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Fusion gene ID: 28662 |
FusionGeneSummary for PRIM2_CRYAB |
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Fusion gene information | Fusion gene name: PRIM2_CRYAB | Fusion gene ID: 28662 | Hgene | Tgene | Gene symbol | PRIM2 | CRYAB | Gene ID | 5558 | 1410 |
Gene name | DNA primase subunit 2 | crystallin alpha B | |
Synonyms | PRIM2A|p58 | CMD1II|CRYA2|CTPP2|CTRCT16|HEL-S-101|HSPB5|MFM2 | |
Cytomap | 6p11.2 | 11q23.1 | |
Type of gene | protein-coding | protein-coding | |
Description | DNA primase large subunitDNA primase 58 kDa subunitprimase (DNA) subunit 2primase, DNA, polypeptide 2 (58kDa) | alpha-crystallin B chainepididymis secretory protein Li 101heat shock protein beta-5heat-shock 20 kD like-proteinrenal carcinoma antigen NY-REN-27rosenthal fiber component | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P02511 | ||
Ensembl transtripts involved in fusion gene | ENST00000607273, ENST00000389488, | ENST00000526180, ENST00000533280, ENST00000525823, ENST00000533475, ENST00000527950, ENST00000227251, ENST00000531198, ENST00000533971, | |
Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 4 X 4 X 2=32 |
# samples | 5 | 4 | |
** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PRIM2 [Title/Abstract] AND CRYAB [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CRYAB | GO:0032387 | negative regulation of intracellular transport | 14752512 |
Tgene | CRYAB | GO:0032463 | negative regulation of protein homooligomerization | 23106396 |
Tgene | CRYAB | GO:0043066 | negative regulation of apoptotic process | 14752512 |
Tgene | CRYAB | GO:0051260 | protein homooligomerization | 16303126 |
Tgene | CRYAB | GO:1905907 | negative regulation of amyloid fibril formation | 23106396 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | EB362401 | PRIM2 | chr6 | 57340351 | + | CRYAB | chr11 | 111779352 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000607273 | ENST00000526180 | PRIM2 | chr6 | 57340351 | + | CRYAB | chr11 | 111779352 | + |
intron-3UTR | ENST00000607273 | ENST00000533280 | PRIM2 | chr6 | 57340351 | + | CRYAB | chr11 | 111779352 | + |
intron-3UTR | ENST00000607273 | ENST00000525823 | PRIM2 | chr6 | 57340351 | + | CRYAB | chr11 | 111779352 | + |
intron-intron | ENST00000607273 | ENST00000533475 | PRIM2 | chr6 | 57340351 | + | CRYAB | chr11 | 111779352 | + |
intron-intron | ENST00000607273 | ENST00000527950 | PRIM2 | chr6 | 57340351 | + | CRYAB | chr11 | 111779352 | + |
intron-intron | ENST00000607273 | ENST00000227251 | PRIM2 | chr6 | 57340351 | + | CRYAB | chr11 | 111779352 | + |
intron-intron | ENST00000607273 | ENST00000531198 | PRIM2 | chr6 | 57340351 | + | CRYAB | chr11 | 111779352 | + |
intron-intron | ENST00000607273 | ENST00000533971 | PRIM2 | chr6 | 57340351 | + | CRYAB | chr11 | 111779352 | + |
intron-3UTR | ENST00000389488 | ENST00000526180 | PRIM2 | chr6 | 57340351 | + | CRYAB | chr11 | 111779352 | + |
intron-3UTR | ENST00000389488 | ENST00000533280 | PRIM2 | chr6 | 57340351 | + | CRYAB | chr11 | 111779352 | + |
intron-3UTR | ENST00000389488 | ENST00000525823 | PRIM2 | chr6 | 57340351 | + | CRYAB | chr11 | 111779352 | + |
intron-intron | ENST00000389488 | ENST00000533475 | PRIM2 | chr6 | 57340351 | + | CRYAB | chr11 | 111779352 | + |
intron-intron | ENST00000389488 | ENST00000527950 | PRIM2 | chr6 | 57340351 | + | CRYAB | chr11 | 111779352 | + |
intron-intron | ENST00000389488 | ENST00000227251 | PRIM2 | chr6 | 57340351 | + | CRYAB | chr11 | 111779352 | + |
intron-intron | ENST00000389488 | ENST00000531198 | PRIM2 | chr6 | 57340351 | + | CRYAB | chr11 | 111779352 | + |
intron-intron | ENST00000389488 | ENST00000533971 | PRIM2 | chr6 | 57340351 | + | CRYAB | chr11 | 111779352 | + |
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FusionProtFeatures for PRIM2_CRYAB |
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Hgene | Tgene |
PRIM2 | CRYAB |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | May contribute to the transparency and refractive indexof the lens. Has chaperone-like activity, preventing aggregationof various proteins under a wide range of stress conditions. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PRIM2_CRYAB |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PRIM2_CRYAB |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PRIM2_CRYAB |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PRIM2_CRYAB |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CRYAB | C1837317 | Alpha-B Crystallinopathy | 3 | CTD_human;ORPHANET;UNIPROT |
Tgene | CRYAB | C3554649 | CARDIOMYOPATHY, DILATED, 1II | 2 | UNIPROT |
Tgene | CRYAB | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Tgene | CRYAB | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
Tgene | CRYAB | C0009375 | Colonic Neoplasms | 1 | CTD_human |
Tgene | CRYAB | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
Tgene | CRYAB | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | CRYAB | C0026640 | Mouth Neoplasms | 1 | CTD_human |
Tgene | CRYAB | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | CRYAB | C0040411 | Tongue Neoplasms | 1 | CTD_human |
Tgene | CRYAB | C0086543 | Cataract | 1 | CTD_human;HPO |
Tgene | CRYAB | C0524851 | Neurodegenerative Disorders | 1 | CTD_human |