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Fusion gene ID: 28595 |
FusionGeneSummary for PRDM11_MRPS9 |
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Fusion gene information | Fusion gene name: PRDM11_MRPS9 | Fusion gene ID: 28595 | Hgene | Tgene | Gene symbol | PRDM11 | MRPS9 | Gene ID | 56981 | 64965 |
Gene name | PR/SET domain 11 | mitochondrial ribosomal protein S9 | |
Synonyms | PFM8 | MRP-S9|RPMS9|S9mt | |
Cytomap | 11p11.2 | 2q12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | PR domain-containing protein 11PR-domain containing protein 11 | 28S ribosomal protein S9, mitochondrialmitochondrial small ribosomal subunit protein uS9m | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9NQV5 | P82933 | |
Ensembl transtripts involved in fusion gene | ENST00000263765, ENST00000530656, ENST00000424263, ENST00000528980, | ENST00000258455, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 3 X 3 X 3=27 |
# samples | 2 | 3 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PRDM11 [Title/Abstract] AND MRPS9 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-AN-A0FT-01A | PRDM11 | chr11 | 45169132 | + | MRPS9 | chr2 | 105687771 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000263765 | ENST00000258455 | PRDM11 | chr11 | 45169132 | + | MRPS9 | chr2 | 105687771 | + |
intron-3CDS | ENST00000530656 | ENST00000258455 | PRDM11 | chr11 | 45169132 | + | MRPS9 | chr2 | 105687771 | + |
5UTR-3CDS | ENST00000424263 | ENST00000258455 | PRDM11 | chr11 | 45169132 | + | MRPS9 | chr2 | 105687771 | + |
intron-3CDS | ENST00000528980 | ENST00000258455 | PRDM11 | chr11 | 45169132 | + | MRPS9 | chr2 | 105687771 | + |
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FusionProtFeatures for PRDM11_MRPS9 |
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Hgene | Tgene |
PRDM11 | MRPS9 |
May be involved in transcription regulation.{ECO:0000269|PubMed:25499759}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PRDM11_MRPS9 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PRDM11_MRPS9 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PRDM11 | MRPS9 | DDX56, HAP1, ICT1, CUL3, CAND1, MRPL3, MRPS2, MRPS25, MRPL13, MRPL32, MRPL39, MRPL40, MRPL38, MRPS7, MRPL42, MRPL21, MRPL55, MRPL41, MRPS16, MRPL50, MRPL23, MRPS28, MRPS18B, MRPL12, MRPS26, MRPS21, EWSR1, ILF3, HNRNPC, SDHA, HNRNPR, LAMTOR3, SLC3A2, RPS18, NPLOC4, HNRNPM, ESR1, C1QBP, SOX2, HECW2, CEP250, TP53, FBXW11, NOL12, RPL13, NSA2, TRA2A, RPL6, HNRNPDL, ZC3H3, RPS8, TRMT10B, HNRNPA1, ZNF707, LUC7L, MRPS31, MRPS5, MRPS11, NTRK1, MRPS22, MRPS23, DAP3, MRPS35, PSMB1, PTCD3, PSMA4, PSMA5, PSMB2, PSMB8, HNRNPU, TERF1, EMC2, APOL2, ATP6V1C2, ZNF746, MRPS34, MRPS27, MRPS15, AURKAIP1, E4F1, SNRNP70, RBM42, CCDC59, RRS1, PDGFB, ZC3HAV1, GLTSCR2, FGF8, ZNF169, ZBTB48, RPL18, ZNF331, ZNF2, ZNF574, STRBP, ZNF550, CDX1, KBTBD7, U2AF2, BHLHA15, RBM3, PARK7 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PRDM11_MRPS9 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PRDM11_MRPS9 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |