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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28667

FusionGeneSummary for PRKAA1_RPL37

check button Fusion gene summary
Fusion gene informationFusion gene name: PRKAA1_RPL37
Fusion gene ID: 28667
HgeneTgene
Gene symbol

PRKAA1

RPL37

Gene ID

5562

6167

Gene nameprotein kinase AMP-activated catalytic subunit alpha 1ribosomal protein L37
SynonymsAMPK|AMPKa1L37
Cytomap

5p13.1

5p13.1

Type of geneprotein-codingprotein-coding
Description5'-AMP-activated protein kinase catalytic subunit alpha-15'-AMP-activated protein kinase, catalytic alpha-1 chainACACA kinaseAMP -activate kinase alpha 1 subunitAMP-activated protein kinase, catalytic, alpha-1AMPK alpha 1AMPK subunit alpha-1HMGCR k60S ribosomal protein L3760S ribosomal protein L37aG1.16large ribosomal subunit protein eL37
Modification date2018052720180523
UniProtAcc

Q13131

P61927

Ensembl transtripts involved in fusion geneENST00000397128, ENST00000354209, 
ENST00000296800, 
ENST00000274242, 
ENST00000509877, ENST00000504562, 
ENST00000508493, 
Fusion gene scores* DoF score2 X 1 X 2=42 X 2 X 2=8
# samples 22
** MAII scorelog2(2/4*10)=2.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: PRKAA1 [Title/Abstract] AND RPL37 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRKAA1

GO:0006468

protein phosphorylation

17028174

HgenePRKAA1

GO:0010508

positive regulation of autophagy

22012985

HgenePRKAA1

GO:0010628

positive regulation of gene expression

17028174


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-B6-A0RS-01APRKAA1chr5

40798165

-RPL37chr5

40834708

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000397128ENST00000274242PRKAA1chr5

40798165

-RPL37chr5

40834708

-
In-frameENST00000397128ENST00000509877PRKAA1chr5

40798165

-RPL37chr5

40834708

-
5CDS-5UTRENST00000397128ENST00000504562PRKAA1chr5

40798165

-RPL37chr5

40834708

-
5CDS-5UTRENST00000397128ENST00000508493PRKAA1chr5

40798165

-RPL37chr5

40834708

-
In-frameENST00000354209ENST00000274242PRKAA1chr5

40798165

-RPL37chr5

40834708

-
In-frameENST00000354209ENST00000509877PRKAA1chr5

40798165

-RPL37chr5

40834708

-
5CDS-5UTRENST00000354209ENST00000504562PRKAA1chr5

40798165

-RPL37chr5

40834708

-
5CDS-5UTRENST00000354209ENST00000508493PRKAA1chr5

40798165

-RPL37chr5

40834708

-
In-frameENST00000296800ENST00000274242PRKAA1chr5

40798165

-RPL37chr5

40834708

-
In-frameENST00000296800ENST00000509877PRKAA1chr5

40798165

-RPL37chr5

40834708

-
5CDS-5UTRENST00000296800ENST00000504562PRKAA1chr5

40798165

-RPL37chr5

40834708

-
5CDS-5UTRENST00000296800ENST00000508493PRKAA1chr5

40798165

-RPL37chr5

40834708

-

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FusionProtFeatures for PRKAA1_RPL37


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRKAA1

Q13131

RPL37

P61927

Catalytic subunit of AMP-activated protein kinase(AMPK), an energy sensor protein kinase that plays a key role inregulating cellular energy metabolism. In response to reduction ofintracellular ATP levels, AMPK activates energy-producing pathwaysand inhibits energy-consuming processes: inhibits protein,carbohydrate and lipid biosynthesis, as well as cell growth andproliferation. AMPK acts via direct phosphorylation of metabolicenzymes, and by longer-term effects via phosphorylation oftranscription regulators. Also acts as a regulator of cellularpolarity by remodeling the actin cytoskeleton; probably byindirectly activating myosin. Regulates lipid synthesis byphosphorylating and inactivating lipid metabolic enzymes such asACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid andcholesterol synthesis by phosphorylating acetyl-CoA carboxylase(ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes,respectively. Regulates insulin-signaling and glycolysis byphosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucoseuptake in muscle by increasing the translocation of the glucosetransporter SLC2A4/GLUT4 to the plasma membrane, possibly bymediating phosphorylation of TBC1D4/AS160. Regulates transcriptionand chromatin structure by phosphorylating transcriptionregulators involved in energy metabolism such as CRTC2/TORC2,FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A,p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator ofglucose homeostasis in liver by phosphorylating CRTC2/TORC2,leading to CRTC2/TORC2 sequestration in the cytoplasm. In responseto stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph),leading to promote transcription. Acts as a key regulator of cellgrowth and proliferation by phosphorylating TSC2, RPTOR andATG1/ULK1: in response to nutrient limitation, negativelyregulates the mTORC1 complex by phosphorylating RPTOR component ofthe mTORC1 complex and by phosphorylating and activating TSC2. Inresponse to nutrient limitation, promotes autophagy byphosphorylating and activating ATG1/ULK1. In response to nutrientlimitation, phosphorylates transcription factor FOXO3 promotingFOXO3 mitochontrial import (By similarity). AMPK also acts as aregulator of circadian rhythm by mediating phosphorylation ofCRY1, leading to destabilize it. May regulate the Wnt signalingpathway by phosphorylating CTNNB1, leading to stabilize it. Alsohas tau-protein kinase activity: in response to amyloid beta A4protein (APP) exposure, activated by CAMKK2, leading tophosphorylation of MAPT/TAU; however the relevance of such dataremains unclear in vivo. Also phosphorylates CFTR, EEF2K, KLC1,NOS3 and SLC12A1. {ECO:0000250|UniProtKB:Q5EG47,ECO:0000269|PubMed:11518699, ECO:0000269|PubMed:11554766,ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:14651849,ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17486097,ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:18184930,ECO:0000269|PubMed:18439900, ECO:0000269|PubMed:20074060,ECO:0000269|PubMed:20160076, ECO:0000269|PubMed:21205641}. Binds to the 23S rRNA. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRKAA1chr5:40798165chr5:40834708ENST00000354209-11033_4142575Nucleotide bindingATP
HgenePRKAA1chr5:40798165chr5:40834708ENST00000397128-1933_4142560Nucleotide bindingATP
TgeneRPL37chr5:40798165chr5:40834708ENST00000274242-0419_37198Zinc fingerC4-type

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRKAA1chr5:40798165chr5:40834708ENST00000354209-11027_27942575DomainProtein kinase
HgenePRKAA1chr5:40798165chr5:40834708ENST00000397128-1927_27942560DomainProtein kinase
HgenePRKAA1chr5:40798165chr5:40834708ENST00000354209-110302_38142575RegionNote=AIS
HgenePRKAA1chr5:40798165chr5:40834708ENST00000397128-19302_38142560RegionNote=AIS


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FusionGeneSequence for PRKAA1_RPL37


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PRKAA1_RPL37


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PRKAA1MTOR, TSC2, FNIP1, CFTR, PRKAG1, DDA1, EIF5B, SUPT16H, FXR2, PA2G4, SND1, G3BP1, PARP1, FMR1, PRKAB2, PRKAB1, RPL35, PRKAA2, PRKAG2, ULK1, HSP90AA1, HSPA4, TUBA1A, CDC37, SIK3, YWHAZ, YWHAE, SIK1, SIK2, VCP, PPP2R1B, PPP2CA, USP2, NUAK1, NUAK2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, SNRK, ELAVL1, PSMD11, CRBN, EPM2A, RPTOR, HDAC5, CRTC2, TOMM34, MAP3K7, NOTCH1, ABI1, CPE, MORC4, GATA1, PLEKHA4, SRPK2, PPARGC1A, MDM4, HSP90AB1, ACACA, FKBP5, EGFR, PPARG, STK11, AES, CDX4, CTBP1, PHC2, GOLGA2, TRIM27, VPS52, TRIP6, BHLHE40, ZBED1, ABI2, RBPMS, IKZF3, MTUS2, RAD54B, ROPN1, THAP1, HOMEZ, HMBOX1, VPS37B, TSC22D4, L3MBTL3, RIMBP3, UBXN11, PNMA5, SSX2IP, KRT40, RFX6, INO80E, TXNIP, EP300, CCDC8, INSR, PPM1F, PPM1E, PPM1A, CAMKK1, MAST3, SUN2, TRAK2, MCL1, DCLRE1C, NUP50, NTRK1, SCLT1, DVL2, ASPM, USP10, MCM2, PRKAG3, STIM2, PHKG2, CUTA, CCKBR, FANCG, FANCA, GLI1, PASKRPL37DDX56, APP, RPL30, RPL27, RPS9, MFAP1, PAN2, MDM2, MDM4, WIF1, TCF3, SQSTM1, POLR1B, ABL1, ARAF, CDK2, MAST3, SRPK1, RPL35A, RPS11, RPS13, RPS15, RPS15A, RPS3, RTF1, RPL37A, UBA52, BLM, SRPK2, NPM1, CDH1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PRKAA1_RPL37


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePRKAA1Q13131DB00914Phenformin5'-AMP-activated protein kinase catalytic subunit alpha-1small moleculeapproved|investigational|withdrawn
HgenePRKAA1Q13131DB00945Acetylsalicylic acid5'-AMP-activated protein kinase catalytic subunit alpha-1small moleculeapproved|vet_approved

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RelatedDiseases for PRKAA1_RPL37


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePRKAA1C0021655Insulin Resistance1CTD_human
HgenePRKAA1C0038356Stomach Neoplasms1CTD_human
HgenePRKAA1C0271650Impaired glucose tolerance1CTD_human