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Fusion gene ID: 28634 |
FusionGeneSummary for PREP_PTPRK |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PREP_PTPRK | Fusion gene ID: 28634 | Hgene | Tgene | Gene symbol | PREP | PTPRK | Gene ID | 5550 | 5796 |
| Gene name | prolyl endopeptidase | protein tyrosine phosphatase, receptor type K | |
| Synonyms | PE|PEP | R-PTP-kappa | |
| Cytomap | 6q21 | 6q22.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | prolyl endopeptidasedJ355L5.1 (prolyl endopeptidase)post-proline cleaving enzymeprolyl oligopeptidase | receptor-type tyrosine-protein phosphatase kappadJ480J14.2.1 (protein tyrosine phosphatase, receptor type, K (R-PTP-KAPPA, protein tyrosine phosphatase kappa , protein tyrosine phosphatase kappaprotein-tyrosine phosphatase kappaprotein-tyrosine phospha | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P48147 | Q15262 | |
| Ensembl transtripts involved in fusion gene | ENST00000369110, | ENST00000368226, ENST00000368227, ENST00000532331, ENST00000368213, ENST00000368210, ENST00000368215, ENST00000368207, ENST00000524481, ENST00000525459, | |
| Fusion gene scores | * DoF score | 12 X 7 X 5=420 | 10 X 8 X 7=560 |
| # samples | 12 | 11 | |
| ** MAII score | log2(12/420*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/560*10)=-2.34792330342031 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PREP [Title/Abstract] AND PTPRK [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PTPRK | GO:0006470 | protein dephosphorylation | 16263724 |
| Tgene | PTPRK | GO:0007165 | signal transduction | 16849327 |
| Tgene | PTPRK | GO:0007179 | transforming growth factor beta receptor signaling pathway | 15899872 |
| Tgene | PTPRK | GO:0008285 | negative regulation of cell proliferation | 15899872|18276111 |
| Tgene | PTPRK | GO:0010839 | negative regulation of keratinocyte proliferation | 16263724 |
| Tgene | PTPRK | GO:0030336 | negative regulation of cell migration | 18276111 |
| Tgene | PTPRK | GO:0034394 | protein localization to cell surface | 18276111 |
| Tgene | PTPRK | GO:0034614 | cellular response to reactive oxygen species | 16849327 |
| Tgene | PTPRK | GO:0034644 | cellular response to UV | 16849327 |
| Tgene | PTPRK | GO:0045786 | negative regulation of cell cycle | 15899872 |
| Tgene | PTPRK | GO:0045892 | negative regulation of transcription, DNA-templated | 18276111 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-MT-A7BN-01A | PREP | chr6 | 105729621 | - | PTPRK | chr6 | 128643455 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000369110 | ENST00000368226 | PREP | chr6 | 105729621 | - | PTPRK | chr6 | 128643455 | - |
| Frame-shift | ENST00000369110 | ENST00000368227 | PREP | chr6 | 105729621 | - | PTPRK | chr6 | 128643455 | - |
| Frame-shift | ENST00000369110 | ENST00000532331 | PREP | chr6 | 105729621 | - | PTPRK | chr6 | 128643455 | - |
| Frame-shift | ENST00000369110 | ENST00000368213 | PREP | chr6 | 105729621 | - | PTPRK | chr6 | 128643455 | - |
| Frame-shift | ENST00000369110 | ENST00000368210 | PREP | chr6 | 105729621 | - | PTPRK | chr6 | 128643455 | - |
| Frame-shift | ENST00000369110 | ENST00000368215 | PREP | chr6 | 105729621 | - | PTPRK | chr6 | 128643455 | - |
| Frame-shift | ENST00000369110 | ENST00000368207 | PREP | chr6 | 105729621 | - | PTPRK | chr6 | 128643455 | - |
| 5CDS-5UTR | ENST00000369110 | ENST00000524481 | PREP | chr6 | 105729621 | - | PTPRK | chr6 | 128643455 | - |
| 5CDS-5UTR | ENST00000369110 | ENST00000525459 | PREP | chr6 | 105729621 | - | PTPRK | chr6 | 128643455 | - |
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FusionProtFeatures for PREP_PTPRK |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PREP | PTPRK |
| Cleaves peptide bonds on the C-terminal side of prolylresidues within peptides that are up to approximately 30 aminoacids long. | Regulation of processes involving cell contact andadhesion such as growth control, tumor invasion, and metastasis.Negative regulator of EGFR signaling pathway. Forms complexes withbeta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be asubstrate for the catalytic activity of PTPRK/PTP-kappa.{ECO:0000269|PubMed:19836242}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PREP_PTPRK |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PREP_PTPRK |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PREP | SIRT7, TARS, BRCA1, SGOL2, AIP, GLO1, HSPA4, HSPD1, HSPH1, KCNAB2, PABPC4, ALDOA, ALDOC, CTH, GDI2, ISYNA1, ME1, OAT, PABPC1, QDPR, NTRK1, SUCO, MTG2, NSMAF, RHPN1, KIF3A, SNCA | PTPRK | PSMD11, TK1, CTNNB1, JUP, CSNK2B, FKBP8, GADD45G, GADD45A, LGALS3, LGALS8, LGALS9, LAMB2, ATRN, CACNA2D2, ECE1, CES3, TCTN2, LRP1B, INSR, PXDN, FRAS1, CACNA2D1, LAMA5, CD109, POGLUT1, ARSK, MEGF8, UBR3, ARSA, GALNS, ARSG, LAMB1, LRIG3, LRIG1, B3GALTL, SCARB1, ADAM9, NPC1, SUSD1, COL6A2, EOGT, PLXNA2, PLXNA3, PLXNA1, EGFR, MOXD1, CCDC102A, CHST10, COL6A1, DNAJB9, MAN2A1, CNTNAP3, PLXNB2, MANBA, ITGA8, MGRN1, ARSB, COL4A2, TMEM67, FBLN1, CLN5, SCARB2, FUT11, GLG1, CERCAM, ERO1LB, DCBLD2, CHST12, AMIGO1, PCSK5, LAMA3, SIAE, GNPTG, CTSF, PLAT, BCHE, ITGA4, GALNT18, MICA, LEPREL2, WNT5A, DGCR2, MAN2A2, BTD, SP3, AMIGO3, ANKRD46, HYAL2, TMEM132A, RIPK3, ATP2A2, SIPA1L3, ARHGAP32, TANC1, MINK1, PKP4, NCKAP5L, PEAK1, PIK3R1, SEC24B, RPL28, PTPRU, DEFA5, PCDHGB1, TUFM, MMP26, NID2, PCDHGB4, LYPD1, ZNF3, TMPRSS11B, BMP7 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PREP_PTPRK |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PREP_PTPRK |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PREP | C0002622 | Amnesia | 1 | CTD_human |
| Hgene | PREP | C0002624 | Retrograde amnesia | 1 | CTD_human |
| Hgene | PREP | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Hgene | PREP | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Hgene | PREP | C0338831 | Manic | 1 | PSYGENET |
| Tgene | PTPRK | C0025202 | melanoma | 2 | CTD_human |
| Tgene | PTPRK | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
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