![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 28661 |
FusionGeneSummary for PRIM2_COL22A1 |
![]() |
Fusion gene information | Fusion gene name: PRIM2_COL22A1 | Fusion gene ID: 28661 | Hgene | Tgene | Gene symbol | PRIM2 | COL22A1 | Gene ID | 5558 | 169044 |
Gene name | DNA primase subunit 2 | collagen type XXII alpha 1 chain | |
Synonyms | PRIM2A|p58 | - | |
Cytomap | 6p11.2 | 8q24.23-q24.3 | |
Type of gene | protein-coding | protein-coding | |
Description | DNA primase large subunitDNA primase 58 kDa subunitprimase (DNA) subunit 2primase, DNA, polypeptide 2 (58kDa) | collagen alpha-1(XXII) chain | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8NFW1 | ||
Ensembl transtripts involved in fusion gene | ENST00000607273, ENST00000389488, | ENST00000341807, ENST00000303045, ENST00000435777, | |
Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 8 X 7 X 5=280 |
# samples | 5 | 7 | |
** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/280*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PRIM2 [Title/Abstract] AND COL22A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | STAD | TCGA-D7-A4YY-01A | PRIM2 | chr6 | 57190843 | + | COL22A1 | chr8 | 139749820 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000607273 | ENST00000341807 | PRIM2 | chr6 | 57190843 | + | COL22A1 | chr8 | 139749820 | - |
5CDS-intron | ENST00000607273 | ENST00000303045 | PRIM2 | chr6 | 57190843 | + | COL22A1 | chr8 | 139749820 | - |
5CDS-intron | ENST00000607273 | ENST00000435777 | PRIM2 | chr6 | 57190843 | + | COL22A1 | chr8 | 139749820 | - |
3UTR-intron | ENST00000389488 | ENST00000341807 | PRIM2 | chr6 | 57190843 | + | COL22A1 | chr8 | 139749820 | - |
3UTR-intron | ENST00000389488 | ENST00000303045 | PRIM2 | chr6 | 57190843 | + | COL22A1 | chr8 | 139749820 | - |
3UTR-intron | ENST00000389488 | ENST00000435777 | PRIM2 | chr6 | 57190843 | + | COL22A1 | chr8 | 139749820 | - |
Top |
FusionProtFeatures for PRIM2_COL22A1 |
![]() |
Hgene | Tgene |
PRIM2 | COL22A1 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Acts as a cell adhesion ligand for skin epithelial cellsand fibroblasts. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for PRIM2_COL22A1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for PRIM2_COL22A1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PRIM2 | RAE1, ELAVL1, POLA1, PRIM1, POLA2, MMS19, KDM1A, SUV39H1, FAM96B, CIAO1, MOV10, KLHL20, PRPS2, OBFC1, GFOD1, NTRK1, BAG6, USP37, DUSP9, NLGN4Y, RNF31, RGS20, DCAF10, PM20D2, ERP44 | COL22A1 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for PRIM2_COL22A1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for PRIM2_COL22A1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | COL22A1 | C0149925 | Small cell carcinoma of lung | 1 | CTD_human |