTTGTCACCCAGCGGGAGACCTCAGCCACGAGTAACCCGGGGAGACACCAGAACCGGGACGGGC
TTTGACTGATTTGCCTACGAGGGTTCCGTAGGAAAGGACGCTTGAATTCGGCGCTTCGGCGGCGGCGGCGGCCGCGCGAGTTCCCTGCTC
ACCCTCCCTCTCCGCGGAAGTCCCCACGAGGTGGCTTCAGGGTGTAACAGAGCGCGCGGCTCCAGTCCGAAGGCAGCGGCCGGGGGAGGG
AAGGAGGGGACCGAACCCCCGAGGAGTTTCGCAGAATCAACTTCTGGTTAGAGTTATGGGAAGCGCGGTTATGGACACCAAGAAGAAAAA
AGATGTTTCCAGCCCCGGCGGGAGCGGCGGCAAGAAAAATGCCAGCCAGAAGAGGCGTTCGCTGCGCGTGCACATTCCGGAAGTTTCAGC
TGATCCTACTGCCACACTCACAGCAGCAGAAGAAAGAAAGGAGAAGGTGCCAAGTCCACACCTCAGTCACCTAGTGGTTTTGACATCTGG
GGATACGCTGTATGGGTTGGCAGAAAGAGTGGTAGCCACGGAATCCTTGGTATTCTTGGCTGAACAGTTTGAGTTCCTTCAGCCACATCT
GGATGCTGTGATGCCTGCAGTCAAAAAGCCCTTTCTTCAGCAGTTCTATTCTCAGACAGTCTCAACCGCCAGTGAACTACGGAAACCAAT
TTACTGGATTGTAGCTGGTAAAGCCCTTGATTATGAACAGATGCTGCTTCTCATGGCTAATGTGAAATGGGATGTAAAAGAAATTATGTC
ACAGCACAACATATATGTAGATGCACTATTAAAGGAATTTGAGCAGTTTAACAGGAGGCTAAATGAAGTTTCTAAGAGAGTTCGCATACC
CTTGCCTGTGTCTAATATACTTTGGGAACATTGTATACGATTGGCTAATCGAACTATTGTAGAAGGATATGCCAATGTCAAGAAATGCAG
TAATGAGGGTCGTGCCCTGATGCAATTGGATTTTCAACAGTTTTTAATGAAACTTGAAAAACTAACAGATATTAGACCCATTCCTGATAA
AGAATTTGTAGAAACTTATATTAAAGCTTATTACCTAACTGAGAATGACATGGAACGGTGGATCAAAGAGCACAGGGAATATTCAACGAA
GCAGCTGACCAATCTGGTGAATGTTTGCCTGGGATCCCATATCAATAAGAAAGCAAGACAAAAACTTCTAGCAGCTATAGATGATATAGA
CAGACCTAAAAGATAATGAACACAGCTCTCTTTCCTCAATGGCATTGATCCTCACTCAACATATATGACCTGAAAGCCAGTTTTTTTATG
CACTTCTGACAACTATCTGCTAAGAAAACTTTGTGCATGTTTTTTTGACTGGAAAGTGGAAAATATTGAAATGTGTGTGGTGTTCTCATG
ACTTTTATATGCTGTGGTCTCTTCAACTTTTGGTCTCATTTGTTGTAATCTGAAATGATGTTGCCGCCTTGTCATAACAATGGTTATGTG


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FusionGenePPI for PRKAG2_CCDC132


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PRKAG2PRKAB1, PRKAB2, PRKAG1, PRKAA2, PRKAA1, MAP1B, MAP1LC3A, PGK1, PFAS, FKBP4, EIF3A, TARS, GMPS, GANAB, MAP1A, ASNS, ELAVL1, WDR83, DCLRE1C, NF2, STIM2, GEMIN2, PHKG2, NEFHCCDC132VCP, SNAP29, BSG, VPS53, VPS54, VPS52, VPS51, TSSC1, AMBRA1, DTNBP1, NTRK1, SCLT1, CRABP2, FANCG, BRF1, ZNF33A, RAPGEF2, SF3B2, DDX19B, R3HDM1, GOLIM4, PHF20L1, SDF4, PPIL3, PPP2R3C, LAMA1, EXOC1, FPR2, SLC39A9, CD79B, UBC, PKN3, NCKAP5L, TFPT, CCHCR1, YEATS4, TUFT1, RABGAP1L, GOLGA5, CLOCK, PSMD9, DZIP3, GRIPAP1, RCOR1, HMG20A, CCDC93, OIP5, PHF21A, PTRF, PHLDB3, HAUS6, RPRD1A, ARNTL, MAX, GIT2, RABGEF1, NUF2, THAP11, KDM1A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PRKAG2_CCDC132


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PRKAG2_CCDC132


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePRKAG2C0043202Wolff-Parkinson-White Syndrome4CTD_human;HPO;UNIPROT
HgenePRKAG2C1833236CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 6 (disorder)3CTD_human;UNIPROT
HgenePRKAG2C1849813Glycogen Storage Disease of Heart, Lethal Congenital1CTD_human;ORPHANET;UNIPROT