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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28663

FusionGeneSummary for PRIM2_MAD2L1BP

check button Fusion gene summary
Fusion gene informationFusion gene name: PRIM2_MAD2L1BP
Fusion gene ID: 28663
HgeneTgene
Gene symbol

PRIM2

MAD2L1BP

Gene ID

5558

9587

Gene nameDNA primase subunit 2MAD2L1 binding protein
SynonymsPRIM2A|p58CMT2
Cytomap

6p11.2

6p21.1

Type of geneprotein-codingprotein-coding
DescriptionDNA primase large subunitDNA primase 58 kDa subunitprimase (DNA) subunit 2primase, DNA, polypeptide 2 (58kDa)MAD2L1-binding proteincaught by MAD2 protein
Modification date2018052320180519
UniProtAcc

Q15013

Ensembl transtripts involved in fusion geneENST00000607273, ENST00000389488, 
ENST00000451025, ENST00000372171, 
ENST00000508232, 
Fusion gene scores* DoF score5 X 3 X 4=601 X 1 X 1=1
# samples 51
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: PRIM2 [Title/Abstract] AND MAD2L1BP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A8-A06O-01APRIM2chr6

57246966

+MAD2L1BPchr6

43607758

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000607273ENST00000451025PRIM2chr6

57246966

+MAD2L1BPchr6

43607758

+
Frame-shiftENST00000607273ENST00000372171PRIM2chr6

57246966

+MAD2L1BPchr6

43607758

+
5CDS-intronENST00000607273ENST00000508232PRIM2chr6

57246966

+MAD2L1BPchr6

43607758

+
3UTR-3CDSENST00000389488ENST00000451025PRIM2chr6

57246966

+MAD2L1BPchr6

43607758

+
3UTR-3CDSENST00000389488ENST00000372171PRIM2chr6

57246966

+MAD2L1BPchr6

43607758

+
3UTR-intronENST00000389488ENST00000508232PRIM2chr6

57246966

+MAD2L1BPchr6

43607758

+

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FusionProtFeatures for PRIM2_MAD2L1BP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRIM2

MAD2L1BP

Q15013

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. May function to silence the spindle checkpoint and allowmitosis to proceed through anaphase by binding MAD2L1 after it hasbecome dissociated from the MAD2L1-CDC20 complex.{ECO:0000269|PubMed:18022368}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PRIM2_MAD2L1BP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PRIM2_MAD2L1BP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PRIM2RAE1, ELAVL1, POLA1, PRIM1, POLA2, MMS19, KDM1A, SUV39H1, FAM96B, CIAO1, MOV10, KLHL20, PRPS2, OBFC1, GFOD1, NTRK1, BAG6, USP37, DUSP9, NLGN4Y, RNF31, RGS20, DCAF10, PM20D2, ERP44MAD2L1BPTRIP13, KRT15, KIAA1377, IGSF21, LRIF1, EEF1A1, KAT5, PTN, SETDB1, TP53, MAD2L1, BUB1B, CDC20, MAD1L1, MAD2L1BP, CDC27, SEPT11, DHX40, ZBTB14, NMI, INPP5K, HOMEZ, NTF3, TSC22D4, WIBG, LBR, RIT1, TOR1AIP1, ZSCAN29, PTPN22, PTPRO, PTPRR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PRIM2_MAD2L1BP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PRIM2_MAD2L1BP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource