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Fusion gene ID: 28498 |
FusionGeneSummary for PPP4R1_DPP4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPP4R1_DPP4 | Fusion gene ID: 28498 | Hgene | Tgene | Gene symbol | PPP4R1 | DPP4 | Gene ID | 9989 | 1803 |
| Gene name | protein phosphatase 4 regulatory subunit 1 | dipeptidyl peptidase 4 | |
| Synonyms | MEG1|PP4(Rmeg)|PP4R1 | ADABP|ADCP2|CD26|DPPIV|TP103 | |
| Cytomap | 18p11.22 | 2q24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein phosphatase 4 regulatory subunit 1serine/threonine phosphatase 4 | dipeptidyl peptidase 4ADCP-2DPP IVT-cell activation antigen CD26adenosine deaminase complexing protein 2dipeptidyl peptidase IVdipeptidylpeptidase 4dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2) | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q8TF05 | P27487 | |
| Ensembl transtripts involved in fusion gene | ENST00000400556, ENST00000400555, ENST00000580583, | ENST00000360534, ENST00000491591, | |
| Fusion gene scores | * DoF score | 6 X 6 X 6=216 | 2 X 2 X 2=8 |
| # samples | 6 | 2 | |
| ** MAII score | log2(6/216*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: PPP4R1 [Title/Abstract] AND DPP4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | DPP4 | GO:0001666 | response to hypoxia | 16670267 |
| Tgene | DPP4 | GO:0006508 | proteolysis | 27198182 |
| Tgene | DPP4 | GO:0008284 | positive regulation of cell proliferation | 17549790 |
| Tgene | DPP4 | GO:0010716 | negative regulation of extracellular matrix disassembly | 16651416 |
| Tgene | DPP4 | GO:0031295 | T cell costimulation | 10900005|17287217 |
| Tgene | DPP4 | GO:0033632 | regulation of cell-cell adhesion mediated by integrin | 11772392 |
| Tgene | DPP4 | GO:0042110 | T cell activation | 7594462 |
| Tgene | DPP4 | GO:0043542 | endothelial cell migration | 16651416 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCEC | TCGA-EY-A3L3-01A | PPP4R1 | chr18 | 9561978 | - | DPP4 | chr2 | 162851882 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000400556 | ENST00000360534 | PPP4R1 | chr18 | 9561978 | - | DPP4 | chr2 | 162851882 | - |
| 5CDS-5UTR | ENST00000400556 | ENST00000491591 | PPP4R1 | chr18 | 9561978 | - | DPP4 | chr2 | 162851882 | - |
| In-frame | ENST00000400555 | ENST00000360534 | PPP4R1 | chr18 | 9561978 | - | DPP4 | chr2 | 162851882 | - |
| 5CDS-5UTR | ENST00000400555 | ENST00000491591 | PPP4R1 | chr18 | 9561978 | - | DPP4 | chr2 | 162851882 | - |
| intron-3CDS | ENST00000580583 | ENST00000360534 | PPP4R1 | chr18 | 9561978 | - | DPP4 | chr2 | 162851882 | - |
| intron-5UTR | ENST00000580583 | ENST00000491591 | PPP4R1 | chr18 | 9561978 | - | DPP4 | chr2 | 162851882 | - |
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FusionProtFeatures for PPP4R1_DPP4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPP4R1 | DPP4 |
| Regulatory subunit of serine/threonine-proteinphosphatase 4. May play a role in regulation of cell division inrenal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role indephosphorylation and regulation of HDAC3.{ECO:0000269|PubMed:15805470}. | Cell surface glycoprotein receptor involved in thecostimulatory signal essential for T-cell receptor (TCR)-mediatedT-cell activation. Acts as a positive regulator of T-cellcoactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Itsbinding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Itsinteraction with ADA also regulates lymphocyte-epithelial celladhesion. In association with FAP is involved in the pericellularproteolysis of the extracellular matrix (ECM), the migration andinvasion of endothelial cells into the ECM. May be involved in thepromotion of lymphatic endothelial cells adhesion, migration andtube formation. When overexpressed, enhanced cell proliferation, aprocess inhibited by GPC3. Acts also as a serine exopeptidase witha dipeptidyl peptidase activity that regulates variousphysiological processes by cleaving peptides in the circulation,including many chemokines, mitogenic growth factors, neuropeptidesand peptide hormones. Removes N-terminal dipeptides sequentiallyfrom polypeptides having unsubstituted N-termini provided that thepenultimate residue is proline. {ECO:0000269|PubMed:10570924,ECO:0000269|PubMed:10593948, ECO:0000269|PubMed:10900005,ECO:0000269|PubMed:10951221, ECO:0000269|PubMed:11772392,ECO:0000269|PubMed:14691230, ECO:0000269|PubMed:16651416,ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:17549790,ECO:0000269|PubMed:18708048}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PPP4R1 | chr18:9561978 | chr2:162851882 | ENST00000400555 | - | 13 | 20 | 127_164 | 597 | 934 | Repeat | Note=HEAT 5 |
| Hgene | PPP4R1 | chr18:9561978 | chr2:162851882 | ENST00000400555 | - | 13 | 20 | 168_206 | 597 | 934 | Repeat | Note=HEAT 6 |
| Hgene | PPP4R1 | chr18:9561978 | chr2:162851882 | ENST00000400555 | - | 13 | 20 | 1_25 | 597 | 934 | Repeat | Note=HEAT 1 |
| Hgene | PPP4R1 | chr18:9561978 | chr2:162851882 | ENST00000400555 | - | 13 | 20 | 208_246 | 597 | 934 | Repeat | Note=HEAT 7 |
| Hgene | PPP4R1 | chr18:9561978 | chr2:162851882 | ENST00000400555 | - | 13 | 20 | 248_285 | 597 | 934 | Repeat | Note=HEAT 8 |
| Hgene | PPP4R1 | chr18:9561978 | chr2:162851882 | ENST00000400555 | - | 13 | 20 | 26_63 | 597 | 934 | Repeat | Note=HEAT 2 |
| Hgene | PPP4R1 | chr18:9561978 | chr2:162851882 | ENST00000400555 | - | 13 | 20 | 287_324 | 597 | 934 | Repeat | Note=HEAT 9 |
| Hgene | PPP4R1 | chr18:9561978 | chr2:162851882 | ENST00000400555 | - | 13 | 20 | 505_542 | 597 | 934 | Repeat | Note=HEAT 10 |
| Hgene | PPP4R1 | chr18:9561978 | chr2:162851882 | ENST00000400555 | - | 13 | 20 | 65_81 | 597 | 934 | Repeat | Note=HEAT 3 |
| Hgene | PPP4R1 | chr18:9561978 | chr2:162851882 | ENST00000400555 | - | 13 | 20 | 82_119 | 597 | 934 | Repeat | Note=HEAT 4 |
| Hgene | PPP4R1 | chr18:9561978 | chr2:162851882 | ENST00000400556 | - | 13 | 20 | 127_164 | 614 | 951 | Repeat | Note=HEAT 5 |
| Hgene | PPP4R1 | chr18:9561978 | chr2:162851882 | ENST00000400556 | - | 13 | 20 | 168_206 | 614 | 951 | Repeat | Note=HEAT 6 |
| Hgene | PPP4R1 | chr18:9561978 | chr2:162851882 | ENST00000400556 | - | 13 | 20 | 1_25 | 614 | 951 | Repeat | Note=HEAT 1 |
| Hgene | PPP4R1 | chr18:9561978 | chr2:162851882 | ENST00000400556 | - | 13 | 20 | 208_246 | 614 | 951 | Repeat | Note=HEAT 7 |
| Hgene | PPP4R1 | chr18:9561978 | chr2:162851882 | ENST00000400556 | - | 13 | 20 | 248_285 | 614 | 951 | Repeat | Note=HEAT 8 |
| Hgene | PPP4R1 | chr18:9561978 | chr2:162851882 | ENST00000400556 | - | 13 | 20 | 26_63 | 614 | 951 | Repeat | Note=HEAT 2 |
| Hgene | PPP4R1 | chr18:9561978 | chr2:162851882 | ENST00000400556 | - | 13 | 20 | 287_324 | 614 | 951 | Repeat | Note=HEAT 9 |
| Hgene | PPP4R1 | chr18:9561978 | chr2:162851882 | ENST00000400556 | - | 13 | 20 | 505_542 | 614 | 951 | Repeat | Note=HEAT 10 |
| Hgene | PPP4R1 | chr18:9561978 | chr2:162851882 | ENST00000400556 | - | 13 | 20 | 568_606 | 614 | 951 | Repeat | Note=HEAT 11 |
| Hgene | PPP4R1 | chr18:9561978 | chr2:162851882 | ENST00000400556 | - | 13 | 20 | 65_81 | 614 | 951 | Repeat | Note=HEAT 3 |
| Hgene | PPP4R1 | chr18:9561978 | chr2:162851882 | ENST00000400556 | - | 13 | 20 | 82_119 | 614 | 951 | Repeat | Note=HEAT 4 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PPP4R1 | chr18:9561978 | chr2:162851882 | ENST00000400555 | - | 13 | 20 | 568_606 | 597 | 934 | Repeat | Note=HEAT 11 |
| Hgene | >PPP4R1 | chr18:9561978 | chr2:162851882 | ENST00000400555 | - | 13 | 20 | 698_734 | 597 | 934 | Repeat | Note=HEAT 12 |
| Hgene | >PPP4R1 | chr18:9561978 | chr2:162851882 | ENST00000400555 | - | 13 | 20 | 799_837 | 597 | 934 | Repeat | Note=HEAT 13 |
| Hgene | >PPP4R1 | chr18:9561978 | chr2:162851882 | ENST00000400555 | - | 13 | 20 | 861_898 | 597 | 934 | Repeat | Note=HEAT 14 |
| Hgene | >PPP4R1 | chr18:9561978 | chr2:162851882 | ENST00000400556 | - | 13 | 20 | 698_734 | 614 | 951 | Repeat | Note=HEAT 12 |
| Hgene | >PPP4R1 | chr18:9561978 | chr2:162851882 | ENST00000400556 | - | 13 | 20 | 799_837 | 614 | 951 | Repeat | Note=HEAT 13 |
| Hgene | >PPP4R1 | chr18:9561978 | chr2:162851882 | ENST00000400556 | - | 13 | 20 | 861_898 | 614 | 951 | Repeat | Note=HEAT 14 |
| Tgene | DPP4 | chr18:9561978 | chr2:162851882 | ENST00000360534 | - | 22 | 26 | 1_6 | 684 | 767 | Topological domain | Cytoplasmic |
| Tgene | DPP4 | chr18:9561978 | chr2:162851882 | ENST00000360534 | - | 22 | 26 | 29_766 | 684 | 767 | Topological domain | Extracellular |
| Tgene | DPP4 | chr18:9561978 | chr2:162851882 | ENST00000360534 | - | 22 | 26 | 7_28 | 684 | 767 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
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FusionGeneSequence for PPP4R1_DPP4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PPP4R1_ENST00000400556_chr18_9561978_-_DPP4_ENST00000360534_chr2_162851882_-_697aa MADLSLLQEDLQEDADGFGVDDYSSESDVIIIPSALDFVSQDEMLTPLGRLDKYAASENIFNRQMVARSLLDTLREVCDDERDCIAVLER ISRLADDSEPTVRAELMEQVPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDVETKVCPVLIEL TAPDSNDDVKTEAVAIMCKMAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVWGVRK ACAECFMAVSCATCQEIRRTKLSALFINLISDPSRWVRQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNRTRDQEAPEDVQ VRPEDTPSDLSVSNSSVILENTMEDHAAEASGKPLGEISVPLDSSLLCTLSSESHQEAASNENDKKPGNYKSMLRPEVGTTSQDSALLDQ ELYNSFHFWRTPLPEIDLDIELEQNSGGKPSPEGPEEESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEVLSAALRASSLD AHEETISIEKRSDLQDELDINELPNCKINQEDSVPLISDAVENMDSTLHYIHSDSDLSNNSSFSPDEERRTKVQNSTVMSRAENFKQVEY >In-frame_PPP4R1_ENST00000400555_chr18_9561978_-_DPP4_ENST00000360534_chr2_162851882_-_680aa MADLSLLQEDLQEDADGSLDFVSQDEMLTPLGRLDKYAASENIFNRQMVARSLLDTLREVCDDERDCIAVLERISRLADDSEPTVRAELM EQVPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDVETKVCPVLIELTAPDSNDDVKTEAVAIM CKMAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVWGVRKACAECFMAVSCATCQEI RRTKLSALFINLISDPSRWVRQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNRTRDQEAPEDVQVRPEDTPSDLSVSNSSV ILENTMEDHAAEASGKPLGEISVPLDSSLLCTLSSESHQEAASNENDKKPGNYKSMLRPEVGTTSQDSALLDQELYNSFHFWRTPLPEID LDIELEQNSGGKPSPEGPEEESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEVLSAALRASSLDAHEETISIEKRSDLQDE LDINELPNCKINQEDSVPLISDAVENMDSTLHYIHSDSDLSNNSSFSPDEERRTKVQNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PPP4R1_ENST00000400556_chr18_9561978_-_DPP4_ENST00000360534_chr2_162851882_-_2091nt ATGGCGGACCTCTCGCTGCTTCAGGAGGACCTGCAGGAGGACGCAGACGGATTTGGTGTGGATGACTACAGCTCAGAGTCTGATGTGATT ATTATACCTTCAGCCCTGGACTTTGTCTCACAAGATGAAATGTTGACGCCCCTGGGGAGATTGGACAAGTATGCTGCAAGTGAGAACATA TTTAACAGACAAATGGTGGCCCGGAGTTTGCTCGATACCTTGAGGGAAGTCTGCGATGATGAAAGAGATTGTATTGCTGTTTTGGAAAGA ATTAGCAGATTGGCCGATGATTCAGAACCAACTGTGAGAGCGGAGCTGATGGAACAGGTGCCTCACATCGCACTGTTTTGTCAAGAAAAC CGGCCTTCAATACCATATGCTTTTTCAAAATTCTTACTACCTATTGTGGTTAGATACCTTGCAGATCAGAATAATCAGGTGAGGAAAACA AGTCAGGCAGCTTTGCTGGCTCTGTTGGAGCAGGAGCTCATTGAACGATTTGATGTGGAGACCAAAGTGTGCCCTGTCCTCATAGAGCTG ACAGCCCCAGATAGCAATGATGATGTGAAAACAGAAGCTGTGGCTATAATGTGCAAAATGGCTCCCATGGTTGGGAAGGATATTACAGAG CGTCTTATCCTCCCTAGGTTTTGTGAGATGTGCTGCGATTGCAGAATGTTTCACGTTCGAAAGGTCTGTGCTGCCAATTTTGGAGATATT TGCAGTGTAGTTGGCCAGCAAGCTACTGAAGAAATGTTGCTGCCCAGATTTTTCCAGCTTTGTTCTGATAATGTATGGGGAGTCCGAAAG GCTTGTGCTGAATGCTTCATGGCGGTTTCATGTGCAACATGTCAAGAAATCCGACGGACCAAATTATCAGCACTTTTTATTAATTTGATC AGTGATCCTTCACGTTGGGTTCGCCAAGCAGCTTTTCAGTCTCTGGGACCTTTCATATCTACTTTTGCTAATCCATCTAGCTCAGGCCAG TATTTTAAAGAAGAAAGCAAAAGTTCAGAAGAGATGTCAGTAGAAAACAAAAATAGGACCAGAGATCAAGAAGCCCCAGAGGATGTACAA GTCAGGCCAGAGGATACTCCTTCAGATCTCAGTGTTAGTAATTCCAGTGTCATACTGGAAAACACGATGGAAGACCATGCTGCTGAGGCA TCCGGGAAGCCTCTAGGTGAAATTAGTGTTCCACTGGACAGCTCTTTACTTTGTACTTTGTCCTCAGAATCTCACCAGGAAGCAGCTAGT AATGAGAATGATAAAAAACCTGGTAACTACAAATCTATGTTACGACCAGAGGTTGGCACCACTTCACAAGATTCAGCTCTCTTAGATCAG GAATTGTATAACTCCTTCCATTTCTGGAGGACTCCTCTTCCTGAAATAGATCTAGACATAGAGCTTGAACAGAACTCTGGGGGAAAACCC AGCCCAGAGGGACCAGAGGAAGAATCTGAGGGCCCTGTGCCCAGTTCTCCAAACATCACCATGGCCACCAGAAAGGAACTGGAAGAAATG ATAGAAAATCTAGAGCCCCACATTGATGATCCAGATGTTAAAGCACAAGTGGAAGTGCTGTCCGCTGCACTACGTGCTTCCAGCCTGGAT GCACATGAAGAGACCATCAGTATAGAAAAGAGAAGTGATTTGCAAGATGAACTGGATATAAATGAGCTACCAAATTGTAAAATAAATCAA GAAGATTCTGTGCCTTTAATCAGCGATGCTGTTGAGAATATGGACTCCACTCTTCACTATATTCACAGCGATTCAGACTTGAGCAACAAT AGCAGTTTTAGCCCTGATGAGGAAAGGAGAACTAAAGTACAAAATTCAACAGTCATGAGCAGAGCTGAAAATTTTAAACAAGTTGAGTAC CTCCTTATTCATGGAACAGCAGATGATAACGTTCACTTTCAGCAGTCAGCTCAGATCTCCAAAGCCCTGGTCGATGTTGGAGTGGATTTC CAGGCAATGTGGTATACTGATGAAGACCATGGAATAGCTAGCAGCACAGCACACCAACATATATATACCCACATGAGCCACTTCATAAAA >In-frame_PPP4R1_ENST00000400555_chr18_9561978_-_DPP4_ENST00000360534_chr2_162851882_-_2040nt ATGGCGGACCTCTCGCTGCTTCAGGAGGACCTGCAGGAGGACGCAGACGGATCCCTGGACTTTGTCTCACAAGATGAAATGTTGACGCCC CTGGGGAGATTGGACAAGTATGCTGCAAGTGAGAACATATTTAACAGACAAATGGTGGCCCGGAGTTTGCTCGATACCTTGAGGGAAGTC TGCGATGATGAAAGAGATTGTATTGCTGTTTTGGAAAGAATTAGCAGATTGGCCGATGATTCAGAACCAACTGTGAGAGCGGAGCTGATG GAACAGGTGCCTCACATCGCACTGTTTTGTCAAGAAAACCGGCCTTCAATACCATATGCTTTTTCAAAATTCTTACTACCTATTGTGGTT AGATACCTTGCAGATCAGAATAATCAGGTGAGGAAAACAAGTCAGGCAGCTTTGCTGGCTCTGTTGGAGCAGGAGCTCATTGAACGATTT GATGTGGAGACCAAAGTGTGCCCTGTCCTCATAGAGCTGACAGCCCCAGATAGCAATGATGATGTGAAAACAGAAGCTGTGGCTATAATG TGCAAAATGGCTCCCATGGTTGGGAAGGATATTACAGAGCGTCTTATCCTCCCTAGGTTTTGTGAGATGTGCTGCGATTGCAGAATGTTT CACGTTCGAAAGGTCTGTGCTGCCAATTTTGGAGATATTTGCAGTGTAGTTGGCCAGCAAGCTACTGAAGAAATGTTGCTGCCCAGATTT TTCCAGCTTTGTTCTGATAATGTATGGGGAGTCCGAAAGGCTTGTGCTGAATGCTTCATGGCGGTTTCATGTGCAACATGTCAAGAAATC CGACGGACCAAATTATCAGCACTTTTTATTAATTTGATCAGTGATCCTTCACGTTGGGTTCGCCAAGCAGCTTTTCAGTCTCTGGGACCT TTCATATCTACTTTTGCTAATCCATCTAGCTCAGGCCAGTATTTTAAAGAAGAAAGCAAAAGTTCAGAAGAGATGTCAGTAGAAAACAAA AATAGGACCAGAGATCAAGAAGCCCCAGAGGATGTACAAGTCAGGCCAGAGGATACTCCTTCAGATCTCAGTGTTAGTAATTCCAGTGTC ATACTGGAAAACACGATGGAAGACCATGCTGCTGAGGCATCCGGGAAGCCTCTAGGTGAAATTAGTGTTCCACTGGACAGCTCTTTACTT TGTACTTTGTCCTCAGAATCTCACCAGGAAGCAGCTAGTAATGAGAATGATAAAAAACCTGGTAACTACAAATCTATGTTACGACCAGAG GTTGGCACCACTTCACAAGATTCAGCTCTCTTAGATCAGGAATTGTATAACTCCTTCCATTTCTGGAGGACTCCTCTTCCTGAAATAGAT CTAGACATAGAGCTTGAACAGAACTCTGGGGGAAAACCCAGCCCAGAGGGACCAGAGGAAGAATCTGAGGGCCCTGTGCCCAGTTCTCCA AACATCACCATGGCCACCAGAAAGGAACTGGAAGAAATGATAGAAAATCTAGAGCCCCACATTGATGATCCAGATGTTAAAGCACAAGTG GAAGTGCTGTCCGCTGCACTACGTGCTTCCAGCCTGGATGCACATGAAGAGACCATCAGTATAGAAAAGAGAAGTGATTTGCAAGATGAA CTGGATATAAATGAGCTACCAAATTGTAAAATAAATCAAGAAGATTCTGTGCCTTTAATCAGCGATGCTGTTGAGAATATGGACTCCACT CTTCACTATATTCACAGCGATTCAGACTTGAGCAACAATAGCAGTTTTAGCCCTGATGAGGAAAGGAGAACTAAAGTACAAAATTCAACA GTCATGAGCAGAGCTGAAAATTTTAAACAAGTTGAGTACCTCCTTATTCATGGAACAGCAGATGATAACGTTCACTTTCAGCAGTCAGCT CAGATCTCCAAAGCCCTGGTCGATGTTGGAGTGGATTTCCAGGCAATGTGGTATACTGATGAAGACCATGGAATAGCTAGCAGCACAGCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PPP4R1_ENST00000400556_chr18_9561978_-_DPP4_ENST00000360534_chr2_162851882_-_3207nt CCGGCTCCCCGGCTCGCGCCGCTCCATGTAGCCCCGGCTCCCCGGGCGGCCGCGGAGGAGGGGGCGACCACAAGATGGCGGACCTCTCGC TGCTTCAGGAGGACCTGCAGGAGGACGCAGACGGATTTGGTGTGGATGACTACAGCTCAGAGTCTGATGTGATTATTATACCTTCAGCCC TGGACTTTGTCTCACAAGATGAAATGTTGACGCCCCTGGGGAGATTGGACAAGTATGCTGCAAGTGAGAACATATTTAACAGACAAATGG TGGCCCGGAGTTTGCTCGATACCTTGAGGGAAGTCTGCGATGATGAAAGAGATTGTATTGCTGTTTTGGAAAGAATTAGCAGATTGGCCG ATGATTCAGAACCAACTGTGAGAGCGGAGCTGATGGAACAGGTGCCTCACATCGCACTGTTTTGTCAAGAAAACCGGCCTTCAATACCAT ATGCTTTTTCAAAATTCTTACTACCTATTGTGGTTAGATACCTTGCAGATCAGAATAATCAGGTGAGGAAAACAAGTCAGGCAGCTTTGC TGGCTCTGTTGGAGCAGGAGCTCATTGAACGATTTGATGTGGAGACCAAAGTGTGCCCTGTCCTCATAGAGCTGACAGCCCCAGATAGCA ATGATGATGTGAAAACAGAAGCTGTGGCTATAATGTGCAAAATGGCTCCCATGGTTGGGAAGGATATTACAGAGCGTCTTATCCTCCCTA GGTTTTGTGAGATGTGCTGCGATTGCAGAATGTTTCACGTTCGAAAGGTCTGTGCTGCCAATTTTGGAGATATTTGCAGTGTAGTTGGCC AGCAAGCTACTGAAGAAATGTTGCTGCCCAGATTTTTCCAGCTTTGTTCTGATAATGTATGGGGAGTCCGAAAGGCTTGTGCTGAATGCT TCATGGCGGTTTCATGTGCAACATGTCAAGAAATCCGACGGACCAAATTATCAGCACTTTTTATTAATTTGATCAGTGATCCTTCACGTT GGGTTCGCCAAGCAGCTTTTCAGTCTCTGGGACCTTTCATATCTACTTTTGCTAATCCATCTAGCTCAGGCCAGTATTTTAAAGAAGAAA GCAAAAGTTCAGAAGAGATGTCAGTAGAAAACAAAAATAGGACCAGAGATCAAGAAGCCCCAGAGGATGTACAAGTCAGGCCAGAGGATA CTCCTTCAGATCTCAGTGTTAGTAATTCCAGTGTCATACTGGAAAACACGATGGAAGACCATGCTGCTGAGGCATCCGGGAAGCCTCTAG GTGAAATTAGTGTTCCACTGGACAGCTCTTTACTTTGTACTTTGTCCTCAGAATCTCACCAGGAAGCAGCTAGTAATGAGAATGATAAAA AACCTGGTAACTACAAATCTATGTTACGACCAGAGGTTGGCACCACTTCACAAGATTCAGCTCTCTTAGATCAGGAATTGTATAACTCCT TCCATTTCTGGAGGACTCCTCTTCCTGAAATAGATCTAGACATAGAGCTTGAACAGAACTCTGGGGGAAAACCCAGCCCAGAGGGACCAG AGGAAGAATCTGAGGGCCCTGTGCCCAGTTCTCCAAACATCACCATGGCCACCAGAAAGGAACTGGAAGAAATGATAGAAAATCTAGAGC CCCACATTGATGATCCAGATGTTAAAGCACAAGTGGAAGTGCTGTCCGCTGCACTACGTGCTTCCAGCCTGGATGCACATGAAGAGACCA TCAGTATAGAAAAGAGAAGTGATTTGCAAGATGAACTGGATATAAATGAGCTACCAAATTGTAAAATAAATCAAGAAGATTCTGTGCCTT TAATCAGCGATGCTGTTGAGAATATGGACTCCACTCTTCACTATATTCACAGCGATTCAGACTTGAGCAACAATAGCAGTTTTAGCCCTG ATGAGGAAAGGAGAACTAAAGTACAAAATTCAACAGTCATGAGCAGAGCTGAAAATTTTAAACAAGTTGAGTACCTCCTTATTCATGGAA CAGCAGATGATAACGTTCACTTTCAGCAGTCAGCTCAGATCTCCAAAGCCCTGGTCGATGTTGGAGTGGATTTCCAGGCAATGTGGTATA CTGATGAAGACCATGGAATAGCTAGCAGCACAGCACACCAACATATATATACCCACATGAGCCACTTCATAAAACAATGTTTCTCTTTAC CTTAGCACCTCAAAATACCATGCCATTTAAAGCTTATTAAAACTCATTTTTGTTTTCATTATCTCAAAACTGCACTGTCAAGATGATGAT GATCTTTAAAATACACACTCAAATCAAGAAACTTAAGGTTACCTTTGTTCCCAAATTTCATACCTATCATCTTAAGTAGGGACTTCTGTC TTCACAACAGATTATTACCTTACAGAAGTTTGAATTATCCGGTCGGGTTTTATTGTTTAAAATCATTTCTGCATCAGCTGCTGAAACAAC AAATAGGAATTGTTTTTATGGAGGCTTTGCATAGATTCCCTGAGCAGGATTTTAATCTTTTTCTAACTGGACTGGTTCAAATGTTGTTCT CTTCTTTAAAGGGATGGCAAGATGTGGGCAGTGATGTCACTAGGGCAGGGACAGGATAAGAGGGATTAGGGAGAGAAGATAGCAGGGCAT GGCTGGGAACCCAAGTCCAAGCATACCAACACGAGCAGGCTACTGTCAGCTCCCCTCGGAGAAGAGCTGTTCACAGCCAGACTGGCACAG TTTTCTGAGAAAGACTATTCAAACAGTCTCAGGAAATCAAATATGCAAAGCACTGACTTCTAAGTAAAACCACAGCAGTTGAAAAGACTC CAAAGAAATGTAAGGGAAACTGCCAGCAACGCAGGCCCCCAGGTGCCAGTTATGGCTATAGGTGCTACAAAAACACAGCAAGGGTGATGG GAAAGCATTGTAAATGTGCTTTTAAAAAAAAATACTGATGTTCCTAGTGAAAGAGGCAGCTTGAAACTGAGATGTGAACACATCAGCTTG CCCTGTTAAAAGATGAAAATATTTGTATCACAAATCTTAACTTGAAGGAGTCCTTGCATCAATTTTTCTTATTTCATTTCTTTGAGTGTC TTAATTAAAAGAATATTTTAACTTCCTTGGACTCATTTTAAAAAATGGAACATAAAATACAATGTTATGTATTATTATTCCCATTCTACA >In-frame_PPP4R1_ENST00000400555_chr18_9561978_-_DPP4_ENST00000360534_chr2_162851882_-_3167nt GCGCGCGTCCACCGGCTCCCCGGCTCGCGCCGCTCCATGTAGCCCCGGCTCCCCGGGCGGCCGCGGAGGAGGGGGCGACCACAAGATGGC GGACCTCTCGCTGCTTCAGGAGGACCTGCAGGAGGACGCAGACGGATCCCTGGACTTTGTCTCACAAGATGAAATGTTGACGCCCCTGGG GAGATTGGACAAGTATGCTGCAAGTGAGAACATATTTAACAGACAAATGGTGGCCCGGAGTTTGCTCGATACCTTGAGGGAAGTCTGCGA TGATGAAAGAGATTGTATTGCTGTTTTGGAAAGAATTAGCAGATTGGCCGATGATTCAGAACCAACTGTGAGAGCGGAGCTGATGGAACA GGTGCCTCACATCGCACTGTTTTGTCAAGAAAACCGGCCTTCAATACCATATGCTTTTTCAAAATTCTTACTACCTATTGTGGTTAGATA CCTTGCAGATCAGAATAATCAGGTGAGGAAAACAAGTCAGGCAGCTTTGCTGGCTCTGTTGGAGCAGGAGCTCATTGAACGATTTGATGT GGAGACCAAAGTGTGCCCTGTCCTCATAGAGCTGACAGCCCCAGATAGCAATGATGATGTGAAAACAGAAGCTGTGGCTATAATGTGCAA AATGGCTCCCATGGTTGGGAAGGATATTACAGAGCGTCTTATCCTCCCTAGGTTTTGTGAGATGTGCTGCGATTGCAGAATGTTTCACGT TCGAAAGGTCTGTGCTGCCAATTTTGGAGATATTTGCAGTGTAGTTGGCCAGCAAGCTACTGAAGAAATGTTGCTGCCCAGATTTTTCCA GCTTTGTTCTGATAATGTATGGGGAGTCCGAAAGGCTTGTGCTGAATGCTTCATGGCGGTTTCATGTGCAACATGTCAAGAAATCCGACG GACCAAATTATCAGCACTTTTTATTAATTTGATCAGTGATCCTTCACGTTGGGTTCGCCAAGCAGCTTTTCAGTCTCTGGGACCTTTCAT ATCTACTTTTGCTAATCCATCTAGCTCAGGCCAGTATTTTAAAGAAGAAAGCAAAAGTTCAGAAGAGATGTCAGTAGAAAACAAAAATAG GACCAGAGATCAAGAAGCCCCAGAGGATGTACAAGTCAGGCCAGAGGATACTCCTTCAGATCTCAGTGTTAGTAATTCCAGTGTCATACT GGAAAACACGATGGAAGACCATGCTGCTGAGGCATCCGGGAAGCCTCTAGGTGAAATTAGTGTTCCACTGGACAGCTCTTTACTTTGTAC TTTGTCCTCAGAATCTCACCAGGAAGCAGCTAGTAATGAGAATGATAAAAAACCTGGTAACTACAAATCTATGTTACGACCAGAGGTTGG CACCACTTCACAAGATTCAGCTCTCTTAGATCAGGAATTGTATAACTCCTTCCATTTCTGGAGGACTCCTCTTCCTGAAATAGATCTAGA CATAGAGCTTGAACAGAACTCTGGGGGAAAACCCAGCCCAGAGGGACCAGAGGAAGAATCTGAGGGCCCTGTGCCCAGTTCTCCAAACAT CACCATGGCCACCAGAAAGGAACTGGAAGAAATGATAGAAAATCTAGAGCCCCACATTGATGATCCAGATGTTAAAGCACAAGTGGAAGT GCTGTCCGCTGCACTACGTGCTTCCAGCCTGGATGCACATGAAGAGACCATCAGTATAGAAAAGAGAAGTGATTTGCAAGATGAACTGGA TATAAATGAGCTACCAAATTGTAAAATAAATCAAGAAGATTCTGTGCCTTTAATCAGCGATGCTGTTGAGAATATGGACTCCACTCTTCA CTATATTCACAGCGATTCAGACTTGAGCAACAATAGCAGTTTTAGCCCTGATGAGGAAAGGAGAACTAAAGTACAAAATTCAACAGTCAT GAGCAGAGCTGAAAATTTTAAACAAGTTGAGTACCTCCTTATTCATGGAACAGCAGATGATAACGTTCACTTTCAGCAGTCAGCTCAGAT CTCCAAAGCCCTGGTCGATGTTGGAGTGGATTTCCAGGCAATGTGGTATACTGATGAAGACCATGGAATAGCTAGCAGCACAGCACACCA ACATATATATACCCACATGAGCCACTTCATAAAACAATGTTTCTCTTTACCTTAGCACCTCAAAATACCATGCCATTTAAAGCTTATTAA AACTCATTTTTGTTTTCATTATCTCAAAACTGCACTGTCAAGATGATGATGATCTTTAAAATACACACTCAAATCAAGAAACTTAAGGTT ACCTTTGTTCCCAAATTTCATACCTATCATCTTAAGTAGGGACTTCTGTCTTCACAACAGATTATTACCTTACAGAAGTTTGAATTATCC GGTCGGGTTTTATTGTTTAAAATCATTTCTGCATCAGCTGCTGAAACAACAAATAGGAATTGTTTTTATGGAGGCTTTGCATAGATTCCC TGAGCAGGATTTTAATCTTTTTCTAACTGGACTGGTTCAAATGTTGTTCTCTTCTTTAAAGGGATGGCAAGATGTGGGCAGTGATGTCAC TAGGGCAGGGACAGGATAAGAGGGATTAGGGAGAGAAGATAGCAGGGCATGGCTGGGAACCCAAGTCCAAGCATACCAACACGAGCAGGC TACTGTCAGCTCCCCTCGGAGAAGAGCTGTTCACAGCCAGACTGGCACAGTTTTCTGAGAAAGACTATTCAAACAGTCTCAGGAAATCAA ATATGCAAAGCACTGACTTCTAAGTAAAACCACAGCAGTTGAAAAGACTCCAAAGAAATGTAAGGGAAACTGCCAGCAACGCAGGCCCCC AGGTGCCAGTTATGGCTATAGGTGCTACAAAAACACAGCAAGGGTGATGGGAAAGCATTGTAAATGTGCTTTTAAAAAAAAATACTGATG TTCCTAGTGAAAGAGGCAGCTTGAAACTGAGATGTGAACACATCAGCTTGCCCTGTTAAAAGATGAAAATATTTGTATCACAAATCTTAA CTTGAAGGAGTCCTTGCATCAATTTTTCTTATTTCATTTCTTTGAGTGTCTTAATTAAAAGAATATTTTAACTTCCTTGGACTCATTTTA AAAAATGGAACATAAAATACAATGTTATGTATTATTATTCCCATTCTACATACTATGGAATTTCTCCCAGTCATTTAATAAATGTGCCTT |
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FusionGenePPI for PPP4R1_DPP4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PPP4R1 | PPP4C, DISC1, CEP63, MAP4, EHBP1L1, GPHN, HNRNPR, MTA2, POLR2A, POLR2C, SPTAN1, TRAF2, TRAF6, PPP2CB, PMPCB, AQR, NTRK1, XPO1, CTNND1, LDHB, NDUFB4, PPP2CA, PPP2R1A, PPP2R1B, CCDC6, MAP7, MED24, SEC61A1, FASTKD5, RALBP1, C1S, KIF1B, TRIM25 | DPP4 | CCL22, CARD11, BCL10, IKBKB, DKK1, FAP, ADA, EGFR |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PPP4R1_DPP4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | DPP4 | P27487 | DB01076 | Atorvastatin | Dipeptidyl peptidase 4 | small molecule | approved |
| Tgene | DPP4 | P27487 | DB06203 | Alogliptin | Dipeptidyl peptidase 4 | small molecule | approved |
| Tgene | DPP4 | P27487 | DB06335 | Saxagliptin | Dipeptidyl peptidase 4 | small molecule | approved |
| Tgene | DPP4 | P27487 | DB08882 | Linagliptin | Dipeptidyl peptidase 4 | small molecule | approved |
| Tgene | DPP4 | P27487 | DB01261 | Sitagliptin | Dipeptidyl peptidase 4 | small molecule | approved|investigational |
| Tgene | DPP4 | P27487 | DB04876 | Vildagliptin | Dipeptidyl peptidase 4 | small molecule | approved|investigational |
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RelatedDiseases for PPP4R1_DPP4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | DPP4 | C0011570 | Mental Depression | 2 | PSYGENET |
| Tgene | DPP4 | C0011581 | Depressive disorder | 2 | PSYGENET |
| Tgene | DPP4 | C0033687 | Proteinuria | 1 | CTD_human |
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