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Fusion gene ID: 28663 |
FusionGeneSummary for PRIM2_MAD2L1BP |
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Fusion gene information | Fusion gene name: PRIM2_MAD2L1BP | Fusion gene ID: 28663 | Hgene | Tgene | Gene symbol | PRIM2 | MAD2L1BP | Gene ID | 5558 | 9587 |
Gene name | DNA primase subunit 2 | MAD2L1 binding protein | |
Synonyms | PRIM2A|p58 | CMT2 | |
Cytomap | 6p11.2 | 6p21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | DNA primase large subunitDNA primase 58 kDa subunitprimase (DNA) subunit 2primase, DNA, polypeptide 2 (58kDa) | MAD2L1-binding proteincaught by MAD2 protein | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q15013 | ||
Ensembl transtripts involved in fusion gene | ENST00000607273, ENST00000389488, | ENST00000451025, ENST00000372171, ENST00000508232, | |
Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 1 X 1 X 1=1 |
# samples | 5 | 1 | |
** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: PRIM2 [Title/Abstract] AND MAD2L1BP [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-A8-A06O-01A | PRIM2 | chr6 | 57246966 | + | MAD2L1BP | chr6 | 43607758 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000607273 | ENST00000451025 | PRIM2 | chr6 | 57246966 | + | MAD2L1BP | chr6 | 43607758 | + |
Frame-shift | ENST00000607273 | ENST00000372171 | PRIM2 | chr6 | 57246966 | + | MAD2L1BP | chr6 | 43607758 | + |
5CDS-intron | ENST00000607273 | ENST00000508232 | PRIM2 | chr6 | 57246966 | + | MAD2L1BP | chr6 | 43607758 | + |
3UTR-3CDS | ENST00000389488 | ENST00000451025 | PRIM2 | chr6 | 57246966 | + | MAD2L1BP | chr6 | 43607758 | + |
3UTR-3CDS | ENST00000389488 | ENST00000372171 | PRIM2 | chr6 | 57246966 | + | MAD2L1BP | chr6 | 43607758 | + |
3UTR-intron | ENST00000389488 | ENST00000508232 | PRIM2 | chr6 | 57246966 | + | MAD2L1BP | chr6 | 43607758 | + |
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FusionProtFeatures for PRIM2_MAD2L1BP |
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Hgene | Tgene |
PRIM2 | MAD2L1BP |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | May function to silence the spindle checkpoint and allowmitosis to proceed through anaphase by binding MAD2L1 after it hasbecome dissociated from the MAD2L1-CDC20 complex.{ECO:0000269|PubMed:18022368}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PRIM2_MAD2L1BP |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PRIM2_MAD2L1BP |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PRIM2 | RAE1, ELAVL1, POLA1, PRIM1, POLA2, MMS19, KDM1A, SUV39H1, FAM96B, CIAO1, MOV10, KLHL20, PRPS2, OBFC1, GFOD1, NTRK1, BAG6, USP37, DUSP9, NLGN4Y, RNF31, RGS20, DCAF10, PM20D2, ERP44 | MAD2L1BP | TRIP13, KRT15, KIAA1377, IGSF21, LRIF1, EEF1A1, KAT5, PTN, SETDB1, TP53, MAD2L1, BUB1B, CDC20, MAD1L1, MAD2L1BP, CDC27, SEPT11, DHX40, ZBTB14, NMI, INPP5K, HOMEZ, NTF3, TSC22D4, WIBG, LBR, RIT1, TOR1AIP1, ZSCAN29, PTPN22, PTPRO, PTPRR |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PRIM2_MAD2L1BP |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PRIM2_MAD2L1BP |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |