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Fusion gene ID: 28559 |
FusionGeneSummary for PPTC7_GPN3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPTC7_GPN3 | Fusion gene ID: 28559 | Hgene | Tgene | Gene symbol | PPTC7 | GPN3 | Gene ID | 160760 | 51184 |
| Gene name | PTC7 protein phosphatase homolog | GPN-loop GTPase 3 | |
| Synonyms | TA-PP2C|TAPP2C | ATPBD1C | |
| Cytomap | 12q24.11 | 12q24.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein phosphatase PTC7 homolog | GPN-loop GTPase 3ATP-binding domain 1 family member Cprotein x 0004 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8NI37 | Q9UHW5 | |
| Ensembl transtripts involved in fusion gene | ENST00000354300, | ENST00000228827, ENST00000543199, ENST00000537466, ENST00000552180, | |
| Fusion gene scores | * DoF score | 5 X 2 X 5=50 | 3 X 4 X 3=36 |
| # samples | 6 | 5 | |
| ** MAII score | log2(6/50*10)=0.263034405833794 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/36*10)=0.473931188332412 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PPTC7 [Title/Abstract] AND GPN3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | CESC | TCGA-EA-A3QD-01A | PPTC7 | chr12 | 111020614 | - | GPN3 | chr12 | 110895439 | - |
| TCGA | LD | OV | TCGA-23-1116-01A | PPTC7 | chr12 | 111020614 | - | GPN3 | chr12 | 110903019 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000354300 | ENST00000228827 | PPTC7 | chr12 | 111020614 | - | GPN3 | chr12 | 110895439 | - |
| Frame-shift | ENST00000354300 | ENST00000543199 | PPTC7 | chr12 | 111020614 | - | GPN3 | chr12 | 110895439 | - |
| Frame-shift | ENST00000354300 | ENST00000537466 | PPTC7 | chr12 | 111020614 | - | GPN3 | chr12 | 110895439 | - |
| 5CDS-intron | ENST00000354300 | ENST00000552180 | PPTC7 | chr12 | 111020614 | - | GPN3 | chr12 | 110895439 | - |
| In-frame | ENST00000354300 | ENST00000228827 | PPTC7 | chr12 | 111020614 | - | GPN3 | chr12 | 110903019 | - |
| In-frame | ENST00000354300 | ENST00000543199 | PPTC7 | chr12 | 111020614 | - | GPN3 | chr12 | 110903019 | - |
| In-frame | ENST00000354300 | ENST00000537466 | PPTC7 | chr12 | 111020614 | - | GPN3 | chr12 | 110903019 | - |
| 5CDS-5UTR | ENST00000354300 | ENST00000552180 | PPTC7 | chr12 | 111020614 | - | GPN3 | chr12 | 110903019 | - |
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FusionProtFeatures for PPTC7_GPN3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPTC7 | GPN3 |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >GPN3 | chr12:111020614 | chr12:110903019 | ENST00000228827 | - | 0 | 8 | 72_74 | 16 | 285 | Motif | Gly-Pro-Asn (GPN)-loop%3B involved in dimer interface |
| Tgene | >GPN3 | chr12:111020614 | chr12:110903019 | ENST00000537466 | - | 0 | 8 | 72_74 | 26 | 295 | Motif | Gly-Pro-Asn (GPN)-loop%3B involved in dimer interface |
| Tgene | >GPN3 | chr12:111020614 | chr12:110903019 | ENST00000543199 | - | 0 | 8 | 72_74 | 55 | 324 | Motif | Gly-Pro-Asn (GPN)-loop%3B involved in dimer interface |
| Tgene | >GPN3 | chr12:111020614 | chr12:110903019 | ENST00000228827 | - | 0 | 8 | 13_18 | 16 | 285 | Nucleotide binding | GTP |
| Tgene | >GPN3 | chr12:111020614 | chr12:110903019 | ENST00000228827 | - | 0 | 8 | 174_177 | 16 | 285 | Nucleotide binding | GTP |
| Tgene | >GPN3 | chr12:111020614 | chr12:110903019 | ENST00000537466 | - | 0 | 8 | 174_177 | 26 | 295 | Nucleotide binding | GTP |
| Tgene | >GPN3 | chr12:111020614 | chr12:110903019 | ENST00000543199 | - | 0 | 8 | 174_177 | 55 | 324 | Nucleotide binding | GTP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PPTC7 | chr12:111020614 | chr12:110903019 | ENST00000354300 | - | 1 | 6 | 17_87 | 74 | 305 | Compositional bias | Note=Gly-rich |
| Hgene | >PPTC7 | chr12:111020614 | chr12:110903019 | ENST00000354300 | - | 1 | 6 | 33_299 | 74 | 305 | Domain | PPM-type phosphatase |
| Tgene | GPN3 | chr12:111020614 | chr12:110903019 | ENST00000537466 | - | 0 | 8 | 13_18 | 26 | 295 | Nucleotide binding | GTP |
| Tgene | GPN3 | chr12:111020614 | chr12:110903019 | ENST00000543199 | - | 0 | 8 | 13_18 | 55 | 324 | Nucleotide binding | GTP |
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FusionGeneSequence for PPTC7_GPN3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PPTC7_ENST00000354300_chr12_111020614_-_GPN3_ENST00000228827_chr12_110903019_-_343aa MFSVLSYGRLVARAVLGGLSQTDPRAGGGGGGDYGLVTAGCGFGKDFRKGLLKKGACYGDDACFVARHRSADVLEHLLCHHGPALXSPQP VCPSCKPGSSSRTLQLLRDGXHPGTDRGGXCNGGXFSAIRSQRRIGILHGVLCQXFXLAGELSWPCRGRLYPFXLSRSDXVVHSPACDET AGPAARAVGVPSLWSFSCXFSVHGGVIQVYFWHLGSPECHDLSRNSASQHHDKNGSAEXKSKKGNXEIFRSRHVFFIRRFYKXLKKQKIQ >In-frame_PPTC7_ENST00000354300_chr12_111020614_-_GPN3_ENST00000543199_chr12_110903019_-_343aa MFSVLSYGRLVARAVLGGLSQTDPRAGGGGGGDYGLVTAGCGFGKDFRKGLLKKGACYGDDACFVARHRSADVLEHLLCHHGPALXSPQP VCPSCKPGSSSRTLQLLRDGXHPGTDRGGXCNGGXFSAIRSQRRIGILHGVLCQXFXLAGELSWPCRGRLYPFXLSRSDXVVHSPACDET AGPAARAVGVPSLWSFSCXFSVHGGVIQVYFWHLGSPECHDLSRNSASQHHDKNGSAEXKSKKGNXEIFRSRHVFFIRRFYKXLKKQKIQ >In-frame_PPTC7_ENST00000354300_chr12_111020614_-_GPN3_ENST00000537466_chr12_110903019_-_343aa MFSVLSYGRLVARAVLGGLSQTDPRAGGGGGGDYGLVTAGCGFGKDFRKGLLKKGACYGDDACFVARHRSADVLEHLLCHHGPALXSPQP VCPSCKPGSSSRTLQLLRDGXHPGTDRGGXCNGGXFSAIRSQRRIGILHGVLCQXFXLAGELSWPCRGRLYPFXLSRSDXVVHSPACDET AGPAARAVGVPSLWSFSCXFSVHGGVIQVYFWHLGSPECHDLSRNSASQHHDKNGSAEXKSKKGNXEIFRSRHVFFIRRFYKXLKKQKIQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PPTC7_ENST00000354300_chr12_111020614_-_GPN3_ENST00000228827_chr12_110903019_-_1030nt ATGTTCTCGGTCCTCTCGTACGGGCGGCTGGTGGCCCGCGCCGTGCTCGGCGGCCTCTCGCAGACCGACCCCAGGGCCGGCGGCGGCGGC GGCGGCGACTACGGACTGGTGACGGCCGGCTGCGGCTTCGGGAAGGACTTCCGTAAGGGCCTCCTCAAGAAGGGCGCGTGCTACGGGGAC GACGCGTGCTTCGTGGCCCGGCACCGTTCCGCGGACGTGCTCGAGCACCTACTGTGCCACCATGGTCCAGCACTGTGAAGCCCTCAACCG GTCTGTCCAAGTTGTAAACCTGGATCCAGCAGCAGAACACTTCAACTACTCCGTGATGGCTGACATCCGGGAACTGATCGAGGTGGATGA TGTAATGGAGGATGATTCTCTGCGATTCGGTCCCAACGGAGGATTGGTATTTTGCATGGAGTACTTTGCCAATAATTTTGACTGGCTGGA GAACTGTCTTGGCCATGTAGAGGACGACTATATCCTTTTTGATTGTCCAGGTCAGATTGAGTTGTACACTCACCTGCCTGTGATGAAACA GCTGGTCCAGCAGCTCGAGCAGTGGGAGTTCCGAGTCTGTGGAGTTTTTCTTGTTGATTCTCAGTTCATGGTGGAGTCATTCAAGTTTAT TTCTGGCATCTTGGCAGCCCTGAGTGCCATGATCTCTCTAGAAATTCCGCAAGTCAACATCATGACAAAAATGGATCTGCTGAGTAAAAA AGCAAAAAAGGAAATTGAGAAATTTTTAGATCCAGACATGTATTCTTTATTAGAAGATTCTACAAGTGACTTAAGAAGCAAAAAATTCAA GAAACTGACTAAAGCTATATGTGGACTGATTGATGACTACAGCATGGTTCGATTTTTACCTTACGATCAGTCAGATGAAGAAAGCATGAA CATTGTATTGCAGCATATTGATTTTGCCATTCAATATGGAGAAGACCTAGAATTTAAAGAACCAAAGGAACGTGAAGATGAGTCTTCCTC >In-frame_PPTC7_ENST00000354300_chr12_111020614_-_GPN3_ENST00000543199_chr12_110903019_-_1030nt ATGTTCTCGGTCCTCTCGTACGGGCGGCTGGTGGCCCGCGCCGTGCTCGGCGGCCTCTCGCAGACCGACCCCAGGGCCGGCGGCGGCGGC GGCGGCGACTACGGACTGGTGACGGCCGGCTGCGGCTTCGGGAAGGACTTCCGTAAGGGCCTCCTCAAGAAGGGCGCGTGCTACGGGGAC GACGCGTGCTTCGTGGCCCGGCACCGTTCCGCGGACGTGCTCGAGCACCTACTGTGCCACCATGGTCCAGCACTGTGAAGCCCTCAACCG GTCTGTCCAAGTTGTAAACCTGGATCCAGCAGCAGAACACTTCAACTACTCCGTGATGGCTGACATCCGGGAACTGATCGAGGTGGATGA TGTAATGGAGGATGATTCTCTGCGATTCGGTCCCAACGGAGGATTGGTATTTTGCATGGAGTACTTTGCCAATAATTTTGACTGGCTGGA GAACTGTCTTGGCCATGTAGAGGACGACTATATCCTTTTTGATTGTCCAGGTCAGATTGAGTTGTACACTCACCTGCCTGTGATGAAACA GCTGGTCCAGCAGCTCGAGCAGTGGGAGTTCCGAGTCTGTGGAGTTTTTCTTGTTGATTCTCAGTTCATGGTGGAGTCATTCAAGTTTAT TTCTGGCATCTTGGCAGCCCTGAGTGCCATGATCTCTCTAGAAATTCCGCAAGTCAACATCATGACAAAAATGGATCTGCTGAGTAAAAA AGCAAAAAAGGAAATTGAGAAATTTTTAGATCCAGACATGTATTCTTTATTAGAAGATTCTACAAGTGACTTAAGAAGCAAAAAATTCAA GAAACTGACTAAAGCTATATGTGGACTGATTGATGACTACAGCATGGTTCGATTTTTACCTTACGATCAGTCAGATGAAGAAAGCATGAA CATTGTATTGCAGCATATTGATTTTGCCATTCAATATGGAGAAGACCTAGAATTTAAAGAACCAAAGGAACGTGAAGATGAGTCTTCCTC >In-frame_PPTC7_ENST00000354300_chr12_111020614_-_GPN3_ENST00000537466_chr12_110903019_-_1030nt ATGTTCTCGGTCCTCTCGTACGGGCGGCTGGTGGCCCGCGCCGTGCTCGGCGGCCTCTCGCAGACCGACCCCAGGGCCGGCGGCGGCGGC GGCGGCGACTACGGACTGGTGACGGCCGGCTGCGGCTTCGGGAAGGACTTCCGTAAGGGCCTCCTCAAGAAGGGCGCGTGCTACGGGGAC GACGCGTGCTTCGTGGCCCGGCACCGTTCCGCGGACGTGCTCGAGCACCTACTGTGCCACCATGGTCCAGCACTGTGAAGCCCTCAACCG GTCTGTCCAAGTTGTAAACCTGGATCCAGCAGCAGAACACTTCAACTACTCCGTGATGGCTGACATCCGGGAACTGATCGAGGTGGATGA TGTAATGGAGGATGATTCTCTGCGATTCGGTCCCAACGGAGGATTGGTATTTTGCATGGAGTACTTTGCCAATAATTTTGACTGGCTGGA GAACTGTCTTGGCCATGTAGAGGACGACTATATCCTTTTTGATTGTCCAGGTCAGATTGAGTTGTACACTCACCTGCCTGTGATGAAACA GCTGGTCCAGCAGCTCGAGCAGTGGGAGTTCCGAGTCTGTGGAGTTTTTCTTGTTGATTCTCAGTTCATGGTGGAGTCATTCAAGTTTAT TTCTGGCATCTTGGCAGCCCTGAGTGCCATGATCTCTCTAGAAATTCCGCAAGTCAACATCATGACAAAAATGGATCTGCTGAGTAAAAA AGCAAAAAAGGAAATTGAGAAATTTTTAGATCCAGACATGTATTCTTTATTAGAAGATTCTACAAGTGACTTAAGAAGCAAAAAATTCAA GAAACTGACTAAAGCTATATGTGGACTGATTGATGACTACAGCATGGTTCGATTTTTACCTTACGATCAGTCAGATGAAGAAAGCATGAA CATTGTATTGCAGCATATTGATTTTGCCATTCAATATGGAGAAGACCTAGAATTTAAAGAACCAAAGGAACGTGAAGATGAGTCTTCCTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PPTC7_ENST00000354300_chr12_111020614_-_GPN3_ENST00000228827_chr12_110903019_-_1869nt ACGCTAGTGGAGCGGAAGATGGCGGCGGCGGCGGCGGCCGCTGCAGCCGGGACTTCAGTTGGGCTGAGGCGGAGGAGCCGCCGCTTCTGA CCTCGCTCTGGCTCCGGTGCGCGCGGCTGAGCGCGTGCGAGGCCCCGCGCGTCGGGCAGGGGCGGCGGCGGCCACTGCGCGCCGCCCTGA GGAGCGCCCCAGCGGCGGCGCGACTGCGGCTGAGGAGAGAGCCGGCTCCGGGCCTCCGCGTCCTCCTGCTCCCCCGGCCCCCCGCCTCCT CGGGGGGGCGGCGGCGGCGATGTTCTCGGTCCTCTCGTACGGGCGGCTGGTGGCCCGCGCCGTGCTCGGCGGCCTCTCGCAGACCGACCC CAGGGCCGGCGGCGGCGGCGGCGGCGACTACGGACTGGTGACGGCCGGCTGCGGCTTCGGGAAGGACTTCCGTAAGGGCCTCCTCAAGAA GGGCGCGTGCTACGGGGACGACGCGTGCTTCGTGGCCCGGCACCGTTCCGCGGACGTGCTCGAGCACCTACTGTGCCACCATGGTCCAGC ACTGTGAAGCCCTCAACCGGTCTGTCCAAGTTGTAAACCTGGATCCAGCAGCAGAACACTTCAACTACTCCGTGATGGCTGACATCCGGG AACTGATCGAGGTGGATGATGTAATGGAGGATGATTCTCTGCGATTCGGTCCCAACGGAGGATTGGTATTTTGCATGGAGTACTTTGCCA ATAATTTTGACTGGCTGGAGAACTGTCTTGGCCATGTAGAGGACGACTATATCCTTTTTGATTGTCCAGGTCAGATTGAGTTGTACACTC ACCTGCCTGTGATGAAACAGCTGGTCCAGCAGCTCGAGCAGTGGGAGTTCCGAGTCTGTGGAGTTTTTCTTGTTGATTCTCAGTTCATGG TGGAGTCATTCAAGTTTATTTCTGGCATCTTGGCAGCCCTGAGTGCCATGATCTCTCTAGAAATTCCGCAAGTCAACATCATGACAAAAA TGGATCTGCTGAGTAAAAAAGCAAAAAAGGAAATTGAGAAATTTTTAGATCCAGACATGTATTCTTTATTAGAAGATTCTACAAGTGACT TAAGAAGCAAAAAATTCAAGAAACTGACTAAAGCTATATGTGGACTGATTGATGACTACAGCATGGTTCGATTTTTACCTTACGATCAGT CAGATGAAGAAAGCATGAACATTGTATTGCAGCATATTGATTTTGCCATTCAATATGGAGAAGACCTAGAATTTAAAGAACCAAAGGAAC GTGAAGATGAGTCTTCCTCTATGTTTGACGAATATTTTCAAGAATGCCAGGATGAATGAAGAGTTTACTAAAAGTAACCATCTAAAGAGC TTGTGGCCAAACCAGCAGAACATTCTTCTCTTCAAAGGATGCAATAGTAGAAAGCTACTTATTTTAATGAAAAAAAGTAAAACTTCGTTC TTTATCAGCCTCATGCCTGAATCAAATTTTTAATTATTCTGAAACTGCTGCTGTTTAAAGTGGAATCTTTTAGTATTATAACAGCATCAC TTTAGATTTTGTAAGTCAAAATTGAAATGAATGCACATAGATTTATATATAAATTAGCACCTGAGCTAAGGTTAAGGCTGGTCTAAACTT ATTTTCACTTTTTGTATTATTTTTGAGATGCAGGAATTACTGTAACAAAATATGTATGTCCGAAGGGAAAAAGCTGCAAGGATATATATA AGACCACTGCTTATCTGTATCTTCCCATTTTCCTATATTGAAAATGTATATTATTTATATAACTTAAAAAGTAAAAATAACTATGTTTTG >In-frame_PPTC7_ENST00000354300_chr12_111020614_-_GPN3_ENST00000543199_chr12_110903019_-_1866nt ACGCTAGTGGAGCGGAAGATGGCGGCGGCGGCGGCGGCCGCTGCAGCCGGGACTTCAGTTGGGCTGAGGCGGAGGAGCCGCCGCTTCTGA CCTCGCTCTGGCTCCGGTGCGCGCGGCTGAGCGCGTGCGAGGCCCCGCGCGTCGGGCAGGGGCGGCGGCGGCCACTGCGCGCCGCCCTGA GGAGCGCCCCAGCGGCGGCGCGACTGCGGCTGAGGAGAGAGCCGGCTCCGGGCCTCCGCGTCCTCCTGCTCCCCCGGCCCCCCGCCTCCT CGGGGGGGCGGCGGCGGCGATGTTCTCGGTCCTCTCGTACGGGCGGCTGGTGGCCCGCGCCGTGCTCGGCGGCCTCTCGCAGACCGACCC CAGGGCCGGCGGCGGCGGCGGCGGCGACTACGGACTGGTGACGGCCGGCTGCGGCTTCGGGAAGGACTTCCGTAAGGGCCTCCTCAAGAA GGGCGCGTGCTACGGGGACGACGCGTGCTTCGTGGCCCGGCACCGTTCCGCGGACGTGCTCGAGCACCTACTGTGCCACCATGGTCCAGC ACTGTGAAGCCCTCAACCGGTCTGTCCAAGTTGTAAACCTGGATCCAGCAGCAGAACACTTCAACTACTCCGTGATGGCTGACATCCGGG AACTGATCGAGGTGGATGATGTAATGGAGGATGATTCTCTGCGATTCGGTCCCAACGGAGGATTGGTATTTTGCATGGAGTACTTTGCCA ATAATTTTGACTGGCTGGAGAACTGTCTTGGCCATGTAGAGGACGACTATATCCTTTTTGATTGTCCAGGTCAGATTGAGTTGTACACTC ACCTGCCTGTGATGAAACAGCTGGTCCAGCAGCTCGAGCAGTGGGAGTTCCGAGTCTGTGGAGTTTTTCTTGTTGATTCTCAGTTCATGG TGGAGTCATTCAAGTTTATTTCTGGCATCTTGGCAGCCCTGAGTGCCATGATCTCTCTAGAAATTCCGCAAGTCAACATCATGACAAAAA TGGATCTGCTGAGTAAAAAAGCAAAAAAGGAAATTGAGAAATTTTTAGATCCAGACATGTATTCTTTATTAGAAGATTCTACAAGTGACT TAAGAAGCAAAAAATTCAAGAAACTGACTAAAGCTATATGTGGACTGATTGATGACTACAGCATGGTTCGATTTTTACCTTACGATCAGT CAGATGAAGAAAGCATGAACATTGTATTGCAGCATATTGATTTTGCCATTCAATATGGAGAAGACCTAGAATTTAAAGAACCAAAGGAAC GTGAAGATGAGTCTTCCTCTATGTTTGACGAATATTTTCAAGAATGCCAGGATGAATGAAGAGTTTACTAAAAGTAACCATCTAAAGAGC TTGTGGCCAAACCAGCAGAACATTCTTCTCTTCAAAGGATGCAATAGTAGAAAGCTACTTATTTTAATGAAAAAAAGTAAAACTTCGTTC TTTATCAGCCTCATGCCTGAATCAAATTTTTAATTATTCTGAAACTGCTGCTGTTTAAAGTGGAATCTTTTAGTATTATAACAGCATCAC TTTAGATTTTGTAAGTCAAAATTGAAATGAATGCACATAGATTTATATATAAATTAGCACCTGAGCTAAGGTTAAGGCTGGTCTAAACTT ATTTTCACTTTTTGTATTATTTTTGAGATGCAGGAATTACTGTAACAAAATATGTATGTCCGAAGGGAAAAAGCTGCAAGGATATATATA AGACCACTGCTTATCTGTATCTTCCCATTTTCCTATATTGAAAATGTATATTATTTATATAACTTAAAAAGTAAAAATAACTATGTTTTG >In-frame_PPTC7_ENST00000354300_chr12_111020614_-_GPN3_ENST00000537466_chr12_110903019_-_1864nt ACGCTAGTGGAGCGGAAGATGGCGGCGGCGGCGGCGGCCGCTGCAGCCGGGACTTCAGTTGGGCTGAGGCGGAGGAGCCGCCGCTTCTGA CCTCGCTCTGGCTCCGGTGCGCGCGGCTGAGCGCGTGCGAGGCCCCGCGCGTCGGGCAGGGGCGGCGGCGGCCACTGCGCGCCGCCCTGA GGAGCGCCCCAGCGGCGGCGCGACTGCGGCTGAGGAGAGAGCCGGCTCCGGGCCTCCGCGTCCTCCTGCTCCCCCGGCCCCCCGCCTCCT CGGGGGGGCGGCGGCGGCGATGTTCTCGGTCCTCTCGTACGGGCGGCTGGTGGCCCGCGCCGTGCTCGGCGGCCTCTCGCAGACCGACCC CAGGGCCGGCGGCGGCGGCGGCGGCGACTACGGACTGGTGACGGCCGGCTGCGGCTTCGGGAAGGACTTCCGTAAGGGCCTCCTCAAGAA GGGCGCGTGCTACGGGGACGACGCGTGCTTCGTGGCCCGGCACCGTTCCGCGGACGTGCTCGAGCACCTACTGTGCCACCATGGTCCAGC ACTGTGAAGCCCTCAACCGGTCTGTCCAAGTTGTAAACCTGGATCCAGCAGCAGAACACTTCAACTACTCCGTGATGGCTGACATCCGGG AACTGATCGAGGTGGATGATGTAATGGAGGATGATTCTCTGCGATTCGGTCCCAACGGAGGATTGGTATTTTGCATGGAGTACTTTGCCA ATAATTTTGACTGGCTGGAGAACTGTCTTGGCCATGTAGAGGACGACTATATCCTTTTTGATTGTCCAGGTCAGATTGAGTTGTACACTC ACCTGCCTGTGATGAAACAGCTGGTCCAGCAGCTCGAGCAGTGGGAGTTCCGAGTCTGTGGAGTTTTTCTTGTTGATTCTCAGTTCATGG TGGAGTCATTCAAGTTTATTTCTGGCATCTTGGCAGCCCTGAGTGCCATGATCTCTCTAGAAATTCCGCAAGTCAACATCATGACAAAAA TGGATCTGCTGAGTAAAAAAGCAAAAAAGGAAATTGAGAAATTTTTAGATCCAGACATGTATTCTTTATTAGAAGATTCTACAAGTGACT TAAGAAGCAAAAAATTCAAGAAACTGACTAAAGCTATATGTGGACTGATTGATGACTACAGCATGGTTCGATTTTTACCTTACGATCAGT CAGATGAAGAAAGCATGAACATTGTATTGCAGCATATTGATTTTGCCATTCAATATGGAGAAGACCTAGAATTTAAAGAACCAAAGGAAC GTGAAGATGAGTCTTCCTCTATGTTTGACGAATATTTTCAAGAATGCCAGGATGAATGAAGAGTTTACTAAAAGTAACCATCTAAAGAGC TTGTGGCCAAACCAGCAGAACATTCTTCTCTTCAAAGGATGCAATAGTAGAAAGCTACTTATTTTAATGAAAAAAAGTAAAACTTCGTTC TTTATCAGCCTCATGCCTGAATCAAATTTTTAATTATTCTGAAACTGCTGCTGTTTAAAGTGGAATCTTTTAGTATTATAACAGCATCAC TTTAGATTTTGTAAGTCAAAATTGAAATGAATGCACATAGATTTATATATAAATTAGCACCTGAGCTAAGGTTAAGGCTGGTCTAAACTT ATTTTCACTTTTTGTATTATTTTTGAGATGCAGGAATTACTGTAACAAAATATGTATGTCCGAAGGGAAAAAGCTGCAAGGATATATATA AGACCACTGCTTATCTGTATCTTCCCATTTTCCTATATTGAAAATGTATATTATTTATATAACTTAAAAAGTAAAAATAACTATGTTTTG 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FusionGenePPI for PPTC7_GPN3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PPTC7 | ELAVL1, ZDHHC17, PPTC7, BNIP3, BNIP3L, TRMT61B, TRMT2B, MRPL22, MRPS18C, SARS2, SPHKAP, C1QBP, RTN4IP1, ASF1B, ASF1A, CD70, DBT, FAM174A, LPAR4, HSDL1, UBB, LAMP2, AIFM1 | GPN3 | WDR48, RPAP2, GPN1, UBC, CUL5, BRCA1, RPRD1A, POLR3K, PIH1D1, POLR2G, POLR3H, POLR1E, POLR1B, ASPM, POLR1A, POLR3A, POLR3E, POLR2A, POLR2D, POLR3B, DAAM1, POLR1C, POLR3D, POLR2I, CRNN, POLR2C, EPHA4, POLR2M, PPP1CA, POLR2L, CD3EAP, POLR2F, POLR1D, RPRD1B, SCN2B, XPO1, SMC6, CXXC4, WWP2, LMO2, ASB6, POLR2E, UXT, VSIG1, CHRM3, MICU1, ZFC3H1, POLR2B, SIGLEC5, TGOLN2, MED18, BHLHA15, SPINT2, VAPB, EPHA1, SIGLECL1, FAS, URI1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PPTC7_GPN3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PPTC7_GPN3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PPTC7 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
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