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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28595

FusionGeneSummary for PRDM11_MRPS9

check button Fusion gene summary
Fusion gene informationFusion gene name: PRDM11_MRPS9
Fusion gene ID: 28595
HgeneTgene
Gene symbol

PRDM11

MRPS9

Gene ID

56981

64965

Gene namePR/SET domain 11mitochondrial ribosomal protein S9
SynonymsPFM8MRP-S9|RPMS9|S9mt
Cytomap

11p11.2

2q12.1

Type of geneprotein-codingprotein-coding
DescriptionPR domain-containing protein 11PR-domain containing protein 1128S ribosomal protein S9, mitochondrialmitochondrial small ribosomal subunit protein uS9m
Modification date2018052320180523
UniProtAcc

Q9NQV5

P82933

Ensembl transtripts involved in fusion geneENST00000263765, ENST00000530656, 
ENST00000424263, ENST00000528980, 
ENST00000258455, 
Fusion gene scores* DoF score2 X 2 X 1=43 X 3 X 3=27
# samples 23
** MAII scorelog2(2/4*10)=2.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PRDM11 [Title/Abstract] AND MRPS9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AN-A0FT-01APRDM11chr11

45169132

+MRPS9chr2

105687771

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000263765ENST00000258455PRDM11chr11

45169132

+MRPS9chr2

105687771

+
intron-3CDSENST00000530656ENST00000258455PRDM11chr11

45169132

+MRPS9chr2

105687771

+
5UTR-3CDSENST00000424263ENST00000258455PRDM11chr11

45169132

+MRPS9chr2

105687771

+
intron-3CDSENST00000528980ENST00000258455PRDM11chr11

45169132

+MRPS9chr2

105687771

+

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FusionProtFeatures for PRDM11_MRPS9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRDM11

Q9NQV5

MRPS9

P82933

May be involved in transcription regulation.{ECO:0000269|PubMed:25499759}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PRDM11_MRPS9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PRDM11_MRPS9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PRDM11MRPS9DDX56, HAP1, ICT1, CUL3, CAND1, MRPL3, MRPS2, MRPS25, MRPL13, MRPL32, MRPL39, MRPL40, MRPL38, MRPS7, MRPL42, MRPL21, MRPL55, MRPL41, MRPS16, MRPL50, MRPL23, MRPS28, MRPS18B, MRPL12, MRPS26, MRPS21, EWSR1, ILF3, HNRNPC, SDHA, HNRNPR, LAMTOR3, SLC3A2, RPS18, NPLOC4, HNRNPM, ESR1, C1QBP, SOX2, HECW2, CEP250, TP53, FBXW11, NOL12, RPL13, NSA2, TRA2A, RPL6, HNRNPDL, ZC3H3, RPS8, TRMT10B, HNRNPA1, ZNF707, LUC7L, MRPS31, MRPS5, MRPS11, NTRK1, MRPS22, MRPS23, DAP3, MRPS35, PSMB1, PTCD3, PSMA4, PSMA5, PSMB2, PSMB8, HNRNPU, TERF1, EMC2, APOL2, ATP6V1C2, ZNF746, MRPS34, MRPS27, MRPS15, AURKAIP1, E4F1, SNRNP70, RBM42, CCDC59, RRS1, PDGFB, ZC3HAV1, GLTSCR2, FGF8, ZNF169, ZBTB48, RPL18, ZNF331, ZNF2, ZNF574, STRBP, ZNF550, CDX1, KBTBD7, U2AF2, BHLHA15, RBM3, PARK7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PRDM11_MRPS9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PRDM11_MRPS9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource