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Fusion gene ID: 28631 |
FusionGeneSummary for PREP_LDLRAD4 |
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Fusion gene information | Fusion gene name: PREP_LDLRAD4 | Fusion gene ID: 28631 | Hgene | Tgene | Gene symbol | PREP | LDLRAD4 | Gene ID | 5550 | 753 |
Gene name | prolyl endopeptidase | low density lipoprotein receptor class A domain containing 4 | |
Synonyms | PE|PEP | C18orf1 | |
Cytomap | 6q21 | 18p11.21 | |
Type of gene | protein-coding | protein-coding | |
Description | prolyl endopeptidasedJ355L5.1 (prolyl endopeptidase)post-proline cleaving enzymeprolyl oligopeptidase | low-density lipoprotein receptor class A domain-containing protein 4clone 22 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P48147 | O15165 | |
Ensembl transtripts involved in fusion gene | ENST00000369110, | ENST00000361205, ENST00000399848, ENST00000359446, ENST00000587757, ENST00000585931, ENST00000586765, ENST00000590308, ENST00000592991, | |
Fusion gene scores | * DoF score | 12 X 7 X 5=420 | 8 X 7 X 5=280 |
# samples | 12 | 11 | |
** MAII score | log2(12/420*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/280*10)=-1.34792330342031 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PREP [Title/Abstract] AND LDLRAD4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | LDLRAD4 | GO:0010991 | negative regulation of SMAD protein complex assembly | 24627487 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-E2-A14V-01A | PREP | chr6 | 105845728 | - | LDLRAD4 | chr18 | 13621116 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000369110 | ENST00000361205 | PREP | chr6 | 105845728 | - | LDLRAD4 | chr18 | 13621116 | + |
Frame-shift | ENST00000369110 | ENST00000399848 | PREP | chr6 | 105845728 | - | LDLRAD4 | chr18 | 13621116 | + |
Frame-shift | ENST00000369110 | ENST00000359446 | PREP | chr6 | 105845728 | - | LDLRAD4 | chr18 | 13621116 | + |
Frame-shift | ENST00000369110 | ENST00000587757 | PREP | chr6 | 105845728 | - | LDLRAD4 | chr18 | 13621116 | + |
5CDS-5UTR | ENST00000369110 | ENST00000585931 | PREP | chr6 | 105845728 | - | LDLRAD4 | chr18 | 13621116 | + |
5CDS-5UTR | ENST00000369110 | ENST00000586765 | PREP | chr6 | 105845728 | - | LDLRAD4 | chr18 | 13621116 | + |
5CDS-intron | ENST00000369110 | ENST00000590308 | PREP | chr6 | 105845728 | - | LDLRAD4 | chr18 | 13621116 | + |
5CDS-intron | ENST00000369110 | ENST00000592991 | PREP | chr6 | 105845728 | - | LDLRAD4 | chr18 | 13621116 | + |
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FusionProtFeatures for PREP_LDLRAD4 |
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Hgene | Tgene |
PREP | LDLRAD4 |
Cleaves peptide bonds on the C-terminal side of prolylresidues within peptides that are up to approximately 30 aminoacids long. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PREP_LDLRAD4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PREP_LDLRAD4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PREP | SIRT7, TARS, BRCA1, SGOL2, AIP, GLO1, HSPA4, HSPD1, HSPH1, KCNAB2, PABPC4, ALDOA, ALDOC, CTH, GDI2, ISYNA1, ME1, OAT, PABPC1, QDPR, NTRK1, SUCO, MTG2, NSMAF, RHPN1, KIF3A, SNCA | LDLRAD4 | RTFDC1, HECW2, HECW1, WWP2, NEDD4, ITCH, NEDD4L, WWP1, TAX1BP1, WWC2, KIDINS220, NCAPD3, UBR3, ARFGEF2, UBR1, VPS18, STXBP4, ACVR2B, ACVR2A, EPN1, MAGI3, DPY19L1, ANKRD13D, ANKRD13A, TOMM40, NCAPH2, DHX38, CMTR1, SMURF1, SMURF2, PLCG1, FLCN, RNF31, CSNK1E, CSNK1D, MAGI1, FGFR1, USP33, CALCOCO2, YAP1, SUFU, SMAD2, SMAD3, RBCK1, CUEDC1, WWOX, UIMC1, USP22, KIAA1033 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PREP_LDLRAD4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PREP_LDLRAD4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PREP | C0002622 | Amnesia | 1 | CTD_human |
Hgene | PREP | C0002624 | Retrograde amnesia | 1 | CTD_human |
Hgene | PREP | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | PREP | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Hgene | PREP | C0338831 | Manic | 1 | PSYGENET |