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Fusion gene ID: 28585 |
FusionGeneSummary for PRCC_TFE3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PRCC_TFE3 | Fusion gene ID: 28585 | Hgene | Tgene | Gene symbol | PRCC | TFE3 | Gene ID | 5546 | 7030 |
| Gene name | papillary renal cell carcinoma (translocation-associated) | transcription factor binding to IGHM enhancer 3 | |
| Synonyms | RCCP1|TPRC | RCCP2|RCCX1|TFEA|bHLHe33 | |
| Cytomap | 1q23.1 | Xp11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | proline-rich protein PRCCpapillary renal cell carcinoma translocation-associated gene protein | transcription factor E3class E basic helix-loop-helix protein 33transcription factor E family, member Atranscription factor for IgH enhancertranscription factor for immunoglobulin heavy-chain enhancer 3 | |
| Modification date | 20180522 | 20180527 | |
| UniProtAcc | Q92733 | P19532 | |
| Ensembl transtripts involved in fusion gene | ENST00000271526, ENST00000353233, ENST00000491853, | ENST00000315869, ENST00000487451, | |
| Fusion gene scores | * DoF score | 6 X 1 X 7=42 | 10 X 9 X 4=360 |
| # samples | 9 | 19 | |
| ** MAII score | log2(9/42*10)=1.09953567355091 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(19/360*10)=-0.921997487998727 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PRCC [Title/Abstract] AND TFE3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PRCC | GO:0007093 | mitotic cell cycle checkpoint | 11717438 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | KIRP | TCGA-BQ-5887-01A | PRCC | chr1 | 156738031 | + | TFE3 | chrX | 48895967 | - |
| TCGA | RV | KIRP | TCGA-BQ-7050-01A | PRCC | chr1 | 156738031 | + | TFE3 | chrX | 48895967 | - |
| TCGA | RV | KIRP | TCGA-BQ-5882-01A | PRCC | chr1 | 156738031 | + | TFE3 | chrX | 48895967 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000271526 | ENST00000315869 | PRCC | chr1 | 156738031 | + | TFE3 | chrX | 48895967 | - |
| 5CDS-5UTR | ENST00000271526 | ENST00000487451 | PRCC | chr1 | 156738031 | + | TFE3 | chrX | 48895967 | - |
| In-frame | ENST00000353233 | ENST00000315869 | PRCC | chr1 | 156738031 | + | TFE3 | chrX | 48895967 | - |
| 5CDS-5UTR | ENST00000353233 | ENST00000487451 | PRCC | chr1 | 156738031 | + | TFE3 | chrX | 48895967 | - |
| intron-3CDS | ENST00000491853 | ENST00000315869 | PRCC | chr1 | 156738031 | + | TFE3 | chrX | 48895967 | - |
| intron-5UTR | ENST00000491853 | ENST00000487451 | PRCC | chr1 | 156738031 | + | TFE3 | chrX | 48895967 | - |
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FusionProtFeatures for PRCC_TFE3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PRCC | TFE3 |
| May regulate cell cycle progression through interactionwith MAD2L2. {ECO:0000269|PubMed:11717438}. | Transcription factor that specifically recognizes andbinds E-box sequences (5'-CANNTG-3'). Efficient DNA-bindingrequires dimerization with itself or with another MiT/TFE familymember such as TFEB or MITF. In association with TFEB, activatesthe expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells andthymus-dependent humoral immunity. Specifically recognizes theMUE3 box, a subset of E-boxes, present in the immunoglobulinenhancer. It also binds very well to a USF/MLTF site. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PRCC | chr1:156738031 | chrX:48895967 | ENST00000271526 | + | 1 | 7 | 18_25 | 156 | 492 | Compositional bias | Note=Poly-Glu |
| Hgene | PRCC | chr1:156738031 | chrX:48895967 | ENST00000271526 | + | 1 | 7 | 52_55 | 156 | 492 | Compositional bias | Note=Poly-Pro |
| Hgene | PRCC | chr1:156738031 | chrX:48895967 | ENST00000271526 | + | 1 | 7 | 79_84 | 156 | 492 | Compositional bias | Note=Poly-Pro |
| Hgene | PRCC | chr1:156738031 | chrX:48895967 | ENST00000271526 | + | 1 | 7 | 91_94 | 156 | 492 | Compositional bias | Note=Poly-Pro |
| Tgene | >TFE3 | chr1:156738031 | chrX:48895967 | ENST00000315869 | - | 2 | 10 | 346_399 | 178 | 576 | Domain | bHLH |
| Tgene | >TFE3 | chr1:156738031 | chrX:48895967 | ENST00000315869 | - | 2 | 10 | 260_271 | 178 | 576 | Region | Strong transcription activation domain |
| Tgene | >TFE3 | chr1:156738031 | chrX:48895967 | ENST00000315869 | - | 2 | 10 | 409_430 | 178 | 576 | Region | Note=Leucine-zipper |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PRCC | chr1:156738031 | chrX:48895967 | ENST00000271526 | + | 1 | 7 | 235_239 | 156 | 492 | Compositional bias | Note=Poly-Thr |
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FusionGeneSequence for PRCC_TFE3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PRCC_ENST00000271526_chr1_156738031_+_TFE3_ENST00000315869_chrX_48895967_-_554aa MSLVAYASSDESEPDEAEPEPEEEEAVAPTSGPALGGLFASLPAPKGPALLPPPPQMLAPAFPPPLLLPPPTGDPRLQPPPPLPFGLGGF PPPPGVSPAEAAGVGEGLGLGLPSPRGPGLNLPPPIGGAGPPLGLPKPKKRKEPVKIAAPELHKGDVQTHLENPTRYHLQQARRQQVKQY LSTTLGPKLASQALTPPPGPASAQPLPAPEAAHTTGPTGSAPNSPMALLTIGSSSEKEIDDVIDEIISLESSYNDEMLSYLPGGTTGLQL PSTLPVSGNLLDVYSSQGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMR WNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSASDSLKPEQLDIEEEGRP GAATFHVGGGPAQNAPHQQPPAPPSDALLDLHFPSDHLGDLGDPFHLGLEDILMEEEEGVVGGLSGGALSPLRAASDPLLSSVSPAVSKA >In-frame_PRCC_ENST00000353233_chr1_156738031_+_TFE3_ENST00000315869_chrX_48895967_-_554aa MSLVAYASSDESEPDEAEPEPEEEEAVAPTSGPALGGLFASLPAPKGPALLPPPPQMLAPAFPPPLLLPPPTGDPRLQPPPPLPFGLGGF PPPPGVSPAEAAGVGEGLGLGLPSPRGPGLNLPPPIGGAGPPLGLPKPKKRKEPVKIAAPELHKGDVQTHLENPTRYHLQQARRQQVKQY LSTTLGPKLASQALTPPPGPASAQPLPAPEAAHTTGPTGSAPNSPMALLTIGSSSEKEIDDVIDEIISLESSYNDEMLSYLPGGTTGLQL PSTLPVSGNLLDVYSSQGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMR WNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSASDSLKPEQLDIEEEGRP GAATFHVGGGPAQNAPHQQPPAPPSDALLDLHFPSDHLGDLGDPFHLGLEDILMEEEEGVVGGLSGGALSPLRAASDPLLSSVSPAVSKA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PRCC_ENST00000271526_chr1_156738031_+_TFE3_ENST00000315869_chrX_48895967_-_1662nt ATGTCGCTGGTTGCTTACGCCAGCAGCGATGAGAGCGAGCCGGATGAGGCTGAGCCCGAGCCGGAGGAAGAGGAGGCGGTGGCTCCTACA TCTGGGCCCGCTTTAGGGGGCTTGTTCGCTTCTCTCCCTGCGCCCAAGGGTCCGGCCTTGCTGCCTCCGCCCCCTCAGATGCTGGCGCCA GCCTTTCCCCCGCCGCTGTTGCTTCCCCCACCCACCGGAGACCCCAGGCTTCAGCCTCCTCCCCCCTTGCCCTTCGGCCTGGGAGGCTTC CCCCCACCTCCAGGCGTGAGCCCGGCTGAAGCGGCGGGAGTTGGGGAGGGACTGGGATTGGGGTTGCCCTCGCCCCGAGGCCCTGGCCTC AATCTGCCCCCTCCAATTGGCGGTGCCGGTCCCCCGCTGGGGCTTCCCAAGCCAAAGAAGAGGAAAGAGCCCGTGAAGATCGCGGCGCCG GAGTTGCATAAGGGAGATGTGCAGACCCATCTGGAGAACCCAACGCGCTACCACCTGCAGCAGGCGCGCCGGCAGCAGGTGAAACAGTAC CTGTCCACCACACTCGGGCCCAAGCTGGCTTCCCAGGCCCTCACCCCACCGCCGGGGCCCGCAAGTGCCCAGCCACTGCCTGCCCCTGAG GCTGCCCACACTACCGGCCCCACAGGCAGTGCGCCCAACAGCCCCATGGCGCTGCTCACCATCGGGTCCAGCTCAGAGAAGGAGATTGAT GATGTCATTGATGAGATCATCAGCCTGGAGTCCAGTTACAATGATGAAATGCTCAGCTATCTGCCCGGAGGCACCACAGGACTGCAGCTC CCCAGCACGCTGCCTGTGTCAGGGAATCTGCTTGATGTGTACAGTAGTCAAGGCGTGGCCACACCAGCCATCACTGTCAGCAACTCCTGC CCAGCTGAGCTGCCCAACATCAAACGGGAGATCTCTGAGACCGAGGCAAAGGCCCTTTTGAAGGAACGGCAGAAGAAAGACAATCACAAC CTAATTGAGCGTCGCAGGCGATTCAACATTAACGACAGGATCAAGGAACTGGGCACTCTCATCCCTAAGTCCAGTGACCCGGAGATGCGC TGGAACAAGGGCACCATCCTGAAGGCCTCTGTGGATTATATCCGCAAGCTGCAGAAGGAGCAGCAGCGCTCCAAAGACCTGGAGAGCCGG CAGCGATCCCTGGAGCAGGCCAACCGCAGCCTGCAGCTCCGAATTCAGGAACTAGAACTGCAGGCCCAGATCCATGGCCTGCCAGTACCT CCCACTCCAGGGCTGCTTTCCTTGGCCACGACTTCGGCTTCTGACAGCCTCAAGCCAGAGCAGCTGGACATTGAGGAGGAGGGCAGGCCA GGCGCAGCAACGTTCCATGTAGGGGGGGGACCTGCCCAGAATGCTCCCCATCAGCAGCCCCCTGCACCGCCCTCAGATGCCCTTCTGGAC CTGCACTTTCCCAGCGACCACCTGGGGGACCTGGGAGACCCCTTCCACCTGGGGCTGGAGGACATTCTGATGGAGGAGGAGGAGGGGGTG GTGGGAGGACTGTCGGGGGGTGCCCTGTCCCCACTGCGGGCTGCCTCCGATCCCCTGCTCTCTTCAGTGTCCCCTGCTGTCTCCAAGGCC >In-frame_PRCC_ENST00000353233_chr1_156738031_+_TFE3_ENST00000315869_chrX_48895967_-_1662nt ATGTCGCTGGTTGCTTACGCCAGCAGCGATGAGAGCGAGCCGGATGAGGCTGAGCCCGAGCCGGAGGAAGAGGAGGCGGTGGCTCCTACA TCTGGGCCCGCTTTAGGGGGCTTGTTCGCTTCTCTCCCTGCGCCCAAGGGTCCGGCCTTGCTGCCTCCGCCCCCTCAGATGCTGGCGCCA GCCTTTCCCCCGCCGCTGTTGCTTCCCCCACCCACCGGAGACCCCAGGCTTCAGCCTCCTCCCCCCTTGCCCTTCGGCCTGGGAGGCTTC CCCCCACCTCCAGGCGTGAGCCCGGCTGAAGCGGCGGGAGTTGGGGAGGGACTGGGATTGGGGTTGCCCTCGCCCCGAGGCCCTGGCCTC AATCTGCCCCCTCCAATTGGCGGTGCCGGTCCCCCGCTGGGGCTTCCCAAGCCAAAGAAGAGGAAAGAGCCCGTGAAGATCGCGGCGCCG GAGTTGCATAAGGGAGATGTGCAGACCCATCTGGAGAACCCAACGCGCTACCACCTGCAGCAGGCGCGCCGGCAGCAGGTGAAACAGTAC CTGTCCACCACACTCGGGCCCAAGCTGGCTTCCCAGGCCCTCACCCCACCGCCGGGGCCCGCAAGTGCCCAGCCACTGCCTGCCCCTGAG GCTGCCCACACTACCGGCCCCACAGGCAGTGCGCCCAACAGCCCCATGGCGCTGCTCACCATCGGGTCCAGCTCAGAGAAGGAGATTGAT GATGTCATTGATGAGATCATCAGCCTGGAGTCCAGTTACAATGATGAAATGCTCAGCTATCTGCCCGGAGGCACCACAGGACTGCAGCTC CCCAGCACGCTGCCTGTGTCAGGGAATCTGCTTGATGTGTACAGTAGTCAAGGCGTGGCCACACCAGCCATCACTGTCAGCAACTCCTGC CCAGCTGAGCTGCCCAACATCAAACGGGAGATCTCTGAGACCGAGGCAAAGGCCCTTTTGAAGGAACGGCAGAAGAAAGACAATCACAAC CTAATTGAGCGTCGCAGGCGATTCAACATTAACGACAGGATCAAGGAACTGGGCACTCTCATCCCTAAGTCCAGTGACCCGGAGATGCGC TGGAACAAGGGCACCATCCTGAAGGCCTCTGTGGATTATATCCGCAAGCTGCAGAAGGAGCAGCAGCGCTCCAAAGACCTGGAGAGCCGG CAGCGATCCCTGGAGCAGGCCAACCGCAGCCTGCAGCTCCGAATTCAGGAACTAGAACTGCAGGCCCAGATCCATGGCCTGCCAGTACCT CCCACTCCAGGGCTGCTTTCCTTGGCCACGACTTCGGCTTCTGACAGCCTCAAGCCAGAGCAGCTGGACATTGAGGAGGAGGGCAGGCCA GGCGCAGCAACGTTCCATGTAGGGGGGGGACCTGCCCAGAATGCTCCCCATCAGCAGCCCCCTGCACCGCCCTCAGATGCCCTTCTGGAC CTGCACTTTCCCAGCGACCACCTGGGGGACCTGGGAGACCCCTTCCACCTGGGGCTGGAGGACATTCTGATGGAGGAGGAGGAGGGGGTG GTGGGAGGACTGTCGGGGGGTGCCCTGTCCCCACTGCGGGCTGCCTCCGATCCCCTGCTCTCTTCAGTGTCCCCTGCTGTCTCCAAGGCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PRCC_ENST00000271526_chr1_156738031_+_TFE3_ENST00000315869_chrX_48895967_-_3361nt ATTGGTGAGGCAAGGAGGAGGCGGAGTGACTCGGCGGCCATTAGCTGTGTGTAGTTGCCCGGGACTAGGAGCTTAAGTGAAGAGGTACGC CTTGTTCGGTGGAAATCAGCCGTAGCCATGAGTTTCTGCCGGGGCTAGCCCTAGAGTACGGAGCAGGCGGACTTTTCGGTTCCCCGCCCC GCCAGGTGGCGGGGCCTACTAGGCCTCCGGGCATCCCCGGTCTCAAGTAGGCCTCATCTGCCGGCAAGGGCGCCCGAAACGCGGGAGGCG CCATGTCGCTGGTTGCTTACGCCAGCAGCGATGAGAGCGAGCCGGATGAGGCTGAGCCCGAGCCGGAGGAAGAGGAGGCGGTGGCTCCTA CATCTGGGCCCGCTTTAGGGGGCTTGTTCGCTTCTCTCCCTGCGCCCAAGGGTCCGGCCTTGCTGCCTCCGCCCCCTCAGATGCTGGCGC CAGCCTTTCCCCCGCCGCTGTTGCTTCCCCCACCCACCGGAGACCCCAGGCTTCAGCCTCCTCCCCCCTTGCCCTTCGGCCTGGGAGGCT TCCCCCCACCTCCAGGCGTGAGCCCGGCTGAAGCGGCGGGAGTTGGGGAGGGACTGGGATTGGGGTTGCCCTCGCCCCGAGGCCCTGGCC TCAATCTGCCCCCTCCAATTGGCGGTGCCGGTCCCCCGCTGGGGCTTCCCAAGCCAAAGAAGAGGAAAGAGCCCGTGAAGATCGCGGCGC CGGAGTTGCATAAGGGAGATGTGCAGACCCATCTGGAGAACCCAACGCGCTACCACCTGCAGCAGGCGCGCCGGCAGCAGGTGAAACAGT ACCTGTCCACCACACTCGGGCCCAAGCTGGCTTCCCAGGCCCTCACCCCACCGCCGGGGCCCGCAAGTGCCCAGCCACTGCCTGCCCCTG AGGCTGCCCACACTACCGGCCCCACAGGCAGTGCGCCCAACAGCCCCATGGCGCTGCTCACCATCGGGTCCAGCTCAGAGAAGGAGATTG ATGATGTCATTGATGAGATCATCAGCCTGGAGTCCAGTTACAATGATGAAATGCTCAGCTATCTGCCCGGAGGCACCACAGGACTGCAGC TCCCCAGCACGCTGCCTGTGTCAGGGAATCTGCTTGATGTGTACAGTAGTCAAGGCGTGGCCACACCAGCCATCACTGTCAGCAACTCCT GCCCAGCTGAGCTGCCCAACATCAAACGGGAGATCTCTGAGACCGAGGCAAAGGCCCTTTTGAAGGAACGGCAGAAGAAAGACAATCACA ACCTAATTGAGCGTCGCAGGCGATTCAACATTAACGACAGGATCAAGGAACTGGGCACTCTCATCCCTAAGTCCAGTGACCCGGAGATGC GCTGGAACAAGGGCACCATCCTGAAGGCCTCTGTGGATTATATCCGCAAGCTGCAGAAGGAGCAGCAGCGCTCCAAAGACCTGGAGAGCC GGCAGCGATCCCTGGAGCAGGCCAACCGCAGCCTGCAGCTCCGAATTCAGGAACTAGAACTGCAGGCCCAGATCCATGGCCTGCCAGTAC CTCCCACTCCAGGGCTGCTTTCCTTGGCCACGACTTCGGCTTCTGACAGCCTCAAGCCAGAGCAGCTGGACATTGAGGAGGAGGGCAGGC CAGGCGCAGCAACGTTCCATGTAGGGGGGGGACCTGCCCAGAATGCTCCCCATCAGCAGCCCCCTGCACCGCCCTCAGATGCCCTTCTGG ACCTGCACTTTCCCAGCGACCACCTGGGGGACCTGGGAGACCCCTTCCACCTGGGGCTGGAGGACATTCTGATGGAGGAGGAGGAGGGGG TGGTGGGAGGACTGTCGGGGGGTGCCCTGTCCCCACTGCGGGCTGCCTCCGATCCCCTGCTCTCTTCAGTGTCCCCTGCTGTCTCCAAGG CCAGCAGCCGCCGCAGCAGCTTCAGCATGGAAGAGGAGTCCTGATCAGGCCTCACCCCTCCCCTGGGACTTTCCCACCCAGGAAAGGAGG ACCAGTCAGGATGAGGCCCCGCCTTTTCCCCCACCCTCCCATGAGACTGCCCTGCCCAGGTATCCTGGGGGAAGAGGAGATGTGATCAGG CCCCACCCCTGTAATCAGGCAAGGAGGAGGAGTCAGATGAGGCCCTGCACCTTCCCCAAAGGAACCGCCCAGTGCAGGTATTTCAGAAGG AGAAGGCTGGAGAAGGACATGAGATCAGGGCCTGCCCCCTGGGGATCACAGCCTCACCCCTGCCCCTGTGGGACTCATCCTTGCCCAGGT GAGGGAAGGAGACAGGATGAGGTCTCGACCCTGTCCCCTAGGGACTGTCCTAGCCAGGTCTCCTGGGAAAGGGAGATGTCAGGATGTTGC TCCATCCTTTGTCTTGGAACCACCAGTCTAGTCCGTCCTGGCACAGAAGAGGAGTCAAGTAATGGAGGTCCCAGCCCTGGGGGTTTAAGC TCTGCCCCTTCCCCATGAACCCTGCCCTGCTCTGCCCAGGCAAGGAACAGAAGTGAGGATGAGACCCAGCCCCTTCCCCTGGGAACTCTC CTGGCCTTCTAGGAATGGAGGAGCCAGGCCCCACCCCTTCCCTATAGGAACAGCCCAGCACAGGTATTTCAGGTGTGAAAGAATCAGTAG GACCAGGCCACCGCTAGTGCTTGTGGAGATCACAGCCCCACCCTTGTCCCTCAGCAACATCCCATCTAAGCATTCCACACTGCAGGGAGG AGTGGTACTTAAGCTCCCCTGCCTTAACCTGGGACCAACCTGACCTAACCTAGGAGGGCTCTGAGCCAACCTTGCTCTTGGGGAAGGGGA CAGATTATGAAATTTCATGGATGAATTTTCCAGACCTATATCTGGAGTGAGAGGCCCCCACCCTTGGGCAGAGTCCTGCCTTCTTCCTTG AGGGGCAGTTTGGGAAGGTGATGGGTATTAGTGGGGGACTGAGTTCAGGTTACCAGAACCAGTACCTCAGTATTCTTTTTCAACATGTAG GGCAAGAGGATGAAGGAAGGGGCTATCCTGGGACCTCCCCAGCCCAGGAAAAACTGGAAGCCTTCCCCCAGCAAGGCAGAAGCTTGGAGG AGGGTTGTAAAAGCATATTGTACCCCCTCATTTGTTTATCTGATTTTTTTATTGCTCCGCATACTGAGAATCTAGGCCACCCCAACCTCT GTTCCCCACCCAGTTCTTCATTTGGAGGAATCACCCCATTTCAGAGTTATCAAGAGACACTCCCCCCTCCATTCCCACCCCTCATACCTA CACCCAAGGTTGTCAGCTTTGGATTGCTGGGGCCAGGCCCCATGGAGGGTATACTGAGGGGTCTATAGGTTTGTGATTAAAATAATAAAA >In-frame_PRCC_ENST00000353233_chr1_156738031_+_TFE3_ENST00000315869_chrX_48895967_-_3307nt TTGCCCGGGACTAGGAGCTTAAGTGAAGAGGTACGCCTTGTTCGGTGGAAATCAGCCGTAGCCATGAGTTTCTGCCGGGGCTAGCCCTAG AGTACGGAGCAGGCGGACTTTTCGGTTCCCCGCCCCGCCAGGTGGCGGGGCCTACTAGGCCTCCGGGCATCCCCGGTCTCAAGTAGGCCT CATCTGCCGGCAAGGGCGCCCGAAACGCGGGAGGCGCCATGTCGCTGGTTGCTTACGCCAGCAGCGATGAGAGCGAGCCGGATGAGGCTG AGCCCGAGCCGGAGGAAGAGGAGGCGGTGGCTCCTACATCTGGGCCCGCTTTAGGGGGCTTGTTCGCTTCTCTCCCTGCGCCCAAGGGTC CGGCCTTGCTGCCTCCGCCCCCTCAGATGCTGGCGCCAGCCTTTCCCCCGCCGCTGTTGCTTCCCCCACCCACCGGAGACCCCAGGCTTC AGCCTCCTCCCCCCTTGCCCTTCGGCCTGGGAGGCTTCCCCCCACCTCCAGGCGTGAGCCCGGCTGAAGCGGCGGGAGTTGGGGAGGGAC TGGGATTGGGGTTGCCCTCGCCCCGAGGCCCTGGCCTCAATCTGCCCCCTCCAATTGGCGGTGCCGGTCCCCCGCTGGGGCTTCCCAAGC CAAAGAAGAGGAAAGAGCCCGTGAAGATCGCGGCGCCGGAGTTGCATAAGGGAGATGTGCAGACCCATCTGGAGAACCCAACGCGCTACC ACCTGCAGCAGGCGCGCCGGCAGCAGGTGAAACAGTACCTGTCCACCACACTCGGGCCCAAGCTGGCTTCCCAGGCCCTCACCCCACCGC CGGGGCCCGCAAGTGCCCAGCCACTGCCTGCCCCTGAGGCTGCCCACACTACCGGCCCCACAGGCAGTGCGCCCAACAGCCCCATGGCGC TGCTCACCATCGGGTCCAGCTCAGAGAAGGAGATTGATGATGTCATTGATGAGATCATCAGCCTGGAGTCCAGTTACAATGATGAAATGC TCAGCTATCTGCCCGGAGGCACCACAGGACTGCAGCTCCCCAGCACGCTGCCTGTGTCAGGGAATCTGCTTGATGTGTACAGTAGTCAAG GCGTGGCCACACCAGCCATCACTGTCAGCAACTCCTGCCCAGCTGAGCTGCCCAACATCAAACGGGAGATCTCTGAGACCGAGGCAAAGG CCCTTTTGAAGGAACGGCAGAAGAAAGACAATCACAACCTAATTGAGCGTCGCAGGCGATTCAACATTAACGACAGGATCAAGGAACTGG GCACTCTCATCCCTAAGTCCAGTGACCCGGAGATGCGCTGGAACAAGGGCACCATCCTGAAGGCCTCTGTGGATTATATCCGCAAGCTGC AGAAGGAGCAGCAGCGCTCCAAAGACCTGGAGAGCCGGCAGCGATCCCTGGAGCAGGCCAACCGCAGCCTGCAGCTCCGAATTCAGGAAC TAGAACTGCAGGCCCAGATCCATGGCCTGCCAGTACCTCCCACTCCAGGGCTGCTTTCCTTGGCCACGACTTCGGCTTCTGACAGCCTCA AGCCAGAGCAGCTGGACATTGAGGAGGAGGGCAGGCCAGGCGCAGCAACGTTCCATGTAGGGGGGGGACCTGCCCAGAATGCTCCCCATC AGCAGCCCCCTGCACCGCCCTCAGATGCCCTTCTGGACCTGCACTTTCCCAGCGACCACCTGGGGGACCTGGGAGACCCCTTCCACCTGG GGCTGGAGGACATTCTGATGGAGGAGGAGGAGGGGGTGGTGGGAGGACTGTCGGGGGGTGCCCTGTCCCCACTGCGGGCTGCCTCCGATC CCCTGCTCTCTTCAGTGTCCCCTGCTGTCTCCAAGGCCAGCAGCCGCCGCAGCAGCTTCAGCATGGAAGAGGAGTCCTGATCAGGCCTCA CCCCTCCCCTGGGACTTTCCCACCCAGGAAAGGAGGACCAGTCAGGATGAGGCCCCGCCTTTTCCCCCACCCTCCCATGAGACTGCCCTG CCCAGGTATCCTGGGGGAAGAGGAGATGTGATCAGGCCCCACCCCTGTAATCAGGCAAGGAGGAGGAGTCAGATGAGGCCCTGCACCTTC CCCAAAGGAACCGCCCAGTGCAGGTATTTCAGAAGGAGAAGGCTGGAGAAGGACATGAGATCAGGGCCTGCCCCCTGGGGATCACAGCCT CACCCCTGCCCCTGTGGGACTCATCCTTGCCCAGGTGAGGGAAGGAGACAGGATGAGGTCTCGACCCTGTCCCCTAGGGACTGTCCTAGC CAGGTCTCCTGGGAAAGGGAGATGTCAGGATGTTGCTCCATCCTTTGTCTTGGAACCACCAGTCTAGTCCGTCCTGGCACAGAAGAGGAG TCAAGTAATGGAGGTCCCAGCCCTGGGGGTTTAAGCTCTGCCCCTTCCCCATGAACCCTGCCCTGCTCTGCCCAGGCAAGGAACAGAAGT GAGGATGAGACCCAGCCCCTTCCCCTGGGAACTCTCCTGGCCTTCTAGGAATGGAGGAGCCAGGCCCCACCCCTTCCCTATAGGAACAGC CCAGCACAGGTATTTCAGGTGTGAAAGAATCAGTAGGACCAGGCCACCGCTAGTGCTTGTGGAGATCACAGCCCCACCCTTGTCCCTCAG CAACATCCCATCTAAGCATTCCACACTGCAGGGAGGAGTGGTACTTAAGCTCCCCTGCCTTAACCTGGGACCAACCTGACCTAACCTAGG AGGGCTCTGAGCCAACCTTGCTCTTGGGGAAGGGGACAGATTATGAAATTTCATGGATGAATTTTCCAGACCTATATCTGGAGTGAGAGG CCCCCACCCTTGGGCAGAGTCCTGCCTTCTTCCTTGAGGGGCAGTTTGGGAAGGTGATGGGTATTAGTGGGGGACTGAGTTCAGGTTACC AGAACCAGTACCTCAGTATTCTTTTTCAACATGTAGGGCAAGAGGATGAAGGAAGGGGCTATCCTGGGACCTCCCCAGCCCAGGAAAAAC TGGAAGCCTTCCCCCAGCAAGGCAGAAGCTTGGAGGAGGGTTGTAAAAGCATATTGTACCCCCTCATTTGTTTATCTGATTTTTTTATTG CTCCGCATACTGAGAATCTAGGCCACCCCAACCTCTGTTCCCCACCCAGTTCTTCATTTGGAGGAATCACCCCATTTCAGAGTTATCAAG AGACACTCCCCCCTCCATTCCCACCCCTCATACCTACACCCAAGGTTGTCAGCTTTGGATTGCTGGGGCCAGGCCCCATGGAGGGTATAC |
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FusionGenePPI for PRCC_TFE3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PRCC | EGFR, SF3A2, MAD2L2, NABP2, RBM10, LSM2, PRPF19, PPIL2, TOE1, CSNK2A1, WRAP73, EWSR1, XPO1, HSF2, PCK2, SORT1, SOD1, YWHAZ, LRP8, PIM2, ZNF281, IWS1, CEP170P1, CDC5L, C19orf57, F11, TKTL2, BCAM, FAF1, BCAS2, HSPA9, FKBP9, CARM1, CRNKL1, SCYL2, SH3GLB1, CDK5, SEPT7, DIS3, CHORDC1, SUB1, SARNP, COPZ1, GORASP2, SEPT11, DRG1, TRIM25 | TFE3 | AKR1B1, CLTC, PHB2, ACLY, CUL2, EPRS, PFAS, VARS, NEDD8, RPL38, TRIM28, EIF3A, RPA3, E2F3, SMARCE1, MITF, TFE3, SMAD3, SMAD4, TFEC, EWSR1, XPO1, TFEB |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PRCC_TFE3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PRCC_TFE3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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