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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 28498

FusionGeneSummary for PPP4R1_DPP4

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP4R1_DPP4
Fusion gene ID: 28498
HgeneTgene
Gene symbol

PPP4R1

DPP4

Gene ID

9989

1803

Gene nameprotein phosphatase 4 regulatory subunit 1dipeptidyl peptidase 4
SynonymsMEG1|PP4(Rmeg)|PP4R1ADABP|ADCP2|CD26|DPPIV|TP103
Cytomap

18p11.22

2q24.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 4 regulatory subunit 1serine/threonine phosphatase 4dipeptidyl peptidase 4ADCP-2DPP IVT-cell activation antigen CD26adenosine deaminase complexing protein 2dipeptidyl peptidase IVdipeptidylpeptidase 4dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)
Modification date2018052320180519
UniProtAcc

Q8TF05

P27487

Ensembl transtripts involved in fusion geneENST00000400556, ENST00000400555, 
ENST00000580583, 
ENST00000360534, 
ENST00000491591, 
Fusion gene scores* DoF score6 X 6 X 6=2162 X 2 X 2=8
# samples 62
** MAII scorelog2(6/216*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: PPP4R1 [Title/Abstract] AND DPP4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDPP4

GO:0001666

response to hypoxia

16670267

TgeneDPP4

GO:0006508

proteolysis

27198182

TgeneDPP4

GO:0008284

positive regulation of cell proliferation

17549790

TgeneDPP4

GO:0010716

negative regulation of extracellular matrix disassembly

16651416

TgeneDPP4

GO:0031295

T cell costimulation

10900005|17287217

TgeneDPP4

GO:0033632

regulation of cell-cell adhesion mediated by integrin

11772392

TgeneDPP4

GO:0042110

T cell activation

7594462

TgeneDPP4

GO:0043542

endothelial cell migration

16651416


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-EY-A3L3-01APPP4R1chr18

9561978

-DPP4chr2

162851882

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000400556ENST00000360534PPP4R1chr18

9561978

-DPP4chr2

162851882

-
5CDS-5UTRENST00000400556ENST00000491591PPP4R1chr18

9561978

-DPP4chr2

162851882

-
In-frameENST00000400555ENST00000360534PPP4R1chr18

9561978

-DPP4chr2

162851882

-
5CDS-5UTRENST00000400555ENST00000491591PPP4R1chr18

9561978

-DPP4chr2

162851882

-
intron-3CDSENST00000580583ENST00000360534PPP4R1chr18

9561978

-DPP4chr2

162851882

-
intron-5UTRENST00000580583ENST00000491591PPP4R1chr18

9561978

-DPP4chr2

162851882

-

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FusionProtFeatures for PPP4R1_DPP4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP4R1

Q8TF05

DPP4

P27487

Regulatory subunit of serine/threonine-proteinphosphatase 4. May play a role in regulation of cell division inrenal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role indephosphorylation and regulation of HDAC3.{ECO:0000269|PubMed:15805470}. Cell surface glycoprotein receptor involved in thecostimulatory signal essential for T-cell receptor (TCR)-mediatedT-cell activation. Acts as a positive regulator of T-cellcoactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Itsbinding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Itsinteraction with ADA also regulates lymphocyte-epithelial celladhesion. In association with FAP is involved in the pericellularproteolysis of the extracellular matrix (ECM), the migration andinvasion of endothelial cells into the ECM. May be involved in thepromotion of lymphatic endothelial cells adhesion, migration andtube formation. When overexpressed, enhanced cell proliferation, aprocess inhibited by GPC3. Acts also as a serine exopeptidase witha dipeptidyl peptidase activity that regulates variousphysiological processes by cleaving peptides in the circulation,including many chemokines, mitogenic growth factors, neuropeptidesand peptide hormones. Removes N-terminal dipeptides sequentiallyfrom polypeptides having unsubstituted N-termini provided that thepenultimate residue is proline. {ECO:0000269|PubMed:10570924,ECO:0000269|PubMed:10593948, ECO:0000269|PubMed:10900005,ECO:0000269|PubMed:10951221, ECO:0000269|PubMed:11772392,ECO:0000269|PubMed:14691230, ECO:0000269|PubMed:16651416,ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:17549790,ECO:0000269|PubMed:18708048}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-1320127_164597934RepeatNote=HEAT 5
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-1320168_206597934RepeatNote=HEAT 6
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-13201_25597934RepeatNote=HEAT 1
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-1320208_246597934RepeatNote=HEAT 7
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-1320248_285597934RepeatNote=HEAT 8
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-132026_63597934RepeatNote=HEAT 2
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-1320287_324597934RepeatNote=HEAT 9
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-1320505_542597934RepeatNote=HEAT 10
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-132065_81597934RepeatNote=HEAT 3
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-132082_119597934RepeatNote=HEAT 4
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-1320127_164614951RepeatNote=HEAT 5
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-1320168_206614951RepeatNote=HEAT 6
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-13201_25614951RepeatNote=HEAT 1
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-1320208_246614951RepeatNote=HEAT 7
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-1320248_285614951RepeatNote=HEAT 8
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-132026_63614951RepeatNote=HEAT 2
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-1320287_324614951RepeatNote=HEAT 9
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-1320505_542614951RepeatNote=HEAT 10
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-1320568_606614951RepeatNote=HEAT 11
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-132065_81614951RepeatNote=HEAT 3
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-132082_119614951RepeatNote=HEAT 4

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-1320568_606597934RepeatNote=HEAT 11
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-1320698_734597934RepeatNote=HEAT 12
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-1320799_837597934RepeatNote=HEAT 13
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-1320861_898597934RepeatNote=HEAT 14
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-1320698_734614951RepeatNote=HEAT 12
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-1320799_837614951RepeatNote=HEAT 13
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-1320861_898614951RepeatNote=HEAT 14
TgeneDPP4chr18:9561978chr2:162851882ENST00000360534-22261_6684767Topological domainCytoplasmic
TgeneDPP4chr18:9561978chr2:162851882ENST00000360534-222629_766684767Topological domainExtracellular
TgeneDPP4chr18:9561978chr2:162851882ENST00000360534-22267_28684767TransmembraneHelical%3B Signal-anchor for type II membrane protein


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FusionGeneSequence for PPP4R1_DPP4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PPP4R1_ENST00000400556_chr18_9561978_-_DPP4_ENST00000360534_chr2_162851882_-_697aa
MADLSLLQEDLQEDADGFGVDDYSSESDVIIIPSALDFVSQDEMLTPLGRLDKYAASENIFNRQMVARSLLDTLREVCDDERDCIAVLER
ISRLADDSEPTVRAELMEQVPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDVETKVCPVLIEL
TAPDSNDDVKTEAVAIMCKMAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVWGVRK
ACAECFMAVSCATCQEIRRTKLSALFINLISDPSRWVRQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNRTRDQEAPEDVQ
VRPEDTPSDLSVSNSSVILENTMEDHAAEASGKPLGEISVPLDSSLLCTLSSESHQEAASNENDKKPGNYKSMLRPEVGTTSQDSALLDQ
ELYNSFHFWRTPLPEIDLDIELEQNSGGKPSPEGPEEESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEVLSAALRASSLD
AHEETISIEKRSDLQDELDINELPNCKINQEDSVPLISDAVENMDSTLHYIHSDSDLSNNSSFSPDEERRTKVQNSTVMSRAENFKQVEY

>In-frame_PPP4R1_ENST00000400555_chr18_9561978_-_DPP4_ENST00000360534_chr2_162851882_-_680aa
MADLSLLQEDLQEDADGSLDFVSQDEMLTPLGRLDKYAASENIFNRQMVARSLLDTLREVCDDERDCIAVLERISRLADDSEPTVRAELM
EQVPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDVETKVCPVLIELTAPDSNDDVKTEAVAIM
CKMAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVWGVRKACAECFMAVSCATCQEI
RRTKLSALFINLISDPSRWVRQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNRTRDQEAPEDVQVRPEDTPSDLSVSNSSV
ILENTMEDHAAEASGKPLGEISVPLDSSLLCTLSSESHQEAASNENDKKPGNYKSMLRPEVGTTSQDSALLDQELYNSFHFWRTPLPEID
LDIELEQNSGGKPSPEGPEEESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEVLSAALRASSLDAHEETISIEKRSDLQDE
LDINELPNCKINQEDSVPLISDAVENMDSTLHYIHSDSDLSNNSSFSPDEERRTKVQNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSA


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PPP4R1_ENST00000400556_chr18_9561978_-_DPP4_ENST00000360534_chr2_162851882_-_2091nt
ATGGCGGACCTCTCGCTGCTTCAGGAGGACCTGCAGGAGGACGCAGACGGATTTGGTGTGGATGACTACAGCTCAGAGTCTGATGTGATT
ATTATACCTTCAGCCCTGGACTTTGTCTCACAAGATGAAATGTTGACGCCCCTGGGGAGATTGGACAAGTATGCTGCAAGTGAGAACATA
TTTAACAGACAAATGGTGGCCCGGAGTTTGCTCGATACCTTGAGGGAAGTCTGCGATGATGAAAGAGATTGTATTGCTGTTTTGGAAAGA
ATTAGCAGATTGGCCGATGATTCAGAACCAACTGTGAGAGCGGAGCTGATGGAACAGGTGCCTCACATCGCACTGTTTTGTCAAGAAAAC
CGGCCTTCAATACCATATGCTTTTTCAAAATTCTTACTACCTATTGTGGTTAGATACCTTGCAGATCAGAATAATCAGGTGAGGAAAACA
AGTCAGGCAGCTTTGCTGGCTCTGTTGGAGCAGGAGCTCATTGAACGATTTGATGTGGAGACCAAAGTGTGCCCTGTCCTCATAGAGCTG
ACAGCCCCAGATAGCAATGATGATGTGAAAACAGAAGCTGTGGCTATAATGTGCAAAATGGCTCCCATGGTTGGGAAGGATATTACAGAG
CGTCTTATCCTCCCTAGGTTTTGTGAGATGTGCTGCGATTGCAGAATGTTTCACGTTCGAAAGGTCTGTGCTGCCAATTTTGGAGATATT
TGCAGTGTAGTTGGCCAGCAAGCTACTGAAGAAATGTTGCTGCCCAGATTTTTCCAGCTTTGTTCTGATAATGTATGGGGAGTCCGAAAG
GCTTGTGCTGAATGCTTCATGGCGGTTTCATGTGCAACATGTCAAGAAATCCGACGGACCAAATTATCAGCACTTTTTATTAATTTGATC
AGTGATCCTTCACGTTGGGTTCGCCAAGCAGCTTTTCAGTCTCTGGGACCTTTCATATCTACTTTTGCTAATCCATCTAGCTCAGGCCAG
TATTTTAAAGAAGAAAGCAAAAGTTCAGAAGAGATGTCAGTAGAAAACAAAAATAGGACCAGAGATCAAGAAGCCCCAGAGGATGTACAA
GTCAGGCCAGAGGATACTCCTTCAGATCTCAGTGTTAGTAATTCCAGTGTCATACTGGAAAACACGATGGAAGACCATGCTGCTGAGGCA
TCCGGGAAGCCTCTAGGTGAAATTAGTGTTCCACTGGACAGCTCTTTACTTTGTACTTTGTCCTCAGAATCTCACCAGGAAGCAGCTAGT
AATGAGAATGATAAAAAACCTGGTAACTACAAATCTATGTTACGACCAGAGGTTGGCACCACTTCACAAGATTCAGCTCTCTTAGATCAG
GAATTGTATAACTCCTTCCATTTCTGGAGGACTCCTCTTCCTGAAATAGATCTAGACATAGAGCTTGAACAGAACTCTGGGGGAAAACCC
AGCCCAGAGGGACCAGAGGAAGAATCTGAGGGCCCTGTGCCCAGTTCTCCAAACATCACCATGGCCACCAGAAAGGAACTGGAAGAAATG
ATAGAAAATCTAGAGCCCCACATTGATGATCCAGATGTTAAAGCACAAGTGGAAGTGCTGTCCGCTGCACTACGTGCTTCCAGCCTGGAT
GCACATGAAGAGACCATCAGTATAGAAAAGAGAAGTGATTTGCAAGATGAACTGGATATAAATGAGCTACCAAATTGTAAAATAAATCAA
GAAGATTCTGTGCCTTTAATCAGCGATGCTGTTGAGAATATGGACTCCACTCTTCACTATATTCACAGCGATTCAGACTTGAGCAACAAT
AGCAGTTTTAGCCCTGATGAGGAAAGGAGAACTAAAGTACAAAATTCAACAGTCATGAGCAGAGCTGAAAATTTTAAACAAGTTGAGTAC
CTCCTTATTCATGGAACAGCAGATGATAACGTTCACTTTCAGCAGTCAGCTCAGATCTCCAAAGCCCTGGTCGATGTTGGAGTGGATTTC
CAGGCAATGTGGTATACTGATGAAGACCATGGAATAGCTAGCAGCACAGCACACCAACATATATATACCCACATGAGCCACTTCATAAAA

>In-frame_PPP4R1_ENST00000400555_chr18_9561978_-_DPP4_ENST00000360534_chr2_162851882_-_2040nt
ATGGCGGACCTCTCGCTGCTTCAGGAGGACCTGCAGGAGGACGCAGACGGATCCCTGGACTTTGTCTCACAAGATGAAATGTTGACGCCC
CTGGGGAGATTGGACAAGTATGCTGCAAGTGAGAACATATTTAACAGACAAATGGTGGCCCGGAGTTTGCTCGATACCTTGAGGGAAGTC
TGCGATGATGAAAGAGATTGTATTGCTGTTTTGGAAAGAATTAGCAGATTGGCCGATGATTCAGAACCAACTGTGAGAGCGGAGCTGATG
GAACAGGTGCCTCACATCGCACTGTTTTGTCAAGAAAACCGGCCTTCAATACCATATGCTTTTTCAAAATTCTTACTACCTATTGTGGTT
AGATACCTTGCAGATCAGAATAATCAGGTGAGGAAAACAAGTCAGGCAGCTTTGCTGGCTCTGTTGGAGCAGGAGCTCATTGAACGATTT
GATGTGGAGACCAAAGTGTGCCCTGTCCTCATAGAGCTGACAGCCCCAGATAGCAATGATGATGTGAAAACAGAAGCTGTGGCTATAATG
TGCAAAATGGCTCCCATGGTTGGGAAGGATATTACAGAGCGTCTTATCCTCCCTAGGTTTTGTGAGATGTGCTGCGATTGCAGAATGTTT
CACGTTCGAAAGGTCTGTGCTGCCAATTTTGGAGATATTTGCAGTGTAGTTGGCCAGCAAGCTACTGAAGAAATGTTGCTGCCCAGATTT
TTCCAGCTTTGTTCTGATAATGTATGGGGAGTCCGAAAGGCTTGTGCTGAATGCTTCATGGCGGTTTCATGTGCAACATGTCAAGAAATC
CGACGGACCAAATTATCAGCACTTTTTATTAATTTGATCAGTGATCCTTCACGTTGGGTTCGCCAAGCAGCTTTTCAGTCTCTGGGACCT
TTCATATCTACTTTTGCTAATCCATCTAGCTCAGGCCAGTATTTTAAAGAAGAAAGCAAAAGTTCAGAAGAGATGTCAGTAGAAAACAAA
AATAGGACCAGAGATCAAGAAGCCCCAGAGGATGTACAAGTCAGGCCAGAGGATACTCCTTCAGATCTCAGTGTTAGTAATTCCAGTGTC
ATACTGGAAAACACGATGGAAGACCATGCTGCTGAGGCATCCGGGAAGCCTCTAGGTGAAATTAGTGTTCCACTGGACAGCTCTTTACTT
TGTACTTTGTCCTCAGAATCTCACCAGGAAGCAGCTAGTAATGAGAATGATAAAAAACCTGGTAACTACAAATCTATGTTACGACCAGAG
GTTGGCACCACTTCACAAGATTCAGCTCTCTTAGATCAGGAATTGTATAACTCCTTCCATTTCTGGAGGACTCCTCTTCCTGAAATAGAT
CTAGACATAGAGCTTGAACAGAACTCTGGGGGAAAACCCAGCCCAGAGGGACCAGAGGAAGAATCTGAGGGCCCTGTGCCCAGTTCTCCA
AACATCACCATGGCCACCAGAAAGGAACTGGAAGAAATGATAGAAAATCTAGAGCCCCACATTGATGATCCAGATGTTAAAGCACAAGTG
GAAGTGCTGTCCGCTGCACTACGTGCTTCCAGCCTGGATGCACATGAAGAGACCATCAGTATAGAAAAGAGAAGTGATTTGCAAGATGAA
CTGGATATAAATGAGCTACCAAATTGTAAAATAAATCAAGAAGATTCTGTGCCTTTAATCAGCGATGCTGTTGAGAATATGGACTCCACT
CTTCACTATATTCACAGCGATTCAGACTTGAGCAACAATAGCAGTTTTAGCCCTGATGAGGAAAGGAGAACTAAAGTACAAAATTCAACA
GTCATGAGCAGAGCTGAAAATTTTAAACAAGTTGAGTACCTCCTTATTCATGGAACAGCAGATGATAACGTTCACTTTCAGCAGTCAGCT
CAGATCTCCAAAGCCCTGGTCGATGTTGGAGTGGATTTCCAGGCAATGTGGTATACTGATGAAGACCATGGAATAGCTAGCAGCACAGCA


* Fusion transcript sequences (Full-length transcript).
>In-frame_PPP4R1_ENST00000400556_chr18_9561978_-_DPP4_ENST00000360534_chr2_162851882_-_3207nt
CCGGCTCCCCGGCTCGCGCCGCTCCATGTAGCCCCGGCTCCCCGGGCGGCCGCGGAGGAGGGGGCGACCACAAGATGGCGGACCTCTCGC
TGCTTCAGGAGGACCTGCAGGAGGACGCAGACGGATTTGGTGTGGATGACTACAGCTCAGAGTCTGATGTGATTATTATACCTTCAGCCC
TGGACTTTGTCTCACAAGATGAAATGTTGACGCCCCTGGGGAGATTGGACAAGTATGCTGCAAGTGAGAACATATTTAACAGACAAATGG
TGGCCCGGAGTTTGCTCGATACCTTGAGGGAAGTCTGCGATGATGAAAGAGATTGTATTGCTGTTTTGGAAAGAATTAGCAGATTGGCCG
ATGATTCAGAACCAACTGTGAGAGCGGAGCTGATGGAACAGGTGCCTCACATCGCACTGTTTTGTCAAGAAAACCGGCCTTCAATACCAT
ATGCTTTTTCAAAATTCTTACTACCTATTGTGGTTAGATACCTTGCAGATCAGAATAATCAGGTGAGGAAAACAAGTCAGGCAGCTTTGC
TGGCTCTGTTGGAGCAGGAGCTCATTGAACGATTTGATGTGGAGACCAAAGTGTGCCCTGTCCTCATAGAGCTGACAGCCCCAGATAGCA
ATGATGATGTGAAAACAGAAGCTGTGGCTATAATGTGCAAAATGGCTCCCATGGTTGGGAAGGATATTACAGAGCGTCTTATCCTCCCTA
GGTTTTGTGAGATGTGCTGCGATTGCAGAATGTTTCACGTTCGAAAGGTCTGTGCTGCCAATTTTGGAGATATTTGCAGTGTAGTTGGCC
AGCAAGCTACTGAAGAAATGTTGCTGCCCAGATTTTTCCAGCTTTGTTCTGATAATGTATGGGGAGTCCGAAAGGCTTGTGCTGAATGCT
TCATGGCGGTTTCATGTGCAACATGTCAAGAAATCCGACGGACCAAATTATCAGCACTTTTTATTAATTTGATCAGTGATCCTTCACGTT
GGGTTCGCCAAGCAGCTTTTCAGTCTCTGGGACCTTTCATATCTACTTTTGCTAATCCATCTAGCTCAGGCCAGTATTTTAAAGAAGAAA
GCAAAAGTTCAGAAGAGATGTCAGTAGAAAACAAAAATAGGACCAGAGATCAAGAAGCCCCAGAGGATGTACAAGTCAGGCCAGAGGATA
CTCCTTCAGATCTCAGTGTTAGTAATTCCAGTGTCATACTGGAAAACACGATGGAAGACCATGCTGCTGAGGCATCCGGGAAGCCTCTAG
GTGAAATTAGTGTTCCACTGGACAGCTCTTTACTTTGTACTTTGTCCTCAGAATCTCACCAGGAAGCAGCTAGTAATGAGAATGATAAAA
AACCTGGTAACTACAAATCTATGTTACGACCAGAGGTTGGCACCACTTCACAAGATTCAGCTCTCTTAGATCAGGAATTGTATAACTCCT
TCCATTTCTGGAGGACTCCTCTTCCTGAAATAGATCTAGACATAGAGCTTGAACAGAACTCTGGGGGAAAACCCAGCCCAGAGGGACCAG
AGGAAGAATCTGAGGGCCCTGTGCCCAGTTCTCCAAACATCACCATGGCCACCAGAAAGGAACTGGAAGAAATGATAGAAAATCTAGAGC
CCCACATTGATGATCCAGATGTTAAAGCACAAGTGGAAGTGCTGTCCGCTGCACTACGTGCTTCCAGCCTGGATGCACATGAAGAGACCA
TCAGTATAGAAAAGAGAAGTGATTTGCAAGATGAACTGGATATAAATGAGCTACCAAATTGTAAAATAAATCAAGAAGATTCTGTGCCTT
TAATCAGCGATGCTGTTGAGAATATGGACTCCACTCTTCACTATATTCACAGCGATTCAGACTTGAGCAACAATAGCAGTTTTAGCCCTG
ATGAGGAAAGGAGAACTAAAGTACAAAATTCAACAGTCATGAGCAGAGCTGAAAATTTTAAACAAGTTGAGTACCTCCTTATTCATGGAA
CAGCAGATGATAACGTTCACTTTCAGCAGTCAGCTCAGATCTCCAAAGCCCTGGTCGATGTTGGAGTGGATTTCCAGGCAATGTGGTATA
CTGATGAAGACCATGGAATAGCTAGCAGCACAGCACACCAACATATATATACCCACATGAGCCACTTCATAAAACAATGTTTCTCTTTAC
CTTAGCACCTCAAAATACCATGCCATTTAAAGCTTATTAAAACTCATTTTTGTTTTCATTATCTCAAAACTGCACTGTCAAGATGATGAT
GATCTTTAAAATACACACTCAAATCAAGAAACTTAAGGTTACCTTTGTTCCCAAATTTCATACCTATCATCTTAAGTAGGGACTTCTGTC
TTCACAACAGATTATTACCTTACAGAAGTTTGAATTATCCGGTCGGGTTTTATTGTTTAAAATCATTTCTGCATCAGCTGCTGAAACAAC
AAATAGGAATTGTTTTTATGGAGGCTTTGCATAGATTCCCTGAGCAGGATTTTAATCTTTTTCTAACTGGACTGGTTCAAATGTTGTTCT
CTTCTTTAAAGGGATGGCAAGATGTGGGCAGTGATGTCACTAGGGCAGGGACAGGATAAGAGGGATTAGGGAGAGAAGATAGCAGGGCAT
GGCTGGGAACCCAAGTCCAAGCATACCAACACGAGCAGGCTACTGTCAGCTCCCCTCGGAGAAGAGCTGTTCACAGCCAGACTGGCACAG
TTTTCTGAGAAAGACTATTCAAACAGTCTCAGGAAATCAAATATGCAAAGCACTGACTTCTAAGTAAAACCACAGCAGTTGAAAAGACTC
CAAAGAAATGTAAGGGAAACTGCCAGCAACGCAGGCCCCCAGGTGCCAGTTATGGCTATAGGTGCTACAAAAACACAGCAAGGGTGATGG
GAAAGCATTGTAAATGTGCTTTTAAAAAAAAATACTGATGTTCCTAGTGAAAGAGGCAGCTTGAAACTGAGATGTGAACACATCAGCTTG
CCCTGTTAAAAGATGAAAATATTTGTATCACAAATCTTAACTTGAAGGAGTCCTTGCATCAATTTTTCTTATTTCATTTCTTTGAGTGTC
TTAATTAAAAGAATATTTTAACTTCCTTGGACTCATTTTAAAAAATGGAACATAAAATACAATGTTATGTATTATTATTCCCATTCTACA

>In-frame_PPP4R1_ENST00000400555_chr18_9561978_-_DPP4_ENST00000360534_chr2_162851882_-_3167nt
GCGCGCGTCCACCGGCTCCCCGGCTCGCGCCGCTCCATGTAGCCCCGGCTCCCCGGGCGGCCGCGGAGGAGGGGGCGACCACAAGATGGC
GGACCTCTCGCTGCTTCAGGAGGACCTGCAGGAGGACGCAGACGGATCCCTGGACTTTGTCTCACAAGATGAAATGTTGACGCCCCTGGG
GAGATTGGACAAGTATGCTGCAAGTGAGAACATATTTAACAGACAAATGGTGGCCCGGAGTTTGCTCGATACCTTGAGGGAAGTCTGCGA
TGATGAAAGAGATTGTATTGCTGTTTTGGAAAGAATTAGCAGATTGGCCGATGATTCAGAACCAACTGTGAGAGCGGAGCTGATGGAACA
GGTGCCTCACATCGCACTGTTTTGTCAAGAAAACCGGCCTTCAATACCATATGCTTTTTCAAAATTCTTACTACCTATTGTGGTTAGATA
CCTTGCAGATCAGAATAATCAGGTGAGGAAAACAAGTCAGGCAGCTTTGCTGGCTCTGTTGGAGCAGGAGCTCATTGAACGATTTGATGT
GGAGACCAAAGTGTGCCCTGTCCTCATAGAGCTGACAGCCCCAGATAGCAATGATGATGTGAAAACAGAAGCTGTGGCTATAATGTGCAA
AATGGCTCCCATGGTTGGGAAGGATATTACAGAGCGTCTTATCCTCCCTAGGTTTTGTGAGATGTGCTGCGATTGCAGAATGTTTCACGT
TCGAAAGGTCTGTGCTGCCAATTTTGGAGATATTTGCAGTGTAGTTGGCCAGCAAGCTACTGAAGAAATGTTGCTGCCCAGATTTTTCCA
GCTTTGTTCTGATAATGTATGGGGAGTCCGAAAGGCTTGTGCTGAATGCTTCATGGCGGTTTCATGTGCAACATGTCAAGAAATCCGACG
GACCAAATTATCAGCACTTTTTATTAATTTGATCAGTGATCCTTCACGTTGGGTTCGCCAAGCAGCTTTTCAGTCTCTGGGACCTTTCAT
ATCTACTTTTGCTAATCCATCTAGCTCAGGCCAGTATTTTAAAGAAGAAAGCAAAAGTTCAGAAGAGATGTCAGTAGAAAACAAAAATAG
GACCAGAGATCAAGAAGCCCCAGAGGATGTACAAGTCAGGCCAGAGGATACTCCTTCAGATCTCAGTGTTAGTAATTCCAGTGTCATACT
GGAAAACACGATGGAAGACCATGCTGCTGAGGCATCCGGGAAGCCTCTAGGTGAAATTAGTGTTCCACTGGACAGCTCTTTACTTTGTAC
TTTGTCCTCAGAATCTCACCAGGAAGCAGCTAGTAATGAGAATGATAAAAAACCTGGTAACTACAAATCTATGTTACGACCAGAGGTTGG
CACCACTTCACAAGATTCAGCTCTCTTAGATCAGGAATTGTATAACTCCTTCCATTTCTGGAGGACTCCTCTTCCTGAAATAGATCTAGA
CATAGAGCTTGAACAGAACTCTGGGGGAAAACCCAGCCCAGAGGGACCAGAGGAAGAATCTGAGGGCCCTGTGCCCAGTTCTCCAAACAT
CACCATGGCCACCAGAAAGGAACTGGAAGAAATGATAGAAAATCTAGAGCCCCACATTGATGATCCAGATGTTAAAGCACAAGTGGAAGT
GCTGTCCGCTGCACTACGTGCTTCCAGCCTGGATGCACATGAAGAGACCATCAGTATAGAAAAGAGAAGTGATTTGCAAGATGAACTGGA
TATAAATGAGCTACCAAATTGTAAAATAAATCAAGAAGATTCTGTGCCTTTAATCAGCGATGCTGTTGAGAATATGGACTCCACTCTTCA
CTATATTCACAGCGATTCAGACTTGAGCAACAATAGCAGTTTTAGCCCTGATGAGGAAAGGAGAACTAAAGTACAAAATTCAACAGTCAT
GAGCAGAGCTGAAAATTTTAAACAAGTTGAGTACCTCCTTATTCATGGAACAGCAGATGATAACGTTCACTTTCAGCAGTCAGCTCAGAT
CTCCAAAGCCCTGGTCGATGTTGGAGTGGATTTCCAGGCAATGTGGTATACTGATGAAGACCATGGAATAGCTAGCAGCACAGCACACCA
ACATATATATACCCACATGAGCCACTTCATAAAACAATGTTTCTCTTTACCTTAGCACCTCAAAATACCATGCCATTTAAAGCTTATTAA
AACTCATTTTTGTTTTCATTATCTCAAAACTGCACTGTCAAGATGATGATGATCTTTAAAATACACACTCAAATCAAGAAACTTAAGGTT
ACCTTTGTTCCCAAATTTCATACCTATCATCTTAAGTAGGGACTTCTGTCTTCACAACAGATTATTACCTTACAGAAGTTTGAATTATCC
GGTCGGGTTTTATTGTTTAAAATCATTTCTGCATCAGCTGCTGAAACAACAAATAGGAATTGTTTTTATGGAGGCTTTGCATAGATTCCC
TGAGCAGGATTTTAATCTTTTTCTAACTGGACTGGTTCAAATGTTGTTCTCTTCTTTAAAGGGATGGCAAGATGTGGGCAGTGATGTCAC
TAGGGCAGGGACAGGATAAGAGGGATTAGGGAGAGAAGATAGCAGGGCATGGCTGGGAACCCAAGTCCAAGCATACCAACACGAGCAGGC
TACTGTCAGCTCCCCTCGGAGAAGAGCTGTTCACAGCCAGACTGGCACAGTTTTCTGAGAAAGACTATTCAAACAGTCTCAGGAAATCAA
ATATGCAAAGCACTGACTTCTAAGTAAAACCACAGCAGTTGAAAAGACTCCAAAGAAATGTAAGGGAAACTGCCAGCAACGCAGGCCCCC
AGGTGCCAGTTATGGCTATAGGTGCTACAAAAACACAGCAAGGGTGATGGGAAAGCATTGTAAATGTGCTTTTAAAAAAAAATACTGATG
TTCCTAGTGAAAGAGGCAGCTTGAAACTGAGATGTGAACACATCAGCTTGCCCTGTTAAAAGATGAAAATATTTGTATCACAAATCTTAA
CTTGAAGGAGTCCTTGCATCAATTTTTCTTATTTCATTTCTTTGAGTGTCTTAATTAAAAGAATATTTTAACTTCCTTGGACTCATTTTA
AAAAATGGAACATAAAATACAATGTTATGTATTATTATTCCCATTCTACATACTATGGAATTTCTCCCAGTCATTTAATAAATGTGCCTT


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FusionGenePPI for PPP4R1_DPP4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PPP4R1PPP4C, DISC1, CEP63, MAP4, EHBP1L1, GPHN, HNRNPR, MTA2, POLR2A, POLR2C, SPTAN1, TRAF2, TRAF6, PPP2CB, PMPCB, AQR, NTRK1, XPO1, CTNND1, LDHB, NDUFB4, PPP2CA, PPP2R1A, PPP2R1B, CCDC6, MAP7, MED24, SEC61A1, FASTKD5, RALBP1, C1S, KIF1B, TRIM25DPP4CCL22, CARD11, BCL10, IKBKB, DKK1, FAP, ADA, EGFR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPP4R1_DPP4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneDPP4P27487DB01076AtorvastatinDipeptidyl peptidase 4small moleculeapproved
TgeneDPP4P27487DB06203AlogliptinDipeptidyl peptidase 4small moleculeapproved
TgeneDPP4P27487DB06335SaxagliptinDipeptidyl peptidase 4small moleculeapproved
TgeneDPP4P27487DB08882LinagliptinDipeptidyl peptidase 4small moleculeapproved
TgeneDPP4P27487DB01261SitagliptinDipeptidyl peptidase 4small moleculeapproved|investigational
TgeneDPP4P27487DB04876VildagliptinDipeptidyl peptidase 4small moleculeapproved|investigational

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RelatedDiseases for PPP4R1_DPP4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDPP4C0011570Mental Depression2PSYGENET
TgeneDPP4C0011581Depressive disorder2PSYGENET
TgeneDPP4C0033687Proteinuria1CTD_human