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Fusion gene ID: 28608 |
FusionGeneSummary for PRDX1_WDR59 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PRDX1_WDR59 | Fusion gene ID: 28608 | Hgene | Tgene | Gene symbol | PRDX1 | WDR59 | Gene ID | 5052 | 79726 |
| Gene name | peroxiredoxin 1 | WD repeat domain 59 | |
| Synonyms | MSP23|NKEF-A|NKEFA|PAG|PAGA|PAGB|PRX1|PRXI|TDPX2 | CDW12|FP977|p90-120 | |
| Cytomap | 1p34.1 | 16q23.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | peroxiredoxin-1natural killer cell-enhancing factor Anatural killer-enhancing factor Aproliferation-associated gene Aproliferation-associated gene proteinthioredoxin peroxidase 2thioredoxin-dependent peroxide reductase 2 | GATOR complex protein WDR59CDw12 antigenWD repeat-containing protein 59 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q06830 | Q6PJI9 | |
| Ensembl transtripts involved in fusion gene | ENST00000262746, ENST00000319248, ENST00000372079, ENST00000483583, | ENST00000262144, ENST00000562331, | |
| Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 5 X 5 X 3=75 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PRDX1 [Title/Abstract] AND WDR59 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PRDX1 | GO:0030101 | natural killer cell activation | 8462106 |
| Hgene | PRDX1 | GO:0042744 | hydrogen peroxide catabolic process | 11986303|18606987 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF763254 | PRDX1 | chr1 | 45976866 | - | WDR59 | chr16 | 74985427 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000262746 | ENST00000262144 | PRDX1 | chr1 | 45976866 | - | WDR59 | chr16 | 74985427 | - |
| intron-5UTR | ENST00000262746 | ENST00000562331 | PRDX1 | chr1 | 45976866 | - | WDR59 | chr16 | 74985427 | - |
| intron-3CDS | ENST00000319248 | ENST00000262144 | PRDX1 | chr1 | 45976866 | - | WDR59 | chr16 | 74985427 | - |
| intron-5UTR | ENST00000319248 | ENST00000562331 | PRDX1 | chr1 | 45976866 | - | WDR59 | chr16 | 74985427 | - |
| intron-3CDS | ENST00000372079 | ENST00000262144 | PRDX1 | chr1 | 45976866 | - | WDR59 | chr16 | 74985427 | - |
| intron-5UTR | ENST00000372079 | ENST00000562331 | PRDX1 | chr1 | 45976866 | - | WDR59 | chr16 | 74985427 | - |
| intron-3CDS | ENST00000483583 | ENST00000262144 | PRDX1 | chr1 | 45976866 | - | WDR59 | chr16 | 74985427 | - |
| intron-5UTR | ENST00000483583 | ENST00000562331 | PRDX1 | chr1 | 45976866 | - | WDR59 | chr16 | 74985427 | - |
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FusionProtFeatures for PRDX1_WDR59 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PRDX1 | WDR59 |
| Thiol-specific peroxidase that catalyzes the reductionof hydrogen peroxide and organic hydroperoxides to water andalcohols, respectively. Plays a role in cell protection againstoxidative stress by detoxifying peroxides and as sensor ofhydrogen peroxide-mediated signaling events. Might participate inthe signaling cascades of growth factors and tumor necrosisfactor-alpha by regulating the intracellular concentrations ofH(2)O(2) (PubMed:9497357). Reduces an intramolecular disulfidebond in GDPD5 that gates the ability to GDPD5 to drive postmitoticmotor neuron differentiation (By similarity).{ECO:0000250|UniProtKB:P0CB50, ECO:0000269|PubMed:9497357}. | As a component of the GATOR subcomplex GATOR2, functionswithin the amino acid-sensing branch of the TORC1 signalingpathway. Indirectly activates mTORC1 and the TORC1 signalingpathway through the inhibition of the GATOR1 subcomplex(PubMed:23723238). It is negatively regulated by the upstreamamino acid sensors SESN2 and CASTOR1 (PubMed:25457612,PubMed:27487210). {ECO:0000269|PubMed:23723238,ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:27487210}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PRDX1_WDR59 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PRDX1_WDR59 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PRDX1_WDR59 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | PRDX1 | Q06830 | DB01593 | Zinc | Peroxiredoxin-1 | small molecule | approved|investigational |
| Hgene | PRDX1 | Q06830 | DB11638 | Artenimol | Peroxiredoxin-1 | small molecule | approved|investigational |
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RelatedDiseases for PRDX1_WDR59 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PRDX1 | C0003949 | Asbestosis | 1 | CTD_human |
| Hgene | PRDX1 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| Hgene | PRDX1 | C0022548 | Keloid | 1 | CTD_human |
| Hgene | PRDX1 | C0024121 | Lung Neoplasms | 1 | CTD_human |
| Hgene | PRDX1 | C0036323 | Schistosomiasis | 1 | CTD_human |
| Hgene | PRDX1 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
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