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Fusion gene ID: 28603 |
FusionGeneSummary for PRDM6_NIPAL4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PRDM6_NIPAL4 | Fusion gene ID: 28603 | Hgene | Tgene | Gene symbol | PRDM6 | NIPAL4 | Gene ID | 93166 | 348938 |
| Gene name | PR/SET domain 6 | NIPA like domain containing 4 | |
| Synonyms | KMT8C|PDA3|PRISM | ARCI6|ICHTHYIN|ICHYN | |
| Cytomap | 5q23.2 | 5q33.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | putative histone-lysine N-methyltransferase PRDM6PR domain 6PR domain containing 6PR domain-containing protein 6PR-domain zinc finger protein 6 | magnesium transporter NIPA4NIPA-like protein 4non-imprinted in Prader-Willi/Angelman syndrome region protein 4 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9NQX0 | Q0D2K0 | |
| Ensembl transtripts involved in fusion gene | ENST00000407847, ENST00000464424, | ENST00000435489, ENST00000311946, ENST00000521390, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 1 X 1=2 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/2*10)=2.32192809488736 | |
| Context | PubMed: PRDM6 [Title/Abstract] AND NIPAL4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | KIRC | TCGA-BP-4986-01A | PRDM6 | chr5 | 122495332 | + | NIPAL4 | chr5 | 156890102 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000407847 | ENST00000435489 | PRDM6 | chr5 | 122495332 | + | NIPAL4 | chr5 | 156890102 | + |
| In-frame | ENST00000407847 | ENST00000311946 | PRDM6 | chr5 | 122495332 | + | NIPAL4 | chr5 | 156890102 | + |
| 5CDS-3UTR | ENST00000407847 | ENST00000521390 | PRDM6 | chr5 | 122495332 | + | NIPAL4 | chr5 | 156890102 | + |
| intron-3CDS | ENST00000464424 | ENST00000435489 | PRDM6 | chr5 | 122495332 | + | NIPAL4 | chr5 | 156890102 | + |
| intron-3CDS | ENST00000464424 | ENST00000311946 | PRDM6 | chr5 | 122495332 | + | NIPAL4 | chr5 | 156890102 | + |
| intron-3UTR | ENST00000464424 | ENST00000521390 | PRDM6 | chr5 | 122495332 | + | NIPAL4 | chr5 | 156890102 | + |
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FusionProtFeatures for PRDM6_NIPAL4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PRDM6 | NIPAL4 |
| Putative histone methyltransferase that acts as atranscriptional repressor of smooth muscle gene expression.Promotes the transition from differentiated to proliferativesmooth muscle by suppressing differentiation and maintaining theproliferative potential of vascular smooth muscle cells. Alsoplays a role in endothelial cells by inhibiting endothelial cellproliferation, survival and differentiation. It is unclear whetherit has histone methyltransferase activity in vivo. According tosome authors, it does not act as a histone methyltransferase byitself and represses transcription by recruiting EHMT2/G9a.According to others, it possesses histone methyltransferaseactivity when associated with other proteins and specificallymethylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylationrepresents a specific tag for epigenetic transcriptionalrepression. {ECO:0000250|UniProtKB:Q3UZD5}. | Acts as a Mg(2+) transporter. Can also transport otherdivalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but toa much less extent than Mg(2+) (By similarity). May be a receptorfor ligands (trioxilins A3 and B3) from the hepoxilin pathway.{ECO:0000250, ECO:0000269|PubMed:15317751}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PRDM6 | chr5:122495332 | chr5:156890102 | ENST00000407847 | + | 5 | 8 | 123_129 | 384 | 596 | Compositional bias | Note=Poly-Ala |
| Hgene | PRDM6 | chr5:122495332 | chr5:156890102 | ENST00000407847 | + | 5 | 8 | 151_162 | 384 | 596 | Compositional bias | Note=Poly-Gly |
| Hgene | PRDM6 | chr5:122495332 | chr5:156890102 | ENST00000407847 | + | 5 | 8 | 228_232 | 384 | 596 | Compositional bias | Note=Poly-Ala |
| Hgene | PRDM6 | chr5:122495332 | chr5:156890102 | ENST00000407847 | + | 5 | 8 | 47_73 | 384 | 596 | Compositional bias | Note=Pro-rich |
| Hgene | PRDM6 | chr5:122495332 | chr5:156890102 | ENST00000407847 | + | 5 | 8 | 97_106 | 384 | 596 | Compositional bias | Note=Poly-Ala |
| Hgene | PRDM6 | chr5:122495332 | chr5:156890102 | ENST00000407847 | + | 5 | 8 | 246_365 | 384 | 596 | Domain | SET |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000311946 | + | 0 | 6 | 139_164 | 74 | 467 | Topological domain | Cytoplasmic |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000311946 | + | 0 | 6 | 186_186 | 74 | 467 | Topological domain | Extracellular |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000311946 | + | 0 | 6 | 208_215 | 74 | 467 | Topological domain | Cytoplasmic |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000311946 | + | 0 | 6 | 237_257 | 74 | 467 | Topological domain | Extracellular |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000311946 | + | 0 | 6 | 279_285 | 74 | 467 | Topological domain | Cytoplasmic |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000311946 | + | 0 | 6 | 307_323 | 74 | 467 | Topological domain | Extracellular |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000311946 | + | 0 | 6 | 345_355 | 74 | 467 | Topological domain | Cytoplasmic |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000311946 | + | 0 | 6 | 377_386 | 74 | 467 | Topological domain | Extracellular |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000311946 | + | 0 | 6 | 408_466 | 74 | 467 | Topological domain | Cytoplasmic |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000435489 | + | 0 | 5 | 139_164 | 74 | 448 | Topological domain | Cytoplasmic |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000435489 | + | 0 | 5 | 186_186 | 74 | 448 | Topological domain | Extracellular |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000435489 | + | 0 | 5 | 208_215 | 74 | 448 | Topological domain | Cytoplasmic |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000435489 | + | 0 | 5 | 237_257 | 74 | 448 | Topological domain | Extracellular |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000435489 | + | 0 | 5 | 279_285 | 74 | 448 | Topological domain | Cytoplasmic |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000435489 | + | 0 | 5 | 307_323 | 74 | 448 | Topological domain | Extracellular |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000435489 | + | 0 | 5 | 345_355 | 74 | 448 | Topological domain | Cytoplasmic |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000435489 | + | 0 | 5 | 377_386 | 74 | 448 | Topological domain | Extracellular |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000435489 | + | 0 | 5 | 408_466 | 74 | 448 | Topological domain | Cytoplasmic |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000311946 | + | 0 | 6 | 118_138 | 74 | 467 | Transmembrane | Helical |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000311946 | + | 0 | 6 | 165_185 | 74 | 467 | Transmembrane | Helical |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000311946 | + | 0 | 6 | 187_207 | 74 | 467 | Transmembrane | Helical |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000311946 | + | 0 | 6 | 216_236 | 74 | 467 | Transmembrane | Helical |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000311946 | + | 0 | 6 | 258_278 | 74 | 467 | Transmembrane | Helical |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000311946 | + | 0 | 6 | 286_306 | 74 | 467 | Transmembrane | Helical |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000311946 | + | 0 | 6 | 324_344 | 74 | 467 | Transmembrane | Helical |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000311946 | + | 0 | 6 | 356_376 | 74 | 467 | Transmembrane | Helical |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000311946 | + | 0 | 6 | 387_407 | 74 | 467 | Transmembrane | Helical |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000435489 | + | 0 | 5 | 118_138 | 74 | 448 | Transmembrane | Helical |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000435489 | + | 0 | 5 | 165_185 | 74 | 448 | Transmembrane | Helical |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000435489 | + | 0 | 5 | 187_207 | 74 | 448 | Transmembrane | Helical |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000435489 | + | 0 | 5 | 216_236 | 74 | 448 | Transmembrane | Helical |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000435489 | + | 0 | 5 | 258_278 | 74 | 448 | Transmembrane | Helical |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000435489 | + | 0 | 5 | 286_306 | 74 | 448 | Transmembrane | Helical |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000435489 | + | 0 | 5 | 324_344 | 74 | 448 | Transmembrane | Helical |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000435489 | + | 0 | 5 | 356_376 | 74 | 448 | Transmembrane | Helical |
| Tgene | >NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000435489 | + | 0 | 5 | 387_407 | 74 | 448 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PRDM6 | chr5:122495332 | chr5:156890102 | ENST00000407847 | + | 5 | 8 | 473_495 | 384 | 596 | Zinc finger | C2H2-type 1%3B degenerate |
| Hgene | >PRDM6 | chr5:122495332 | chr5:156890102 | ENST00000407847 | + | 5 | 8 | 501_523 | 384 | 596 | Zinc finger | C2H2-type 2 |
| Hgene | >PRDM6 | chr5:122495332 | chr5:156890102 | ENST00000407847 | + | 5 | 8 | 529_551 | 384 | 596 | Zinc finger | C2H2-type 3 |
| Hgene | >PRDM6 | chr5:122495332 | chr5:156890102 | ENST00000407847 | + | 5 | 8 | 557_579 | 384 | 596 | Zinc finger | C2H2-type 4%3B degenerate |
| Tgene | NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000311946 | + | 0 | 6 | 1_117 | 74 | 467 | Topological domain | Extracellular |
| Tgene | NIPAL4 | chr5:122495332 | chr5:156890102 | ENST00000435489 | + | 0 | 5 | 1_117 | 74 | 448 | Topological domain | Extracellular |
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FusionGeneSequence for PRDM6_NIPAL4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PRDM6_ENST00000407847_chr5_122495332_+_NIPAL4_ENST00000435489_chr5_156890102_+_758aa MLKPGDPGGSAFLKVDPAYLQHWQQLFPHGGAGPLKGSGAAGLLSAPQPLQPPPPPPPPERAEPPPDSLRPRPASLSSASSTPASSSTSA SSASSCAAAAAAAALAGLSALPVSQLPVFAPLAAAAVAAEPLPPKELCLGATSGPGPVKCGGGGGGGGEGRGAPRFRCSAEELDYYLYGQ QRMEIIPLNQHTSDPNNRCDMCADNRNGECPMHGPLHSLRRLVGTSSAAAAAPPPELPEWLRDLPREVCLCTSTVPGLAYGICAAQRIQQ GTWIGPFQGVLLPPEKVQAGAVRNTQHLWEIYDQDGTLQHFIDGGEPSKSSWMRYIRCARHCGEQNLTVVQYRSNIFYRACIDIPRGTEL LVWYNDSYTSFFGIPLQCIAQDENCSLLHLYCSSQEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKK KGLLRLVATGATRAVAAGEVANFGAYAFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIME MASKMKDTGFIVFAVLLLVSCLILIFVIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLST QVNFLNRALDIFNTSLVFPIYYVFFTTVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHMHKNPPPSPA >In-frame_PRDM6_ENST00000407847_chr5_122495332_+_NIPAL4_ENST00000311946_chr5_156890102_+_777aa MLKPGDPGGSAFLKVDPAYLQHWQQLFPHGGAGPLKGSGAAGLLSAPQPLQPPPPPPPPERAEPPPDSLRPRPASLSSASSTPASSSTSA SSASSCAAAAAAAALAGLSALPVSQLPVFAPLAAAAVAAEPLPPKELCLGATSGPGPVKCGGGGGGGGEGRGAPRFRCSAEELDYYLYGQ QRMEIIPLNQHTSDPNNRCDMCADNRNGECPMHGPLHSLRRLVGTSSAAAAAPPPELPEWLRDLPREVCLCTSTVPGLAYGICAAQRIQQ GTWIGPFQGVLLPPEKVQAGAVRNTQHLWEIYDQDGTLQHFIDGGEPSKSSWMRYIRCARHCGEQNLTVVQYRSNIFYRACIDIPRGTEL LVWYNDSYTSFFGIPLQCIAQDENCSLLHLYCSSQEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKK KGLLRLVATGATRAVDGGFGYLKDAMWWAGFLTMAAGEVANFGAYAFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAG STVMVIHAPEEEKVTTIMEMASKMKDTGFIVFAVLLLVSCLILIFVIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPV VRHPLPYILSLILALSLSTQVNFLNRALDIFNTSLVFPIYYVFFTTVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PRDM6_ENST00000407847_chr5_122495332_+_NIPAL4_ENST00000435489_chr5_156890102_+_2274nt ATGCTGAAGCCCGGAGACCCCGGCGGTTCGGCCTTCCTCAAAGTGGACCCAGCCTACCTGCAGCACTGGCAGCAACTCTTCCCTCACGGA GGCGCAGGCCCGCTCAAGGGCAGCGGCGCCGCGGGTCTCCTGAGCGCGCCGCAGCCTCTTCAGCCGCCGCCGCCGCCCCCGCCCCCGGAG CGCGCTGAGCCTCCGCCGGACAGCCTGCGCCCGCGGCCCGCCTCTCTCTCCTCCGCCTCGTCCACGCCGGCTTCCTCTTCCACCTCCGCC TCCTCCGCCTCCTCCTGCGCTGCTGCGGCCGCTGCCGCCGCGCTGGCTGGTCTCTCGGCCCTGCCGGTGTCGCAGCTGCCGGTGTTCGCG CCTCTAGCCGCCGCTGCCGTCGCCGCCGAGCCGCTGCCCCCCAAGGAACTGTGCCTCGGCGCCACCTCCGGCCCCGGGCCCGTCAAGTGC GGTGGTGGTGGCGGCGGCGGCGGGGAGGGTCGCGGCGCCCCGCGCTTCCGCTGCAGCGCAGAGGAGCTGGACTATTACCTGTATGGCCAG CAGCGCATGGAGATCATCCCGCTCAACCAGCACACCAGCGACCCCAACAACCGTTGCGACATGTGCGCGGACAACCGCAACGGCGAGTGC CCTATGCATGGGCCACTGCACTCGCTGCGCCGGCTTGTGGGCACCAGCAGCGCTGCGGCCGCCGCGCCCCCGCCGGAGCTGCCGGAGTGG CTGCGGGACCTGCCTCGCGAGGTGTGCCTCTGCACCAGTACTGTGCCCGGCCTGGCCTACGGCATCTGCGCGGCGCAGAGGATCCAGCAA GGCACCTGGATTGGACCTTTCCAAGGCGTGCTTCTGCCCCCAGAGAAGGTGCAGGCAGGCGCCGTGAGGAACACGCAGCATCTCTGGGAG ATATATGACCAGGATGGGACACTACAGCACTTTATTGATGGTGGGGAACCTAGTAAGTCGAGCTGGATGAGGTATATCCGATGTGCAAGG CACTGCGGAGAACAGAATCTAACAGTAGTTCAGTACAGGTCGAATATATTCTACCGAGCCTGTATAGATATCCCTAGGGGCACCGAGCTT CTGGTGTGGTACAATGACAGCTATACGTCTTTCTTTGGGATCCCCTTACAATGCATTGCCCAGGATGAAAACTGTTCCCTGCTCCACCTC TACTGCTCCTCCCAAGAAGTCCTGTGCCAGATTGTCAATGACCTCAGCCCTGAGGTGCCCAGCAATGCCACCTTTCACAGCTGGCAGGAA AGAATCAGGCAGAACTATGGCTTCTACATCGGCCTGGGCCTGGCATTCCTGTCTAGCTTCCTCATCGGCAGCAGCGTCATCCTCAAGAAG AAAGGCCTCTTGCGACTCGTGGCCACGGGAGCCACTCGAGCTGTGGCTGCTGGAGAAGTTGCCAACTTTGGAGCCTACGCATTTGCACCT GCAACAGTCGTCACGCCTCTGGGAGCGCTGAGTGTCCTCATAAGTGCCATCCTCTCCTCATATTTCCTGAGGGAGAGTCTGAACCTGCTG GGGAAGCTGGGCTGTGTGATCTGTGTGGCCGGAAGCACAGTGATGGTGATACATGCTCCTGAGGAAGAGAAGGTCACTACCATCATGGAG ATGGCTTCCAAGATGAAAGACACAGGGTTCATCGTGTTTGCTGTGCTTCTGCTGGTGTCATGCCTCATCCTCATCTTTGTCATTGCCCCA CGTTACGGGCAAAGGAATATCCTCATCTACATCATCATCTGCTCTGTGATCGGGGCCTTCTCTGTGGCTGCTGTCAAGGGGCTGGGCATC ACCATCAAGAACTTCTTCCAGGGGCTGCCAGTTGTCCGGCACCCGCTCCCCTACATCCTGTCCCTCATCCTGGCACTGTCCCTCAGCACT CAGGTCAACTTCCTCAACAGAGCACTGGACATTTTCAACACTTCCCTGGTGTTCCCCATCTACTACGTGTTCTTCACCACGGTGGTCGTT ACCTCGTCCATCATCCTCTTCAAGGAGTGGTACAGCATGTCTGCTGTGGACATTGCAGGCACCCTCTCGGGCTTTGTCACCATCATCTTG GGCGTGTTCATGCTGCATGCTTTCAAAGACCTGGACATCAGCTGCGCCAGCTTGCCCCACATGCACAAAAACCCACCCCCTTCTCCCGCC CCGGAACCCACTGTTATTAGACTGGAAGACAAGAACGTCCTTGTGGACAATATAGAACTTGCCAGCACCTCATCACCAGAAGAGAAACCC >In-frame_PRDM6_ENST00000407847_chr5_122495332_+_NIPAL4_ENST00000311946_chr5_156890102_+_2331nt ATGCTGAAGCCCGGAGACCCCGGCGGTTCGGCCTTCCTCAAAGTGGACCCAGCCTACCTGCAGCACTGGCAGCAACTCTTCCCTCACGGA GGCGCAGGCCCGCTCAAGGGCAGCGGCGCCGCGGGTCTCCTGAGCGCGCCGCAGCCTCTTCAGCCGCCGCCGCCGCCCCCGCCCCCGGAG CGCGCTGAGCCTCCGCCGGACAGCCTGCGCCCGCGGCCCGCCTCTCTCTCCTCCGCCTCGTCCACGCCGGCTTCCTCTTCCACCTCCGCC TCCTCCGCCTCCTCCTGCGCTGCTGCGGCCGCTGCCGCCGCGCTGGCTGGTCTCTCGGCCCTGCCGGTGTCGCAGCTGCCGGTGTTCGCG CCTCTAGCCGCCGCTGCCGTCGCCGCCGAGCCGCTGCCCCCCAAGGAACTGTGCCTCGGCGCCACCTCCGGCCCCGGGCCCGTCAAGTGC GGTGGTGGTGGCGGCGGCGGCGGGGAGGGTCGCGGCGCCCCGCGCTTCCGCTGCAGCGCAGAGGAGCTGGACTATTACCTGTATGGCCAG CAGCGCATGGAGATCATCCCGCTCAACCAGCACACCAGCGACCCCAACAACCGTTGCGACATGTGCGCGGACAACCGCAACGGCGAGTGC CCTATGCATGGGCCACTGCACTCGCTGCGCCGGCTTGTGGGCACCAGCAGCGCTGCGGCCGCCGCGCCCCCGCCGGAGCTGCCGGAGTGG CTGCGGGACCTGCCTCGCGAGGTGTGCCTCTGCACCAGTACTGTGCCCGGCCTGGCCTACGGCATCTGCGCGGCGCAGAGGATCCAGCAA GGCACCTGGATTGGACCTTTCCAAGGCGTGCTTCTGCCCCCAGAGAAGGTGCAGGCAGGCGCCGTGAGGAACACGCAGCATCTCTGGGAG ATATATGACCAGGATGGGACACTACAGCACTTTATTGATGGTGGGGAACCTAGTAAGTCGAGCTGGATGAGGTATATCCGATGTGCAAGG CACTGCGGAGAACAGAATCTAACAGTAGTTCAGTACAGGTCGAATATATTCTACCGAGCCTGTATAGATATCCCTAGGGGCACCGAGCTT CTGGTGTGGTACAATGACAGCTATACGTCTTTCTTTGGGATCCCCTTACAATGCATTGCCCAGGATGAAAACTGTTCCCTGCTCCACCTC TACTGCTCCTCCCAAGAAGTCCTGTGCCAGATTGTCAATGACCTCAGCCCTGAGGTGCCCAGCAATGCCACCTTTCACAGCTGGCAGGAA AGAATCAGGCAGAACTATGGCTTCTACATCGGCCTGGGCCTGGCATTCCTGTCTAGCTTCCTCATCGGCAGCAGCGTCATCCTCAAGAAG AAAGGCCTCTTGCGACTCGTGGCCACGGGAGCCACTCGAGCTGTGGATGGAGGCTTCGGCTACCTGAAAGATGCAATGTGGTGGGCTGGA TTTCTCACCATGGCTGCTGGAGAAGTTGCCAACTTTGGAGCCTACGCATTTGCACCTGCAACAGTCGTCACGCCTCTGGGAGCGCTGAGT GTCCTCATAAGTGCCATCCTCTCCTCATATTTCCTGAGGGAGAGTCTGAACCTGCTGGGGAAGCTGGGCTGTGTGATCTGTGTGGCCGGA AGCACAGTGATGGTGATACATGCTCCTGAGGAAGAGAAGGTCACTACCATCATGGAGATGGCTTCCAAGATGAAAGACACAGGGTTCATC GTGTTTGCTGTGCTTCTGCTGGTGTCATGCCTCATCCTCATCTTTGTCATTGCCCCACGTTACGGGCAAAGGAATATCCTCATCTACATC ATCATCTGCTCTGTGATCGGGGCCTTCTCTGTGGCTGCTGTCAAGGGGCTGGGCATCACCATCAAGAACTTCTTCCAGGGGCTGCCAGTT GTCCGGCACCCGCTCCCCTACATCCTGTCCCTCATCCTGGCACTGTCCCTCAGCACTCAGGTCAACTTCCTCAACAGAGCACTGGACATT TTCAACACTTCCCTGGTGTTCCCCATCTACTACGTGTTCTTCACCACGGTGGTCGTTACCTCGTCCATCATCCTCTTCAAGGAGTGGTAC AGCATGTCTGCTGTGGACATTGCAGGCACCCTCTCGGGCTTTGTCACCATCATCTTGGGCGTGTTCATGCTGCATGCTTTCAAAGACCTG GACATCAGCTGCGCCAGCTTGCCCCACATGCACAAAAACCCACCCCCTTCTCCCGCCCCGGAACCCACTGTTATTAGACTGGAAGACAAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PRDM6_ENST00000407847_chr5_122495332_+_NIPAL4_ENST00000435489_chr5_156890102_+_2828nt CTCTCTCACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACTCACTCTATTTTGTGCTGT CGTAAAACCCACGTGTCCAGCCGGGAAGCTGCCAGAGCGTGGAACCAAGGAGCCAGGACGCGGCAGCGGCCAAGCGCAGCAGCCCACGGC GGTTGAGTCGGGCGCCCAGGTCCGTCCGCACTCTCGCGCCCTCCGCGGGCCTCCCAATTTTCTCGCTTGCAGGTCGGGAGGTTTCCGGGC GGCACAATCTCTAGGACTCTCCTCCCGCGCTGCTCAGGGGCATGTAGCGCACGCAGGGCGCACACTCTCGCGCACCCGCACGCTCACCGA GACACCCGCACGCACCCACCGGCAGCACCGAGTTTTCAGTTCGAGGCGCCGGACATGCTGAAGCCCGGAGACCCCGGCGGTTCGGCCTTC CTCAAAGTGGACCCAGCCTACCTGCAGCACTGGCAGCAACTCTTCCCTCACGGAGGCGCAGGCCCGCTCAAGGGCAGCGGCGCCGCGGGT CTCCTGAGCGCGCCGCAGCCTCTTCAGCCGCCGCCGCCGCCCCCGCCCCCGGAGCGCGCTGAGCCTCCGCCGGACAGCCTGCGCCCGCGG CCCGCCTCTCTCTCCTCCGCCTCGTCCACGCCGGCTTCCTCTTCCACCTCCGCCTCCTCCGCCTCCTCCTGCGCTGCTGCGGCCGCTGCC GCCGCGCTGGCTGGTCTCTCGGCCCTGCCGGTGTCGCAGCTGCCGGTGTTCGCGCCTCTAGCCGCCGCTGCCGTCGCCGCCGAGCCGCTG CCCCCCAAGGAACTGTGCCTCGGCGCCACCTCCGGCCCCGGGCCCGTCAAGTGCGGTGGTGGTGGCGGCGGCGGCGGGGAGGGTCGCGGC GCCCCGCGCTTCCGCTGCAGCGCAGAGGAGCTGGACTATTACCTGTATGGCCAGCAGCGCATGGAGATCATCCCGCTCAACCAGCACACC AGCGACCCCAACAACCGTTGCGACATGTGCGCGGACAACCGCAACGGCGAGTGCCCTATGCATGGGCCACTGCACTCGCTGCGCCGGCTT GTGGGCACCAGCAGCGCTGCGGCCGCCGCGCCCCCGCCGGAGCTGCCGGAGTGGCTGCGGGACCTGCCTCGCGAGGTGTGCCTCTGCACC AGTACTGTGCCCGGCCTGGCCTACGGCATCTGCGCGGCGCAGAGGATCCAGCAAGGCACCTGGATTGGACCTTTCCAAGGCGTGCTTCTG CCCCCAGAGAAGGTGCAGGCAGGCGCCGTGAGGAACACGCAGCATCTCTGGGAGATATATGACCAGGATGGGACACTACAGCACTTTATT GATGGTGGGGAACCTAGTAAGTCGAGCTGGATGAGGTATATCCGATGTGCAAGGCACTGCGGAGAACAGAATCTAACAGTAGTTCAGTAC AGGTCGAATATATTCTACCGAGCCTGTATAGATATCCCTAGGGGCACCGAGCTTCTGGTGTGGTACAATGACAGCTATACGTCTTTCTTT GGGATCCCCTTACAATGCATTGCCCAGGATGAAAACTGTTCCCTGCTCCACCTCTACTGCTCCTCCCAAGAAGTCCTGTGCCAGATTGTC AATGACCTCAGCCCTGAGGTGCCCAGCAATGCCACCTTTCACAGCTGGCAGGAAAGAATCAGGCAGAACTATGGCTTCTACATCGGCCTG GGCCTGGCATTCCTGTCTAGCTTCCTCATCGGCAGCAGCGTCATCCTCAAGAAGAAAGGCCTCTTGCGACTCGTGGCCACGGGAGCCACT CGAGCTGTGGCTGCTGGAGAAGTTGCCAACTTTGGAGCCTACGCATTTGCACCTGCAACAGTCGTCACGCCTCTGGGAGCGCTGAGTGTC CTCATAAGTGCCATCCTCTCCTCATATTTCCTGAGGGAGAGTCTGAACCTGCTGGGGAAGCTGGGCTGTGTGATCTGTGTGGCCGGAAGC ACAGTGATGGTGATACATGCTCCTGAGGAAGAGAAGGTCACTACCATCATGGAGATGGCTTCCAAGATGAAAGACACAGGGTTCATCGTG TTTGCTGTGCTTCTGCTGGTGTCATGCCTCATCCTCATCTTTGTCATTGCCCCACGTTACGGGCAAAGGAATATCCTCATCTACATCATC ATCTGCTCTGTGATCGGGGCCTTCTCTGTGGCTGCTGTCAAGGGGCTGGGCATCACCATCAAGAACTTCTTCCAGGGGCTGCCAGTTGTC CGGCACCCGCTCCCCTACATCCTGTCCCTCATCCTGGCACTGTCCCTCAGCACTCAGGTCAACTTCCTCAACAGAGCACTGGACATTTTC AACACTTCCCTGGTGTTCCCCATCTACTACGTGTTCTTCACCACGGTGGTCGTTACCTCGTCCATCATCCTCTTCAAGGAGTGGTACAGC ATGTCTGCTGTGGACATTGCAGGCACCCTCTCGGGCTTTGTCACCATCATCTTGGGCGTGTTCATGCTGCATGCTTTCAAAGACCTGGAC ATCAGCTGCGCCAGCTTGCCCCACATGCACAAAAACCCACCCCCTTCTCCCGCCCCGGAACCCACTGTTATTAGACTGGAAGACAAGAAC GTCCTTGTGGACAATATAGAACTTGCCAGCACCTCATCACCAGAAGAGAAACCCAAAGTATTTATAATCCATTCCTGAAGCTTGGAATAT GTGAGTGAGAGGATGAGTCCGATGGTACAGCCTGCCCTCCCAATTTCAAAACCACCTGGTTATTTTCCAGTGCAACTGTTACCAATGGGC >In-frame_PRDM6_ENST00000407847_chr5_122495332_+_NIPAL4_ENST00000311946_chr5_156890102_+_4502nt CTCTCTCACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACTCACTCTATTTTGTGCTGT CGTAAAACCCACGTGTCCAGCCGGGAAGCTGCCAGAGCGTGGAACCAAGGAGCCAGGACGCGGCAGCGGCCAAGCGCAGCAGCCCACGGC GGTTGAGTCGGGCGCCCAGGTCCGTCCGCACTCTCGCGCCCTCCGCGGGCCTCCCAATTTTCTCGCTTGCAGGTCGGGAGGTTTCCGGGC GGCACAATCTCTAGGACTCTCCTCCCGCGCTGCTCAGGGGCATGTAGCGCACGCAGGGCGCACACTCTCGCGCACCCGCACGCTCACCGA GACACCCGCACGCACCCACCGGCAGCACCGAGTTTTCAGTTCGAGGCGCCGGACATGCTGAAGCCCGGAGACCCCGGCGGTTCGGCCTTC CTCAAAGTGGACCCAGCCTACCTGCAGCACTGGCAGCAACTCTTCCCTCACGGAGGCGCAGGCCCGCTCAAGGGCAGCGGCGCCGCGGGT CTCCTGAGCGCGCCGCAGCCTCTTCAGCCGCCGCCGCCGCCCCCGCCCCCGGAGCGCGCTGAGCCTCCGCCGGACAGCCTGCGCCCGCGG CCCGCCTCTCTCTCCTCCGCCTCGTCCACGCCGGCTTCCTCTTCCACCTCCGCCTCCTCCGCCTCCTCCTGCGCTGCTGCGGCCGCTGCC GCCGCGCTGGCTGGTCTCTCGGCCCTGCCGGTGTCGCAGCTGCCGGTGTTCGCGCCTCTAGCCGCCGCTGCCGTCGCCGCCGAGCCGCTG CCCCCCAAGGAACTGTGCCTCGGCGCCACCTCCGGCCCCGGGCCCGTCAAGTGCGGTGGTGGTGGCGGCGGCGGCGGGGAGGGTCGCGGC GCCCCGCGCTTCCGCTGCAGCGCAGAGGAGCTGGACTATTACCTGTATGGCCAGCAGCGCATGGAGATCATCCCGCTCAACCAGCACACC AGCGACCCCAACAACCGTTGCGACATGTGCGCGGACAACCGCAACGGCGAGTGCCCTATGCATGGGCCACTGCACTCGCTGCGCCGGCTT GTGGGCACCAGCAGCGCTGCGGCCGCCGCGCCCCCGCCGGAGCTGCCGGAGTGGCTGCGGGACCTGCCTCGCGAGGTGTGCCTCTGCACC AGTACTGTGCCCGGCCTGGCCTACGGCATCTGCGCGGCGCAGAGGATCCAGCAAGGCACCTGGATTGGACCTTTCCAAGGCGTGCTTCTG CCCCCAGAGAAGGTGCAGGCAGGCGCCGTGAGGAACACGCAGCATCTCTGGGAGATATATGACCAGGATGGGACACTACAGCACTTTATT GATGGTGGGGAACCTAGTAAGTCGAGCTGGATGAGGTATATCCGATGTGCAAGGCACTGCGGAGAACAGAATCTAACAGTAGTTCAGTAC AGGTCGAATATATTCTACCGAGCCTGTATAGATATCCCTAGGGGCACCGAGCTTCTGGTGTGGTACAATGACAGCTATACGTCTTTCTTT GGGATCCCCTTACAATGCATTGCCCAGGATGAAAACTGTTCCCTGCTCCACCTCTACTGCTCCTCCCAAGAAGTCCTGTGCCAGATTGTC AATGACCTCAGCCCTGAGGTGCCCAGCAATGCCACCTTTCACAGCTGGCAGGAAAGAATCAGGCAGAACTATGGCTTCTACATCGGCCTG GGCCTGGCATTCCTGTCTAGCTTCCTCATCGGCAGCAGCGTCATCCTCAAGAAGAAAGGCCTCTTGCGACTCGTGGCCACGGGAGCCACT CGAGCTGTGGATGGAGGCTTCGGCTACCTGAAAGATGCAATGTGGTGGGCTGGATTTCTCACCATGGCTGCTGGAGAAGTTGCCAACTTT GGAGCCTACGCATTTGCACCTGCAACAGTCGTCACGCCTCTGGGAGCGCTGAGTGTCCTCATAAGTGCCATCCTCTCCTCATATTTCCTG AGGGAGAGTCTGAACCTGCTGGGGAAGCTGGGCTGTGTGATCTGTGTGGCCGGAAGCACAGTGATGGTGATACATGCTCCTGAGGAAGAG AAGGTCACTACCATCATGGAGATGGCTTCCAAGATGAAAGACACAGGGTTCATCGTGTTTGCTGTGCTTCTGCTGGTGTCATGCCTCATC CTCATCTTTGTCATTGCCCCACGTTACGGGCAAAGGAATATCCTCATCTACATCATCATCTGCTCTGTGATCGGGGCCTTCTCTGTGGCT GCTGTCAAGGGGCTGGGCATCACCATCAAGAACTTCTTCCAGGGGCTGCCAGTTGTCCGGCACCCGCTCCCCTACATCCTGTCCCTCATC CTGGCACTGTCCCTCAGCACTCAGGTCAACTTCCTCAACAGAGCACTGGACATTTTCAACACTTCCCTGGTGTTCCCCATCTACTACGTG TTCTTCACCACGGTGGTCGTTACCTCGTCCATCATCCTCTTCAAGGAGTGGTACAGCATGTCTGCTGTGGACATTGCAGGCACCCTCTCG GGCTTTGTCACCATCATCTTGGGCGTGTTCATGCTGCATGCTTTCAAAGACCTGGACATCAGCTGCGCCAGCTTGCCCCACATGCACAAA AACCCACCCCCTTCTCCCGCCCCGGAACCCACTGTTATTAGACTGGAAGACAAGAACGTCCTTGTGGACAATATAGAACTTGCCAGCACC TCATCACCAGAAGAGAAACCCAAAGTATTTATAATCCATTCCTGAAGCTTGGAATATGTGAGTGAGAGGATGAGTCCGATGGTACAGCCT GCCCTCCCAATTTCAAAACCACCTGGTTATTTTCCAGTGCAACTGTTACCAATGGGCTCTCTTTTCTTGAGAAGTTCATTTATACCTCAT CACTGTTTCCAGGAGAAAAATCTTTACCCAAATAGCAATGGTGGCAGAACTTCCTGGAAACAGATTCAGTGACCAAATACCCAAGTTTAC ATCAGTGCCTGCAGGTTCCCTGGACCTTCCTTCTCATTCATTCTTTCGGTGCCATCTCTATGCCGTTGGGAAGAAGATGGAGTCTGACCC ACTGAATGTAGCACAGTCCAAGGACTTCTCTAAGATATTGGTCATTGGAAGTTCCTTCACACCAATTCTCCTCCTGAGACGGAATCTCCG TTGTTGTTGTTGTTGTTGTTTTCTAGCCCAAGGATGACATAGAGCTGGCTCCCAGAGGCCCACAGAGCAATTGGCCATGCCTCCCTATCC AGAGCTGACAGGGACACAACCAGTGTAAAATATCCTGTTGCCTTTGTCACTTCCTCTTTGGAGGCAGAAGCAAGACCTCAGCTGACCTTC TTACTGTGAAAGCCACTTGATGTCTCAGGGAAAAATTTCAACCAGCTCATTCCCCGAGCACTCCAGCCTGGCAGTCAGCACCTCGGCATC CACCCAGTCCATCCCACCATCACCCCTTCCCCCTCTACTTACATCCTAAGGAGTCGGTCACTGAGACATAAAGGCAGTAATCGCAGAACT GGAAACAAAACAATAATAGAGCCACAGCCAAACTCTGGTGGCCAAACCCAGTGTTGCATTTTGTCTTACTCTGAAAGAAGAACAGCAAAT TCACTGCTTCAAAGTGGCCTGGCTGCCAAGCTAGAATTTGGCAGAACGCACTTTACTATTCCTCAAGGAGTCAACCAACCTATGATCTGG GGAGGTGGGAAGAGGATGAGGAGCAAAGTTGGGATTTGGCAGAAGGCAGTCCCAGGCTCTCTGGATACTAGGGGCTAACTTTTGTGTTGA CTCTGGTGCTCATCTGGGAACTTAGGAGAAACGAGCTCAGGGGTAATTTCTGGGTTGCAGCCTTAAAGGCTTGGACAGCTGTGAATCTCA ATGGCCAACTGGAGGTGCAGACTTGGCATGGGGTGCATTCTAGCTGTTGACCAGATTGCTACCGAGTCCCCTCCTCCACTGATGAGCTGC CCACACTGGGAAGCAGCATGCCCTGACTGTTCCAACACCACCTGCTATGGGGAGTACCTTTGGTCCCCTCACATTTGGCCAGAGGCATAC AAAAAACCAGAGCAGCTGGAGAGGGAGATAATTACTATTCCTTCCCTTCCTATCTCCTTTCTAGCCACAAGAGTGTGGGGGTTGGAGAAG AACCATTAGAAAGGGAAATTAGTGGGCTGGTGTATCTGGAAAGAGGGAAGACTTGATCCTCAGCCCCGAGGTTGGTGCAGGGCCTCCCCT GTGTGACTCTACCTGCACTCTGTGTTTATATCCTGTGCCCTAAGTGGGCCAAGCCCAGGTAAATTCCTGCTGGCCTTGGAACTCCAAGGT TTGGCTGACCAGCAGACTGGCTCCCTGACTCTTCAGCCTCAAATCCCCAGTTTTTGATGAATGTGGATTTCTGTCTGTAATTAAAAGCAA TGCAACAAGTTGGCTCTTGAGAATGGCAGTAAACTGAGGGCCCTAAGAGTGTGGTCTGCAGGGTCAAGAATAAAGATTACAGATTATATT |
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FusionGenePPI for PRDM6_NIPAL4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PRDM6 | PRDM6, CBX1, HDAC1, HDAC2, HDAC3, EP300, EHMT1, HIST1H3A, CBFA2T2, TCF4, SYCE3, PRDM14 | NIPAL4 | DUSP11 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PRDM6_NIPAL4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PRDM6_NIPAL4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | NIPAL4 | C2677065 | ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 6 | 3 | CTD_human;UNIPROT |
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