|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 28664 |
FusionGeneSummary for PRIM2_NKAIN2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PRIM2_NKAIN2 | Fusion gene ID: 28664 | Hgene | Tgene | Gene symbol | PRIM2 | NKAIN2 | Gene ID | 5558 | 154215 |
| Gene name | DNA primase subunit 2 | sodium/potassium transporting ATPase interacting 2 | |
| Synonyms | PRIM2A|p58 | FAM77B|NKAIP2|TCBA|TCBA1 | |
| Cytomap | 6p11.2 | 6q22.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA primase large subunitDNA primase 58 kDa subunitprimase (DNA) subunit 2primase, DNA, polypeptide 2 (58kDa) | sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 2Na+/K+ transporting ATPase interacting 2T-cell lymphoma breakpoint-associated target protein 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q5VXU1 | ||
| Ensembl transtripts involved in fusion gene | ENST00000607273, ENST00000389488, | ENST00000368416, ENST00000368417, ENST00000546092, ENST00000545433, ENST00000476571, | |
| Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 8 X 4 X 4=128 |
| # samples | 5 | 9 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/128*10)=-0.508146903670325 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PRIM2 [Title/Abstract] AND NKAIN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-O2-A52V-01A | PRIM2 | chr6 | 57190843 | + | NKAIN2 | chr6 | 124676413 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000607273 | ENST00000368416 | PRIM2 | chr6 | 57190843 | + | NKAIN2 | chr6 | 124676413 | + |
| In-frame | ENST00000607273 | ENST00000368417 | PRIM2 | chr6 | 57190843 | + | NKAIN2 | chr6 | 124676413 | + |
| In-frame | ENST00000607273 | ENST00000546092 | PRIM2 | chr6 | 57190843 | + | NKAIN2 | chr6 | 124676413 | + |
| In-frame | ENST00000607273 | ENST00000545433 | PRIM2 | chr6 | 57190843 | + | NKAIN2 | chr6 | 124676413 | + |
| 5CDS-3UTR | ENST00000607273 | ENST00000476571 | PRIM2 | chr6 | 57190843 | + | NKAIN2 | chr6 | 124676413 | + |
| 3UTR-3CDS | ENST00000389488 | ENST00000368416 | PRIM2 | chr6 | 57190843 | + | NKAIN2 | chr6 | 124676413 | + |
| 3UTR-3CDS | ENST00000389488 | ENST00000368417 | PRIM2 | chr6 | 57190843 | + | NKAIN2 | chr6 | 124676413 | + |
| 3UTR-3CDS | ENST00000389488 | ENST00000546092 | PRIM2 | chr6 | 57190843 | + | NKAIN2 | chr6 | 124676413 | + |
| 3UTR-3CDS | ENST00000389488 | ENST00000545433 | PRIM2 | chr6 | 57190843 | + | NKAIN2 | chr6 | 124676413 | + |
| 3UTR-3UTR | ENST00000389488 | ENST00000476571 | PRIM2 | chr6 | 57190843 | + | NKAIN2 | chr6 | 124676413 | + |
Top |
FusionProtFeatures for PRIM2_NKAIN2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PRIM2 | NKAIN2 |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >NKAIN2 | chr6:57190843 | chr6:124676413 | ENST00000368416 | + | 1 | 4 | 153_173 | 64 | 189 | Transmembrane | Helical |
| Tgene | >NKAIN2 | chr6:57190843 | chr6:124676413 | ENST00000368416 | + | 1 | 4 | 62_82 | 64 | 189 | Transmembrane | Helical |
| Tgene | >NKAIN2 | chr6:57190843 | chr6:124676413 | ENST00000368417 | + | 1 | 7 | 153_173 | 64 | 209 | Transmembrane | Helical |
| Tgene | >NKAIN2 | chr6:57190843 | chr6:124676413 | ENST00000368417 | + | 1 | 7 | 62_82 | 64 | 209 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | NKAIN2 | chr6:57190843 | chr6:124676413 | ENST00000368416 | + | 1 | 4 | 1_23 | 64 | 189 | Transmembrane | Helical |
| Tgene | NKAIN2 | chr6:57190843 | chr6:124676413 | ENST00000368416 | + | 1 | 4 | 35_55 | 64 | 189 | Transmembrane | Helical |
| Tgene | NKAIN2 | chr6:57190843 | chr6:124676413 | ENST00000368417 | + | 1 | 7 | 1_23 | 64 | 209 | Transmembrane | Helical |
| Tgene | NKAIN2 | chr6:57190843 | chr6:124676413 | ENST00000368417 | + | 1 | 7 | 35_55 | 64 | 209 | Transmembrane | Helical |
Top |
FusionGeneSequence for PRIM2_NKAIN2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PRIM2_ENST00000607273_chr6_57190843_+_NKAIN2_ENST00000368416_chr6_124676413_+_278aa MEFSGRKWRKLRLAGDQRNASYPHCLQFYLQPPSENISLIEFENLAIDRVKLLKSVENLGVSYVKGTEQYQSKLESELRKLKFSYRENLE DEYEPRRRDHISHFILRLAYCQSEELRRWFIQQEMDLLRFRFSILPKDKIQDFLKDSQLQFEAYAVWLVLWVTWNVFVICFYLEAGDLSK ETDLILTFNISMHRSWWMENGPGCTVTSVTPAPDWAPEDHRYITVSGCLLEYQYIEVAHSSLQIVLAVSVGSQPLLLVPLGLFYFCANSV >In-frame_PRIM2_ENST00000607273_chr6_57190843_+_NKAIN2_ENST00000368417_chr6_124676413_+_298aa MEFSGRKWRKLRLAGDQRNASYPHCLQFYLQPPSENISLIEFENLAIDRVKLLKSVENLGVSYVKGTEQYQSKLESELRKLKFSYRENLE DEYEPRRRDHISHFILRLAYCQSEELRRWFIQQEMDLLRFRFSILPKDKIQDFLKDSQLQFEAYAVWLVLWVTWNVFVICFYLEAGDLSK ETDLILTFNISMHRSWWMENGPGCTVTSVTPAPDWAPEDHRYITVSGCLLEYQYIEVAHSSLQIVLALAGFIYACYVVKCITEEEDSFDF >In-frame_PRIM2_ENST00000607273_chr6_57190843_+_NKAIN2_ENST00000546092_chr6_124676413_+_229aa MEFSGRKWRKLRLAGDQRNASYPHCLQFYLQPPSENISLIEFENLAIDRVKLLKSVENLGVSYVKGTEQYQSKLESELRKLKFSYRENLE DEYEPRRRDHISHFILRLAYCQSEELRRWFIQQEMDLLRFRFSILPKDKIQDFLKDSQLQFEAYAVWLVLWVTWNVFVICFYLEAGDLSK >In-frame_PRIM2_ENST00000607273_chr6_57190843_+_NKAIN2_ENST00000545433_chr6_124676413_+_296aa MEFSGRKWRKLRLAGDQRNASYPHCLQFYLQPPSENISLIEFENLAIDRVKLLKSVENLGVSYVKGTEQYQSKLESELRKLKFSYRENLE DEYEPRRRDHISHFILRLAYCQSEELRRWFIQQEMDLLRFRFSILPKDKIQDFLKDSQLQFEAYAVWLVLWVTWNVFVICFYLEAGDLSK ETDLILTFNISMHRSWWMENGPGCTVTSVTPAPDWAPEDHRYITVSGCLLEYQYIEVAHSSLQIVLALAGFIYACYVVKCITEEEDSFDF |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PRIM2_ENST00000607273_chr6_57190843_+_NKAIN2_ENST00000368416_chr6_124676413_+_834nt ATGGAGTTTTCTGGAAGAAAGTGGAGGAAGCTGAGGTTGGCAGGTGACCAGAGGAATGCTTCCTACCCTCATTGCCTTCAGTTTTACTTG CAGCCACCTTCTGAAAACATATCTTTAATAGAATTTGAAAACTTGGCTATTGATAGAGTTAAATTGTTAAAATCAGTTGAAAATCTTGGA GTGAGCTATGTGAAAGGAACTGAACAATACCAGAGTAAGTTGGAGAGTGAGCTTCGGAAGCTCAAGTTTTCCTACAGAGAAAACTTAGAA GATGAATATGAACCACGAAGAAGAGATCATATTTCTCATTTTATTTTGCGGCTTGCTTATTGCCAGTCTGAAGAACTTAGACGCTGGTTC ATTCAACAAGAAATGGATCTCCTTCGATTTAGATTTAGTATTTTACCCAAGGATAAAATTCAGGATTTCTTAAAGGATAGCCAATTGCAG TTTGAGGCTTATGCTGTCTGGCTAGTCCTCTGGGTTACGTGGAATGTGTTTGTTATCTGCTTCTATTTGGAGGCTGGGGACCTCTCAAAG GAAACAGACCTTATCCTGACTTTTAATATATCAATGCACCGATCTTGGTGGATGGAGAATGGACCAGGATGTACGGTGACGTCAGTGACA CCTGCCCCAGACTGGGCCCCAGAAGACCATCGCTACATCACGGTCTCAGGGTGTTTGCTGGAGTACCAGTACATAGAAGTGGCTCATAGT TCCCTCCAGATTGTCCTCGCAGTAAGTGTTGGCAGCCAACCGCTCCTTCTAGTGCCTCTGGGGTTGTTTTATTTCTGTGCGAACTCAGTG >In-frame_PRIM2_ENST00000607273_chr6_57190843_+_NKAIN2_ENST00000368417_chr6_124676413_+_894nt ATGGAGTTTTCTGGAAGAAAGTGGAGGAAGCTGAGGTTGGCAGGTGACCAGAGGAATGCTTCCTACCCTCATTGCCTTCAGTTTTACTTG CAGCCACCTTCTGAAAACATATCTTTAATAGAATTTGAAAACTTGGCTATTGATAGAGTTAAATTGTTAAAATCAGTTGAAAATCTTGGA GTGAGCTATGTGAAAGGAACTGAACAATACCAGAGTAAGTTGGAGAGTGAGCTTCGGAAGCTCAAGTTTTCCTACAGAGAAAACTTAGAA GATGAATATGAACCACGAAGAAGAGATCATATTTCTCATTTTATTTTGCGGCTTGCTTATTGCCAGTCTGAAGAACTTAGACGCTGGTTC ATTCAACAAGAAATGGATCTCCTTCGATTTAGATTTAGTATTTTACCCAAGGATAAAATTCAGGATTTCTTAAAGGATAGCCAATTGCAG TTTGAGGCTTATGCTGTCTGGCTAGTCCTCTGGGTTACGTGGAATGTGTTTGTTATCTGCTTCTATTTGGAGGCTGGGGACCTCTCAAAG GAAACAGACCTTATCCTGACTTTTAATATATCAATGCACCGATCTTGGTGGATGGAGAATGGACCAGGATGTACGGTGACGTCAGTGACA CCTGCCCCAGACTGGGCCCCAGAAGACCATCGCTACATCACGGTCTCAGGGTGTTTGCTGGAGTACCAGTACATAGAAGTGGCTCATAGT TCCCTCCAGATTGTCCTCGCACTGGCAGGTTTCATCTACGCCTGTTATGTTGTGAAATGTATAACTGAAGAAGAGGACAGCTTTGATTTC >In-frame_PRIM2_ENST00000607273_chr6_57190843_+_NKAIN2_ENST00000546092_chr6_124676413_+_687nt ATGGAGTTTTCTGGAAGAAAGTGGAGGAAGCTGAGGTTGGCAGGTGACCAGAGGAATGCTTCCTACCCTCATTGCCTTCAGTTTTACTTG CAGCCACCTTCTGAAAACATATCTTTAATAGAATTTGAAAACTTGGCTATTGATAGAGTTAAATTGTTAAAATCAGTTGAAAATCTTGGA GTGAGCTATGTGAAAGGAACTGAACAATACCAGAGTAAGTTGGAGAGTGAGCTTCGGAAGCTCAAGTTTTCCTACAGAGAAAACTTAGAA GATGAATATGAACCACGAAGAAGAGATCATATTTCTCATTTTATTTTGCGGCTTGCTTATTGCCAGTCTGAAGAACTTAGACGCTGGTTC ATTCAACAAGAAATGGATCTCCTTCGATTTAGATTTAGTATTTTACCCAAGGATAAAATTCAGGATTTCTTAAAGGATAGCCAATTGCAG TTTGAGGCTTATGCTGTCTGGCTAGTCCTCTGGGTTACGTGGAATGTGTTTGTTATCTGCTTCTATTTGGAGGCTGGGGACCTCTCAAAG CTGGCAGGTTTCATCTACGCCTGTTATGTTGTGAAATGTATAACTGAAGAAGAGGACAGCTTTGATTTCATAGGTGGCTTTGACTCTTAT >In-frame_PRIM2_ENST00000607273_chr6_57190843_+_NKAIN2_ENST00000545433_chr6_124676413_+_888nt ATGGAGTTTTCTGGAAGAAAGTGGAGGAAGCTGAGGTTGGCAGGTGACCAGAGGAATGCTTCCTACCCTCATTGCCTTCAGTTTTACTTG CAGCCACCTTCTGAAAACATATCTTTAATAGAATTTGAAAACTTGGCTATTGATAGAGTTAAATTGTTAAAATCAGTTGAAAATCTTGGA GTGAGCTATGTGAAAGGAACTGAACAATACCAGAGTAAGTTGGAGAGTGAGCTTCGGAAGCTCAAGTTTTCCTACAGAGAAAACTTAGAA GATGAATATGAACCACGAAGAAGAGATCATATTTCTCATTTTATTTTGCGGCTTGCTTATTGCCAGTCTGAAGAACTTAGACGCTGGTTC ATTCAACAAGAAATGGATCTCCTTCGATTTAGATTTAGTATTTTACCCAAGGATAAAATTCAGGATTTCTTAAAGGATAGCCAATTGCAG TTTGAGGCTTATGCTGTCTGGCTAGTCCTCTGGGTTACGTGGAATGTGTTTGTTATCTGCTTCTATTTGGAGGCTGGGGACCTCTCAAAG GAAACAGACCTTATCCTGACTTTTAATATATCAATGCACCGATCTTGGTGGATGGAGAATGGACCAGGATGTACGGTGACGTCAGTGACA CCTGCCCCAGACTGGGCCCCAGAAGACCATCGCTACATCACGGTCTCAGGGTGTTTGCTGGAGTACCAGTACATAGAAGTGGCTCATAGT TCCCTCCAGATTGTCCTCGCACTGGCAGGTTTCATCTACGCCTGTTATGTTGTGAAATGTATAACTGAAGAAGAGGACAGCTTTGATTTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PRIM2_ENST00000607273_chr6_57190843_+_NKAIN2_ENST00000368416_chr6_124676413_+_1400nt GGTTTCATATGAACTCTCCCGCCACCCGGGAACAGTGGCTGCCACCGTTTGTGTTTTCCCGAGTTTGAATTCTTGCAGGTGACCAAGATG GAGTTTTCTGGAAGAAAGTGGAGGAAGCTGAGGTTGGCAGGTGACCAGAGGAATGCTTCCTACCCTCATTGCCTTCAGTTTTACTTGCAG CCACCTTCTGAAAACATATCTTTAATAGAATTTGAAAACTTGGCTATTGATAGAGTTAAATTGTTAAAATCAGTTGAAAATCTTGGAGTG AGCTATGTGAAAGGAACTGAACAATACCAGAGTAAGTTGGAGAGTGAGCTTCGGAAGCTCAAGTTTTCCTACAGAGAAAACTTAGAAGAT GAATATGAACCACGAAGAAGAGATCATATTTCTCATTTTATTTTGCGGCTTGCTTATTGCCAGTCTGAAGAACTTAGACGCTGGTTCATT CAACAAGAAATGGATCTCCTTCGATTTAGATTTAGTATTTTACCCAAGGATAAAATTCAGGATTTCTTAAAGGATAGCCAATTGCAGTTT GAGGCTTATGCTGTCTGGCTAGTCCTCTGGGTTACGTGGAATGTGTTTGTTATCTGCTTCTATTTGGAGGCTGGGGACCTCTCAAAGGAA ACAGACCTTATCCTGACTTTTAATATATCAATGCACCGATCTTGGTGGATGGAGAATGGACCAGGATGTACGGTGACGTCAGTGACACCT GCCCCAGACTGGGCCCCAGAAGACCATCGCTACATCACGGTCTCAGGGTGTTTGCTGGAGTACCAGTACATAGAAGTGGCTCATAGTTCC CTCCAGATTGTCCTCGCAGTAAGTGTTGGCAGCCAACCGCTCCTTCTAGTGCCTCTGGGGTTGTTTTATTTCTGTGCGAACTCAGTGCAC ACAAATGGAATCTGTGGGTAAAGTGTGGCCTTTTTGCTTTTTCCTCATTAATGCGACTTTTAACAGGAAATCCTCAGGTTAAACTAAACC ATCCTCTGGACTTAGTGTGCTGATTTTCTTCGACAATTAGTAAATACCCTTTGTTATCATCAGCATTTTACATAGGAAATCCAATCAGTC AAGATGTGATTACGTGACTTTTGGTAGACTTTTCCAAGGATTCTGAAGGGATGATCAGAGATTTTTTTCATAACGTTCTACAGTACTCAA AATTATAAGATTTCCATAAGTGTTTTCTCTTTTAGTGCTTCTTTTGGCTGTGCTGCTAGCCCTGGGATTTCTCTTTTTCATTTGCCCTAT CTCCTTCTTCCTTCCTAGATTTCTCCCAGGCACCATCCATCACCTTTAATCTCCCACTTTTTTTCCAGAAAAAATCACATTTTCTATAGA >In-frame_PRIM2_ENST00000607273_chr6_57190843_+_NKAIN2_ENST00000368417_chr6_124676413_+_3409nt GGTTTCATATGAACTCTCCCGCCACCCGGGAACAGTGGCTGCCACCGTTTGTGTTTTCCCGAGTTTGAATTCTTGCAGGTGACCAAGATG GAGTTTTCTGGAAGAAAGTGGAGGAAGCTGAGGTTGGCAGGTGACCAGAGGAATGCTTCCTACCCTCATTGCCTTCAGTTTTACTTGCAG CCACCTTCTGAAAACATATCTTTAATAGAATTTGAAAACTTGGCTATTGATAGAGTTAAATTGTTAAAATCAGTTGAAAATCTTGGAGTG AGCTATGTGAAAGGAACTGAACAATACCAGAGTAAGTTGGAGAGTGAGCTTCGGAAGCTCAAGTTTTCCTACAGAGAAAACTTAGAAGAT GAATATGAACCACGAAGAAGAGATCATATTTCTCATTTTATTTTGCGGCTTGCTTATTGCCAGTCTGAAGAACTTAGACGCTGGTTCATT CAACAAGAAATGGATCTCCTTCGATTTAGATTTAGTATTTTACCCAAGGATAAAATTCAGGATTTCTTAAAGGATAGCCAATTGCAGTTT GAGGCTTATGCTGTCTGGCTAGTCCTCTGGGTTACGTGGAATGTGTTTGTTATCTGCTTCTATTTGGAGGCTGGGGACCTCTCAAAGGAA ACAGACCTTATCCTGACTTTTAATATATCAATGCACCGATCTTGGTGGATGGAGAATGGACCAGGATGTACGGTGACGTCAGTGACACCT GCCCCAGACTGGGCCCCAGAAGACCATCGCTACATCACGGTCTCAGGGTGTTTGCTGGAGTACCAGTACATAGAAGTGGCTCATAGTTCC CTCCAGATTGTCCTCGCACTGGCAGGTTTCATCTACGCCTGTTATGTTGTGAAATGTATAACTGAAGAAGAGGACAGCTTTGATTTCATA GGTGGCTTTGACTCTTATGGCTATCAAGGGCCTCAGAAGACATCTCATTTACAACTACAGCCTATGTACATGTCAAAATAATACAGATGA CTTCAGTATGTCAGCCCATGGACCTTTCAAAGAACTTTTTTCGCAGTGGCCTCCTGCATTTCATGAAGAGCAAGAAGCAACTGAGTTTAA ATACATACACGTATTAACAAAACAAATGCAAAGCCTCTACATACAACACTGACACACACACACACACACACGTGAGCACGCACACACCAA TTCCACTTGACCTCCTCTTTCTAACTGAAACAGACAAATATGCAGGACACGCCCATCTTGGATTTCCTGAAAGCAGGCCCCTTTCTCCCA GGCCTTCGGAAAGTTCAGAAGGAGATGTGTTGATGCCCAACGGTTGCCGGCCATTGCTAACTCCTCTGCAGCCCAGCGGGTTGGCCTCTG TGAGCTGGGAAGTCATCCAAGGCACATTAGTTTGAGAGCTCTGTCTTCTGCACTCCATACATCTTGACAGCACCACGGCTACTTAGGCAA TGTAATTGCAAAAACAAACGAAACATGCCATGATGACCTTGTACCCGAAGTCCGAAATGGCAGATTGTTTGCCCTAAAGGCTGTACCGTA CATACTTGCCTTAACCCACCTACATTGTGTGCCCAAGAATCCCAGTGCAGACAGCCCCAAGCCACTTCCTTTAGGCTAACACACTGCTAT TAATTCTAAATGAGTTCAAGCCTGTGTGTTTCATGTCAAGGAACAAGACTGAATAGCTCAGCAGCTCCAGTGTGTCTGTATAAGAAAAGT GCCAGCTGTCAGCAAAGTGCTTTACCATAGAGCCTCCATGGTGGCCCAAAAGAGACAAGTAACAATAACAATATCTGTCATCTTTATAAT TCTAAAATATGGTCTTCTGATGGGGTTGGGGGTGGGACAGAGTAAAACATTAATCTACTAAACTCACTAATCTACTGGAAGCAGAAAGCA GAAATGGCTTAACTCGCTGATTTTATTTATTGCACTCTAGGTGCTTTTATAAGTATCTACAATTGTCTTTTACTAACACAGAAACAGCTG TGGATTTCTATCAACAGAGGCCAACTGAATATGTATTAGCTATGTTTACTCTTTTATATCTAATTCAAATTGAAGACTCTACGTAGGTGA ACTTTTTTTTCTAACTTCAGTGTACAAGATTATTTTTGGGTGGGTGGGGGGAGCAATAGTTACCTTGGTGAAATATTTGAGATCTTTTTG TGGTATTTGGGGGATCTGTTGTGTGTTAGAGTGTATTTCAACCCTCCTGTATTATTGTGGCAGAAAAACTGTGCTGTTAACGTAGTTGGC AACAAGATGCCTTTGGAAACTTAATAGTAGGTCAATGTGTTTATGGAATATTCTGAACTCCTAGGAAATTTTGTTCTATATTTTAAAGCA TTATTTGGTTTTCATTAGTGGAAAACATAATTAGCTCAGGCTTATCAGGAACTCAGATGAGTCATATTTTTTCTTGGATACACCTGAGAC ATTAAACTCAATTTTTTAAAACTAACACACCATTCTTTAGTGCAGTGAAATTCAAAAGTTATAAATTGGCATGGAGCAAGTTTTTTCTTT GATTTCTATGAAGTTTCAGTTATTGGATTAAACTACTTTAGACCTTAGCCCATTCGGATCTACATACACCAGTTCCATTACTGTGTTTGC ATGGATGTCTGTAATATACACACACATATACATTTGAAAATGATAGAGGAACAAAGAGTTATCATTGGAACATAAACTATAAAAAAAGAT TCCAGCACTCATGCTTGAATTTCCTCAGTGGGTTGTATGTTTGTCCATACATACATGTATAAAATAAACAATTGCAAACATGTCAGTGAA ACCTCATATGACGCTTTTATAGTGACATGCATGTTTAATGTATGAGAAAAATATTTACCAATGTATTGTCCTTTGAGTCCTAAAATATAA ATACTATACATGCCAGAAACTATTCTAATGTGACTTTTAATGTGACTATTAAAAATGAGGTTTCACTGTACATTCATGCTGTGATGCGAT TTCACCTTATAGTACATGTATATGGGTACAGAAAATAAACCCTCATATTCCTGCTTTAAGTTACAGCCAAGTTTTCACCAAATCACAACT ATCATCACCACCAAAATTTTAAAAAACAGTAGTTGACTACTAAAAAGTAATCAGTGGACAGGTCATTTATGGGATCAGTAAGCACAGTAG TGTGATTATATCTGGGAAAACATCTACAGTTGTACAGCTGTATCCTCCTCAAAATCCGGTGAAGAATGCTATTTTTCTAGGCTGAGCTTT TGTTATAAACTTAATATTCAGAAGGCAAGGGTTATGATCCTGATGTGTCCTTTTTTTTTGCATTTGTTAATTCTGAATGTATTTTTAACA >In-frame_PRIM2_ENST00000607273_chr6_57190843_+_NKAIN2_ENST00000546092_chr6_124676413_+_774nt GGTTTCATATGAACTCTCCCGCCACCCGGGAACAGTGGCTGCCACCGTTTGTGTTTTCCCGAGTTTGAATTCTTGCAGGTGACCAAGATG GAGTTTTCTGGAAGAAAGTGGAGGAAGCTGAGGTTGGCAGGTGACCAGAGGAATGCTTCCTACCCTCATTGCCTTCAGTTTTACTTGCAG CCACCTTCTGAAAACATATCTTTAATAGAATTTGAAAACTTGGCTATTGATAGAGTTAAATTGTTAAAATCAGTTGAAAATCTTGGAGTG AGCTATGTGAAAGGAACTGAACAATACCAGAGTAAGTTGGAGAGTGAGCTTCGGAAGCTCAAGTTTTCCTACAGAGAAAACTTAGAAGAT GAATATGAACCACGAAGAAGAGATCATATTTCTCATTTTATTTTGCGGCTTGCTTATTGCCAGTCTGAAGAACTTAGACGCTGGTTCATT CAACAAGAAATGGATCTCCTTCGATTTAGATTTAGTATTTTACCCAAGGATAAAATTCAGGATTTCTTAAAGGATAGCCAATTGCAGTTT GAGGCTTATGCTGTCTGGCTAGTCCTCTGGGTTACGTGGAATGTGTTTGTTATCTGCTTCTATTTGGAGGCTGGGGACCTCTCAAAGCTG GCAGGTTTCATCTACGCCTGTTATGTTGTGAAATGTATAACTGAAGAAGAGGACAGCTTTGATTTCATAGGTGGCTTTGACTCTTATGGC >In-frame_PRIM2_ENST00000607273_chr6_57190843_+_NKAIN2_ENST00000545433_chr6_124676413_+_975nt GGTTTCATATGAACTCTCCCGCCACCCGGGAACAGTGGCTGCCACCGTTTGTGTTTTCCCGAGTTTGAATTCTTGCAGGTGACCAAGATG GAGTTTTCTGGAAGAAAGTGGAGGAAGCTGAGGTTGGCAGGTGACCAGAGGAATGCTTCCTACCCTCATTGCCTTCAGTTTTACTTGCAG CCACCTTCTGAAAACATATCTTTAATAGAATTTGAAAACTTGGCTATTGATAGAGTTAAATTGTTAAAATCAGTTGAAAATCTTGGAGTG AGCTATGTGAAAGGAACTGAACAATACCAGAGTAAGTTGGAGAGTGAGCTTCGGAAGCTCAAGTTTTCCTACAGAGAAAACTTAGAAGAT GAATATGAACCACGAAGAAGAGATCATATTTCTCATTTTATTTTGCGGCTTGCTTATTGCCAGTCTGAAGAACTTAGACGCTGGTTCATT CAACAAGAAATGGATCTCCTTCGATTTAGATTTAGTATTTTACCCAAGGATAAAATTCAGGATTTCTTAAAGGATAGCCAATTGCAGTTT GAGGCTTATGCTGTCTGGCTAGTCCTCTGGGTTACGTGGAATGTGTTTGTTATCTGCTTCTATTTGGAGGCTGGGGACCTCTCAAAGGAA ACAGACCTTATCCTGACTTTTAATATATCAATGCACCGATCTTGGTGGATGGAGAATGGACCAGGATGTACGGTGACGTCAGTGACACCT GCCCCAGACTGGGCCCCAGAAGACCATCGCTACATCACGGTCTCAGGGTGTTTGCTGGAGTACCAGTACATAGAAGTGGCTCATAGTTCC CTCCAGATTGTCCTCGCACTGGCAGGTTTCATCTACGCCTGTTATGTTGTGAAATGTATAACTGAAGAAGAGGACAGCTTTGATTTCATA |
Top |
FusionGenePPI for PRIM2_NKAIN2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PRIM2 | RAE1, ELAVL1, POLA1, PRIM1, POLA2, MMS19, KDM1A, SUV39H1, FAM96B, CIAO1, MOV10, KLHL20, PRPS2, OBFC1, GFOD1, NTRK1, BAG6, USP37, DUSP9, NLGN4Y, RNF31, RGS20, DCAF10, PM20D2, ERP44 | NKAIN2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for PRIM2_NKAIN2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for PRIM2_NKAIN2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | NKAIN2 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|