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Fusion gene ID: 28546 |
FusionGeneSummary for PPP6R3_SPTBN2 |
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Fusion gene information | Fusion gene name: PPP6R3_SPTBN2 | Fusion gene ID: 28546 | Hgene | Tgene | Gene symbol | PPP6R3 | SPTBN2 | Gene ID | 55291 | 6712 |
Gene name | protein phosphatase 6 regulatory subunit 3 | spectrin beta, non-erythrocytic 2 | |
Synonyms | C11orf23|PP6R3|SAP190|SAPL|SAPLa|SAPS3 | GTRAP41|SCA5|SCAR14 | |
Cytomap | 11q13.2 | 11q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein phosphatase 6 regulatory subunit 3SAPS domain family, member 3sporulation-induced transcript 4-associated protein SAPL | spectrin beta chain, non-erythrocytic 2beta-III spectringlutamate transporter EAAT4-associated protein 41spectrin beta III sigma 2spectrin beta chain, brain 2spectrin, non-erythroid beta chain 2spinocerebellar ataxia 5 protein | |
Modification date | 20180520 | 20180522 | |
UniProtAcc | Q5H9R7 | O15020 | |
Ensembl transtripts involved in fusion gene | ENST00000393799, ENST00000530427, ENST00000393800, ENST00000534534, ENST00000524845, ENST00000265637, ENST00000524904, ENST00000393801, ENST00000265636, ENST00000529710, ENST00000527403, | ENST00000533211, ENST00000309996, ENST00000529997, | |
Fusion gene scores | * DoF score | 18 X 11 X 10=1980 | 4 X 4 X 2=32 |
# samples | 28 | 4 | |
** MAII score | log2(28/1980*10)=-2.82200169802201 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PPP6R3 [Title/Abstract] AND SPTBN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PPP6R3 | GO:0043666 | regulation of phosphoprotein phosphatase activity | 16716191 |
Tgene | SPTBN2 | GO:0016192 | vesicle-mediated transport | 9826670 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-GM-A3NW-01A | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000393799 | ENST00000533211 | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
5UTR-3CDS | ENST00000393799 | ENST00000309996 | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
5UTR-3CDS | ENST00000393799 | ENST00000529997 | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
3UTR-3CDS | ENST00000530427 | ENST00000533211 | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
3UTR-3CDS | ENST00000530427 | ENST00000309996 | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
3UTR-3CDS | ENST00000530427 | ENST00000529997 | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
5UTR-3CDS | ENST00000393800 | ENST00000533211 | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
5UTR-3CDS | ENST00000393800 | ENST00000309996 | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
5UTR-3CDS | ENST00000393800 | ENST00000529997 | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
5UTR-3CDS | ENST00000534534 | ENST00000533211 | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
5UTR-3CDS | ENST00000534534 | ENST00000309996 | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
5UTR-3CDS | ENST00000534534 | ENST00000529997 | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
5UTR-3CDS | ENST00000524845 | ENST00000533211 | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
5UTR-3CDS | ENST00000524845 | ENST00000309996 | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
5UTR-3CDS | ENST00000524845 | ENST00000529997 | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
5UTR-3CDS | ENST00000265637 | ENST00000533211 | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
5UTR-3CDS | ENST00000265637 | ENST00000309996 | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
5UTR-3CDS | ENST00000265637 | ENST00000529997 | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
5UTR-3CDS | ENST00000524904 | ENST00000533211 | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
5UTR-3CDS | ENST00000524904 | ENST00000309996 | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
5UTR-3CDS | ENST00000524904 | ENST00000529997 | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
5UTR-3CDS | ENST00000393801 | ENST00000533211 | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
5UTR-3CDS | ENST00000393801 | ENST00000309996 | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
5UTR-3CDS | ENST00000393801 | ENST00000529997 | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
5UTR-3CDS | ENST00000265636 | ENST00000533211 | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
5UTR-3CDS | ENST00000265636 | ENST00000309996 | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
5UTR-3CDS | ENST00000265636 | ENST00000529997 | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
5UTR-3CDS | ENST00000529710 | ENST00000533211 | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
5UTR-3CDS | ENST00000529710 | ENST00000309996 | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
5UTR-3CDS | ENST00000529710 | ENST00000529997 | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
intron-3CDS | ENST00000527403 | ENST00000533211 | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
intron-3CDS | ENST00000527403 | ENST00000309996 | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
intron-3CDS | ENST00000527403 | ENST00000529997 | PPP6R3 | chr11 | 68228295 | + | SPTBN2 | chr11 | 66483452 | - |
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FusionProtFeatures for PPP6R3_SPTBN2 |
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Hgene | Tgene |
PPP6R3 | SPTBN2 |
Probably plays an important role in neuronal membraneskeleton. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PPP6R3_SPTBN2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PPP6R3_SPTBN2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PPP6R3 | KDM6A, TNFAIP3, USP21, USP36, USP49, PPP6C, PRKDC, HDAC1, HDAC2, ELAVL1, SIRT7, TERF2IP, TINF2, TFAP4, GRK5, PFAS, BRCA1, ECT2, NOTCH1, LATS1, GPSM1, HDAC11, USP10, ANKRD28, MOB1A, MOB1B, ACAD11, ANKRD44, ANKRD52, AP1B1, AP2A1, AP2A2, AURKA, DNAJC11, ECH1, ERLIN2, PPP6R1, PPP6R2, CDC37, ENAH, ETFA, HSP90AA1, HSP90AB1, RUVBL2, SRRT, TPM1, USP7, CSNK1E, SNAI2, RNF2, GPHA2, RPS6KB2, UNK, DIEXF, NSUN5, EIF4A3, TIPRL, NTRK1, CEP44, CEP19, XPO1, ZNRF2, ZNF746, TRMT2A, TRIM25, TES | SPTBN2 | UNC13B, ACTR1A, ACTB, APC, SIRT7, SPTAN1, KDM5C, OBSL1, CCDC8, CORO1B, EXOC2, ILF2, MLH1, NCAPD3, CAPZA2, FLNA, MYH9, MYO1C, PPP1CB, SORT1, IQGAP1, SYNPO, ASF1A, ATAD2, SGTB, MYO19, MYO18A, CDH1, CTDSPL, TRIM25, UBE2A |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PPP6R3_SPTBN2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PPP6R3_SPTBN2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SPTBN2 | C0752123 | Spinocerebellar Ataxia Type 5 | 2 | ORPHANET;UNIPROT |
Tgene | SPTBN2 | C0036341 | Schizophrenia | 1 | PSYGENET |